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Home Other Building Blocks 477845-12-8
477845-12-8,MFCD00663768
Catalog No.:AA006Z5E

477845-12-8 | PIM-1 Inhibitor 2

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$46.00   $32.00
- +
5mg
≥98%
in stock  
$156.00   $109.00
- +
10mg
≥98%
in stock  
$219.00   $153.00
- +
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA006Z5E
Chemical Name:
PIM-1 Inhibitor 2
CAS Number:
477845-12-8
Molecular Formula:
C17H11ClN4O
Molecular Weight:
322.7484
MDL Number:
MFCD00663768
SMILES:
Clc1ccc(cc1)c1onc2c1cc(cc2)c1ccnc(n1)N
Properties
Computed Properties
 
Complexity:
404  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
2  
XLogP3:
3.6  

Literature

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Hit to lead account of the discovery of a new class of inhibitors of Pim kinases and crystallographic studies revealing an unusual kinase binding mode.

Journal: Journal of medicinal chemistry 20090409

Title: Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.

Journal: Journal of medicinal chemistry 20090108

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