[1]OrganicLetters,2010,vol.12,#14,p.3140-3143
[1]Tetrahedron,2004,vol.60,#50,p.11571-11586
[2]Tetrahedron,2004,vol.60,#50,p.11571-11586
[3]Tetrahedron,2004,vol.60,#50,p.11571-11586
[1]Tetrahedron,2004,vol.60,#50,p.11571-11586
[1]Tetrahedron,2004,vol.60,#50,p.11571-11586
[1]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
[2]CurrentPatentAssignee:ELANCOANIMALHEALTHINC-US6291523,2001,B1
[1]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
[1]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
[1]Tetrahedron,2004,vol.60,p.11571-11586
[1]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
[2]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
[3]Acemoglu,Murat;Allmendinger,Thomas;Calienni,John;Cercus,Jacques;Loiseleur,Olivier;Sedelmeier,GottfriedH.;Xu,David[Tetrahedron,2004,vol.60,#50,p.11571-11586]
Title: Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.
Journal: Journal of applied toxicology : JAT 20160101
Title: A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20140101
Title: Semi-mechanistic modeling of the interaction between the central and peripheral effects in the antinociceptive response to lumiracoxib in rats.
Journal: The AAPS journal 20121201
Title: Effect of nonsteroidal antiinflammatory drugs on the C-reactive protein level in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Journal: Arthritis and rheumatism 20121101
Title: Designing multitarget anti-inflammatory agents: chemical modulation of the lumiracoxib structure toward dual thromboxane antagonists-COX-2 inhibitors.
Journal: ChemMedChem 20120901
Title: Role of ATP-sensitive K+ channels in the antinociception induced by non-steroidal anti-inflammatory drugs in streptozotocin-diabetic and non-diabetic rats.
Journal: Pharmacology, biochemistry, and behavior 20120701
Title: Severe acute liver injury associated with lumiracoxib.
Journal: Journal of gastroenterology and hepatology 20120601
Title: A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity.
Journal: Rheumatology international 20120601
Title: Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
Journal: Journal of molecular histology 20120601
Title: Lessons from Lumiracoxib: are cyclooxygenase-2 inhibitors less hepatotoxic than non-selective non-steroidal anti-inflammatory drugs?
Journal: Journal of gastroenterology and hepatology 20120601
Title: How informative is a negative finding in a small pharmacogenetic study?
Journal: The pharmacogenomics journal 20120401
Title: Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.
Journal: Journal of medicinal chemistry 20120308
Title: Double-blind randomized trials of single-tablet ibuprofen/high-dose famotidine vs. ibuprofen alone for reduction of gastric and duodenal ulcers.
Journal: The American journal of gastroenterology 20120301
Title: Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer's disease.
Journal: The Cochrane database of systematic reviews 20120215
Title: A comparison of the therapeutic efficacy of diclofenac in osteoarthritis: a systematic review of randomised controlled trials.
Journal: Current medical research and opinion 20120101
Title: Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial.
Journal: PloS one 20120101
Title: Non-steroidal anti-inflammatory drugs for the treatment of pain and immobility-associated osteoarthritis: consensus guidance for primary care.
Journal: BMC family practice 20120101
Title: Efficacy of etoricoxib, celecoxib, lumiracoxib, non-selective NSAIDs, and acetaminophen in osteoarthritis: a mixed treatment comparison.
Journal: The open rheumatology journal 20120101
Title: Genetics and the potential for predictive tests in adverse drug reactions.
Journal: Chemical immunology and allergy 20120101
Title: Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
Journal: Drugs 20111224
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: A 13-week, multicenter, randomized, double-blind study of lumiracoxib in hip osteoarthritis.
Journal: Clinical rheumatology 20111101
Title: Haemoglobin decreases in NSAID users over time: an analysis of two large outcome trials.
Journal: Alimentary pharmacology & therapeutics 20111001
Title: Cardiovascular risk with non-steroidal anti-inflammatory drugs: systematic review of population-based controlled observational studies.
Journal: PLoS medicine 20110901
Title: Prevention of NSAID-associated gastroduodenal injury in healthy volunteers-a randomized, double-blind, multicenter study comparing DA-9601 with misoprostol.
Journal: Journal of Korean medical science 20110801
Title: Defects in mouse nephrogenesis induced by selective and non-selective cyclooxygenase-2 inhibitors.
Journal: British journal of pharmacology 20110701
Title: Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20110601
Title: Mechanisms of drug-induced liver injury: from bedside to bench.
Journal: Nature reviews. Gastroenterology & hepatology 20110401
Title: Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.
Journal: British journal of pharmacology 20110101
Title: Cardiovascular safety of non-steroidal anti-inflammatory drugs: network meta-analysis.
Journal: BMJ (Clinical research ed.) 20110101
Title: NSAID use selectively increases the risk of non-fatal myocardial infarction: a systematic review of randomised trials and observational studies.
Journal: PloS one 20110101
Title: Common secondary causes of resistant hypertension and rational for treatment.
Journal: International journal of hypertension 20110101
Title: A double-blind, randomized clinical trial assessing the effects of a single dose of preemptive anti-inflammatory treatment in orthodontic pain.
Journal: Progress in orthodontics 20110101
Title: Etoricoxibium picrate.
Journal: Acta crystallographica. Section E, Structure reports online 20110101
Title: Prostacyclin: an inflammatory paradox.
Journal: Frontiers in pharmacology 20110101
Title: Safety aspects and rational use of a naproxen + esomeprazole combination in the treatment of rheumatoid disease.
Journal: Drug, healthcare and patient safety 20110101
Title: Skeletal muscle protein metabolism in the elderly: Interventions to counteract the 'anabolic resistance' of ageing.
Journal: Nutrition & metabolism 20110101
Title: Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous ADR reporting.
Journal: PloS one 20110101
Title: Lumiracoxib for acute postoperative dental pain: a systematic review of randomized clinical trials.
Journal: Sao Paulo medical journal = Revista paulista de medicina 20110101
Title: Efficacy and Safety of COX-2 Inhibitors in the Clinical Management of Arthritis: Mini Review.
Journal: ISRN pharmacology 20110101
Title: Paracetamol and the placebo effect in osteoarthritis trials: a missing link?
Journal: Pain research and treatment 20110101
Title: An observational study of the discrediting of COX-2 NSAIDs in Australia: Vioxx or class effect?
Journal: BMC public health 20110101
Title: A predictive ligand-based Bayesian model for human drug-induced liver injury.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20101201
Title: Treatment of experimental periodontal disease by a selective inhibitor of cyclooxygenase-2 with scaling and root planing (SRP).
Journal: Inflammopharmacology 20101201
Title: Synthesis, characterization and pharmacological evaluation of 1-(2-chloro-6-fluorophenyl)-5-methylindolin-2-one: a new anti-inflammatory compound with reduced gastric ulceration properties.
Journal: Molecules (Basel, Switzerland) 20101108
Title: Is the sulphonamide radical in the celecoxib molecule essential for its analgesic activity?
Journal: Pharmacological research 20101101
Title: Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.
Journal: Protoplasma 20101001
Title: Selective cyclooxygenase-2 silencing mediated by engineered E. coli and RNA interference induces anti-tumour effects in human colon cancer cells.
Journal: British journal of cancer 20100928
Title: Do the blood pressure effects of nonsteroidal antiinflammatory drugs influence cardiovascular morbidity and mortality?
Journal: Current hypertension reports 20100801
Title: A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury.
Journal: Nature genetics 20100801
Title: Cardiovascular safety of celecoxib on top of dual antiplatelet therapy.
Journal: Korean circulation journal 20100701
Title: Prostaglandin modulation of airway inflammation and hyperresponsiveness in mice sensitized without adjuvant.
Journal: Prostaglandins & other lipid mediators 20100601
Title: A novel transdermal delivery system for the anti-inflammatory lumiracoxib: influence of oleic acid on in vitro percutaneous absorption and in vivo potential cutaneous irritation.
Journal: AAPS PharmSciTech 20100601
Title: The effects of lumiracoxib 100 mg once daily vs. ibuprofen 600 mg three times daily on the blood pressure profiles of hypertensive osteoarthritis patients taking different classes of antihypertensive agents.
Journal: International journal of clinical practice 20100501
Title: Dual COXIB/TP antagonists: a possible new twist in NSAID pharmacology and cardiovascular risk.
Journal: Trends in pharmacological sciences 20100301
Title: Liquid chromatographic determination of lumiracoxib in pharmaceutical formulations.
Journal: Journal of pharmaceutical and biomedical analysis 20100205
Title: Assessment of zymosan-induced leukocyte influx in a rat model using sulfated polysaccharides.
Journal: Planta medica 20100201
Title: Influence of cyclooxygenase inhibitors on the function of the prostaglandin transporter organic anion-transporting polypeptide 2A1 expressed in human gastroduodenal mucosa.
Journal: The Journal of pharmacology and experimental therapeutics 20100201
Title: Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20100201
Title: Pharmacokinetic-pharmacodynamic modelling of the analgesic effects of lumiracoxib, a selective inhibitor of cyclooxygenase-2, in rats.
Journal: British journal of pharmacology 20100101
Title: Progress in COX-2 inhibitors: a journey so far.
Journal: Current medicinal chemistry 20100101
Title: The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies.
Journal: International journal of cell biology 20100101
Title: Design of group IIA secreted/synovial phospholipase A(2) inhibitors: an oxadiazolone derivative suppresses chondrocyte prostaglandin E(2) secretion.
Journal: PloS one 20100101
Title: Single dose oral lumiracoxib for postoperative pain in adults.
Journal: The Cochrane database of systematic reviews 20100101
Title: Influence of oleic acid on the rheology and in vitro release of lumiracoxib from poloxamer gels.
Journal: Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20100101
Title: Pharmacogenetics and pharmacogenomics: practical applications in routine medical practice.
Journal: Genome medicine 20100101
Title: Inhibitory effect of selective cyclooxygenase-2 inhibitor lumiracoxib on human organic anion transporters hOAT1 and hOAT3.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Comparing etoricoxib and celecoxib for preemptive analgesia for acute postoperative pain in patients undergoing arthroscopic anterior cruciate ligament reconstruction: a randomized controlled trial.
Journal: BMC musculoskeletal disorders 20100101
Title: Behavioral, medical imaging and histopathological features of a new rat model of bone cancer pain.
Journal: PloS one 20100101
Title: Optimal management of chronic cyclical pelvic pain: an evidence-based and pragmatic approach.
Journal: International journal of women's health 20100101
Title: Investigational pharmacology for low back pain.
Journal: Journal of pain research 20100101
Title: Do COX-2 inhibitors raise blood pressure more than nonselective NSAIDs and placebo? An updated meta-analysis.
Journal: Journal of hypertension 20091201
Title: A comparison of cost effectiveness using data from randomized trials or actual clinical practice: selective cox-2 inhibitors as an example.
Journal: PLoS medicine 20091201
Title: Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression.
Journal: Nuclear medicine and biology 20091101
Title: Cellular membranes function as a storage compartment for celecoxib.
Journal: Journal of molecular medicine (Berlin, Germany) 20091001
Title: Effect of COX-2 inhibitor after TNBS-induced colitis in Wistar rats.
Journal: Journal of molecular histology 20090801
Title: Dissociation of airway inflammation and hyperresponsiveness by cyclooxygenase inhibition in allergen challenged mice.
Journal: The European respiratory journal 20090701
Title: Role of central muscarinic cholinergic receptors in the formalin-induced pain in rats.
Journal: Indian journal of pharmacology 20090601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090401
Title: Antinociceptive activity of buprenorphine and lumiracoxib in the rat orofacial formalin test: a combination analysis study.
Journal: European journal of pharmacology 20090301
Title: Lumiracoxib inhibits cyclo-oxygenase 2 completely at the 50 mg dose: is liver toxicity avoidable by adequate dosing?
Journal: Annals of the rheumatic diseases 20090201
Title: [Evaluation of the analgesic effects of the lumiracoxib compared with placebo in the 24 first postoperative hours].
Journal: Revista do Colegio Brasileiro de Cirurgioes 20090201
Title: Bioactivation of lumiracoxib by peroxidases and human liver microsomes: identification of multiple quinone imine intermediates and GSH adducts.
Journal: Chemical research in toxicology 20090101
Title: A review of the benefits and risks of nonsteroidal anti-inflammatory drugs in the management of mild-to-moderate osteoarthritis.
Journal: Osteopathic medicine and primary care 20090101
Title: Treatment and chemoprevention of NSAID-associated gastrointestinal complications.
Journal: Therapeutics and clinical risk management 20090101
Title: Cost effectiveness of COX 2 selective inhibitors and traditional NSAIDs alone or in combination with a proton pump inhibitor for people with osteoarthritis.
Journal: BMJ (Clinical research ed.) 20090101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20090101
Title: A patient with osteoarthritis and cardiovascular disease presenting with bilateral hip pain: a case report.
Journal: Cases journal 20090101
Title: Celecoxib in arthritis: relative risk management profile and implications for patients.
Journal: Therapeutics and clinical risk management 20090101
Title: Prevention of NSAID-related upper gastrointestinal toxicity: a meta-analysis of traditional NSAIDs with gastroprotection and COX-2 inhibitors.
Journal: Drug, healthcare and patient safety 20090101
Title: COX-2 selective inhibitors in the treatment of osteoarthritis.
Journal: Seminars in arthritis and rheumatism 20081201
Title: Lack of effects of acemetacin on signalling pathways for leukocyte adherence may explain its gastrointestinal safety.
Journal: British journal of pharmacology 20081101
Title: A randomised, double-blind study comparing lumiracoxib with naproxen for acute musculoskeletal pain.
Journal: International journal of clinical practice 20081101
Title: Risk management profile of etoricoxib: an example of personalized medicine.
Journal: Therapeutics and clinical risk management 20081001
Title: Characterization of eltenac and novel COX-2 selective thiopheneacetic acid analogues in vitro and in vivo.
Journal: Biochemical pharmacology 20080915
Title: Can drug removals involving cyclooxygenase-2 inhibitors be avoided? A plea for human pharmacology.
Journal: Trends in pharmacological sciences 20080801
Title: Effect on blood pressure of lumiracoxib versus ibuprofen in patients with osteoarthritis and controlled hypertension: a randomized trial.
Journal: Journal of hypertension 20080801
Title: A comparison of the blood pressure changes of lumiracoxib with those of ibuprofen and naproxen.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20080801
Title: The anti-proliferative potency of celecoxib is not a class effect of coxibs.
Journal: Biochemical pharmacology 20080715
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080601
Title: Clinical trial: comparison of the gastrointestinal safety of lumiracoxib with traditional nonselective nonsteroidal anti-inflammatory drugs early after the initiation of treatment--findings from the Therapeutic Arthritis Research and Gastrointestinal Event Trial.
Journal: Alimentary pharmacology & therapeutics 20080501
Title: Less small-bowel injury with lumiracoxib compared with naproxen plus omeprazole.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20080501
Title: Effect of lumiracoxib on proliferation and apoptosis of human nonsmall cell lung cancer cells in vitro.
Journal: Chinese medical journal 20080405
Title: Efficacy and tolerability of lumiracoxib 200 mg once daily for treatment of primary dysmenorrhea: results from two randomized controlled trials.
Journal: Journal of women's health (2002) 20080401
Title: Cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs (etodolac, meloxicam, celecoxib, rofecoxib, etoricoxib, valdecoxib and lumiracoxib) for osteoarthritis and rheumatoid arthritis: a systematic review and economic evaluation.
Journal: Health technology assessment (Winchester, England) 20080401
Title: Review of the cardiovascular safety of COXIBs compared to NSAIDS.
Journal: Cardiovascular journal of Africa 20080401
Title: Efficacy and tolerability of lumiracoxib, a highly selective cyclo-oxygenase-2 (COX2) inhibitor, in the management of pain and osteoarthritis.
Journal: Therapeutics and clinical risk management 20080401
Title: Clinical use and pharmacological properties of selective COX-2 inhibitors.
Journal: European journal of clinical pharmacology 20080301
Title: Examination of the interaction between peripheral lumiracoxib and opioids on the 1% formalin test in rats.
Journal: European journal of pain (London, England) 20080201
Title: In vitro metabolic activation of lumiracoxib in rat and human liver preparations.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20080201
Title: Anti-inflammatory effect of alpha, beta-Amyrin, a pentacyclic triterpene from Protium heptaphyllum in rat model of acute periodontitis.
Journal: Inflammopharmacology 20080201
Title: Pharmacovigilance: Safety matters….
Journal: Indian journal of pharmacology 20080201
Title: Lumiracoxib 400 mg compared with celecoxib 400 mg and placebo for treating pain following dental surgery: a randomized, controlled trial.
Journal: The journal of pain : official journal of the American Pain Society 20080101
Title: Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: systematic review of randomized trials using autologous chromium-labelled erythrocytes.
Journal: Arthritis research & therapy 20080101
Title: Long-term retention on treatment with lumiracoxib 100 mg once or twice daily compared with celecoxib 200 mg once daily: a randomised controlled trial in patients with osteoarthritis.
Journal: BMC musculoskeletal disorders 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Discontinuation rates in clinical trials in musculoskeletal pain: meta-analysis from etoricoxib clinical trial reports.
Journal: Arthritis research & therapy 20080101
Title: Tolerability of lumiracoxib in patients with analgesic intolerance.
Journal: Journal of investigational allergology & clinical immunology 20080101
Title: A 6-week, multicentre, randomised, double-blind, double-dummy, active-controlled, clinical safety study of lumiracoxib and rofecoxib in osteoarthritis patients.
Journal: BMC musculoskeletal disorders 20080101
Title: Long-term efficacy and safety of lumiracoxib 100 mg: an open-label extension of a 13-week randomized controlled trial in patients with primary osteoarthritis of the knee.
Journal: Clinical and experimental rheumatology 20080101
Title: Lipooxygenase inhibition in osteoarthritis: a potential symptomatic and disease modifying effect?
Journal: Arthritis research & therapy 20080101
Title: New horizons and perspectives in the treatment of osteoarthritis.
Journal: Arthritis research & therapy 20080101
Title: Nitric oxide and cardiovascular effects: new insights in the role of nitric oxide for the management of osteoarthritis.
Journal: Arthritis research & therapy 20080101
Title: Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors.
Journal: Cost effectiveness and resource allocation : C/E 20080101
Title: Preemptive versus postoperative lumiracoxib for analgesia in ambulatory arthroscopic knee surgery.
Journal: Journal of pain research 20080101
Title: Antagonism of thromboxane receptors by diclofenac and lumiracoxib.
Journal: British journal of pharmacology 20071201
Title: [What is new about nonsteroidal antiinflamatory drugs?].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20071201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071101
Title: COX 2 inhibitor rejected in North America but retained in Europe.
Journal: BMJ (Clinical research ed.) 20071020
Title: COX-2-dependent and potentially cardioprotective effects of negative inotropic substances released after ischemia.
Journal: American journal of physiology. Heart and circulatory physiology 20071001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20071001
Title: Selective COX-2 inhibitors, NSAIDs and cardiovascular events - is celecoxib the safest choice?
Journal: Therapeutics and clinical risk management 20071001
Title: [Lumiracoxib taken off the market in Australia. What does that mean for our patients? (interview by Dr. Judith Neumaier)].
Journal: MMW Fortschritte der Medizin 20070927
Title: Advice for nurses on drug withdrawal.
Journal: Australian nursing journal (July 1993) 20070901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20070901
Title: Australian drugs regulator cancels registration of COX 2 inhibitor.
Journal: BMJ (Clinical research ed.) 20070825
Title: Celecoxib dilates guinea-pig coronaries and rat aortic rings and amplifies NO/cGMP signaling by PDE5 inhibition.
Journal: Cardiovascular research 20070715
Title: Risk of myocardial infarction associated with selective COX-2 inhibitors: meta-analysis of randomised controlled trials.
Journal: Pharmacoepidemiology and drug safety 20070701
Title: Lumiracoxib 400 mg once daily is comparable to indomethacin 50 mg three times daily for the treatment of acute flares of gout.
Journal: Rheumatology (Oxford, England) 20070701
Title: Gastrointestinal safety of cyclooxygenase-2 inhibitors: a Cochrane Collaboration systematic review.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20070701
Title: Effect of risk factors on complicated and uncomplicated ulcers in the TARGET lumiracoxib outcomes study.
Journal: Gastroenterology 20070701
Title: Lumiracoxib in the management of osteoarthritis and acute pain.
Journal: Expert opinion on pharmacotherapy 20070701
Title: Cardiovascular outcomes in high risk patients with osteoarthritis treated with ibuprofen, naproxen or lumiracoxib.
Journal: Annals of the rheumatic diseases 20070601
Title: Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.
Journal: The Journal of biological chemistry 20070601
Title: COX-2 inhibitors ameliorate experimental autoimmune encephalomyelitis through modulating IFN-gamma and IL-10 production by inhibiting T-bet expression.
Journal: Journal of neuroimmunology 20070501
Title: [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain].
Journal: Nederlands tijdschrift voor geneeskunde 20070407
Title: Structural and functional basis of cyclooxygenase inhibition.
Journal: Journal of medicinal chemistry 20070405
Title: Lumiracoxib.
Journal: Drugs of today (Barcelona, Spain : 1998) 20070301
Title: The coxibs and traditional nonsteroidal anti-inflammatory drugs: a current perspective on cardiovascular risks.
Journal: The Canadian journal of cardiology 20070201
Title: Pharmacodynamic of cyclooxygenase inhibitors in humans.
Journal: Prostaglandins & other lipid mediators 20070101
Title: Evaluation of the patient acceptable symptom state in a pooled analysis of two multicentre, randomised, double-blind, placebo-controlled studies evaluating lumiracoxib and celecoxib in patients with osteoarthritis.
Journal: Arthritis research & therapy 20070101
Title: Proton-pump inhibitors are associated with a reduced risk for bleeding and perforated gastroduodenal ulcers attributable to non-steroidal anti-inflammatory drugs: a nested case-control study.
Journal: Arthritis research & therapy 20070101
Title: Arthritis and pain. Future targets to control osteoarthritis pain.
Journal: Arthritis research & therapy 20070101
Title: An economic model of long-term use of celecoxib in patients with osteoarthritis.
Journal: BMC gastroenterology 20070101
Title: Cyclo-oxygenase-2 selective inhibitors and nonsteroidal anti-inflammatory drugs: balancing gastrointestinal and cardiovascular risk.
Journal: BMC musculoskeletal disorders 20070101
Title: Efficacy of the newest COX-2 selective inhibitors in rheumatic disease.
Journal: Current pharmaceutical design 20070101
Title: Global gastrointestinal safety profile of etoricoxib and lumiracoxib.
Journal: Current pharmaceutical design 20070101
Title: Single dose oral lumiracoxib for postoperative pain.
Journal: The Cochrane database of systematic reviews 20070101
Title: [Lumiracoxib--Prexigem].
Journal: Journal de pharmacie de Belgique 20070101
Title: Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study.
Journal: Arthritis research & therapy 20070101
Title: A case of takotsubo cardiomyopathy precipitated by lumiracoxib, a selective COX-2 inhibitor.
Journal: Cardiovascular journal of Africa 20070101
Title: Lumiracoxib: the evidence of its clinical impact on the treatment of osteoarthritis.
Journal: Core evidence 20070101
Title: Do selective COX-2 inhibitors increase the risk of cerebrovascular events? A meta-analysis of randomized controlled trials.
Journal: Journal of clinical pharmacy and therapeutics 20061201
Title: Cardiovascular and cerebrovascular events in the randomized, controlled Alzheimer's Disease Anti-Inflammatory Prevention Trial (ADAPT).
Journal: PLoS clinical trials 20061101
Title: Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta-analysis of randomized trials.
Journal: JAMA 20061004
Title: A validated high-performance liquid chromatographic assay for determination of lumiracoxib in human plasma.
Journal: Biomedical chromatography : BMC 20061001
Title: COX-2 inhibitors and cardiovascular risk. Inferences based on biology and clinical studies.
Journal: Thrombosis and haemostasis 20061001
Title: Selective COX-2 inhibitors and risk of thromboembolic events - regulatory aspects.
Journal: Thrombosis and haemostasis 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: [What do we know about the cardiovascular toxicity of the NSAIDs?].
Journal: Presse medicale (Paris, France : 1983) 20060901
Title: [Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
Journal: Presse medicale (Paris, France : 1983) 20060901
Title: [Are there any differences in the cardiovascular tolerance between classical NSAIDs and coxibs?].
Journal: Presse medicale (Paris, France : 1983) 20060901
Title: [Cyclooxygenase-2: a new therapeutic target in atherosclerosis?].
Journal: Medicina clinica 20060527
Title: Different COX-independent effects of the COX-2 inhibitors etoricoxib and lumiracoxib.
Journal: Biochemical and biophysical research communications 20060414
Title: Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301
Title: Lumiracoxib is effective in the treatment of osteoarthritis of the knee: a prospective randomized 13-week study versus placebo and celecoxib.
Journal: Clinical rheumatology 20060201
Title: Systemic inflammation induces COX-2 mediated prostaglandin D2 biosynthesis in mice spinal cord.
Journal: Neuropharmacology 20060201
Title: Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study.
Journal: Arthritis research & therapy 20060101
Title: Systematic review: coxibs, non-steroidal anti-inflammatory drugs or no cyclooxygenase inhibitors in gastroenterological high-risk patients?
Journal: Alimentary pharmacology & therapeutics 20060101
Title: Gastrointestinal tolerability of lumiracoxib in patients with osteoarthritis and rheumatoid arthritis.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20060101
Title: First-dose analgesic effect of the cyclo-oxygenase-2 selective inhibitor lumiracoxib in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled comparison with celecoxib [NCT00267215].
Journal: Arthritis research & therapy 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: Patients, their doctors, nonsteroidal anti-inflammatory drugs and the perception of risk.
Journal: Arthritis research & therapy 20060101
Title: Accounting for the increase in NSAID expenditure: substitution or leakage?
Journal: Cost effectiveness and resource allocation : C/E 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications.
Journal: BMC medicine 20060101
Title: Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis.
Journal: Arthritis research & therapy 20060101
Title: Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice.
Journal: BMC musculoskeletal disorders 20060101
Title: Oral administration of lumiracoxib reduces choroidal neovascular membrane development in the rat laser-trauma model.
Journal: Retina (Philadelphia, Pa.) 20051201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051201
Title: The post-operative analgesic efficacy and tolerability of lumiracoxib compared with placebo and naproxen after total knee or hip arthroplasty.
Journal: Acta anaesthesiologica Scandinavica 20051101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20051101
Title: Lumiracoxib does not affect the ex vivo antiplatelet aggregation activity of low-dose aspirin in healthy subjects.
Journal: Journal of clinical pharmacology 20051001
Title: Lumiracoxib is effective in the treatment of episodic tension-type headache.
Journal: Headache 20051001
Title: Update on cyclooxygenase inhibitors: has a third COX isoform entered the fray?
Journal: Current medical research and opinion 20050801
Title: Monocyte cyclooxygenase-2 activity: a new therapeutic target for atherosclerosis?
Journal: Current drug targets. Cardiovascular & haematological disorders 20050801
Title: Cardiovascular safety of lumiracoxib: a meta-analysis of all randomized controlled trials > or =1 week and up to 1 year in duration of patients with osteoarthritis and rheumatoid arthritis.
Journal: Clinical therapeutics 20050801
Title: Pharmacodynamic behaviour of the selective cyclooxygenase-2 inhibitor lumiracoxib in the lipopolysaccharide-stimulated rat air pouch model.
Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20050501
Title: Lumiracoxib, a highly selective COX-2 inhibitor.
Journal: Expert review of clinical immunology 20050501
Title: Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Journal: European journal of pharmacology 20050418
Title: Clinical pharmacology of lumiracoxib, a second-generation cyclooxygenase 2 selective inhibitor.
Journal: Expert opinion on investigational drugs 20050401
Title: Efficacy and tolerability of lumiracoxib 100 mg once daily in knee osteoarthritis: a 13-week, randomized, double-blind study vs. placebo and celecoxib.
Journal: Current medical research and opinion 20050401
Title: The effects of selective and nonselective cyclooxygenase inhibitors on endothelin-1-induced fever in rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20050301
Title: Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2.
Journal: British journal of pharmacology 20050201
Title: The safety of lumiracoxib when used in the treatment of arthritis.
Journal: Expert opinion on pharmacotherapy 20050201
Title: Efficacy of lumiracoxib in osteoarthritis: a review of nine studies.
Journal: The Journal of international medical research 20050101
Title: Lumiracoxib reduced ulcer complications compared with ibuprofen and naproxen in osteoarthritis and did not increase cardiovascular outcomes.
Journal: ACP journal club 20050101
Title: Efficacy and tolerability of lumiracoxib in the treatment of osteoarthritis of the knee: a 13-week, randomized, double-blind comparison with celecoxib and placebo.
Journal: Clinical therapeutics 20050101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050101
Title: [Lumiracoxib reduces ulcer complications in comparison to NSAR].
Journal: Zeitschrift fur Orthopadie und ihre Grenzgebiete 20050101
Title: Lumiracoxib in the treatment of osteoarthritis, rheumatoid arthritis and acute postoperative dental pain: results of three dose-response studies.
Journal: Current medical research and opinion 20050101
Title: Relative thromboembolic risks associated with COX-2 inhibitors.
Journal: The Annals of pharmacotherapy 20050101
Title: COX-2 selective inhibitors in the treatment of arthritis: a rheumatologist perspective.
Journal: Current topics in medicinal chemistry 20050101
Title: Treatment of osteoarthritis of the knee with a topical diclofenac solution: a randomised controlled, 6-week trial [ISRCTN53366886].
Journal: BMC musculoskeletal disorders 20050101
Title: Current state of therapy for pain and inflammation.
Journal: Arthritis research & therapy 20050101
Title: Cardiovascular and gastrointestinal effects of COX-2 inhibitors and NSAIDs: achieving a balance.
Journal: Arthritis research & therapy 20050101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050101
Title: Safety and efficacy of lumiracoxib compared with NSAIDs.
Journal: Nature clinical practice. Gastroenterology & hepatology 20050101
Title: Clinical pharmacology of lumiracoxib: a selective cyclo-oxygenase-2 inhibitor.
Journal: Clinical pharmacokinetics 20050101
Title: The future of traditional nonsteroidal antiinflammatory drugs and cyclooxygenase-2 inhibitors in the treatment of inflammation and pain.
Journal: Pharmacological reports : PR 20050101
Title: Novel insights and therapeutical applications in the field of inhibitors of COX-2.
Journal: Current medicinal chemistry 20041201
Title: COX-2 drug may help treat osteoarthritis.
Journal: Health news (Waltham, Mass.) 20041201
Title: Lumiracoxib is effective in the treatment of osteoarthritis of the knee: a 13 week, randomised, double blind study versus placebo and celecoxib.
Journal: Annals of the rheumatic diseases 20041101
Title: Evidence in practice--number 3: Cox 2 inhibitors.
Journal: The British journal of general practice : the journal of the Royal College of General Practitioners 20041101
Title: Efficacy, safety and tolerability of lumiracoxib in patients with rheumatoid arthritis.
Journal: International journal of clinical practice 20041101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20041101
Title: Lumiracoxib does not affect methotrexate pharmacokinetics in rheumatoid arthritis patients.
Journal: The Annals of pharmacotherapy 20041001
Title: Gastroduodenal safety and tolerability of lumiracoxib compared with Ibuprofen and celecoxib in patients with osteoarthritis.
Journal: The Journal of rheumatology 20040901
Title: Efficacy and safety of four doses of lumiracoxib versus diclofenac in patients with knee or hip primary osteoarthritis: a phase II, four-week, multicenter, randomized, double-blind, placebo-controlled trial.
Journal: Arthritis and rheumatism 20040815
Title: No influence of moderate hepatic impairment on the pharmacokinetics of lumiracoxib, an oral COX-2 selective inhibitor.
Journal: Pharmacological research 20040801
Title: The second generation of COX-2 inhibitors: clinical pharmacological point of view.
Journal: Mini reviews in medicinal chemistry 20040801
Title: A coxib a day won't keep the doctor away.
Journal: Lancet (London, England) 20040801
Title: Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), reduction in ulcer complications: randomised controlled trial.
Journal: Lancet (London, England) 20040801
Title: Comparison of lumiracoxib with naproxen and ibuprofen in the Therapeutic Arthritis Research and Gastrointestinal Event Trial (TARGET), cardiovascular outcomes: randomised controlled trial.
Journal: Lancet (London, England) 20040801
Title: Therapeutic arthritis research and gastrointestinal event trial of lumiracoxib - study design and patient demographics.
Journal: Alimentary pharmacology & therapeutics 20040701
Title: Gastrointestinal side-effects of traditional non-steroidal anti-inflammatory drugs and new formulations.
Journal: Alimentary pharmacology & therapeutics 20040701
Title: Concomitant administration of lumiracoxib and a triphasic oral contraceptive does not affect contraceptive activity or pharmacokinetic profile.
Journal: Journal of clinical pharmacology 20040601
Title: Reduced incidence of gastroduodenal ulcers associated with lumiracoxib compared with ibuprofen in patients with rheumatoid arthritis.
Journal: Alimentary pharmacology & therapeutics 20040601
Title: Lumiracoxib (Prexige): a new selective COX-2 inhibitor.
Journal: International journal of clinical practice 20040601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040601
Title: Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20040501
Title: Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
Title: Efficacy and tolerability of lumiracoxib in the treatment of primary dysmenorrhoea.
Journal: International journal of clinical practice 20040401
Title: [Pharmacology and classification of cyclooxygenase inhibitors].
Journal: Gastroenterologie clinique et biologique 20040401
Title: Assessment of lumiracoxib bioavailability from targeted sites in the human intestine using remotely activated capsules and gamma scintigraphy.
Journal: Pharmaceutical research 20040301
Title: Analgesic efficacy of a single dose of lumiracoxib compared with rofecoxib, celecoxib and placebo in the treatment of post-operative dental pain.
Journal: International journal of clinical practice 20040301
Title: Analgesic efficacy of single oral doses of lumiracoxib and ibuprofen in patients with postoperative dental pain.
Journal: International journal of clinical practice 20040301
Title: Lumiracoxib: pharmacokinetic and pharmacodynamic profile when coadministered with fluconazole in healthy subjects.
Journal: Journal of clinical pharmacology 20040201
Title: Pharmacology and gastrointestinal safety of lumiracoxib, a novel cyclooxygenase-2 selective inhibitor: An integrated study.
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20040201
Title: Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat.
Journal: Pain 20040101
Title: Clinical pharmacology of novel selective COX-2 inhibitors.
Journal: Current pharmaceutical design 20040101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040101
Title: Lack of effect of omeprazole or of an aluminium hydroxide/magnesium hydroxide antacid on the pharmacokinetics of lumiracoxib.
Journal: Clinical pharmacokinetics 20040101
Title: Selective cyclooxygenase-2 inhibitors: similarities and differences.
Journal: Scandinavian journal of rheumatology 20040101
Title: Pharmacokinetics of lumiracoxib in plasma and synovial fluid.
Journal: Clinical pharmacokinetics 20040101
Title: Lumiracoxib.
Journal: Drugs 20040101
Title: Efficacy and tolerability of lumiracoxib versus placebo in patients with osteoarthritis of the hand.
Journal: Clinical and experimental rheumatology 20040101
Title: Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial [ISRCTN70292892].
Journal: BMC complementary and alternative medicine 20040101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20031001
Title: Gastroduodenal tolerability of lumiracoxib vs placebo and naproxen: a pilot endoscopic study in healthy male subjects.
Journal: Alimentary pharmacology & therapeutics 20030901
Title: Gateways to clinical trials. March 2003.
Journal: Methods and findings in experimental and clinical pharmacology 20030301
Title: The second generation of COX-2 inhibitors: what advantages do the newest offer?
Journal: Drugs 20030101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030101
Title: COX-2: Where are we in 2003? - Be strong and resolute: continue to use COX-2 selective inhibitors at recommended dosages in appropriate patients.
Journal: Arthritis research & therapy 20030101
Title: COX-2: where are we in 2003?--distinction from NSAIDs becoming blurred.
Journal: Arthritis research & therapy 20030101
Title: Meloxicam and selective COX-2 inhibitors in the management of pain in the palliative care population.
Journal: The American journal of hospice & palliative care 20030101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030101
Title: Clinical pharmacology of selective COX-2 inhibitors.
Journal: International journal of immunopathology and pharmacology 20030101
Title: Lumiracoxib (Novartis).
Journal: IDrugs : the investigational drugs journal 20021201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20021101
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020901
Title: Ronald Esser, et al. Preclinical pharmacology of lumiracoxib: a novel selective inhibitor of cyclooxygenase-2. Br J Pharmacol. 2005 Feb;144(4):538-50.
Title: Alyson Fox, et al. Anti-hyperalgesic activity of the cox-2 inhibitor lumiracoxib in a model of bone cancer pain in the rat. Pain
