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390811-95-7,MFCD09743847
Catalog No.:AA0076I2

390811-95-7 | 1-Cyclohexyl-2-(3-furanyl)-1h-benzimidazole-5-carboxylic acid

Pack Size
Purity
Availability
Price(USD)
Quantity
  
100mg
95%
in stock  
$300.00   $210.00
- +
250mg
95%
in stock  
$443.00   $310.00
- +
1g
95%
in stock  
$1,744.00   $1,221.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0076I2
Chemical Name:
1-Cyclohexyl-2-(3-furanyl)-1h-benzimidazole-5-carboxylic acid
CAS Number:
390811-95-7
Molecular Formula:
C18H18N2O3
Molecular Weight:
310.3471
MDL Number:
MFCD09743847
SMILES:
OC(=O)c1ccc2c(c1)nc(n2C1CCCCC1)c1cocc1
Properties
Computed Properties
 
Complexity:
438  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.4  

Downstream Synthesis Route
139393-02-5    390811-95-7   
3-{2-carboxy-2-(1-cyclohexyl-2-furan-3-yl-1<i>H</i>-benzoimidazole-5-carbonyl)-amino-ethyl}-1<i>H</i>-indole-5-carboxylicacid 
 
3-(5-carbamoyl-1<i>H</i>-indol-3-yl)-2-(1-cyclohexyl-2-furan-3-yl-1<i>H</i>-benzoimidazole-5-carbonyl)-amino-propionicacid 

[1]BioorganicandMedicinalChemistryLetters,2004,vol.14,p.967-971

4985-46-0    390811-95-7   
1-cyclohexyl-2-furan-3-yl-1<i>H</i>-benzoimidazole-5-carboxylicacid1-carbamoyl-2-(4-hydroxy-phenyl)-ethyl-amide 

[1]JournalofMedicinalChemistry,2004,vol.47,p.6884-6892

[1]JournalofMedicinalChemistry,2004,vol.47,p.6884-6892

[1]Patent:WO2005/121132,2005,A1.Locationinpatent:Page/Pagecolumn42

[1]BioorganicandMedicinalChemistryLetters,2010,vol.20,p.196-200

Literature

Title: N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.

Journal: Bioorganic & medicinal chemistry letters 20100201

Title: Pyrazolo[1,5-a]pyrimidine-based inhibitors of HCV polymerase.

Journal: Bioorganic & medicinal chemistry letters 20091115

Title: 1-Cyclo-hexyl-2-(3-fur-yl)-1H-benzimidazole-5-carboxylic acid.

Journal: Acta crystallographica. Section E, Structure reports online 20090901

Title: Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: Finger loop inhibitors of the HCV NS5B polymerase: discovery and prospects for new HCV therapy.

Journal: Current opinion in drug discovery & development 20060901

Title: Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase.

Journal: Bioorganic & medicinal chemistry letters 20050201

Title: Non-nucleoside benzimidazole-based allosteric inhibitors of the hepatitis C virus NS5B polymerase: inhibition of subgenomic hepatitis C virus RNA replicons in Huh-7 cells.

Journal: Journal of medicinal chemistry 20041230

Title: Binding mode determination of benzimidazole inhibitors of the hepatitis C virus RNA polymerase by a structure and dynamics strategy.

Journal: Angewandte Chemie (International ed. in English) 20040820

Title: Inhibitors of the HCV NS5B polymerase: new hope for the treatment of hepatitis C infections.

Journal: Current opinion in investigational drugs (London, England : 2000) 20040801

Title: Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Journal: Bioorganic & medicinal chemistry letters 20040223

Title: Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Journal: Bioorganic & medicinal chemistry letters 20040105

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Tags:390811-95-7 Molecular Formula|390811-95-7 MDL|390811-95-7 SMILES|390811-95-7 1-Cyclohexyl-2-(3-furanyl)-1h-benzimidazole-5-carboxylic acid