Home Carboxes 118292-40-3
118292-40-3,MFCD00867628
Catalog No.:AA0076R1

118292-40-3 | ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate

Pack Size
Purity
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1mg
97%
in stock  
$9.00   $7.00
- +
5mg
98%(HPLC)
in stock  
$24.00   $17.00
- +
10mg
97%
in stock  
$32.00   $22.00
- +
50mg
97%
in stock  
$51.00   $36.00
- +
100mg
97%
in stock  
$93.00   $65.00
- +
250mg
97%
in stock  
$136.00   $96.00
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1g
97%
in stock  
$338.00   $237.00
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  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA0076R1
Chemical Name:
ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate
CAS Number:
118292-40-3
Molecular Formula:
C21H21NO2S
Molecular Weight:
351.4619
MDL Number:
MFCD00867628
SMILES:
CCOC(=O)c1ccc(nc1)C#Cc1ccc2c(c1)C(C)(C)CCS2
Properties
Computed Properties
 
Complexity:
547  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
5  
XLogP3:
4.9  

Upstream Synthesis Route

[1]Patent:WO2009/116075,2009,A2,.Locationinpatent:Page/Pagecolumn12

[2]Patent:WO2015/107542,2015,A2,.Locationinpatent:Page/Pagecolumn12

[3]Patent:WO2015/107542,2015,A3,.Locationinpatent:Page/Pagecolumn12

[1]Patent:US5602130,1997,A,

[2]Patent:US5089509,1992,A,

[1]Patent:WO2006/59345,2006,A2,.Locationinpatent:Page/Pagecolumn20-21

[2]Patent:WO2006/59345,2006,A2,.Locationinpatent:Page/Pagecolumn22

[1]Patent:US2007/238881,2007,A1,.Locationinpatent:Page/Pagecolumn6

[1]Patent:US5089509,1992,A,

Downstream Synthesis Route

[1]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-WO2005/123713,2005,A1Locationinpatent:Page/Pagecolumn13

[2]CurrentPatentAssignee:GLENMARKPHARMACEUTICALSLTD-US2007/238881,2007,A1Locationinpatent:Page/Pagecolumn7

[1]Patent:WO2006/59345,2006,A2.Locationinpatent:Page/Pagecolumn20-21

[2]Patent:WO2006/59345,2006,A2.Locationinpatent:Page/Pagecolumn22

[1]CurrentPatentAssignee:P&RSPA-US2006/205950,2006,A1Locationinpatent:Page/Pagecolumn4;5

[2]CurrentPatentAssignee:P&RSPA-EP1700855,2006,A1Locationinpatent:Page/Pagecolumn6

[3]Frigoli,Samuele;Fuganti,Claudio;Malpezzi,Luciana;Serra,Stefano[OrganicProcessResearchandDevelopment,2005,vol.9,#5,p.646-650]

118292-06-1   
ethyl6-chloronicotinoate 
  118292-40-3 

[1]Patent:US5602130,1997,A

[2]Patent:US5089509,1992,A

[1]CurrentPatentAssignee:ABBVIEINC-US5602130,1997,A

[2]CurrentPatentAssignee:ABBVIEINC-US5089509,1992,A

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Title: Efficacy and tolerability of adapalene 0.3% gel compared to tazarotene 0.1% gel in the treatment of acne vulgaris.

Journal: Journal of drugs in dermatology : JDD 20080601

Title: Is switching retinoids a sound strategy for the treatment of acne vulgaris?

Journal: Journal of drugs in dermatology : JDD 20080601

Title: Adapalene 0.1% gel compared to tazarotene 0.1% cream in the treatment of acne vulgaris.

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Title: Pharmacologic retinoid signaling and physiologic retinoic acid receptor signaling inhibit basal cell carcinoma tumorigenesis.

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Title: Effects of topically applied acitretin in reconstructed human epidermis and the rhino mouse.

Journal: The Journal of investigative dermatology 20080101

Title: Response of juvenile circumscribed pityriasis rubra pilaris to topical tazarotene treatment.

Journal: Pediatric dermatology 20080101

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Journal: PloS one 20080101

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Journal: BMC medical genomics 20080101

Title: Adapalene 0.1% and benzoyl peroxide 2.5% as a fixed-dose combination gel is as well tolerated as the individual components alone in terms of cumulative irritancy.

Journal: European journal of dermatology : EJD 20080101

Title: Psoriasis treatment in difficult locations: scalp, nails, and intertriginous areas.

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Journal: BMC genomics 20080101

Title: Cosmeceuticals: focus on topical retinoids in photoaging.

Journal: Clinics in dermatology 20080101

Title: Downregulation of tazarotene induced gene-2 (TIG2) in skin squamous cell carcinoma.

Journal: European journal of dermatology : EJD 20080101

Title: Topical retinoids in acne vulgaris: update on efficacy and safety.

Journal: American journal of clinical dermatology 20080101

Title: A Web-based and Grid-enabled dChip version for the analysis of large sets of gene expression data.

Journal: BMC bioinformatics 20080101

Title: Comparative study of calcipotriol (0.005%) ointment and tazarotene (0.05% and 0.1%) gel in the treatment of stable plaque psoriasis.

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Title: Wrinkles.

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Title: Randomized double-blind trial of prophylactic oral minocycline and topical tazarotene for cetuximab-associated acne-like eruption.

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Title: Update on the treatment of cutaneous T-cell lymphoma (CTCL): Focus on vorinostat.

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Title: Treatment of ichthyosiform diseases with topically applied tazarotene: risk of systemic absorption.

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Title: Tazarotene-induced irritation causing vitiligo by Koebnerization.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20070801

Title: Treatment of locally metastatic melanoma: a novel approach.

Journal: Journal of drugs in dermatology : JDD 20070801

Title: A review of the use of adapalene for the treatment of acne vulgaris.

Journal: Therapeutics and clinical risk management 20070801

Title: Tazarotene 0.1 percent cream plus clindamycin 1 percent gel versus tretinoin 0.025 percent gel plus clindamycin 1 percent gel in the treatment of facial acne vulgaris.

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Title: Successful treatment of Favre-Racouchot disease with 0.05% tazarotene gel.

Journal: Archives of dermatology 20070601

Title: Tolerability comparison of adapalene gel, 0.3% versus tazarotene cream, 0.05% in subjects with healthy skin.

Journal: Journal of drugs in dermatology : JDD 20070601

Title: Progesterone regulation of implantation-related genes: new insights into the role of oestrogen.

Journal: Cellular and molecular life sciences : CMLS 20070401

Title: Disseminated superficial actinic porokeratosis of the scalp.

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Title: Palliative treatment of fingernail lichen planus.

Journal: Journal of drugs in dermatology : JDD 20070201

Title: Multiple keratoacanthomas in a young woman: report of a case emphasizing medical management and a review of the spectrum of multiple keratoacanthomas.

Journal: International journal of dermatology 20070101

Title: Supervised group Lasso with applications to microarray data analysis.

Journal: BMC bioinformatics 20070101

Title: Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: a double-blind, randomized, right-left comparison study.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: New lesions on the knees with palmoplantar keratoderma.

Journal: Cutis 20070101

Title: Treatment of psoriatic nails with tazarotene cream 0.1% vs. clobetasol propionate 0.05% cream: a double-blind study.

Journal: Acta dermato-venereologica 20070101

Title: Pharmacological treatments for basal cell carcinoma.

Journal: Drugs 20070101

Title: Effect of tazarotene on ichthyosiform erythroderma of Tay's syndrome.

Journal: Indian journal of dermatology, venereology and leprology 20070101

Title: Childhood nail psoriasis: a useful treatment with tazarotene 0.05%.

Journal: Pediatric dermatology 20070101

Title: Heteroarotinoids with anti-cancer activity against ovarian cancer cells.

Journal: The open medicinal chemistry journal 20070101

Title: Gene expression profiling in familial adenomatous polyposis adenomas and desmoid disease.

Journal: Hereditary cancer in clinical practice 20070101

Title: Etanercept in psoriasis: the evidence of its therapeutic impact.

Journal: Core evidence 20070101

Title: Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety.

Journal: Clinical interventions in aging 20061201

Title: Lamellar ichthyosis treated with tazarotene 0.1% gel.

Journal: Journal of the American Academy of Dermatology 20061101

Title: Tazarotene 0.1 percent cream fares better than erbium:YAG laser or incision and drainage in a patient with eruptive vellus hair cysts.

Journal: Dermatology online journal 20061031

Title: Schools of pharmacology: retinoid update.

Journal: Journal of drugs in dermatology : JDD 20061001

Title: Enhancement of sodium/iodide symporter expression in thyroid and breast cancer.

Journal: Endocrine-related cancer 20060901

Title: Tazarotene versus tazarotene plus hydroquinone in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized study.

Journal: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20060901

Title: [Elastosis perforans serpiginosa in a patient with pseudoxanthoma elasticum].

Journal: Actas dermo-sifiliograficas 20060901

Title: [Inhibition of promyelocytic leukemia gene by tazarotene in hyperproliferative epidermis of psoriasis].

Journal: Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060801

Title: Combination topical therapy in the treatment of acne.

Journal: Cutis 20060801

Title: Combining clindamycin 1%-benzoyl peroxide 5% gel with multiple therapeutic options.

Journal: Cutis 20060801

Title: Chronic plaque psoriasis.

Journal: Clinical evidence 20060601

Title: Comparison of tazarotene and minocycline maintenance therapies in acne vulgaris: a multicenter, double-blind, randomized, parallel-group study.

Journal: Archives of dermatology 20060501

Title: A distinct molecular profile associated with mucinous epithelial ovarian cancer.

Journal: British journal of cancer 20060327

Title: Tazarotene versus tazarotene plus clindamycin/benzoyl peroxide in the treatment of acne vulgaris: a multicenter, double-blind, randomized parallel-group trial.

Journal: Journal of drugs in dermatology : JDD 20060301

Title: Skin treatments and dermatological procedures to promote youthful skin.

Journal: Clinical interventions in aging 20060301

Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.

Journal: Journal of cellular biochemistry 20060201

Title: [From the Cochrane Library: Improvement of photodamaged skin with retinoid creams and not with other local treatments].

Journal: Nederlands tijdschrift voor geneeskunde 20060121

Title: Linear Darier's disease successfully treated with 0.1% tazarotene gel 'short-contact' therapy.

Journal: European journal of dermatology : EJD 20060101

Title: Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled study.

Journal: Cutis 20060101

Title: Ichthyosis bullosa of Siemens: response to topical tazarotene.

Journal: Indian journal of dermatology, venereology and leprology 20060101

Title: [Topical tazarotene for severe congenital ichthyosis].

Journal: Annales de dermatologie et de venereologie 20060101

Title: Short contact therapy with tazarotene in psoriasis vulgaris.

Journal: Dermatology (Basel, Switzerland) 20060101

Title: Receptor-selective retinoids for psoriasis: focus on tazarotene.

Journal: American journal of clinical dermatology 20060101

Title: Management of refractory early-stage cutaneous T-cell lymphoma.

Journal: American journal of clinical dermatology 20060101

Title: Quality of life in patients with psoriasis.

Journal: Health and quality of life outcomes 20060101

Title: Evaluation of CXCL9 and CXCL10 as circulating biomarkers of human cardiac allograft rejection.

Journal: BMC cardiovascular disorders 20060101

Title: Computational expression deconvolution in a complex mammalian organ.

Journal: BMC bioinformatics 20060101

Title: Comparison of growth-inhibitory agents by fluorescence imaging of human skin re-epithelialization in vitro.

Journal: Acta dermato-venereologica 20060101

Title: Erythrokeratoderma variabilis successfully treated with topical tazarotene.

Journal: Pediatric dermatology 20060101

Title: Cumulative irritancy comparison of topical retinoid and antimicrobial combination therapies.

Journal: Skinmed 20060101

Title: Confluent and reticulated papillomatosis : a review of the literature.

Journal: American journal of clinical dermatology 20060101

Title: Update on retinoid therapy of psoriasis in: an update on the use of retinoids in dermatology.

Journal: Dermatologic therapy 20060101

Title: Retinoid therapy of pigmentary disorders.

Journal: Dermatologic therapy 20060101

Title: The use of retinoids in the treatment of photoaging.

Journal: Dermatologic therapy 20060101

Title: Ligand-based approach to in silico pharmacology: nuclear receptor profiling.

Journal: Journal of chemical information and modeling 20060101

Title: Heterogeneity of mammary lesions represent molecular differences.

Journal: BMC cancer 20060101

Title: Successful treatment of inflammatory linear verrucous epidermal nevus with tacrolimus and fluocinonide.

Journal: Journal of cutaneous medicine and surgery 20060101

Title: Treatment of childhood psoriasis.

Journal: Acta dermatovenerologica Croatica : ADC 20060101

Title: Wrinkles.

Journal: Clinical evidence 20051201

Title: Disposition and biotransformation of the acetylenic retinoid tazarotene in humans.

Journal: Journal of pharmaceutical sciences 20051001

Title: [Effects of all-trans-retinoic acid, acitretin and tazarotene on apoptosis and Bax/Bcl-2 expressions of human melanoma cells A375 and the significance].

Journal: Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20050801

Title: Corticosteroids: options in the era of steroid-sparing therapy.

Journal: Journal of the American Academy of Dermatology 20050701

Title: A clinician's paradigm in the treatment of psoriasis.

Journal: Journal of the American Academy of Dermatology 20050701

Title: Open-label pilot study of alitretinoin gel 0.1% in the treatment of photoaging.

Journal: Cutis 20050701

Title: A pilot study on the use of topical tazarotene to treat squamous cell carcinoma in situ.

Journal: Journal of the American Academy of Dermatology 20050601

Title: Prediction of genotoxicity of chemical compounds by statistical learning methods.

Journal: Chemical research in toxicology 20050601

Title: Topical retinoids in the treatment of photoaging.

Journal: Journal of cosmetic dermatology 20050601

Title: Treatment of trachyonychia with tazarotene.

Journal: Clinical and experimental dermatology 20050501

Title: Cumulative irritation potential of adapalene 0.1% cream and gel compared with tazarotene cream 0.05% and 0.1%.

Journal: Cutis 20050501

Title: Modern modified 'ultra' Goeckerman therapy: a PASI assessment of a very effective therapy for psoriasis resistant to both prebiologic and biologic therapies.

Journal: The Journal of dermatological treatment 20050401

Title: The potential immunomodulatory effects of topical retinoids.

Journal: Dermatology online journal 20050301

Title: The use of topical retinoids for inflammatory acne: a review of the pharmacoeconomic considerations.

Journal: Managed care interface 20050301

Title: Potential future therapies for psoriasis.

Journal: Seminars in cutaneous medicine and surgery 20050301

Title: A multicenter, randomized, double-blind trial of tazarotene 0.1% cream in the treatment of photodamage.

Journal: Journal of the American Academy of Dermatology 20050201

Title: Dermoscopic monitoring of tazarotene treatment of superficial basal cell carcinoma.

Journal: Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 20050201

Title: An update on the safety and efficacy of topical retinoids.

Journal: Cutis 20050201

Title: Topical retinoids in inflammatory acne: a retrospective, investigator-blinded, vehicle-controlled, photographic assessment.

Journal: Clinical therapeutics 20050201

Title: Interventions for photodamaged skin.

Journal: The Cochrane database of systematic reviews 20050125

Title: Advances in therapy for psoriasis: an overview of infliximab, etanercept, efalizumab, alefacept, adalimumab, tazarotene, and pimecrolimus.

Journal: Current pharmaceutical design 20050101

Title: Retinoid therapy for acne. A comparative review.

Journal: American journal of clinical dermatology 20050101

Title: Mechanisms of the comedolytic and anti-inflammatory properties of topical retinoids.

Journal: Journal of drugs in dermatology : JDD 20050101

Title: Tazarotene cream versus adapalene cream in the treatment of facial acne vulgaris: a multicenter, double-blind, randomized, parallel-group study.

Journal: Journal of drugs in dermatology : JDD 20050101

Title: Tazarotene cream (0.1%) in combination with betamethasone valerate foam (0.12%) for plaque-type psoriasis.

Journal: Journal of drugs in dermatology : JDD 20050101

Title: The role of topical retinoids in the treatment of photoaging.

Journal: Drugs 20050101

Title: The protective role of pregnancy in breast cancer.

Journal: Breast cancer research : BCR 20050101

Title: Comparison of tazarotene 0.1% gel plus petrolatum once daily versus calcipotriol 0.005% ointment twice daily in the treatment of plaque psoriasis.

Journal: Acta dermato-venereologica 20050101

Title: Topical tazarotene: a review of its use in the treatment of plaque psoriasis.

Journal: American journal of clinical dermatology 20050101

Title: Topical tazarotene 0.05% versus glycolic acid 70% treatment in X-linked ichthyosis due to extensive deletion of the STS gene.

Journal: Acta dermato-venereologica 20050101

Title: Effects of ATRA, acitretin and tazarotene on growth and apoptosis of Tca8113 cells.

Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20050101

Title: Topical halobetasol propionate in the treatment of plaque psoriasis: a review.

Journal: American journal of clinical dermatology 20050101

Title: Comedolytic effect of a novel RARgamma-specific retinoid, ER36009: comparison with retinoic acid in the rhino mouse model.

Journal: European journal of dermatology : EJD 20050101

Title: An evaluation of the efficacy and safety of tazarotene (0.1%) cream in acne vulgaris.

Journal: Indian journal of dermatology, venereology and leprology 20050101

Title: A retinoic acid receptor beta/gamma-selective prodrug (tazarotene) plus a retinoid X receptor ligand induces extracellular signal-regulated kinase activation, retinoblastoma hypophosphorylation, G0 arrest, and cell differentiation.

Journal: Molecular pharmacology 20041201

Title: Histological effects of tazarotene 0.1% cream vs. vehicle on photodamaged skin: a 6-month, multicentre, double-blind, randomized, vehicle-controlled study in patients with photodamaged facial skin.

Journal: The British journal of dermatology 20041201

Title: The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene.

Journal: The Journal of investigative dermatology 20041201

Title: Wrinkles.

Journal: Clinical evidence 20041201

Title: Phase II trial of the antiangiogenic agent IM862 in metastatic renal cell carcinoma.

Journal: British journal of cancer 20041101

Title: Effects of tazarotene 0.1 % cream in the treatment of facial acne vulgaris: pooled results from two multicenter, double-blind, randomized, vehicle-controlled, parallel-group trials.

Journal: Clinical therapeutics 20041101

Title: Retinoid therapy for psoriasis.

Journal: Dermatologic clinics 20041001

Title: Topical retinoids in the management of acne: the best path to clear results.

Journal: Cutis 20041001

Title: Topical tazarotene: The BEST (balancing efficacy, speed, and tolerability) in acne trial.

Journal: Cutis 20041001

Title: Meta-analysis of topical tazarotene in the treatment of mild to moderate acne.

Journal: Cutis 20041001

Title: Topical tazarotene in acne vulgaris: treatment approaches.

Journal: Cutis 20041001

Title: Keratosis punctata palmoplantaris controlled with topical retinoids: a case report and review of the literature.

Journal: Cutis 20040901

Title: Topical tazarotene chemoprevention reduces Basal cell carcinoma number and size in Ptch1+/- mice exposed to ultraviolet or ionizing radiation.

Journal: Cancer research 20040701

Title: Questions & answers. Of all the treatments that promise to improve the appearance of aging skin, which ones have been medically proven to actually work?

Journal: Health news (Waltham, Mass.) 20040701

Title: Topical treatment of basal cell carcinoma with tazarotene: a clinicopathological study on a large series of cases.

Journal: The British journal of dermatology 20040701

Title: Established treatments of psoriasis.

Journal: Current drug targets. Inflammation and allergy 20040601

Title: Tazarotene 0.1% cream versus tretinoin 0.05% emollient cream in the treatment of photodamaged facial skin: a multicenter, double-blind, randomized, parallel-group study.

Journal: Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology 20040601

Title: Chronic plaque psoriasis.

Journal: Clinical evidence 20040601

Title: Tazarotene 0.1% gel for refractory mycosis fungoides lesions: an open-label pilot study.

Journal: Journal of the American Academy of Dermatology 20040401

Title: Seborrheic keratoses: a study comparing the standard cryosurgery with topical calcipotriene, topical tazarotene, and topical imiquimod.

Journal: International journal of dermatology 20040401

Title: Evidence of increased apoptosis and reduced proliferation in basal cell carcinomas treated with tazarotene.

Journal: The Journal of investigative dermatology 20040401

Title: Tazarotene 0.1% cream for the treatment of photodamage.

Journal: Skin therapy letter 20040401

Title: [Prescribe topical treatments for psoriasis].

Journal: La Revue du praticien 20040115

Title: Treatment of lentigo maligna with tazarotene 0.1% gel.

Journal: Journal of the American Academy of Dermatology 20040101

Title: Tazarotene: therapeutic strategies in the treatment of psoriasis, acne and photoaging.

Journal: Skin pharmacology and physiology 20040101

Title: Oral tazarotene and oral pimecrolimus: novel oral therapies in development for psoriasis.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Topical retinoid and antibiotic combination therapy for acne management.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Adapalene: a review of its use in the treatment of acne vulgaris.

Journal: Drugs 20040101

Title: Tazarotene does not affect the pharmacokinetics and efficacy of a norethindrone/ethinylestradiol oral contraceptive.

Journal: Clinical pharmacokinetics 20040101

Title: Current management strategies for cutaneous T-cell lymphoma.

Journal: Clinics in dermatology 20040101

Title: Elephantiasis nostrum verrucosa of the abdomen: clinical results with tazarotene.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Spotlight on adapalene in acne vulgaris.

Journal: American journal of clinical dermatology 20040101

Title: Comparison of topical retinoids in the treatment of acne.

Journal: Clinics in dermatology 20040101

Title: Facial tolerability of topical retinoid therapy.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: Treatment of Nevus comedonicus with topical tazarotene and calcipotriene.

Journal: Journal of drugs in dermatology : JDD 20040101

Title: An open study to evaluate the efficacy and safety of tazarotene gel (0.1%) in acne vulgaris.

Journal: Indian journal of dermatology, venereology and leprology 20040101

Title: Characterization of human circulating TIG2 as a ligand for the orphan receptor ChemR23.

Journal: FEBS letters 20031218

Title: The efficacy of topical tazarotene monotherapy and combination therapies in psoriasis.

Journal: Expert opinion on pharmacotherapy 20031201

Title: Wrinkles.

Journal: Clinical evidence 20031201

Title: [Medication of the month. Tazarotene 0.05%-0.1% (Zorac)].

Journal: Revue medicale de Liege 20031101

Title: Comparison of prognostic factors in patients in phase I trials of cytotoxic drugs vs new noncytotoxic agents.

Journal: British journal of cancer 20031006

Title: Tazarotene-induced gene 3 is suppressed in basal cell carcinomas and reversed in vivo by tazarotene application.

Journal: The Journal of investigative dermatology 20031001

Title: [Treatment options in monogenic disorders of keratinization].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20031001

Title: [Porokeratotic eccrine ostial and dermal duct naevus (PEODDN)].

Journal: Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20031001

Title: A phase 1 study of tazarotene in adults with advanced cancer.

Journal: British journal of cancer 20030901

Title: Investigational therapies for psoriasis.

Journal: Journal of the American Academy of Dermatology 20030801

Title: Type I lamellar ichthyosis improved by tazarotene 0.1% gel.

Journal: Clinical and experimental dermatology 20030701

Title: Cumulative irritation comparison of adapalene gel and solution with 2 tazarotene gels and 3 tretinoin formulations.

Journal: Cutis 20030701

Title: Tazarotene 0.1% gel for psoriasis of the fingernails and toenails: an open, prospective study.

Journal: The British journal of dermatology 20030701

Title: Confluent and reticulated papillomatosis: response to tazarotene.

Journal: Journal of the American Academy of Dermatology 20030501

Title: Tazarotene cream in the treatment of psoriasis: Two multicenter, double-blind, randomized, vehicle-controlled studies of the safety and efficacy of tazarotene creams 0.05% and 0.1% applied once daily for 12 weeks.

Journal: Journal of the American Academy of Dermatology 20030501

Title: Cytochrome P450 2C8 and flavin-containing monooxygenases are involved in the metabolism of tazarotenic acid in humans.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20030401

Title: Acne cream can reverse sun damage.

Journal: Health news (Waltham, Mass.) 20030201

Title: A systematic review of adverse effects associated with topical treatments for psoriasis.

Journal: Dermatology online journal 20030201

Title: Management of acne.

Journal: The Journal of family practice 20030101

Title: The rationale for using a topical retinoid for inflammatory acne.

Journal: American journal of clinical dermatology 20030101

Title: Optimizing treatment with topical tazarotene.

Journal: American journal of clinical dermatology 20030101

Title: The topical treatment of psoriasis.

Journal: Skin pharmacology and applied skin physiology 20030101

Title: Short-contact therapy with tazarotene in psoriasis vulgaris.

Journal: Dermatology (Basel, Switzerland) 20030101

Title: Pharmacokinetics of tazarotene cream 0.1% after a single dose and after repeat topical applications at clinical or exaggerated application rates in patients with acne vulgaris or photodamaged skin.

Journal: Clinical pharmacokinetics 20030101

Title: Treatment of occupational koilonychia with tazarotene gel.

Journal: Acta dermato-venereologica 20030101

Title: Retrospective analysis of the treatment of psoriasis of the palms and soles.

Journal: The Journal of dermatological treatment 20030101

Title: Efficacy of 0.1% tazarotene cream for the treatment of photodamage: a 12-month multicenter, randomized trial.

Journal: Archives of dermatology 20021101

Title: Questionable techniques for evaluating photodamage.

Journal: Archives of dermatology 20021101

Title: Oral lichen planus: a preliminary clinical study on treatment with tazarotene.

Journal: Oral diseases 20021101

Title: [Immunosuppresive agents, retinoids and new trends in the therapy of psoriasis].

Journal: Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20021101

Title: A comparison of psoralen plus ultraviolet A (PUVA) monotherapy, tacalcitol plus PUVA and tazarotene plus PUVA in patients with chronic plaque-type psoriasis.

Journal: The British journal of dermatology 20021001

Title: [Psoriatic onycho-pachydermo- periostitis].

Journal: Zeitschrift fur Rheumatologie 20021001

Title: Treating keratosis pilaris.

Journal: Journal of the American Academy of Dermatology 20020901

Title: Tazarotene (tazorac) for acne.

Journal: The Medical letter on drugs and therapeutics 20020610

Title: Combination of calcipotriene (Dovonex) ointment and tazarotene (Tazorac) gel versus clobetasol ointment in the treatment of plaque psoriasis: a pilot study.

Journal: Journal of the American Academy of Dermatology 20020601

Title: Refining retinoids with heteroatoms.

Journal: Mini reviews in medicinal chemistry 20020601

Title: Instrumental evaluation of retinoid-induced skin irritation.

Journal: Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) 20020501

Title: Is TIG1 a new tumor suppressor in prostate cancer?

Journal: Journal of the National Cancer Institute 20020403

Title: Successful treatment of acne vulgaris using a new method: results of a randomized vehicle-controlled trial of short-contact therapy with 0.1% tazarotene gel.

Journal: Archives of dermatology 20020401

Title: Topical tazarotene therapy for psoriasis, acne vulgaris, and photoaging.

Journal: Skin therapy letter 20020301

Title: Treatment of warty dyskeratoma with tazarotenic acid.

Journal: Journal of the American Academy of Dermatology 20020201

Title: Tazarotene is an effective therapy for elastosis perforans serpiginosa.

Journal: Archives of dermatology 20020201

Title: Once-daily tazarotene 0.1 % gel versus once-daily tretinoin 0.1 % microsponge gel for the treatment of facial acne vulgaris: a double-blind randomized trial.

Journal: Cutis 20020201

Title: Optimizing the use of tazarotene for the treatment of facial acne vulgaris through combination therapy.

Journal: Cutis 20020201

Title: A multicenter, double-blind, randomized comparison study of the efficacy and tolerability of once-daily tazarotene 0.1% gel and adapalene 0.1% gel for the treatment of facial acne vulgaris.

Journal: Cutis 20020201

Title: Topical agents for the treatment of psoriasis, past, present and future.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Drug interactions in psoriasis: the pros and cons of combining topical psoriasis therapies.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Treatment of cutaneous T cell lymphoma: current status and future directions.

Journal: American journal of clinical dermatology 20020101

Title: A clinical evaluation of tazarotene 0.1% gel, with and without a high- or mid-high-potency corticosteroid, in patients with stable plaque psoriasis.

Journal: Journal of cutaneous medicine and surgery 20020101

Title: Epithelial malignancies in organ transplant patients: clinical presentation and new methods of treatment.

Journal: Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer 20020101

Title: Potential anti-inflammatory effects of topical retinoids and retinoid analogues.

Journal: Advances in therapy 20020101

Title: Practical management of psoriasis in the elderly: epidemiology, clinical aspects, quality of life, patient education and treatment options.

Journal: Drugs & aging 20020101

Title: Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks.

Journal: Archives of dermatology 20011201

Title: The efficacy of 308nm laser treatment of psoriasis compared to historical controls.

Journal: Dermatology online journal 20011201

Title: Tazarotene 0.1% gel in the treatment of fingernail psoriasis: a double-blind, randomized, vehicle-controlled study.

Journal: Cutis 20011101

Title: Treatment of psoriasis. Part 1. Topical therapy and phototherapy.

Journal: Journal of the American Academy of Dermatology 20011001

Title: Developments in topical retinoid therapy for acne.

Journal: Seminars in cutaneous medicine and surgery 20010901

Title: A pilot study to determine the effect of tazarotene gel 0.1% on steroid-induced epidermal atrophy.

Journal: International journal of dermatology 20010701

Title: [Successful symptomatic tazarotene treatment of juvenile acanthosis nigricans of the familial obesity-associated type in insulin resistance].

Journal: Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20010601

Title: Comparison of treatment of acne vulgaris with alternate-day applications of tazarotene 0.1% gel and once-daily applications of adapalene 0.1% gel: a randomized trial.

Journal: Cutis 20010601

Title: Randomized facial tolerability studies comparing gel formulations of retinoids used to treat acne vulgaris.

Journal: Cutis 20010601

Title: Efficacy and tolerability of once-daily tazarotene 0.1% gel versus once-daily tretinoin 0.025% gel in the treatment of facial acne vulgaris: a randomized trial.

Journal: Cutis 20010601

Title: Altered expression of angiopoietins and Tie2 endothelium receptor in psoriasis.

Journal: The Journal of investigative dermatology 20010501

Title: 1,25-dihydroxyvitamin D3 and retonic acid analogues induce differentiation in breast cancer cells with function- and cell-specific additive effects.

Journal: Breast cancer research and treatment 20010501

Title: Retinoids for the treatment of psoriasis: outlook for the future.

Journal: Current opinion in investigational drugs (London, England : 2000) 20010501

Title: Investigator-masked comparison of tazarotene gel q.d. plus mometasone furoate cream q.d. vs. mometasone furoate cream b.i.d. in the treatment of plaque psoriasis.

Journal: International journal of dermatology 20010301

Title: Are 2 combined antimicrobial mechanisms better than 1 for the treatment of acne vulgaris? Clinical and antimicrobial results of a topical combination product containing 1% clindamycin and 5% benzoyl peroxide. Introduction.

Journal: Cutis 20010201

Title: Focal acral hyperkeratosis.

Journal: Dermatology online journal 20010201

Title: Duration of improvement in psoriasis after treatment with tazarotene 0.1% gel plus clobetasol propionate 0.05% ointment: comparison of maintenance treatments.

Journal: International journal of dermatology 20010101

Title: New developments in the treatment of psoriasis.

Journal: Skin pharmacology and applied skin physiology 20010101

Title: The modern age of acne therapy: a review of current treatment options.

Journal: The Mount Sinai journal of medicine, New York 20010101

Title: Management of scalp psoriasis: guidelines for corticosteroid use in combination treatment.

Journal: Drugs 20010101

Title: Retinoids--which dermatological indications will benefit in the near future?

Journal: Skin pharmacology and applied skin physiology 20010101

Title: Tazarotene: a review of its pharmacological profile and potential for clinical use in psoriasis.

Journal: Expert opinion on investigational drugs 19971001

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Title: Tang-Liu DD, et al. Clinical pharmacokinetics and drug metabolism of tazarotene: a novel topical treatment for acne and psoriasis. Clin Pharmacokinet. 1999 Oct;37(4):273-87.

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Tags:118292-40-3 Molecular Formula|118292-40-3 MDL|118292-40-3 SMILES|118292-40-3 ethyl 6-[2-(4,4-dimethyl-3,4-dihydro-2H-1-benzothiopyran-6-yl)ethynyl]pyridine-3-carboxylate