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383432-38-0,MFCD15144738
Catalog No.:AA0079YQ

383432-38-0 | CP-724714

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$53.00   $37.00
- +
5mg
≥95%
in stock  
$203.00   $142.00
- +
10mg
≥95%
in stock  
$380.00   $266.00
- +
25mg
98%
in stock  
$745.00   $522.00
- +
50mg
≥98%
in stock  
$1,075.00   $753.00
- +
100mg
≥98%
in stock  
$1,574.00   $1,102.00
- +
250mg
≥98%
in stock  
$3,470.00   $2,429.00
- +
1000mg
98% by HPLC
in stock  
$11,279.00   $7,896.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA0079YQ
Chemical Name:
CP-724714
CAS Number:
383432-38-0
Molecular Formula:
C27H27N5O3
Molecular Weight:
469.5350
MDL Number:
MFCD15144738
SMILES:
COCC(=O)NC/C=C/c1ccc2c(c1)c(ncn2)Nc1ccc(c(c1)C)Oc1ccc(nc1)C
Properties
Computed Properties
 
Complexity:
692  
Covalently-Bonded Unit Count:
1  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
9  
XLogP3:
4.3  

Literature

Title: Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives.

Journal: European journal of medicinal chemistry 20110601

Title: Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20090401

Title: Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach.

Journal: Journal of medicinal chemistry 20080626

Title: Pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors: correlations with clinical characteristics and safety.

Journal: Cancer chemotherapy and pharmacology 20080601

Title: A quantitative analysis of kinase inhibitor selectivity.

Journal: Nature biotechnology 20080101

Title: Population pharmacokinetics of a HER2 tyrosine kinase inhibitor CP-724,714 in patients with advanced malignant HER2 positive solid tumors.

Journal: Cancer chemotherapy and pharmacology 20071101

Title: Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor.

Journal: Cancer research 20071015

Title: First study of the safety, tolerability, and pharmacokinetics of CP-724,714 in patients with advanced malignant solid HER2-expressing tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20070215

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SDS
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