Home Amines 108612-45-9
108612-45-9,MFCD00864625
Catalog No.:AA007C3L

108612-45-9 | 2-[(1-{1-[(4-fluorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}piperidin-4-yl)(methyl)amino]-3,4-dihydropyrimidin-4-one

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Purity
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1g
98%
in stock  
$87.00   $61.00
- +
5g
98%
in stock  
$311.00   $218.00
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25g
98%
in stock  
$1,208.00   $846.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007C3L
Chemical Name:
2-[(1-{1-[(4-fluorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}piperidin-4-yl)(methyl)amino]-3,4-dihydropyrimidin-4-one
CAS Number:
108612-45-9
Molecular Formula:
C24H25FN6O
Molecular Weight:
432.4933
MDL Number:
MFCD00864625
SMILES:
Fc1ccc(cc1)Cn1c(nc2c1cccc2)N1CCC(CC1)N(c1[nH]ccc(=O)n1)C
Properties
Computed Properties
 
Complexity:
728  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
5  
XLogP3:
3.2  

Literature

Title: Why are most phospholipidosis inducers also hERG blockers?

Journal: Archives of toxicology 20171201

Title: Trace analysis of three antihistamines in human urine by on-line single drop liquid-liquid-liquid microextraction coupled to sweeping micellar electrokinetic chromatography and its application to pharmacokinetic study.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120901

Title: Cetirizine and loratadine: minimal risk of QT prolongation.

Journal: Prescrire international 20100201

Title: Reversible anti-settlement activity against Amphibalanus (=Balanus) amphitrite, Bugula neritina, and Hydroides elegans by a nontoxic pharmaceutical compound, mizolastine.

Journal: Biofouling 20091101

Title: [Efficacy and safety of Mizolastine in the treatment of perennial allergic rhinitis].

Journal: Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20070601

Title: Development of a CZE method for the determination of mizolastine and its impurities in pharmaceutical preparations using response surface methodology.

Journal: Electrophoresis 20070201

Title: Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers.

Journal: Journal of medicinal chemistry 20061116

Title: Allergic reactions due to mizolastine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20060801

Title: [Mizolastine improves the quality of life in patients with perennial allergic rhinitis: a randomized, double blind, controlled study].

Journal: Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery 20060701

Title: Influence of mizolastine on antigen-induced activation of signalling pathways in murine mast cells.

Journal: Clinical and experimental dermatology 20060301

Title: [Inhibitory effects of mizolastine on substance P-induced production of leukotriene B4 and interleukin 5 in mouse skin].

Journal: Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20060301

Title: Hypersensitivity reaction to mizolastine: study of cross reactions.

Journal: Journal of investigational allergology & clinical immunology 20060101

Title: The effect of mizolastine on expression of vascular endothelial cell growth factor, tumour necrosis factor-alpha and keratinocyte-derived chemokine in murine mast cells, compared with dexamethasone and loratadine.

Journal: Clinical and experimental dermatology 20050301

Title: [Comparative activity of antihistamines on area under dose-response curve from histamine-induced wheal and flare responses in human skin].

Journal: Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20041201

Title: Anaphylaxis to mizolastine.

Journal: The Journal of allergy and clinical immunology 20041001

Title: Comparison of pharmacokinetics and metabolism of desloratadine, fexofenadine, levocetirizine and mizolastine in humans.

Journal: Fundamental & clinical pharmacology 20040801

Title: [Clinical examination of mizolastine in the seasonal allergic rhinitis].

Journal: Lin chuang er bi yan hou ke za zhi = Journal of clinical otorhinolaryngology 20040801

Title: Mizolastine and fexofenadine modulate cytokine pattern after nasal allergen challenge.

Journal: European annals of allergy and clinical immunology 20040401

Title: Differential modulation of mediator release from human basophils and mast cells by mizolastine.

Journal: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20040201

Title: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: [Antihistaminics. Side effects also after raising dosage at the placebo level].

Journal: MMW Fortschritte der Medizin 20030529

Title: Mizolastine in primary acquired cold urticaria.

Journal: Journal of the American Academy of Dermatology 20030401

Title: Inhibition of mediator and cytokine release from dispersed nasal polyp cells by mizolastine.

Journal: Allergy 20021101

Title: Mizolastine provides effective symptom relief in patients suffering from perennial allergic rhinitis: a double-blind, placebo-controlled study versus loratadine.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020901

Title: Comparative activity of cetirizine and mizolastine on histamine-induced skin wheal and flare responses at 24 h.

Journal: British journal of clinical pharmacology 20020301

Title: A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020201

Title: [Hepatotoxicity of mizolastine (Mizollen) : report of 2 cases].

Journal: Gastroenterologie clinique et biologique 20011201

Title: UV erythema reducing capacity of mizolastine compared to acetylsalicylic acid or both combined in comparison to indomethacin.

Journal: Photochemistry and photobiology 20011001

Title: Mizolastine in the treatment of seasonal allergic rhinoconjunctivitis: a European clinical experience with 5408 patients managed in daily practice (PANEOS SAR Study).

Journal: Allergy 20010701

Title: Population pharmacokinetic analysis and optimization of the experimental design for mizolastine solution in children.

Journal: Journal of pharmacokinetics and pharmacodynamics 20010601

Title: One-year treatment of chronic urticaria with mizolastine: efficacy and safety. J Eur Acad Dermatol Venereol 2000; 14: 83-90.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20010101

Title: Clinical pharmacokinetics of mizolastine.

Journal: Clinical pharmacokinetics 20010101

Title: Inhibition of HERG1 K(+) channels by the novel second-generation antihistamine mizolastine.

Journal: British journal of pharmacology 20001101

Title: Antiallergic effects of H1-receptor antagonists.

Journal: Allergy 20000101

Title: Efficacy and safety of mizolastine 10 mg in a placebo-controlled comparison with loratadine in chronic idiopathic urticaria: results of the MILOR Study.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 19990101

Title: Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria.

Journal: BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy 19980701

Title: Prakash A, et al. Mizolastine: a review of its use in allergic rhinitis and chronic idiopathic urticaria. BioDrugs. 1998 Jul;10(1):41-63.

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SDS
Tags:108612-45-9 Molecular Formula|108612-45-9 MDL|108612-45-9 SMILES|108612-45-9 2-[(1-{1-[(4-fluorophenyl)methyl]-1H-1,3-benzodiazol-2-yl}piperidin-4-yl)(methyl)amino]-3,4-dihydropyrimidin-4-one