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Home Amines 17279-56-0
17279-56-0,MFCD00428681
Catalog No.:AA007CCD

17279-56-0 | (2-Amino-4-phenyl-thiazol-5-yl)-phenyl-methanone

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Purity
Availability
Price(USD)
Quantity
  
1g
95%
in stock  
$344.00   $241.00
- +
5g
95%
in stock  
$1,175.00   $823.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007CCD
Chemical Name:
(2-Amino-4-phenyl-thiazol-5-yl)-phenyl-methanone
CAS Number:
17279-56-0
Molecular Formula:
C16H12N2OS
Molecular Weight:
280.3443
MDL Number:
MFCD00428681
SMILES:
Nc1nc(c(s1)C(=O)c1ccccc1)c1ccccc1
Properties
Computed Properties
 
Complexity:
337  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Sun,Jiyun;Ge,Huaibin;Zhen,Xiaohua;An,Xuechan;Zhang,Guangtao;Zhang-Negrerie,Daisy;Du,Yunfei;Zhao,Kang[Tetrahedron,2018,vol.74,#17,p.2107-2114]

[2]Dahiya,Rajinder;Pujari,H.K.[IndianJournalofChemistry-SectionBOrganicandMedicinalChemistry,1986,vol.25,p.966]

[3]King;Hlavacek[JournaloftheAmericanChemicalSociety,1950,vol.72,p.3722]

[4]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2012/28100,2012,A1Locationinpatent:Page/Pagecolumn11-12

[5]CurrentPatentAssignee:GLAXOSMITHKLINEPLC-WO2012/100734,2012,A1Locationinpatent:Page/Pagecolumn29

[6]Wang,Yonghui;Cai,Wei;Zhang,Guifeng;Yang,Ting;Liu,Qian;Cheng,Yaobang;Zhou,Ling;Ma,Yingli;Cheng,Ziqiang;Lu,Sijie;Zhao,Yong-Gang;Zhang,Wei;Xiang,Zhijun;Wang,Shuai;Yang,Liuqing;Wu,Qianqian;Orband-Miller,LisaA.;Xu,Yan;Zhang,Jing;Gao,Ruina;Huxdorf,Melanie;Xiang,Jia-Ning;Zhong,Zhong;Elliott,JohnD.;Leung,Stewart;Lin,Xichen[BioorganicandMedicinalChemistry,2014,vol.22,#2,p.692-702]

[1]Patent:WO2012/28100,2012,A1.Locationinpatent:Page/Pagecolumn12

[1]BioorganicandMedicinalChemistry,2014,vol.22,p.692-702

[2]Patent:WO2012/28100,2012,A1.Locationinpatent:Page/Pagecolumn14-15

[3]Patent:WO2012/100734,2012,A1.Locationinpatent:Page/Pagecolumn30

862574-89-8    17279-56-0   
1-(benzod1,3dioxol-5-yl)-N-(5-benzoyl-4-phenylthiazol-2-yl)cyclopropanecarboxamide 

[1]EuropeanJournalofMedicinalChemistry,2018,vol.144,p.179-200

[1]Liessi,Nara;Cichero,Elena;Pesce,Emanuela;Arkel,Maria;Salis,Annalisa;Tomati,Valeria;Paccagnella,Matteo;Damonte,Gianluca;Tasso,Bruno;Galietta,LuisJ.V.;Pedemonte,Nicoletta;Fossa,Paola;Millo,Enrico[EuropeanJournalofMedicinalChemistry,2018,vol.144,p.179-200]

[2]Benvenuti,Mirko;Cichero,Elena;Damonte,Gianluca;Millo,Enrico;Parodi,Alice;Pastorino,Cristina;Pedemonte,Nicoletta;Pesce,Emanuela;Righetti,Giada;Salis,Annalisa;Tasso,Bruno;Tomati,Valeria[Pharmaceuticals,2022,vol.15,#3]

Literature

Title: 2-Amino-5-benzoyl-4-phenylthiazoles: Development of potent and selective adenosine A1 receptor antagonists.

Journal: Bioorganic & medicinal chemistry 20100315

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