[1]JournalofMedicinalChemistry,1992,vol.35,p.1092-1101
[1]Perregaard;Arnt;Bogeso;Hyttel;Sanchez[JournalofMedicinalChemistry,1992,vol.35,#6,p.1092-1101]
[1]Perregaard;Arnt;Bogeso;Hyttel;Sanchez[JournalofMedicinalChemistry,1992,vol.35,#6,p.1092-1101]
[1]Perregaard;Arnt;Bogeso;Hyttel;Sanchez[JournalofMedicinalChemistry,1992,vol.35,#6,p.1092-1101]
[1]Perregaard;Arnt;Bogeso;Hyttel;Sanchez[JournalofMedicinalChemistry,1992,vol.35,#6,p.1092-1101]
Title: Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model.
Journal: Toxicological sciences : an official journal of the Society of Toxicology 20131201
Title: The efficacy and safety of 12 weeks of treatment with sertindole or olanzapine in patients with chronic schizophrenia who did not respond successfully to their previous treatments: a randomized, double-blind, parallel-group, flexible-dose study.
Journal: International clinical psychopharmacology 20121101
Title: Drug safety and efficacy evaluation of sertindole for schizophrenia.
Journal: Expert opinion on drug safety 20121101
Title: Effects of sertindole on cognition in clozapine-treated schizophrenia patients.
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Title: Sertindole in the long-term treatment of schizophrenia.
Journal: International clinical psychopharmacology 20120701
Title: Augmenting clozapine with sertindole: a double-blind, randomized, placebo-controlled study.
Journal: Journal of clinical psychopharmacology 20120401
Title: Effects of quetiapine and sertindole on subchronic ketamine-induced deficits in attentional set-shifting in rats.
Journal: Psychopharmacology 20120301
Title: Driving ability under sertindole.
Journal: Pharmacopsychiatry 20120301
Title: Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo.
Journal: European journal of pharmacology 20120215
Title: Second-generation antipsychotic drugs and extrapyramidal side effects: a systematic review and meta-analysis of head-to-head comparisons.
Journal: Schizophrenia bulletin 20120101
Title: Recent advances in imaging of dopaminergic neurons for evaluation of neuropsychiatric disorders.
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Title: Critical appraisal of lurasidone in the management of schizophrenia.
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Title: Sudden death of cardiac origin and psychotropic drugs.
Journal: Frontiers in pharmacology 20120101
Title: Role of aripiprazole in treatment-resistant schizophrenia.
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Title: Sertindole, a potent antagonist at dopamine D₂ receptors, induces autophagy by increasing reactive oxygen species in SH-SY5Y neuroblastoma cells.
Journal: Biological & pharmaceutical bulletin 20120101
Title: Prediction of chemical-protein interactions network with weighted network-based inference method.
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Title: A pharmacoeconomic analysis of sertindole in the treatment of schizophrenia in Sweden.
Journal: Nordic journal of psychiatry 20111201
Title: The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers.
Journal: Journal of psychopharmacology (Oxford, England) 20111201
Title: Effects of olanzapine, sertindole and clozapine on MK-801 induced visual memory deficits in mice.
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Title: Antipsychotic drugs rapidly induce dopamine neuron depolarization block in a developmental rat model of schizophrenia.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20110824
Title: Serotonin control of sleep-wake behavior.
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Title: Sertindole-associated deep venous thrombosis.
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Title: Relationship between P-glycoprotein and second-generation antipsychotics.
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Title: Computer simulations of structure-activity relationships for HERG channel blockers.
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Title: Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.
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Title: Metabolic parameters in the short- and long-term treatment of schizophrenia with sertindole or risperidone.
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Title: Pain, affect and psychotic illness.
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Title: Effects on prolongation of Bazett's corrected QT interval of seven second-generation antipsychotics in the treatment of schizophrenia: a meta-analysis.
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Title: Effects of olanzapine, sertindole and clozapine on learning and memory in the Morris water maze test in naive and MK-801-treated mice.
Journal: Pharmacology, biochemistry, and behavior 20110501
Title: Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation.
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Title: Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.
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Title: The effects of NMDA receptor antagonists on attentional set-shifting task performance in mice.
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Title: Androgen insensitivity and liability to drug-induced extrapyramidal symptoms.
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Title: A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
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Title: Analysis of Relationship between Levofloxacin and Corrected QT Prolongation Using a Clinical Data Warehouse.
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Title: Dose-response relationship of sertindole and haloperidol using the pharmacopsychometric triangle.
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Title: A double-blind, randomized study comparing the efficacy and safety of sertindole and risperidone in patients with treatment-resistant schizophrenia.
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Title: The use of PET imaging in studying cognition, genetics and pharmacotherapeutic interventions in schizophrenia.
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Title: Risperidone versus other atypical antipsychotics for schizophrenia.
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Title: Identification and synthesis of impurities formed during sertindole preparation.
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Title: Paliperidone extended-release: does it have a place in antipsychotic therapy?
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Title: Pharmacotherapy for treatment-resistant schizophrenia.
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Title: AUTISM Spectrum Disorders and Suicidality.
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Title: hERGAPDbase: a database documenting hERG channel inhibitory potentials and APD-prolongation activities of chemical compounds.
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Title: Role of sublingual asenapine in treatment of schizophrenia.
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Title: [The experience of using the atypical antipsychotic sertindole in psychiatric inpatient clinics in Russia].
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Title: Clinical potential of lurasidone in the management of schizophrenia.
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Title: A novel study design for antibiotic trials in acute exacerbations of COPD: MAESTRAL methodology.
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Title: Drug-emergent metabolic syndrome in patients with schizophrenia receiving atypical (second-generation) antipsychotics.
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Title: Open-label study of the short-term effects of memantine on FDG-PET in frontotemporal dementia.
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Title: Long-acting injectable risperidone in partially adherent and nonadherent patients with schizophrenia.
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Title: Identification of novel functional inhibitors of acid sphingomyelinase.
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Title: Assessment of effectiveness measures in patients with schizophrenia initiated on risperidone long-acting therapy: the SOURCE study results.
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Title: Human engineered heart tissue as a versatile tool in basic research and preclinical toxicology.
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Title: Clinical utility of the risperidone formulations in the management of schizophrenia.
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Title: Pisa syndrome and laryngeal dystonia induced by novel antipsychotics.
Journal: The Israel journal of psychiatry and related sciences 20110101
Title: Effect of neuroleptics on cytochrome P450 2C11 (CYP2C11) in rat liver.
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Title: An open, large, 6-month naturalistic study of outcome in schizophrenic outpatients, treated with olanzapine.
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Title: Suicide attempts in a prospective cohort of patients with schizophrenia treated with sertindole or risperidone.
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Title: Sertindole for the treatment of schizophrenia.
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Title: Identification of human Ether-à-go-go related gene modulators by three screening platforms in an academic drug-discovery setting.
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Title: Gateways to clinical trials.
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Title: Combined treatment with quetiapine and sertindole in therapy refractory insomnia after clozapine discontinuation.
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Title: Safety of sertindole versus risperidone in schizophrenia: principal results of the sertindole cohort prospective study (SCoP).
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Title: Head-to-head comparisons of metabolic side effects of second generation antipsychotics in the treatment of schizophrenia: a systematic review and meta-analysis.
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Title: A head-to-head comparison of sertindole and risperidone on metabolic parameters.
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Title: Mortality in schizophrenia: a measurable clinical endpoint.
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Title: Antipsychotic-associated all-cause and cardiac mortality: what should we worry about and how should the risk be assessed?
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Title: Exploring the neuroleptic substituent in octoclothepin: potential ligands for positron emission tomography with subnanomolar affinity for α(1)-adrenoceptors.
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Title: Divergent acute and chronic modulation of glutamatergic postsynaptic density genes expression by the antipsychotics haloperidol and sertindole.
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Title: Validation and pharmacological characterisation of MK-801-induced locomotor hyperactivity in BALB/C mice as an assay for detection of novel antipsychotics.
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Title: Treatment with antipsychotics and the risk of diabetes in clinical practice.
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Title: Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.
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Title: Pharmacologic treatment of schizophrenia.
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Title: Antipsychotic drug-induced increases in ventral tegmental area dopamine neuron population activity via activation of the nucleus accumbens-ventral pallidum pathway.
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Title: Sertindole and fluoxetine overdose with benign outcome.
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Title: Sertindole and impaired atrioventricular function, in the absence of Q-T prolongation: a case report.
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Title: The effect of sertindole on QTD and TPTE.
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Title: Oculogyric crisis with sertindole monotherapy.
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Title: The amiodarone derivative KB130015 activates hERG1 potassium channels via a novel mechanism.
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Title: Ejaculatory dysfunction in patient with schizophrenia on sertindole.
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Title: The European post-marketing observational sertindole study: an investigation of the safety of antipsychotic drug treatment.
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Title: Zotepine versus other atypical antipsychotics for schizophrenia.
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Title: Mazindol attenuates ketamine-induced cognitive deficit in the attentional set shifting task in rats.
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Title: Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms.
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Title: Quetiapine versus other atypical antipsychotics for schizophrenia.
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Title: QT alterations in psychopharmacology: proven candidates and suspects.
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Title: Olanzapine versus other atypical antipsychotics for schizophrenia.
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Title: New atypical antipsychotics for schizophrenia: iloperidone.
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Title: Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.
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Title: Emerging role of sertindole in the management of schizophrenia.
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Title: Profile of olanzapine long-acting injection for the maintenance treatment of adult patients with schizophrenia.
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Title: Not all partial dopamine D(2) receptor agonists are the same in treating schizophrenia. Exploring the effects of bifeprunox and aripiprazole using a computer model of a primate striatal dopaminergic synapse.
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Title: Predictably irrational: assaying cognitive inflexibility in mouse models of schizophrenia.
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Title: Zotepine versus other atypical antipsychotics for schizophrenia.
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Title: Clozapine versus other atypical antipsychotics for schizophrenia.
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Title: Development, clinical utility, and place in therapy of posaconazole for prevention and treatment of invasive fungal infections.
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Title: Translational Aspects of the Novel Object Recognition Task in Rats Abstinent Following Sub-Chronic Treatment with Phencyclidine (PCP): Effects of Modafinil and Relevance to Cognitive Deficits in Schizophrenia.
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Title: Therapeutic drug monitoring of seven psychotropic drugs and four metabolites in human plasma by HPLC-MS.
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Title: Comparative Analysis of Cognitive Function in Schizophrenia with and without Obsessive Compulsive Disorder.
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Title: The pNNx Heart Rate Variability Statistics: An Application to Neuroautonomic Dysfunction of Clozapine-Treated Subjects.
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Title: Mechanisms of action of antipsychotic drugs of different classes, refractoriness to therapeutic effects of classical neuroleptics, and individual variation in sensitivity to their actions: Part II.
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Title: Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting.
Journal: Psychopharmacology 20091101
Title: Asenapine effects in animal models of psychosis and cognitive function.
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Title: Sertindole causes distinct electrocardiographic T-wave morphology changes.
Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20091001
Title: FDG-PET and MRI imaging of the effects of sertindole and haloperidol in the prefrontal lobe in schizophrenia.
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Title: Effect of sertindole on extracellular dopamine, acetylcholine, and glutamate in the medial prefrontal cortex of conscious rats: a comparison with risperidone and exploration of mechanisms involved.
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Title: Iatrogenic QT Abnormalities and Fatal Arrhythmias: Mechanisms and Clinical Significance.
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Title: Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers.
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Title: Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D2 receptor occupancy and behavioural conditioned avoidance response.
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Title: Further characterization of the discriminative stimulus properties of the atypical antipsychotic drug clozapine in C57BL/6 mice: role of 5-HT(2A) serotonergic and alpha (1) adrenergic antagonism.
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Title: Review of the efficacy of placebo in comparative clinical trials between typical and atypical antipsychotics.
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Title: Stability of medication in early psychosis: a comparison between second-generation and low-dose first-generation antipsychotics.
Journal: Early intervention in psychiatry 20090201
Title: Comparison of haloperidol, risperidone, sertindole, and modafinil to reverse an attentional set-shifting impairment following subchronic PCP administration in the rat--a back translational study.
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Title: Effects of Subchronic Phencyclidine (PCP) Treatment on Social Behaviors, and Operant Discrimination and Reversal Learning in C57BL/6J Mice.
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Title: Sertindole versus other atypical antipsychotics for schizophrenia.
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Title: Treatment of schizophrenia with antipsychotics in Norwegian emergency wards, a cross-sectional national study.
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Title: Combination therapy or monotherapy for the depressed type of schizoaffective disorder.
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Title: rTMS of the left dorsolateral prefrontal cortex modulates dopamine release in the ipsilateral anterior cingulate cortex and orbitofrontal cortex.
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Title: Antipsychotics and risk of venous thromboembolism: A population-based case-control study.
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Title: The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha1A1-adrenoceptors.
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Title: Reversal of subchronic PCP-induced deficits in attentional set shifting in rats by sertindole and a 5-HT6 receptor antagonist: comparison among antipsychotics.
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Title: Do we need another atypical antipsychotic?
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Title: Orthostatic hypotensive effect of antipsychotic drugs in Wistar rats by in vivo and in vitro studies of alpha1-adrenoceptor function.
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Title: Recruitment of beta-arrestin2 to the dopamine D2 receptor: insights into anti-psychotic and anti-parkinsonian drug receptor signaling.
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Title: Dopamine D2(High) receptors moderately elevated by sertindole.
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Title: Associations between venous thromboembolism and antipsychotics. A study of the WHO database of adverse drug reactions.
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Title: The Sertindole Safety Survey: a retrospective analysis under a named patient use programme in Europe.
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Title: The effect of antipsychotic medication on sexual function and serum prolactin levels in community-treated schizophrenic patients: results from the Schizophrenia Trial of Aripiprazole (STAR) study (NCT00237913).
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Title: Course of recovery of cognitive impairment in patients with schizophrenia: a randomised double-blind study comparing sertindole and haloperidol.
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Title: Marked elevation of creatine kinase with sertindole: a case report.
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Title: Pharmacological causes of hyperprolactinemia.
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Title: Reversal of PCP-induced learning and memory deficits in the Morris' water maze by sertindole and other antipsychotics.
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Title: The European sertindole safety and exposure survey: a follow-up study of 8600 patients.
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Title: An alternative approach to measuring treatment persistence with antipsychotic agents among patients with schizophrenia in the Veterans Health Administration.
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Title: Metabolic syndrome in Thai schizophrenic patients: a naturalistic one-year follow-up study.
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Title: Clinical pharmacokinetics of atypical antipsychotics: a critical review of the relationship between plasma concentrations and clinical response.
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Title: Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes.
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Title: Chlorpromazine, clozapine and olanzapine inhibit anionic amino acid transport in cultured human fibroblasts.
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Title: Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea-pigs.
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Title: Adjunctive treatment with mianserin enhances effects of raclopride on cortical dopamine output and, in parallel, its antipsychotic-like effect.
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Title: Comparison of methanol and acetonitrile as solvents for the separation of sertindole and its major metabolites by capillary zone electrophoresis.
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Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20050301
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Title: Electrophysiological safety of sertindole in dogs with normal and remodeled hearts.
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Title: Alpha(1) adrenoceptor subtype selectivity. 3D-QSAR models for a new class of alpha(1) adrenoceptor antagonists derived from the novel antipsychotic sertindole.
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Journal: Pharmacoepidemiology and drug safety 20030601
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Journal: Pharmacoepidemiology and drug safety 20030601
Title: The relevance of prolonged QTc measurement to pediatric psychopharmacology.
Journal: Journal of the American Academy of Child and Adolescent Psychiatry 20030601
Title: Understanding the structure-activity relationship of the human ether-a-go-go-related gene cardiac K+ channel. A model for bad behavior.
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Journal: Lancet (London, England) 20030510
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Title: Influence of classic and atypical neuroleptics on caffeine oxidation in rat liver microsomes.
Journal: Polish journal of pharmacology 20030101
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Journal: Dialogues in clinical neuroscience 20021201
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Title: Obesity and related metabolic abnormalities during antipsychotic drug administration: mechanisms, management and research perspectives.
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Title: A comparison of the receptor binding and HERG channel affinities for a series of antipsychotic drugs.
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Title: Stimulation by antipsychotic agents of mitogen-activated protein kinase (MAPK) coupled to cloned, human (h)serotonin (5-HT)(1A) receptors.
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Title: Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol.
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Journal: Pharmacoepidemiology and drug safety 20020601
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Journal: The Journal of pharmacology and experimental therapeutics 20020101
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Journal: Drugs 20020101
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Journal: Actas espanolas de psiquiatria 20020101
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Journal: Adverse drug reactions and toxicological reviews 20020101
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Journal: Medicina (Kaunas, Lithuania) 20020101
Title: Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells.
Journal: European journal of pharmacology 20011214
Title: Novel antipsychotics and acute dystonic reactions.
Journal: The international journal of neuropsychopharmacology 20011201
Title: Treatments for chronic psychosis.
Journal: Dialogues in clinical neuroscience 20011201
Title: Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death.
Journal: The American journal of psychiatry 20011101
Title: Development and evaluation of high throughput functional assay methods for HERG potassium channel.
Journal: Journal of biomolecular screening 20011001
Title: Sertindole is a serotonin 5-HT2c inverse agonist and decreases agonist but not antagonist binding to 5-HT2c receptors after chronic treatment.
Journal: Psychopharmacology 20010901
Title: The antipsychotic drugs sertindole and pimozide block erg3, a human brain K(+) channel.
Journal: Biochemical and biophysical research communications 20010824
Title: Effects of acute versus chronic treatment with typical or atypical antipsychotics on d-amphetamine-induced sensorimotor gating deficits in rats.
Journal: Psychopharmacology 20010701
Title: Comparative study of mortality rates and cardiac dysrhythmias in post-marketing surveillance studies of sertindole and two other atypical antipsychotic drugs, risperidone and olanzapine.
Journal: Journal of psychopharmacology (Oxford, England) 20010601
Title: Recent developments in the biology and medicinal chemistry of potassium channel modulators: update from a decade of progress.
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Title: The canine Purkinje fiber: an in vitro model system for acquired long QT syndrome and drug-induced arrhythmogenesis.
Journal: Journal of cardiovascular pharmacology 20010501
Title: The muscarinic receptor agonist BuTAC, a novel potential antipsychotic, does not impair learning and memory in mouse passive avoidance.
Journal: Schizophrenia research 20010415
Title: Traditional and new antipsychotic drugs differentially alter neurotransmission markers in basal ganglia-thalamocortical neural pathways.
Journal: Synapse (New York, N.Y.) 20010201
Title: Effects of newer atypical antipsychotics on autonomic neurocardiac function: a comparison between amisulpride, olanzapine, sertindole, and clozapine.
Journal: Journal of clinical psychopharmacology 20010201
Title: Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia.
Journal: Annual review of medicine 20010101
Title: Cost effectiveness of the newer atypical antipsychotics: a review of the pharmacoeconomic research evidence.
Journal: Current opinion in investigational drugs (London, England : 2000) 20010101
Title: Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Journal: The Journal of pharmacology and experimental therapeutics 20001001
Title: Quinpirole, 8-OH-DPAT and ketanserin modulate catalepsy induced by high doses of atypical antipsychotics.
Journal: Methods and findings in experimental and clinical pharmacology 19991101
Title: Efficacy and extrapyramidal side-effects of the new antipsychotics olanzapine, quetiapine, risperidone, and sertindole compared to conventional antipsychotics and placebo. A meta-analysis of randomized controlled trials.
Journal: Schizophrenia research 19990104
Title: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Journal: European journal of pharmacology 19980821
Title: Antipsychotic drugs which elicit little or no parkinsonism bind more loosely than dopamine to brain D2 receptors, yet occupy high levels of these receptors.
Journal: Molecular psychiatry 19980301
Title: Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence.
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Title: Atypical neuroleptics have low affinity for dopamine D2 receptors or are selective for D4 receptors.
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Title: Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
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Title: Differential effects of classical and newer antipsychotics on the hypermotility induced by two dose levels of D-amphetamine.
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