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108409-83-2,MFCD01212888
Catalog No.:AA007CLR

108409-83-2 | β-Catenin/Tcf Inhibitor, FH535

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1mg
98%
in stock  
$16.00   $11.00
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10mg
98%
in stock  
$56.00   $39.00
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007CLR
Chemical Name:
β-Catenin/Tcf Inhibitor, FH535
CAS Number:
108409-83-2
Molecular Formula:
C13H10Cl2N2O4S
Molecular Weight:
361.2005
MDL Number:
MFCD01212888
SMILES:
Clc1ccc(c(c1)S(=O)(=O)Nc1ccc(cc1C)[N+](=O)[O-])Cl
Properties
Computed Properties
 
Complexity:
505  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
3  
XLogP3:
3.9  

Downstream Synthesis Route

[1]Zhang,Wen;Sviripa,VitaliyM.;Kril,LiliiaM.;Yu,Tianxin;Xie,Yanqi;Hubbard,W.Brad;Sullivan,PatrickG.;Chen,Xi;Zhan,Chang-Guo;Yang-Hartwich,Yang;Evers,B.Mark;Spear,BrettT.;Gedaly,Roberto;Watt,DavidS.;Liu,Chunming[JournalofMedicinalChemistry,2019,vol.62,#24,p.11348-11358]

[2]CurrentPatentAssignee:YALEUNIVERSITY;UNIVERSITYOFKENTUCKY-WO2020/168290,2020,A1Locationinpatent:Paragraph0104

Literature

Title: Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/β-Catenin Pathway.

Journal: Molecular neurobiology 20151201

Title: Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression.

Journal: Toxicology 20141105

Title: IL-6 augmented motility of airway epithelial cell BEAS-2B via Akt/GSK-3β signaling pathway.

Journal: Journal of cellular biochemistry 20121101

Title: Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.

Journal: Toxicology and applied pharmacology 20121015

Title: Influence of five potential anticancer drugs on wnt pathway and cell survival in human biliary tract cancer cells.

Journal: International journal of biological sciences 20120101

Title: FH535 potentiation of cigarette smoke condensate cytotoxicity is associated with changes in β-catenin and EGR-1 signaling.

Journal: International journal of toxicology 20120101

Title: A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.

Journal: Molecular cancer therapeutics 20080301

Title: Handeli S, et al. A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities. Mol Cancer Ther. 2008 Mar;7(3):521-9.

Title: Wu MY, et al. FH535 inhibited metastasis and growth of pancreatic cancer cells. Onco Targets Ther. 2015 Jul 6;8:1651-70.

Title: Liu L, et al. FH535, a β-catenin pathway inhibitor, represses pancreatic cancer xenograft growth and angiogenesis. Oncotarget. 2016 Jul 26;7(30):47145-47162.

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SDS
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