Title: Aldosterone activates transcription factor Nrf2 in kidney cells both in vitro and in vivo.
Journal: Antioxidants & redox signaling 20141120
Title: Identification of (R)-6-(1-(4-cyano-3-methylphenyl)-5-cyclopentyl-4,5-dihydro-1H-pyrazol-3-yl)-2-methoxynicotinic acid, a highly potent and selective nonsteroidal mineralocorticoid receptor antagonist.
Journal: Journal of medicinal chemistry 20140522
Title: Prostate effect in dogs with the aldosterone receptor blocker eplerenone.
Journal: Toxicologic pathology 20130201
Title: WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone.
Journal: Biochemical and biophysical research communications 20121102
Title: Permanent muscular sodium overload and persistent muscle edema in Duchenne muscular dystrophy: a possible contributor of progressive muscle degeneration.
Journal: Journal of neurology 20121101
Title: Mineralocorticoid receptor blocker eplerenone reduces pain behaviors in vivo and decreases excitability in small-diameter sensory neurons from local inflamed dorsal root ganglia in vitro.
Journal: Anesthesiology 20121101
Title: [Is eplerenone nephrotoxic?].
Journal: Deutsche medizinische Wochenschrift (1946) 20121101
Title: Usefulness of matrix metalloproteinase-9 plasma levels to identify patients with preserved left ventricular systolic function after acute myocardial infarction who could benefit from eplerenone.
Journal: The American journal of cardiology 20121015
Title: Aldosterone receptor antagonists in cardiovascular disease: a review of the recent literature and insight into potential future indications.
Journal: Clinical cardiology 20121001
Title: Who needs a transplant and when?
Journal: Current opinion in organ transplantation 20121001
Title: Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice.
Journal: Hypertension (Dallas, Tex. : 1979) 20121001
Title: Mineralocorticoid receptor antagonists for the treatment of hypertension and diabetic nephropathy.
Journal: Journal of medicinal chemistry 20120927
Title: Eplerenone inhibits aldosterone-induced renal expression of cyclooxygenase.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120901
Title: A diastereoselective synthesis of 7α-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone.
Journal: Steroids 20120901
Title: Positive effect of eplerenone treatment on endothelial progenitor cells in patients with chronic heart failure.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120901
Title: The role of aldosterone receptor antagonists in the management of heart failure: an update.
Journal: Cleveland Clinic journal of medicine 20120901
Title: Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension.
Journal: Circulation 20120821
Title: Long-term effects of aldosterone blockade in resistant hypertension associated with chronic kidney disease.
Journal: Journal of human hypertension 20120801
Title: Role of mineralocorticoid receptor/Rho/Rho-kinase pathway in obesity-related renal injury.
Journal: International journal of obesity (2005) 20120801
Title: Spironolactone, but not eplerenone, impairs glucose tolerance in a rat model of metabolic syndrome.
Journal: The Journal of veterinary medical science 20120801
Title: Eplerenone and new-onset diabetes in patients with mild heart failure: results from the Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure (EMPHASIS-HF).
Journal: European journal of heart failure 20120801
Title: Eplerenone, an aldosterone blocker, is more effective in reducing blood pressure in patients with, than without, metabolic syndrome.
Journal: Therapeutic advances in cardiovascular disease 20120801
Title: Discovery of BAY 94-8862: a nonsteroidal antagonist of the mineralocorticoid receptor for the treatment of cardiorenal diseases.
Journal: ChemMedChem 20120801
Title: Eplerenone is not superior to older and less expensive aldosterone antagonists.
Journal: The American journal of medicine 20120801
Title: Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.
Journal: The Journal of clinical investigation 20120702
Title: Mitochondrial dysfunction accounts for aldosterone-induced epithelial-to-mesenchymal transition of renal proximal tubular epithelial cells.
Journal: Free radical biology & medicine 20120701
Title: The 2012 ESC Guidelines on Heart Failure.
Journal: European heart journal 20120701
Title: Eplerenone for the treatment of cardiovascular disorders.
Journal: Expert review of cardiovascular therapy 20120701
Title: The meaning of hypokalemia in heart failure.
Journal: International journal of cardiology 20120628
Title: Cisplatin-induced acute renal failure in mice is mediated by chymase-activated angiotensin-aldosterone system and interleukin-18.
Journal: European journal of pharmacology 20120615
Title: Angiotensin II- and salt-induced kidney injury through Rac1-mediated mineralocorticoid receptor activation.
Journal: Journal of the American Society of Nephrology : JASN 20120601
Title: Low-dose spironolactone prevents apoptosis repressor with caspase recruitment domain degradation during myocardial infarction.
Journal: Hypertension (Dallas, Tex. : 1979) 20120601
Title: Aldosterone inhibits antifibrotic factors in mouse hypertensive heart.
Journal: Hypertension (Dallas, Tex. : 1979) 20120601
Title: Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease.
Journal: European journal of heart failure 20120601
Title: Hypo- and hyperglycemia predict outcome in patients with left ventricular dysfunction after acute myocardial infarction: data from EPHESUS.
Journal: Journal of cardiac failure 20120601
Title: Safety of mineralocorticoid receptor antagonists in patients receiving hemodialysis.
Journal: The Annals of pharmacotherapy 20120601
Title: Recent developments in the management of heart failure.
Journal: The Practitioner 20120601
Title: Genes implicated in insulin resistance are down-regulated in primary aldosteronism patients.
Journal: Molecular and cellular endocrinology 20120515
Title: Cardiac complications associated with trastuzumab in the setting of adjuvant chemotherapy for breast cancer overexpressing human epidermal growth factor receptor type 2 - a prospective study.
Journal: Archives of medical science : AMS 20120509
Title: Heart failure: EMPHASIS-HF links eplerenone with reduced risk of new-onset AF.
Journal: Nature reviews. Cardiology 20120508
Title: Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.
Journal: Cancer research 20120501
Title: Adipocytes produce aldosterone through calcineurin-dependent signaling pathways: implications in diabetes mellitus-associated obesity and vascular dysfunction.
Journal: Hypertension (Dallas, Tex. : 1979) 20120501
Title: Eplerenone and atrial fibrillation in mild systolic heart failure: results from the EMPHASIS-HF (Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure) study.
Journal: Journal of the American College of Cardiology 20120501
Title: Cost-effectiveness of aldosterone antagonists for the treatment of post-myocardial infarction heart failure.
Journal: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research 20120501
Title: Rationale for treating oedema in Duchenne muscular dystrophy with eplerenone.
Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20120501
Title: Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma.
Journal: The Journal of steroid biochemistry and molecular biology 20120401
Title: Activation of mineralocorticoid receptors in the rostral ventrolateral medulla is involved in hypertensive mechanisms in stroke-prone spontaneously hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120401
Title: Update on aldosterone antagonists use in heart failure with reduced left ventricular ejection fraction. Heart Failure Society of America Guidelines Committee.
Journal: Journal of cardiac failure 20120401
Title: Effect of eplerenone, a selective aldosterone blocker, on the development of diabetic nephropathy in type 2 diabetic rats.
Journal: Diabetes & metabolism journal 20120401
Title: Molecular pharmacology of the mineralocorticoid receptor: prospects for novel therapeutics.
Journal: Molecular and cellular endocrinology 20120324
Title: Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction.
Journal: Biochemical and biophysical research communications 20120309
Title: The long-term antiproteinuric effect of eplerenone, a selective aldosterone blocker, in patients with non-diabetic chronic kidney disease.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20120301
Title: Long-term mineralocorticoid receptor blockade ameliorates progression of experimental diabetic renal disease.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20120301
Title: Aldosterone does not contribute to renal p21 expression during the development of angiotensin II-induced hypertension in mice.
Journal: American journal of hypertension 20120301
Title: Antiapolipoprotein A-1 IgG chronotropic effects require nongenomic action of aldosterone on L-type calcium channels.
Journal: Endocrinology 20120301
Title: Aldosterone blunts tubuloglomerular feedback by activating macula densa mineralocorticoid receptors.
Journal: Hypertension (Dallas, Tex. : 1979) 20120301
Title: Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats.
Journal: Diabetes, obesity & metabolism 20120201
Title: Aldosterone stimulates nuclear factor-kappa B activity and transcription of intercellular adhesion molecule-1 and connective tissue growth factor in rat mesangial cells via serum- and glucocorticoid-inducible protein kinase-1.
Journal: Clinical and experimental nephrology 20120201
Title: Eplerenone use in primary aldosteronism during pregnancy.
Journal: Hypertension (Dallas, Tex. : 1979) 20120201
Title: Clinical and biochemical consequences of CYP17A1 inhibition with abiraterone given with and without exogenous glucocorticoids in castrate men with advanced prostate cancer.
Journal: The Journal of clinical endocrinology and metabolism 20120201
Title: Aldosterone induces vascular insulin resistance by increasing insulin-like growth factor-1 receptor and hybrid receptor.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20120201
Title: Mineralocorticoid receptor blocker eplerenone improves endothelial function and inhibits Rho-associated kinase activity in patients with hypertension.
Journal: Clinical pharmacology and therapeutics 20120201
Title: Eplerenone works. Does it matter how?
Journal: Expert review of cardiovascular therapy 20120201
Title: Determinants and consequences of renal function variations with aldosterone blocker therapy in heart failure patients after myocardial infarction: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study.
Journal: Circulation 20120117
Title: Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.
Journal: Bioorganic & medicinal chemistry letters 20120115
Title: The effect of treatment on monocyte and lymphocyte cytokine release in patients with aldosteronoma.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20120101
Title: The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities.
Journal: European heart journal 20120101
Title: Eplerenone improved hypokalemia in a patient with Gitelman's syndrome.
Journal: Internal medicine (Tokyo, Japan) 20120101
Title: Effects of ACE-inhibitors and angiotensin receptor blockers on inflammation.
Journal: Current pharmaceutical design 20120101
Title: Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer.
Journal: Drug design, development and therapy 20120101
Title: The epidermal growth factor receptor is involved in angiotensin II but not aldosterone/salt-induced cardiac remodelling.
Journal: PloS one 20120101
Title: How full is our antihypertensives pipeline?
Journal: Journal of pharmacology & pharmacotherapeutics 20120101
Title: Targeting NADPH oxidases in vascular pharmacology.
Journal: Vascular pharmacology 20120101
Title: Developments in heart failure 2011.
Journal: Congestive heart failure (Greenwich, Conn.) 20120101
Title: Mineralocorticoid receptor antagonist for renal protection.
Journal: Renal failure 20120101
Title: Mineralocorticoid Receptor Blocker Protects against Podocyte-Dependent Glomerulosclerosis.
Journal: Nephron extra 20120101
Title: Laboratory monitoring of patients treated with antihypertensive drugs and newly exposed to non steroidal anti-inflammatory drugs: a cohort study.
Journal: PloS one 20120101
Title: Hepatoprotective effect of the selective mineralocorticoid receptor antagonist, eplerenone against carbon tetrachloride-induced liver injury in rats.
Journal: Annals of hepatology 20120101
Title: The role of Na+/H+ exchanger in Ca2+ overload and ischemic myocardial damage in hearts from type 2 diabetic db/db mice.
Journal: Cardiovascular diabetology 20120101
Title: Cardiovascular magnetic resonance in systemic hypertension.
Journal: Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20120101
Title: The Relationship between Reactive Oxygen Species and Cardiac Fibrosis in the Dahl Salt-Sensitive Rat under ACEI Administration.
Journal: Veterinary medicine international 20120101
Title: Antiarrhythmic potential of aldosterone antagonists in atrial fibrillation.
Journal: Cardiology journal 20120101
Title: Aldosterone inhibits the fetal program and increases hypertrophy in the heart of hypertensive mice.
Journal: PloS one 20120101
Title: Angiotensin II, Aldosterone, and Anti-Inflammatory Lymphocytes: Interplay and Therapeutic Opportunities.
Journal: International journal of hypertension 20120101
Title: Antioxidants in kidney diseases: the impact of bardoxolone methyl.
Journal: International journal of nephrology 20120101
Title: Oxidative stress-induced glomerular mineralocorticoid receptor activation limits the benefit of salt reduction in Dahl salt-sensitive rats.
Journal: PloS one 20120101
Title: Sex and gender differences in cardiovascular drug therapy.
Journal: Handbook of experimental pharmacology 20120101
Title: Degradation Pathway for Eplerenone by Validated Stability Indicating UP-LC Method.
Journal: ISRN pharmaceutics 20120101
Title: Identification of benzoxazin-3-one derivatives as novel, potent, and selective nonsteroidal mineralocorticoid receptor antagonists.
Journal: Journal of medicinal chemistry 20111222
Title: Mineralocorticoid receptor activation is crucial in the signalling pathway leading to the Anrep effect.
Journal: The Journal of physiology 20111215
Title: Study of the mechanisms of aldosterone prothrombotic effect in rats.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20111201
Title: Effects of aldosterone and related steroids on LPS-induced increased expression of inducible NOS in rat aortic smooth muscle cells.
Journal: British journal of pharmacology 20111201
Title: Aldosterone-induced osteopontin gene transcription in vascular smooth muscle cells involves glucocorticoid response element.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111201
Title: Aldosterone and cortisol predict medium-term left ventricular remodelling following myocardial infarction.
Journal: European journal of heart failure 20111201
Title: Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20111201
Title: Improvement of sodium status to optimize the efficacy of Renin-Angiotensin system blockade.
Journal: Current hypertension reports 20111201
Title: What is the role of aldosterone excess in resistant hypertension and how should it be investigated and treated?
Journal: Current cardiology reports 20111201
Title: A sensitive and specific HPLC-MS/MS analysis and preliminary pharmacokinetic characterization of isoforskolin in beagle dogs.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111201
Title: Heart failure and non-ST-segment elevation myocardial infarction: a review for a widespread situation.
Journal: European journal of internal medicine 20111201
Title: Mineralocorticoid receptor antagonists for heart failure.
Journal: Expert opinion on pharmacotherapy 20111201
Title: Mineralocorticoid receptor antagonists for heart failure.
Journal: Expert opinion on pharmacotherapy 20111201
Title: Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Journal: PLoS computational biology 20111201
Title: Mechanisms mediating sodium-induced pressor responses in the PVN of Dahl rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20111101
Title: The central mechanism underlying hypertension: a review of the roles of sodium ions, epithelial sodium channels, the renin-angiotensin-aldosterone system, oxidative stress and endogenous digitalis in the brain.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111101
Title: Therapeutic perspectives in hypertension: novel means for renin-angiotensin-aldosterone system modulation and emerging device-based approaches.
Journal: European heart journal 20111101
Title: Effects of a novel aldosterone synthase inhibitor for treatment of primary hypertension: results of a randomized, double-blind, placebo- and active-controlled phase 2 trial.
Journal: Circulation 20111101
Title: Effect of eplerenone on blood pressure and the renin-angiotensin-aldosterone system in oligo-anuric chronic hemodialysis patients - a pilot study.
Journal: Clinical nephrology 20111101
Title: Aldosterone stimulates the cardiac Na(+)/H(+) exchanger via transactivation of the epidermal growth factor receptor.
Journal: Hypertension (Dallas, Tex. : 1979) 20111101
Title: Eplerenone survival benefits in heart failure patients post-myocardial infarction are independent from its diuretic and potassium-sparing effects. Insights from an EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study) substudy.
Journal: Journal of the American College of Cardiology 20111101
Title: The month after a novel tale on eplerenone, but with a different ending.
Journal: Journal of the American College of Cardiology 20111101
Title: Osteopontin deficiency protects against aldosterone-induced inflammation, oxidative stress, and interstitial fibrosis in the kidney.
Journal: American journal of physiology. Renal physiology 20111001
Title: The effect of body mass index and fasting glucose on the relationship between blood pressure and incident diabetes mellitus: a 5-year follow-up study.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20111001
Title: Eplerenone, an aldosterone antagonist, reduces hospitalization and death in heart failure patients with NYHA class II and an ejection fraction of less than 30%.
Journal: Internal and emergency medicine 20111001
Title: Clinical trials update from the European Society of Cardiology Heart Failure meeting 2011: TEHAF, WHICH, CARVIVA, and atrial fibrillation in GISSI-HF and EMPHASIS-HF.
Journal: European journal of heart failure 20111001
Title: Mineralocorticoid hypertension.
Journal: Indian journal of endocrinology and metabolism 20111001
Title: Pediatric endocrine hypertension.
Journal: Indian journal of endocrinology and metabolism 20111001
Title: Mild hyperkalemia and low eGFR a tedious recipe for cardiac disaster in the elderly: an unusual reversible cause of syncope and heart block.
Journal: Heart international 20110929
Title: Eplerenone suppresses aldosterone/ salt-induced expression of NOX-4.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20110901
Title: Efficacy of eplerenone added to renin-angiotensin blockade in elderly hypertensive patients: the Jichi-Eplerenone Treatment (JET) study.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20110901
Title: Dehydroepiandrosterone-induced phosphorylation and translocation of FoxO1 depend on the mineralocorticoid receptor.
Journal: Hypertension (Dallas, Tex. : 1979) 20110901
Title: Adipocyte-derived factors regulate vascular smooth muscle cells through mineralocorticoid and glucocorticoid receptors.
Journal: Hypertension (Dallas, Tex. : 1979) 20110901
Title: Delineating the receptor mechanisms underlying the rapid vascular contractile effects of aldosterone and estradiol.
Journal: Canadian journal of physiology and pharmacology 20110901
Title: Aldosterone blockers (mineralocorticoid receptor antagonism) and potassium-sparing diuretics.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110901
Title: [Pharmacological sheet: eplerenone (Inspra), orally].
Journal: Journal de pharmacie de Belgique 20110901
Title: The selective mineralocorticoid receptor antagonist eplerenone is protective in mild anti-GBM glomeru-lonephritis.
Journal: International journal of clinical and experimental pathology 20110815
Title: Eplerenone reduces risk of cardiovascular death or hospitalisation in heart failure patients with reduced ejection fraction.
Journal: Evidence-based medicine 20110801
Title: An ouabain-like factor is secreted from immortalized hypothalamic cells in an aldosterone-dependent manner.
Journal: Neurochemistry international 20110801
Title: Spironolactone is more effective than eplerenone at lowering blood pressure in patients with primary aldosteronism.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110801
Title: Results of the Randomized Aldosterone Antagonism in Heart Failure with Preserved Ejection Fraction trial (RAAM-PEF).
Journal: Journal of cardiac failure 20110801
Title: Glucocorticoid and mineralocorticoid receptors regulate paracellular permeability in a primary cultured gill epithelium.
Journal: The Journal of experimental biology 20110715
Title: Eplerenone potentiates protective effects of amlodipine against cardiovascular injury in salt-sensitive hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110701
Title: Eplerenone, amlodipine and experimental hypertension: one plus one equals three.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110701
Title: [Aldosterone and kidney diseases: an emergent paradigm with important clinical implications].
Journal: Nephrologie & therapeutique 20110601
Title: Aldosterone antagonists in heart failure.
Journal: Journal of cardiovascular pharmacology and therapeutics 20110601
Title: Proinflammatory protein CARD9 is essential for infiltration of monocytic fibroblast precursors and cardiac fibrosis caused by Angiotensin II infusion.
Journal: American journal of hypertension 20110601
Title: Angiotensin II and aldosterone-induced neuronal damage in neurons through an astrocyte-dependent mechanism.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110601
Title: Mineralocorticoid receptor activation: a major contributor to salt-induced renal injury and hypertension in young rats.
Journal: American journal of physiology. Renal physiology 20110601
Title: Eplerenone reverses spironolactone-induced painful gynaecomastia in cirrhotics.
Journal: Hepatology international 20110601
Title: Protective effects of eplerenone on podocyte injury in adriamycin nephropathy rats.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20110601
Title: Impairment of endothelial progenitor cell function and vascularization capacity by aldosterone in mice and humans.
Journal: European heart journal 20110501
Title: Role of mineralocorticoid receptor on atrial structural remodeling and inducibility of atrial fibrillation in hypertensive rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110501
Title: Impact of diabetes mellitus on outcomes in patients with acute myocardial infarction and systolic heart failure.
Journal: European journal of heart failure 20110501
Title: Mineralocorticoid receptor activation and blockade: an emerging paradigm in chronic kidney disease.
Journal: Kidney international 20110501
Title: A double-blind, randomized study comparing the antihypertensive effect of eplerenone and spironolactone in patients with hypertension and evidence of primary aldosteronism.
Journal: Journal of hypertension 20110501
Title: Mitochondrial dysfunction mediates aldosterone-induced podocyte damage: a therapeutic target of PPARγ.
Journal: The American journal of pathology 20110501
Title: [The EMPHASIS-HF study].
Journal: Giornale italiano di cardiologia (2006) 20110501
Title: Advances in cardiology: clinical trial update.
Journal: Future cardiology 20110501
Title: Investigating the function of an aldosterone response pathway in primary human adrenocortical cells obtained from Conn's and phaeochromocytoma patients.
Journal: European journal of pharmacology 20110425
Title: Evidence-based diuretic therapy for improving cardiovascular prognosis in systemic hypertension.
Journal: The American journal of cardiology 20110415
Title: Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives.
Journal: Journal of medicinal chemistry 20110414
Title: Eplerenone in mild heart failure.
Journal: The New England journal of medicine 20110407
Title: Eplerenone in mild heart failure.
Journal: The New England journal of medicine 20110407
Title: Eplerenone in mild heart failure.
Journal: The New England journal of medicine 20110407
Title: Eplerenone in mild heart failure.
Journal: The New England journal of medicine 20110407
Title: Timing of defibrillator implant after acute myocardial infarction: what's new?
Journal: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20110401
Title: The kidneys and aldosterone/mineralocorticoid receptor system in salt-sensitive hypertension.
Journal: Current hypertension reports 20110401
Title: Evaluation of the efficacy and safety of RLY5016, a polymeric potassium binder, in a double-blind, placebo-controlled study in patients with chronic heart failure (the PEARL-HF) trial.
Journal: European heart journal 20110401
Title: Macrophage activation is responsible for loss of anticontractile function in inflamed perivascular fat.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20110401
Title: Clinical trials update from the American Heart Association meeting 2010: EMPHASIS-HF, RAFT, TIM-HF, Tele-HF, ASCEND-HF, ROCKET-AF, and PROTECT.
Journal: European journal of heart failure 20110401
Title: [Heart failure].
Journal: Deutsche medizinische Wochenschrift (1946) 20110401
Title: Disparate effects of eplerenone, amlodipine and telmisartan on podocyte injury in aldosterone-infused rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110301
Title: Effects of eplerenone on nephrotic syndrome in a patient with renovascular hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110301
Title: Aldosterone-receptor antagonists in heart failure: insights after EMPHASIS-HF.
Journal: Current heart failure reports 20110301
Title: Primary aldosteronism: A Japanese perspective.
Journal: Reviews in endocrine & metabolic disorders 20110301
Title: Treatment of primary aldosteronism: Where are we now?
Journal: Reviews in endocrine & metabolic disorders 20110301
Title: Eplerenone for gitelman syndrome in pregnancy.
Journal: Nephrology (Carlton, Vic.) 20110301
Title: Primary aldosteronism, diagnosis and treatment in Japan.
Journal: Reviews in endocrine & metabolic disorders 20110301
Title: Effects of spironolactone in spontaneously hypertensive adult rats subjected to high salt intake.
Journal: Clinics (Sao Paulo, Brazil) 20110301
Title: Recent insights into diabetic renal injury from the db/db mouse model of type 2 diabetic nephropathy.
Journal: American journal of physiology. Renal physiology 20110201
Title: Aldosterone/Mineralocorticoid receptor stimulation induces cellular senescence in the kidney.
Journal: Endocrinology 20110201
Title: Effects of mineralocorticoid receptor blockade on glucocorticoid-induced renal injury in adrenalectomized rats.
Journal: Journal of hypertension 20110201
Title: Clinical Trials Update AHA Congress 2010.
Journal: Cardiovascular drugs and therapy 20110201
Title: Effect of eplerenone on hypertension-associated renal damage in rats: potential role of peroxisome proliferator activated receptor gamma (PPAR-γ).
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110201
Title: Eplerenone in patients with systolic heart failure and mild symptoms.
Journal: The New England journal of medicine 20110106
Title: Aldosterone antagonists--last man standing?
Journal: The New England journal of medicine 20110106
Title: Stereoselective construction of a steroid 5α,7α-oxymethylene derivative and its use in the synthesis of eplerenone.
Journal: Steroids 20110101
Title: High plasma aldosterone concentration is a novel risk factor of cognitive impairment in patients with hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20110101
Title: 11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- mice.
Journal: Endocrinology 20110101
Title: Pathophysiological roles of aldosterone and mineralocorticoid receptor in the kidney.
Journal: Journal of pharmacological sciences 20110101
Title: Treatment considerations with aldosterone receptor antagonists.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20110101
Title: Heart failure: Placing an EMPHASIS on the mineralocorticoid receptor--benefit of eplerenone in mild HF.
Journal: Nature reviews. Cardiology 20110101
Title: Evolution of ligand specificity in vertebrate corticosteroid receptors.
Journal: BMC evolutionary biology 20110101
Title: Resistant hypertension workup and approach to treatment.
Journal: International journal of hypertension 20110101
Title: Aortocaval fistula in rat: a unique model of volume-overload congestive heart failure and cardiac hypertrophy.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Pathophysiology of resistant hypertension: the role of sympathetic nervous system.
Journal: International journal of hypertension 20110101
Title: Aldosteronism and resistant hypertension.
Journal: International journal of hypertension 20110101
Title: SM-368229, a novel selective and potent non-steroidal mineralocorticoid receptor antagonist with strong urinary Na+ excretion activity.
Journal: Journal of pharmacological sciences 20110101
Title: Cardiorenal syndrome in acute heart failure syndromes.
Journal: International journal of nephrology 20110101
Title: Adrenocortical causes of hypertension.
Journal: International journal of hypertension 20110101
Title: Role of the kidneys in resistant hypertension.
Journal: International journal of hypertension 20110101
Title: Study on the bioequivalence of two formulations of eplerenone in healthy volunteers under fasting conditions: data from a single-center, randomized, single-dose, open-label, 2-way crossover bioequivalence study.
Journal: Arzneimittel-Forschung 20110101
Title: Hyponatremia and congestive heart failure: a marker of increased mortality and a target for therapy.
Journal: International journal of nephrology 20110101
Title: The causes, consequences, and treatment of left or right heart failure.
Journal: Vascular health and risk management 20110101
Title: Long-term use of aldosterone-receptor antagonists in uncontrolled hypertension: a retrospective analysis.
Journal: International journal of hypertension 20110101
Title: Cardiorenal syndrome: an unsolved clinical problem.
Journal: International journal of nephrology 20110101
Title: Pharmacological management of cardiorenal syndromes.
Journal: International journal of nephrology 20110101
Title: [Summary of the article: Zannad F, McMurray JJV, Krum H et al.; for the EMPHASIS-HF Study Group. Eplerenone in patients with systolic heart failure and mild symptoms. N Engl J Med, 2011; 364: 11-21].
Journal: Kardiologia polska 20110101
Title: Diabetic microvascular complications: possible targets for improved macrovascular outcomes.
Journal: International journal of nephrology and renovascular disease 20110101
Title: Abiraterone acetate, an inhibitor of adrenal androgen synthesis in 'hormone refractory prostate cancer'.
Journal: Indian journal of medical and paediatric oncology : official journal of Indian Society of Medical & Paediatric Oncology 20110101
Title: Aldosterone and aldosterone receptor antagonists in patients with chronic heart failure.
Journal: Vascular health and risk management 20110101
Title: Cardiac hypertrophy and fibrosis in the metabolic syndrome: a role for aldosterone and the mineralocorticoid receptor.
Journal: International journal of hypertension 20110101
Title: Management of hypertension in high-risk ethnic minority with heart failure.
Journal: International journal of hypertension 20110101
Title: Left ventricular hypertrophy: major risk factor in patients with hypertension: update and practical clinical applications.
Journal: International journal of hypertension 20110101
Title: Diabetic nephropathy - Epidemiology in Asia and the current state of treatment.
Journal: Indian journal of nephrology 20110101
Title: Role of the Renin-Angiotensin system and aldosterone on cardiometabolic syndrome.
Journal: International journal of hypertension 20110101
Title: Animal models of calcific aortic valve disease.
Journal: International journal of inflammation 20110101
Title: Changes in the perceived epidemiology of primary hyperaldosteronism.
Journal: International journal of hypertension 20110101
Title: Cardiac magnetic resonance imaging parameters as surrogate endpoints in clinical trials of acute myocardial infarction.
Journal: Trials 20110101
Title: Hypertension and other morbidities with Cushing's syndrome associated with corticosteroids: a review.
Journal: Integrated blood pressure control 20110101
Title: Short- and long-term physiologic and pharmacologic control of blood pressure in pediatric patients.
Journal: Integrated blood pressure control 20110101
Title: Oxidative damages in tubular epithelial cells in IgA nephropathy: role of crosstalk between angiotensin II and aldosterone.
Journal: Journal of translational medicine 20110101
Title: Eplerenone prevents salt-induced vascular stiffness in Zucker diabetic fatty rats: a preliminary report.
Journal: Cardiovascular diabetology 20110101
Title: The use of plasma aldosterone and urinary sodium to potassium ratio as translatable quantitative biomarkers of mineralocorticoid receptor antagonism.
Journal: Journal of translational medicine 20110101
Title: Moderate antiproteinuric effect of add-on aldosterone blockade with eplerenone in non-diabetic chronic kidney disease. A randomized cross-over study.
Journal: PloS one 20110101
Title: Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population.
Journal: Neuropsychiatric disease and treatment 20110101
Title: Role of aldosterone on lung structural remodelling and right ventricular function in congestive heart failure.
Journal: BMC cardiovascular disorders 20110101
Title: Simultaneous identification and quantification of canrenone and 11-α-hydroxy-canrenone by LC-MS and HPLC-UVD.
Journal: Journal of biomedicine & biotechnology 20110101
Title: Early peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass.
Journal: BMC medical genomics 20110101
Title: Novel Pharmacological Interventions to Maintain Sinus Rhythm after DC Cardioversion.
Journal: ISRN cardiology 20110101
Title: [Aldosterone blocker in heart failure: life prolonging even in mild symptoms].
Journal: MMW Fortschritte der Medizin 20101202
Title: Interference between eplerenone and digoxin in fluorescence polarization immunoassay, microparticle enzyme immunoassay, and affinity column-mediated immunoassay.
Journal: Therapeutic drug monitoring 20101201
Title: Acid retention during kidney failure induces endothelin and aldosterone production which lead to progressive GFR decline, a situation ameliorated by alkali diet.
Journal: Kidney international 20101201
Title: Review article: eplerenone: an underused medication?
Journal: Journal of cardiovascular pharmacology and therapeutics 20101201
Title: Aldosterone enhances IGF-I-mediated signaling and biological function in vascular smooth muscle cells.
Journal: Endocrinology 20101201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20101201
Title: Increased renal alpha-epithelial sodium channel (ENAC) protein and increased ENAC activity in normal pregnancy.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20101101
Title: BK channels and a new form of hypertension.
Journal: Kidney international 20101101
Title: Effect of eplerenone versus spironolactone on cortisol and hemoglobin A₁(c) levels in patients with chronic heart failure.
Journal: American heart journal 20101101
Title: [Prothrombotic aldosterone action--a new side of the hormone].
Journal: Postepy higieny i medycyny doswiadczalnej (Online) 20101018
Title: Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin.
Journal: The Journal of investigative dermatology 20101001
Title: Effects of selective mineralocorticoid receptor antagonism on atrial ion currents and early ionic tachycardia-induced electrical remodelling in rabbits.
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20101001
Title: Spironolactone use in heart failure patients with end-stage renal disease on hemodialysis: is it safe?
Journal: Clinical cardiology 20101001
Title: Aldosterone receptor blockade inhibits degenerative processes in the early stage of calcific aortic stenosis.
Journal: European journal of pharmacology 20100910
Title: Effect of eplerenone on endothelial progenitor cells and oxidative stress in ischemic hindlimb.
Journal: American journal of hypertension 20100901
Title: Mineralocorticoid receptor activation contributes to salt-induced hypertension and renal injury in prepubertal Dahl salt-sensitive rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100901
Title: Reduction of endothelial tight junction proteins is related to cerebral aneurysm formation in rats.
Journal: Journal of hypertension 20100901
Title: Aldosterone blockade in chronic kidney disease: can it improve outcome?
Journal: Current opinion in nephrology and hypertension 20100901
Title: Aldosterone and angiogenesis.
Journal: American journal of hypertension 20100901
Title: World Congress on the Insulin Resistance Syndrome, 2009: the kidney, the liver, and insulin resistance.
Journal: Diabetes care 20100901
Title: Genetic analyses of the chimeric CYP11B1/CYP11B2 gene in a Korean family with glucocorticoid-remediable aldosteronism.
Journal: Journal of Korean medical science 20100901
Title: Clinical Inquiries: Which drugs should post-MI patients routinely receive?
Journal: The Journal of family practice 20100901
Title: The effect of aldosterone antagonists for ventricular arrhythmia: a meta-analysis.
Journal: Clinical cardiology 20100901
Title: Discovery of novel cyanodihydropyridines as potent mineralocorticoid receptor antagonists.
Journal: Journal of medicinal chemistry 20100826
Title: Discovery of (3S,3aR)-2-(3-chloro-4-cyanophenyl)-3-cyclopentyl-3,3a,4,5-tetrahydro-2H-benzo[g]indazole-7-carboxylic acid (PF-3882845), an orally efficacious mineralocorticoid receptor (MR) antagonist for hypertension and nephropathy.
Journal: Journal of medicinal chemistry 20100826
Title: The efficacy and safety of the novel aldosterone antagonist eplerenone in children with hypertension: a randomized, double-blind, dose-response study.
Journal: The Journal of pediatrics 20100801
Title: Reduction of fibrosis-related arrhythmias by chronic renin-angiotensin-aldosterone system inhibitors in an aged mouse model.
Journal: American journal of physiology. Heart and circulatory physiology 20100801
Title: Increased cytochrome P4502E1 expression and altered hydroxyeicosatetraenoic acid formation mediate diabetic vascular dysfunction: rescue by guanylyl-cyclase activation.
Journal: Diabetes 20100801
Title: Drug mechanisms to help in managing resistant hypertension in obesity.
Journal: Current hypertension reports 20100801
Title: Activation of the aldosterone/mineralocorticoid receptor system in chronic kidney disease and metabolic syndrome.
Journal: Clinical and experimental nephrology 20100801
Title: Mineralocorticoid receptor antagonists and the metabolic syndrome.
Journal: Current hypertension reports 20100801
Title: Novel therapeutic targets for hypertension.
Journal: Nature reviews. Cardiology 20100801
Title: Aldosterone inhibition and cardiovascular protection: more important than it once appeared.
Journal: Cardiovascular drugs and therapy 20100801
Title: Optimal antagonism of the Renin-Angiotensin-aldosterone system: do we need dual or triple therapy?
Journal: Drugs 20100709
Title: Cardioprotective effects of mineralocorticoid receptor antagonists at reperfusion.
Journal: European heart journal 20100701
Title: Microvascular obstruction remains a portent of adverse remodeling in optimally treated patients with left ventricular systolic dysfunction after acute myocardial infarction.
Journal: Circulation. Cardiovascular imaging 20100701
Title: Eplerenone suppresses salt-induced vascular endothelial growth factor expression in the kidney.
Journal: Kidney & blood pressure research 20100701
Title: Blockade of mineralocorticoid receptors improves salt-induced left-ventricular systolic dysfunction through attenuation of enhanced sympathetic drive in mice with pressure overload.
Journal: Journal of hypertension 20100701
Title: Differential actions of eplerenone and spironolactone on the protective effect of testosterone against cardiomyocyte apoptosis in vitro.
Journal: Revista espanola de cardiologia 20100701
Title: The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Journal: European journal of pharmacology 20100610
Title: Clinical effects of eplerenone, a selective aldosterone blocker, in Japanese patients with essential hypertension.
Journal: Journal of human hypertension 20100601
Title: Sensitivity of NOS-dependent vascular relaxation pathway to mineralocorticoid receptor blockade in caveolin-1-deficient mice.
Journal: American journal of physiology. Heart and circulatory physiology 20100601
Title: Rationale and design of the Eplerenone combination Versus conventional Agents to Lower blood pressure on Urinary Antialbuminuric Treatment Effect (EVALUATE) trial: a double-blinded randomized placebo-controlled trial to evaluate the antialbuminuric effects of an aldosterone blocker in hypertensive patients with albuminuria.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100601
Title: Rationale and design of the Eplerenone in Mild Patients Hospitalization And SurvIval Study in Heart Failure (EMPHASIS-HF).
Journal: European journal of heart failure 20100601
Title: Activation of mineralocorticoid receptors by exogenous glucocorticoids and the development of cardiovascular inflammatory responses in adrenalectomized rats.
Journal: Endocrinology 20100601
Title: The effects of the selective mineralocorticoid receptor antagonist eplerenone on hepatic fibrosis induced by bile duct ligation in rat.
Journal: International journal of molecular medicine 20100601
Title: Eplerenone in chronic renal disease: the EVALUATE trial.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100601
Title: Aortic cell apoptosis in rat primary aldosteronism model.
Journal: Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20100601
Title: Stereochemical requirements for the mineralocorticoid receptor antagonist activity of dihydropyridines.
Journal: Journal of medicinal chemistry 20100527
Title: Tissue plasminogen activator antigen predicts medium-term left ventricular end-systolic volume after acute myocardial infarction.
Journal: Journal of thrombosis and thrombolysis 20100501
Title: Eplerenone, a selective mineralocorticoid receptor blocker, exerts anxiolytic effects accompanied by changes in stress hormone release.
Journal: Journal of psychopharmacology (Oxford, England) 20100501
Title: Aldosterone stimulates the proliferation of uterine leiomyoma cells.
Journal: Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20100501
Title: Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats.
Journal: Clinical and experimental pharmacology & physiology 20100501
Title: Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20100501
Title: Monocyte chemoattractant protein-1: a dichotomous role in cardiac remodeling following acute myocardial infarction in man?
Journal: Cytokine 20100501
Title: Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction.
Journal: Circulation. Heart failure 20100501
Title: Selective aldosterone blocker, eplerenone, attenuates hepatocellular carcinoma growth and angiogenesis in mice.
Journal: Hepatology research : the official journal of the Japan Society of Hepatology 20100501
Title: Abiraterone acetate: a promising drug for the treatment of castration-resistant prostate cancer.
Journal: Future oncology (London, England) 20100501
Title: A systematic review and economic evaluation of the clinical effectiveness and cost-effectiveness of aldosterone antagonists for postmyocardial infarction heart failure.
Journal: Health technology assessment (Winchester, England) 20100501
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100501
Title: Physiologic tailoring of treatment in resistant hypertension.
Journal: Current cardiology reviews 20100501
Title: Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess.
Journal: American journal of physiology. Heart and circulatory physiology 20100401
Title: Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation.
Journal: British journal of pharmacology 20100401
Title: Aldosterone receptor antagonists--how cardiovascular actions may explain their beneficial effects in heart failure.
Journal: Journal of veterinary pharmacology and therapeutics 20100401
Title: Effects of mineralocorticoid and angiotensin II receptor blockers on proteinuria and glomerular podocyte protein expression in a model of minimal change nephrotic syndrome.
Journal: Nephrology (Carlton, Vic.) 20100401
Title: Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney.
Journal: Biochemical and biophysical research communications 20100319
Title: Mineralocorticoid receptor blockade enhances the antiproteinuric effect of an angiotensin II blocker through inhibiting podocyte injury in type 2 diabetic rats.
Journal: The Journal of pharmacology and experimental therapeutics 20100301
Title: Involvement of mineralocorticoid receptor in high glucose-induced big mitogen-activated protein kinase 1 activation and mesangial cell proliferation.
Journal: Journal of hypertension 20100301
Title: Aldosterone receptor inhibition alters the viscoelastic biomechanical behavior of the aortic wall.
Journal: Experimental biology and medicine (Maywood, N.J.) 20100301
Title: Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice.
Journal: Regulatory peptides 20100225
Title: Aldosterone receptor antagonists: effective but often forgotten.
Journal: Circulation 20100223
Title: [Mineralocorticoid receptor antagonists: inhibition of the renin angiotensin system].
Journal: MMW Fortschritte der Medizin 20100211
Title: Cost-effectiveness of antihypertensive treatment in patients 80 years of age or older in Switzerland: an analysis of the HYVET study from a Swiss perspective.
Journal: Journal of human hypertension 20100201
Title: Agents with antialdosterone properties should be the preferred diuretics for reducing hypertension related atrial fibrillation.
Journal: European journal of internal medicine 20100201
Title: Eplerenone improves vascular function and reduces platelet activation in diabetic rats.
Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100201
Title: Serum soluble ST2: a potential novel mediator in left ventricular and infarct remodeling after acute myocardial infarction.
Journal: Journal of the American College of Cardiology 20100119
Title: Eplerenone administration has beneficial effect on hepatic paraoxonase 1 activity in diabetic mice.
Journal: Atherosclerosis 20100101
Title: High-salt diet increases plasma adiponectin levels independent of blood pressure in hypertensive rats: the role of the renin-angiotensin-aldosterone system.
Journal: Journal of hypertension 20100101
Title: Cost effectiveness of eplerenone in patients with heart failure after acute myocardial infarction who were taking both ACE inhibitors and beta-blockers: subanalysis of the EPHESUS.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20100101
Title: Skeletal muscle insulin resistance in endocrine disease.
Journal: Journal of biomedicine & biotechnology 20100101
Title: Aldosterone-sensitive nucleus tractus solitarius neurons regulate sensitivity of the baroreceptor reflex in high sodium-loaded rats.
Journal: Journal of pharmacological sciences 20100101
Title: [Chronic kidney disease and the aldosterone/mineralocorticoid receptor system].
Journal: Nihon Jinzo Gakkai shi 20100101
Title: Aldosterone-producing adenoma and other surgically correctable forms of primary aldosteronism.
Journal: Orphanet journal of rare diseases 20100101
Title: Diabetes is an independent predictor of survival 17 years after myocardial infarction: follow-up of the TRACE registry.
Journal: Cardiovascular diabetology 20100101
Title: Cost-effectiveness of oral alitretinoin in patients with severe chronic hand eczema--a long-term analysis from a Swiss perspective.
Journal: BMC dermatology 20100101
Title: [Preoperative and postoperative management of adrenal masses].
Journal: Il Giornale di chirurgia 20100101
Title: Impact of medical therapy on atheroma volume measured by different cardiovascular imaging modalities.
Journal: Cardiology research and practice 20100101
Title: Effect of ramipril alone compared to ramipril with eplerenone on diabetic nephropathy in streptozocin-induced diabetic rats.
Journal: Pharmacology 20100101
Title: Adherence to aldosterone-blocking agents in patients with heart failure.
Journal: American journal of therapeutics 20100101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20100101
Title: Advances in systolic heart failure.
Journal: F1000 medicine reports 20100101
Title: A population approach to eplerenone pharmacokinetics and saturable protein binding.
Journal: Drug metabolism and pharmacokinetics 20100101
Title: Successful blood pressure control with additive administration of eplerenone, an aldosterone receptor blocker, in a patient with bilateral renovascular hypertension treated with angioplasty.
Journal: Internal medicine (Tokyo, Japan) 20100101
Title: Experimental models of duchenne muscular dystrophy: relationship with cardiovascular disease.
Journal: The open cardiovascular medicine journal 20100101
Title: Signaling of reactive oxygen and nitrogen species in Diabetes mellitus.
Journal: Oxidative medicine and cellular longevity 20100101
Title: Evidence-based approach for managing hypertension in type 2 diabetes.
Journal: Integrated blood pressure control 20100101
Title: Critical appraisal of the differential effects of antihypertensive agents on arterial stiffness.
Journal: Integrated blood pressure control 20100101
Title: Is tetrahydrobiopterin a therapeutic option in diabetic hypertensive patients?
Journal: Integrated blood pressure control 20100101
Title: Successful effect of triple blockade of renin-angiotensin-aldosterone system on massive proteinuria in a patient with chronic kidney disease.
Journal: Clinical and experimental nephrology 20091201
Title: At the bottom of the differential diagnosis list: unusual causes of pediatric hypertension.
Journal: Pediatric nephrology (Berlin, Germany) 20091101
Title: Timing of eplerenone initiation and outcomes in patients with heart failure after acute myocardial infarction complicated by left ventricular systolic dysfunction: insights from the EPHESUS trial.
Journal: European journal of heart failure 20091101
Title: Natural history of markers of collagen turnover in patients with early diastolic dysfunction and impact of eplerenone.
Journal: Journal of the American College of Cardiology 20091027
Title: Heritable forms of hypertension.
Journal: Pediatric nephrology (Berlin, Germany) 20091001
Title: Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice.
Journal: Cardiovascular research 20091001
Title: Blocking aldosterone in heart failure.
Journal: Therapeutic advances in cardiovascular disease 20091001
Title: Update in primary aldosteronism.
Journal: The Journal of clinical endocrinology and metabolism 20091001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20091001
Title: Mineralocorticoid receptor blockade and calcium channel blockade have different renoprotective effects on glomerular and interstitial injury in rats.
Journal: American journal of physiology. Renal physiology 20090901
Title: Electrophysiological responses of sympathetic preganglionic neurons to ANG II and aldosterone.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090901
Title: Role of mineralocorticoid receptor on experimental cerebral aneurysms in rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20090901
Title: The effects of eplerenone on length of stay and total days of heart failure hospitalization after myocardial infarction in patients with left ventricular systolic dysfunction.
Journal: American heart journal 20090901
Title: Differential expression of determinants of glucocorticoid sensitivity in androgen-dependent and androgen-independent human prostate cancer cell lines.
Journal: The Journal of steroid biochemistry and molecular biology 20090801
Title: Aberrant ENaC activation in Dahl salt-sensitive rats.
Journal: Journal of hypertension 20090801
Title: The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090801
Title: Aldosterone in clinical nephrology--old hormone, new questions.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090801
Title: Effects of aldosterone on Cx43 gap junction expression in neonatal rat cultured cardiomyocytes.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20090801
Title: Hypertension of Kcnmb1-/- is linked to deficient K secretion and aldosteronism.
Journal: Proceedings of the National Academy of Sciences of the United States of America 20090714
Title: Cardiac aldosterone overexpression prevents harmful effects of diabetes in the mouse heart by preserving capillary density.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090701
Title: Eplerenone does not attenuate diabetes-associated atherosclerosis.
Journal: Journal of hypertension 20090701
Title: Establishment of HPLC-ESI-MS method for the determination of eplerenone in human plasma and its pharmacokinetics.
Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20090701
Title: Plasma apelin concentration is depressed following acute myocardial infarction in man.
Journal: European journal of heart failure 20090601
Title: New therapeutic options in patients prone to hypertension: a focus on direct Renin inhibition and aldosterone blockade.
Journal: The American journal of the medical sciences 20090601
Title: Fenofibrate inhibits aldosterone-induced apoptosis in adult rat ventricular myocytes via stress-activated kinase-dependent mechanisms.
Journal: American journal of physiology. Heart and circulatory physiology 20090601
Title: Aldosterone blockade attenuates development of an electrophysiological substrate associated with ventricular tachyarrhythmias in heart failure.
Journal: Heart rhythm 20090601
Title: Usefulness of abnormal heart rate turbulence to predict cardiovascular mortality in high-risk patients with acute myocardial infarction and left ventricular dysfunction (from the EPHESUS study).
Journal: The American journal of cardiology 20090601
Title: Left ventricular remodeling after acute myocardial infarction: does eplerenone have an effect?
Journal: American heart journal 20090601
Title: [The use of aldosterone antagonists in the cardiovascular diseases].
Journal: Kardiologia polska 20090601
Title: [Eplerenone in resistant hypertension with previous spironolactone intolerance].
Journal: Medicina clinica 20090523
Title: A history of systemic hypertension and incident heart failure hospitalization in patients with acute myocardial infarction and left ventricular systolic dysfunction.
Journal: The American journal of cardiology 20090515
Title: Extracellular cardiac matrix biomarkers in patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure: insights from the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS) study.
Journal: Circulation 20090512
Title: Effects of eplerenone, a selective mineralocorticoid receptor antagonist, on clinical and experimental salt-sensitive hypertension.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20090501
Title: Prevention of myocardial dysfunction by Eplerenon in experimental tachycardiomyopathy.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20090501
Title: Aldosterone Receptor Antagonism Reduces Urinary C-Reactive Protein Excretion in Angiotensin II-Infused, Hypertensive Rats.
Journal: Journal of the American Society of Hypertension : JASH 20090501
Title: [Aldosterone antagonists for all patients with heart failure?].
Journal: MMW Fortschritte der Medizin 20090409
Title: Enhancement of aldosterone-induced catecholamine production by bone morphogenetic protein-4 through activating Rho and SAPK/JNK pathway in adrenomedullar cells.
Journal: American journal of physiology. Endocrinology and metabolism 20090401
Title: Anti-inflammatory effects of eplerenone on viral myocarditis.
Journal: European journal of heart failure 20090401
Title: A comparison of the aldosterone-blocking agents eplerenone and spironolactone.
Journal: Clinical cardiology 20090401
Title: The clinical pharmacology of eplerenone.
Journal: Expert opinion on drug metabolism & toxicology 20090401
Title: Aldosterone-receptor antagonism in hypertension.
Journal: Journal of hypertension 20090401
Title: Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats.
Journal: Journal of hypertension 20090401
Title: Sex-specific impact of aldosterone receptor antagonism on ventricular remodeling and gene expression after myocardial infarction.
Journal: Clinical and translational science 20090401
Title: Aldosterone and mineralocorticoid receptors: Clinical studies and basic biology.
Journal: Molecular and cellular endocrinology 20090325
Title: CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer.
Journal: British journal of cancer 20090310
Title: Hypotension due to the drug interaction of voriconazole with eplerenone and nifedipine.
Journal: European journal of clinical pharmacology 20090301
Title: Mechanisms in the PVN mediating local and central sodium-induced hypertension in Wistar rats.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20090301
Title: Role of aldosterone receptor antagonist eplerenone in aortic stenosis.
Journal: American heart journal 20090301
Title: Eplerenone treatment of aortic stenosis. [letter].
Journal: American heart journal 20090301
Title: Aldosterone blockade and left ventricular dysfunction: a systematic review of randomized clinical trials.
Journal: European heart journal 20090201
Title: Patient health status and costs in heart failure: insights from the eplerenone post-acute myocardial infarction heart failure efficacy and survival study (EPHESUS).
Journal: Circulation 20090127
Title: Effect of eplerenone, enalapril and their combination treatment on diabetic nephropathy in type II diabetic rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20090101
Title: Contrasting effects of eplerenone and spironolactone on adrenal cell steroidogenesis.
Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090101
Title: Is abiraterone acetate well tolerated and effective in the treatment of castration-resistant prostate cancer?
Journal: Nature clinical practice. Oncology 20090101
Title: Eplerenone decreases inflammatory foci in spontaneously hypertensive rat hearts with minimal effects on blood pressure.
Journal: Journal of cardiovascular pharmacology 20090101
Title: Graz Endocrine Causes of Hypertension (GECOH) study: a diagnostic accuracy study of aldosterone to active renin ratio in screening for primary aldosteronism.
Journal: BMC endocrine disorders 20090101
Title: Candesartan cilexetil in the treatment of chronic heart failure.
Journal: Vascular health and risk management 20090101
Title: A comparative study of the prevalence of hyperkalemia with the use of angiotensin-converting enzyme inhibitors versus angiotensin receptor blockers.
Journal: Therapeutics and clinical risk management 20090101
Title: Predictors of hyperkalemia risk following hypertension control with aldosterone blockade.
Journal: American journal of nephrology 20090101
Title: Prevention of atherosclerosis by interference with the vascular nitric oxide system.
Journal: Current pharmaceutical design 20090101
Title: Drugs associated with more suicidal ideations are also associated with more suicide attempts.
Journal: PloS one 20090101
Title: [The antiproteinuric effect of the blockage of the renin-angiotensin-aldosterone system (RAAS) in obese patients. Which treatment option is the most effective? ].
Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20090101
Title: Management of hypertension in the elderly patient.
Journal: Clinical interventions in aging 20090101
Title: Review of the treatment of acute coronary syndrome in elderly patients.
Journal: Clinical interventions in aging 20090101
Title: Acute diastolic mitral regurgitation as a mechanism of left ventricular failure in a patient with normal systolic function.
Journal: Indian heart journal 20090101
Title: Manifestation of renal disease in obesity: pathophysiology of obesity-related dysfunction of the kidney.
Journal: International journal of nephrology and renovascular disease 20090101
Title: Clinical approach in treatment of resistant hypertension.
Journal: Integrated blood pressure control 20090101
Title: Aldosterone induces myofibroblastic transdifferentiation and collagen gene expression through the Rho-kinase dependent signaling pathway in rat mesangial cells.
Journal: Experimental cell research 20081210
Title: Endocrine arterial hypertension: therapeutic approach in clinical practice.
Journal: Minerva endocrinologica 20081201
Title: Eplerenone in patients with acute myocardial infarction complicated by heart failure.
Journal: Hypertension (Dallas, Tex. : 1979) 20081201
Title: Possible underlying mechanisms responsible for aldosterone and mineralocorticoid receptor-dependent renal injury.
Journal: Journal of pharmacological sciences 20081201
Title: Expression of NAD(P)H oxidase subunits and their contribution to cardiovascular damage in aldosterone/salt-induced hypertensive rat.
Journal: Journal of Korean medical science 20081201
Title: Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system.
Journal: Regulatory peptides 20081129
Title: Serum potassium and clinical outcomes in the Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study (EPHESUS).
Journal: Circulation 20081014
Title: Hyperkalemia associated with inhibitors of the renin-angiotensin-aldosterone system: balancing risk and benefit.
Journal: Circulation 20081014
Title: [Pharmacology profile and clinical findings of Selara Tablets (eplerenone)].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20081001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20081001
Title: Inhibition of mineralocorticoid receptors with eplerenone alleviates short-term cyclosporin A nephrotoxicity in conscious rats.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20080901
Title: Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline.
Journal: The Journal of clinical endocrinology and metabolism 20080901
Title: Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes.
Journal: American journal of physiology. Heart and circulatory physiology 20080901
Title: Mineralocorticoid receptor antagonists and endothelial function.
Journal: Current opinion in investigational drugs (London, England : 2000) 20080901
Title: Aldosterone enhances ligand-stimulated nitric oxide production in endothelial cells.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080901
Title: Effect of single treatment with the antihypertensive drug eplerenone on hormone levels and anxiety-like behaviour in rats.
Journal: Endocrine regulations 20080901
Title: Cost-effectiveness analysis of aldosterone blockade with eplerenone in patients with heart failure after acute myocardial infarction in the French context: the EPHESUS study.
Journal: Archives of cardiovascular diseases 20080901
Title: Aldosterone modifies hemostasis via upregulation of the protein-C receptor in human vascular endothelium.
Journal: Biochemical and biophysical research communications 20080822
Title: Aldosterone and glomerular podocyte injury.
Journal: Clinical and experimental nephrology 20080801
Title: Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080801
Title: History of hypertension and eplerenone in patients with acute myocardial infarction complicated by heart failure.
Journal: Hypertension (Dallas, Tex. : 1979) 20080801
Title: Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder.
Journal: Hypertension (Dallas, Tex. : 1979) 20080801
Title: Aldosterone, but not angiotensin II, reduces angiotensin converting enzyme 2 gene expression levels in cultured neonatal rat cardiomyocytes.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20080801
Title: A randomized trial of the aldosterone-receptor antagonist eplerenone in asymptomatic moderate-severe aortic stenosis.
Journal: American heart journal 20080801
Title: Vasoconstrictor effect of aldosterone via angiotensin II type 1 (AT1) receptor: possible role of AT1 receptor dimerization.
Journal: Cardiovascular research 20080701
Title: Aldosterone induces mesangial cell apoptosis both in vivo and in vitro.
Journal: American journal of physiology. Renal physiology 20080701
Title: Synergy of aldosterone and high salt induces vascular smooth muscle hypertrophy through up-regulation of NOX1.
Journal: The Journal of steroid biochemistry and molecular biology 20080701
Title: Paradoxical mineralocorticoid receptor activation and left ventricular diastolic dysfunction under high oxidative stress conditions.
Journal: Journal of hypertension 20080701
Title: Eplerenone improves prognosis in postmyocardial infarction diabetic patients with heart failure: results from EPHESUS.
Journal: Diabetes, obesity & metabolism 20080601
Title: The specific mineralocorticoid receptor blocker eplerenone attenuates left ventricular remodeling in mice lacking the gene encoding guanylyl cyclase-A.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080601
Title: [Misdiagnosed emergency: heart failure symptoms after infarct. Rapid aldosterone block can safe the tired heart].
Journal: MMW Fortschritte der Medizin 20080529
Title: Mineralocorticoid receptor is essential for corticosteroid-induced up-regulation of L-type calcium currents in cultured neonatal cardiomyocytes.
Journal: Pflugers Archiv : European journal of physiology 20080501
Title: Therapeutic strategies to slow chronic kidney disease progression.
Journal: Pediatric nephrology (Berlin, Germany) 20080501
Title: Eplerenone in the treatment of Gitelman's syndrome.
Journal: Internal medicine journal 20080501
Title: Aldosterone-to-renin ratio as a screening test for primary aldosteronism--the Dutch ARRAT Study.
Journal: The Netherlands journal of medicine 20080501
Title: Eplerenone ethanol solvate.
Journal: Acta crystallographica. Section E, Structure reports online 20080501
Title: Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines.
Journal: Circulation 20080429
Title: A lifetime of aldosterone excess: long-term consequences of altered regulation of aldosterone production for cardiovascular function.
Journal: Endocrine reviews 20080401
Title: Immediate mineralocorticoid receptor blockade improves myocardial infarct healing by modulation of the inflammatory response.
Journal: Hypertension (Dallas, Tex. : 1979) 20080401
Title: Translational research goes both ways: lessons from clinical studies.
Journal: Clinical and experimental pharmacology & physiology 20080401
Title: Aldosterone and the vascular system.
Journal: The Journal of steroid biochemistry and molecular biology 20080401
Title: A comparison of the aldosterone-blocking agents eplerenone and spironolactone.
Journal: Clinical cardiology 20080401
Title: Hypertension in children with chronic kidney disease: pathophysiology and management.
Journal: Pediatric nephrology (Berlin, Germany) 20080301
Title: Aldosterone induces superoxide generation via Rac1 activation in endothelial cells.
Journal: Endocrinology 20080301
Title: Eplerenone potentiates the antiproteinuric effects of enalapril in experimental nephrotic syndrome.
Journal: American journal of physiology. Renal physiology 20080301
Title: Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability.
Journal: Hypertension (Dallas, Tex. : 1979) 20080301
Title: A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity.
Journal: Hypertension (Dallas, Tex. : 1979) 20080301
Title: Spironolactone versus eplerenone for the treatment of idiopathic hyperaldosteronism.
Journal: Expert opinion on pharmacotherapy 20080301
Title: Willingness to pay for a reduction in mortality risk after a myocardial infarction: an application of the contingent valuation method to the case of eplerenone.
Journal: The European journal of health economics : HEPAC : health economics in prevention and care 20080201
Title: Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients.
Journal: Hypertension (Dallas, Tex. : 1979) 20080201
Title: Aldosterone receptor blockade in patients with left ventricular systolic dysfunction following acute myocardial infarction.
Journal: Cardiology clinics 20080201
Title: Aldosterone nongenomically produces NADPH oxidase-dependent reactive oxygen species and induces myocyte apoptosis.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080201
Title: [Antialdosteronic agents: their role in heart failure].
Journal: Medicina clinica 20080119
Title: Drug Insight: eplerenone, a mineralocorticoid-receptor antagonist.
Journal: Nature clinical practice. Endocrinology & metabolism 20080101
Title: Eplerenone after myocardial infarction?
Journal: Drug and therapeutics bulletin 20080101
Title: Development of a simplified assay for determination of the antimineralocorticoid activity of compounds dosed in rats.
Journal: Journal of pharmacological and toxicological methods 20080101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20080101
Title: Practical aspects in the management of hypokalemic periodic paralysis.
Journal: Journal of translational medicine 20080101
Title: Drug therapy for chronic heart failure due to left ventricular systolic dysfunction. II. Diuretics.
Journal: Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20080101
Title: [Cardiorenal syndrome].
Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20080101
Title: Blockade of renin-angiotensin-aldosterone system in kidney and heart disease: how much do we need?
Journal: Acta medica Indonesiana 20080101
Title: Effectiveness of the selective aldosterone blocker, eplerenone, in patients with resistant hypertension.
Journal: Journal of the American Society of Hypertension : JASH 20080101
Title: (S)-N-{3-[1-cyclopropyl-1-(2,4-difluoro-phenyl)-ethyl]-1H-indol-7-yl}-methanesulfonamide: a potent, nonsteroidal, functional antagonist of the mineralocorticoid receptor.
Journal: Journal of medicinal chemistry 20071227
Title: Eplerenone relieves spironolactone-induced painful gynaecomastia in patients with decompensated hepatitis B-related cirrhosis.
Journal: Scandinavian journal of gastroenterology 20071201
Title: Effect of long-term monotherapy with the aldosterone receptor blocker eplerenone on cytoskeletal proteins and matrix metalloproteinases in dogs with heart failure.
Journal: Cardiovascular drugs and therapy 20071201
Title: Evaluation of the aldosterone-blocking agent eplerenone in hypertension and heart failure.
Journal: Expert opinion on pharmacotherapy 20071201
Title: Combining neuroendocrine inhibitors in heart failure: reflections on safety and efficacy.
Journal: The American journal of medicine 20071201
Title: Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis.
Journal: Current drug metabolism 20071201
Title: Optimizing care of heart failure after acute MI with an aldosterone receptor antagonist.
Journal: Current heart failure reports 20071201
Title: [Pathophysiology of heart failure and the biomarkers; brain natriuretic hormone as the class-1 recommendation by the new Japanese Guideline for Heart Failure].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20071201
Title: Aldosterone induces CTGF in mesangial cells by activation of the glucocorticoid receptor.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071101
Title: Mineralocorticoid receptor blockade improves vasomotor dysfunction and vascular oxidative stress early after myocardial infarction.
Journal: Hypertension (Dallas, Tex. : 1979) 20071101
Title: Avoiding vicious circles: mineralocorticoid receptor antagonism prevents vascular oxidative stress early after myocardial infarction.
Journal: Hypertension (Dallas, Tex. : 1979) 20071101
Title: Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress.
Journal: Hypertension (Dallas, Tex. : 1979) 20071101
Title: Does glucocorticoid receptor blockade exacerbate tissue damage after mineralocorticoid/salt administration?
Journal: Endocrinology 20071001
Title: Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells.
Journal: Hypertension (Dallas, Tex. : 1979) 20071001
Title: Intact female stroke-prone hypertensive rats lack responsiveness to mineralocorticoid receptor antagonists.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20071001
Title: Effects of aldosterone and angiotensin II receptor blockade on cardiac angiotensinogen and angiotensin-converting enzyme 2 expression in Dahl salt-sensitive hypertensive rats.
Journal: American journal of hypertension 20071001
Title: Aldosterone antagonism in heart failure.
Journal: Vascular health and risk management 20071001
Title: Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin.
Journal: American journal of physiology. Renal physiology 20070901
Title: [Role of aldosterone in oxidative stress and renal injury].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901
Title: [Molecular mechanism of cardiovascular damage induced by aldosterone].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070901
Title: Acute aldosterone infusion enhances thrombosis development in normotensive rats.
Journal: Thrombosis and haemostasis 20070901
Title: Construction of 3D models of the CYP11B family as a tool to predict ligand binding characteristics.
Journal: Journal of computer-aided molecular design 20070801
Title: Arterial stiffness and pharmacological interventions--the TRanscend arterial stiffNess Substudy (TRANS study).
Journal: Vascular health and risk management 20070801
Title: Pretreatment with eplerenone reduces stroke volume in mouse middle cerebral artery occlusion model.
Journal: European journal of pharmacology 20070702
Title: Aldosterone receptor antagonism exacerbates intrarenal angiotensin II augmentation in ANG II-dependent hypertension.
Journal: American journal of physiology. Renal physiology 20070701
Title: Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus.
Journal: The Journal of clinical endocrinology and metabolism 20070701
Title: Drug insight: aldosterone-receptor antagonists in heart failure--the journey continues.
Journal: Nature clinical practice. Cardiovascular medicine 20070701
Title: [Aldosterone receptor antagonists].
Journal: Revue medicale suisse 20070530
Title: [Eplerenone for treatment of heart failure].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: [Aldosterone antagonists: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070528
Title: Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.
Journal: American journal of physiology. Renal physiology 20070501
Title: Dual blockade of aldosterone and angiotensin II additively suppresses TGF-beta and NADPH oxidase in the hypertensive kidney.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070501
Title: Eplerenone attenuates myocardial fibrosis in the angiotensin II-induced hypertensive mouse: involvement of tenascin-C induced by aldosterone-mediated inflammation.
Journal: Journal of cardiovascular pharmacology 20070501
Title: [Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20070428
Title: Primary percutaneous coronary intervention.
Journal: The New England journal of medicine 20070412
Title: Angiotensin II receptor type 1-mediated vascular oxidative stress and proinflammatory gene expression in aldosterone-induced hypertension: the possible role of local renin-angiotensin system.
Journal: Endocrinology 20070401
Title: A German family with glucocorticoid-remediable aldosteronism.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070401
Title: Treatment of heart failure with ACE inhibitors and beta-blockers: what is next? Aldosterone receptor antagonists?
Journal: Clinical research in cardiology : official journal of the German Cardiac Society 20070401
Title: Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?
Journal: Expert opinion on pharmacotherapy 20070401
Title: Current guidelines for treatment of heart failure: 2006 update.
Journal: Pharmacotherapy 20070401
Title: Increased cyclooxygenase-2 expression in hypothalamic paraventricular nucleus in rats with heart failure: role of nuclear factor kappaB.
Journal: Hypertension (Dallas, Tex. : 1979) 20070301
Title: Interactions between aldosterone and connective tissue growth factor in vascular and renal damage in spontaneously hypertensive rats.
Journal: Journal of hypertension 20070301
Title: Dose-dependent endothelial cell growth and stiffening by aldosterone: endothelial protection by eplerenone.
Journal: Journal of hypertension 20070301
Title: Mineralocorticoid receptor antagonists.
Journal: Current hypertension reports 20070301
Title: Rapid effects of aldosterone on clonal human vascular smooth muscle cells.
Journal: American journal of physiology. Cell physiology 20070201
Title: Elevated cardiac tissue level of aldosterone and mineralocorticoid receptor in diastolic heart failure: Beneficial effects of mineralocorticoid receptor blocker.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20070201
Title: Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1.
Journal: Hypertension (Dallas, Tex. : 1979) 20070201
Title: Eplerenone suppresses neointima after coronary stenting in pigs: could it be extrapolated to stent restenosis in humans?
Journal: International journal of cardiology 20070131
Title: Eplerenone offsets cardiac and aortic adverse remodeling in spontaneously hypertensive rats.
Journal: International journal of cardiology 20070102
Title: Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR.
Journal: American journal of physiology. Heart and circulatory physiology 20070101
Title: Eplerenone relieves spironolactone-induced painful gynaecomastia in a patient with primary aldosteronism.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20070101
Title: Novel therapies blocking the renin-angiotensin-aldosterone system in the management of hypertension and related disorders.
Journal: Journal of hypertension 20070101
Title: Aldosterone antagonists: the most underutilized class of heart failure medications.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20070101
Title: Update of diuretics in the treatment of hypertension.
Journal: American journal of therapeutics 20070101
Title: Clinical trials update from the American College of Cardiology 2007: ALPHA, EVEREST, FUSION II, VALIDD, PARR-2, REMODEL, SPICE, COURAGE, COACH, REMADHE, pro-BNP for the evaluation of dyspnoea and THIS-diet.
Journal: European journal of heart failure 20070101
Title: The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology.
Journal: Nuclear receptor signaling 20070101
Title: [Pathophysiological role of aldosterone in acute renal failure].
Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20070101
Title: The risks and benefits of therapy with aldosterone receptor antagonist therapy.
Journal: Current drug safety 20070101
Title: Heart failure.
Journal: BMJ clinical evidence 20070101
Title: The role of the glucocorticoid receptor in mineralocorticoid/salt-mediated cardiac fibrosis.
Journal: Endocrinology 20061201
Title: Spironolactone induces apoptosis and inhibits NF-kappaB independent of the mineralocorticoid receptor.
Journal: Apoptosis : an international journal on programmed cell death 20061201
Title: Why are mineralocorticoid receptor antagonists cardioprotective?
Journal: Naunyn-Schmiedeberg's archives of pharmacology 20061201
Title: Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors.
Journal: Journal of the American Society of Nephrology : JASN 20061201
Title: Sexual function in hypertensive patients receiving treatment.
Journal: Vascular health and risk management 20061201
Title: Candesartan in heart failure.
Journal: Clinical interventions in aging 20061201
Title: Mineralocorticoid receptor antagonist reduces renal injury in rodent models of types 1 and 2 diabetes mellitus.
Journal: Endocrinology 20061101
Title: Does eplerenone have a future in the management of hypertension in Europe?
Journal: Journal of human hypertension 20061101
Title: Antiangiogenic effects of spironolactone and other potassium-sparing diuretics in human umbilical vein endothelial cells and in fibrin gel chambers implanted in rats.
Journal: Journal of hypertension 20061101
Title: Aldosterone blockade: an emerging strategy for abrogating progressive renal disease.
Journal: The American journal of medicine 20061101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061101
Title: [Cardioverter-defibrillator (ICD) and resynchronization in every patient with cardiac failure].
Journal: Deutsche medizinische Wochenschrift (1946) 20061013
Title: Aldosterone blockade in post-acute myocardial infarction heart failure.
Journal: Clinical cardiology 20061001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20061001
Title: Novel effect of mineralocorticoid receptor antagonism to reduce proinflammatory cytokines and hypothalamic activation in rats with ischemia-induced heart failure.
Journal: Circulation research 20060929
Title: [Antihypertensive agents used as first line agents: beta-blockers under pressure].
Journal: Revue medicale suisse 20060913
Title: [The revived interest in aldosterone antagonists].
Journal: Revue medicale suisse 20060913
Title: [Modern pharmacological aspects of hyperaldosteronism therapy].
Journal: Der Internist 20060901
Title: Eplerenone prevents adverse cardiac remodelling induced by pressure overload in atrial natriuretic peptide-null mice.
Journal: Clinical and experimental pharmacology & physiology 20060901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060901
Title: Selective aldosterone blockade with eplerenone reduces albuminuria in patients with type 2 diabetes.
Journal: Clinical journal of the American Society of Nephrology : CJASN 20060901
Title: Eplerenone: hypertension, heart failure and the importance of mineralocorticoid receptor blockade.
Journal: Future cardiology 20060901
Title: MDM2: a novel mineralocorticoid-responsive gene involved in aldosterone-induced human vascular structural remodeling.
Journal: The American journal of pathology 20060801
Title: Effects of eplerenone and salt intake on left ventricular remodeling after myocardial infarction in rats.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060801
Title: Mineralocorticoid receptor blockade but not steroid withdrawal reverses renal fibrosis in deoxycorticosterone/salt rats.
Journal: Endocrinology 20060701
Title: Molecular mechanism of the inhibitory effect of aldosterone on endothelial NO synthase activity.
Journal: Hypertension (Dallas, Tex. : 1979) 20060701
Title: Eplerenone inhibits tumour necrosis factor alpha shedding process by tumour necrosis factor alpha converting enzyme in monocytes from patients with congestive heart failure.
Journal: Heart (British Cardiac Society) 20060701
Title: [Cardiovascular action of aldosterone].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701
Title: [Cardioprotective effect of aldosterone antagonists for ventricular remodeling].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060701
Title: [Aldosterone receptor blockade after acute myocardial infarction with heart failure].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20060615
Title: [Combination drug therapy after myocardial infarction. Early aldosterone blocking protects risk patients].
Journal: MMW Fortschritte der Medizin 20060615
Title: Podocyte injury underlies the glomerulopathy of Dahl salt-hypertensive rats and is reversed by aldosterone blocker.
Journal: Hypertension (Dallas, Tex. : 1979) 20060601
Title: Can the dextroenantiomer of the aromatase inhibitor fadrozole be useful for clinical investigation of aldosterone-synthase inhibition?
Journal: Journal of hypertension 20060601
Title: Cost-effectiveness of eplerenone in patients with left ventricular dysfunction after myocardial infarction--an analysis of the EPHESUS study from a Swiss perspective.
Journal: Cardiovascular drugs and therapy 20060601
Title: Valsartan in the treatment of heart attack survivors.
Journal: Vascular health and risk management 20060601
Title: [Deficiency of 11beta-hydroxysteroid dehydrogenase type 2 (syndrome of apparent mineralocorticoid excess)].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20060528
Title: Improving outcomes in post-acute myocardial infarction heart failure: incorporation of aldosterone blockade into combination therapy to optimize neurohormonal blockade.
Journal: The American journal of cardiology 20060522
Title: Role of aldosterone blockade for treatment of heart failure and post-acute myocardial infarction.
Journal: The American journal of cardiology 20060522
Title: A new approach to the furan degradation problem involving ozonolysis of the trans-enedione and its use in a cost-effective synthesis of eplerenone.
Journal: Organic letters 20060511
Title: Protective effect of spironolactone on endothelial cell apoptosis.
Journal: Endocrinology 20060501
Title: Evaluation of eplerenone in the subgroup of EPHESUS patients with baseline left ventricular ejection fraction <or=30%.
Journal: European journal of heart failure 20060501
Title: Selective aldosterone blockade suppresses atrial tachyarrhythmias in heart failure.
Journal: Journal of cardiovascular electrophysiology 20060501
Title: Aldosterone antagonism as an antiarrhythmic approach for atrial arrhythmias in heart failure.
Journal: Journal of cardiovascular electrophysiology 20060501
Title: [Antihypertensive drugs in clinical development].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060501
Title: Hypertension and ethnic group: eplerenone may have role in hypertension related atrial fibrillation.
Journal: BMJ (Clinical research ed.) 20060422
Title: Eplerenone with valsartan effectively reduces atherosclerotic lesion by attenuation of oxidative stress and inflammation.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20060401
Title: Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?
Journal: Hypertension (Dallas, Tex. : 1979) 20060401
Title: Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and failure in low-aldosterone hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20060401
Title: Mineralocorticoid receptors and cardiovascular damage: it's not just aldosterone.
Journal: Hypertension (Dallas, Tex. : 1979) 20060401
Title: Cardioprotective mechanisms of eplerenone on cardiac performance and remodeling in failing rat hearts.
Journal: Hypertension (Dallas, Tex. : 1979) 20060401
Title: The pharmacological treatment of primary aldosteronism.
Journal: Expert opinion on pharmacotherapy 20060401
Title: Eplerenone: new drug. Recent myocardial infarction with heart failure: a spironolactone me too.
Journal: Prescrire international 20060401
Title: Aldosterone receptor antagonists and cardiovascular disease: do we need a change of the guard?
Journal: Cardiovascular & hematological agents in medicinal chemistry 20060401
Title: The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.
Journal: Cardiovascular drugs and therapy 20060401
Title: Combination therapy with aldosterone blockade and renin-angiotensin inhibitors confers organ protection.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20060401
Title: Direct effects of aldosterone on cardiomyocytes in the presence of normal and elevated extracellular sodium.
Journal: Endocrinology 20060301
Title: Aldosterone receptor antagonists for heart failure: current status, future indications.
Journal: Cleveland Clinic journal of medicine 20060301
Title: Aldosterone inhibition reduces the risk of sudden cardiac death in patients with heart failure.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20060301
Title: Differences between cardiac and arterial fibrosis and stiffness in aldosterone-salt rats: effect of eplerenone.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20060301
Title: Beneficial effect of eplerenone on cardiac remodelling and electrical properties of the failing heart.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20060301
Title: Eplerenone suppresses neointimal formation after coronary stent implantation in swine.
Journal: International journal of cardiology 20060215
Title: Effects of enalapril, tempol, and eplerenone on salt-induced hypertension in dahl salt-sensitive rats.
Journal: Clinical and experimental hypertension (New York, N.Y. : 1993) 20060201
Title: Adjunctive treatment with eplerenone reduced 30 day all cause mortality in acute myocardial infarction.
Journal: Evidence-based medicine 20060201
Title: [The latest developments in endocrinology 2004/2005].
Journal: Medizinische Klinik (Munich, Germany : 1983) 20060115
Title: Aldosterone antagonists in the treatment of heart failure.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20060101
Title: Adjunctive treatment with eplerenone reduced 30-day all-cause mortality in acute myocardial infarction.
Journal: ACP journal club 20060101
Title: Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effects of aldosterone blockade.
Journal: Journal of pharmacological sciences 20060101
Title: Hospital protocols and evidence-based therapies: the importance of integrating aldosterone blockade into the management of patients with post-acute myocardial infarction heart failure.
Journal: Clinical cardiology 20060101
Title: Mineralocorticoid receptor blockade in the protection of target organ damage.
Journal: Cardiovascular & hematological agents in medicinal chemistry 20060101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20060101
Title: [Diuretic therapy in heart failure].
Journal: Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20060101
Title: [Contemporary approaches to the treatment of chronic heart failure in adults (after materials of recommendations of American College of Cardiology and American Heart Association, 2005)].
Journal: Kardiologiia 20060101
Title: Aldosterone remodels human endothelium.
Journal: Acta physiologica (Oxford, England) 20060101
Title: Application of continuous positive airway pressure in hypoxemic acute respiratory failure associated with diastolic dysfunction in pregnancy.
Journal: Congestive heart failure (Greenwich, Conn.) 20060101
Title: Cardiomyopathy, familial dilated.
Journal: Orphanet journal of rare diseases 20060101
Title: Aldosterone and thrombosis formation: implications for ischemic and atherosclerotic heart disease.
Journal: Journal of endocrinological investigation 20060101
Title: Pfizer launches Inspra for heart failure.
Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101
Title: Eplerenone reduces morbidity and mortality after acute MI.
Journal: Cardiovascular journal of South Africa : official journal for Southern Africa Cardiac Society [and] South African Society of Cardiac Practitioners 20060101
Title: Aldosterone antagonists: a new treatment option for patients with post-myocardial infarction heart failure.
Journal: Cardiovascular revascularization medicine : including molecular interventions 20060101
Title: Effects of eplerenone on transcriptional factors and mRNA expression related to cardiac remodelling after myocardial infarction.
Journal: Heart (British Cardiac Society) 20051201
Title: Mechanisms for nongenomic and genomic effects of aldosterone on Na+/H+ exchange in vascular smooth muscle cells.
Journal: Journal of hypertension 20051201
Title: Aldosterone antagonists in the treatment and prevention of heart failure.
Journal: Current treatment options in cardiovascular medicine 20051201
Title: Does eplerenone benefit postinfarction patients with heart failure and left ventricular systolic dysfunction?
Journal: Nature clinical practice. Cardiovascular medicine 20051201
Title: Aldosterone receptor antagonists in the medical management of chronic heart failure.
Journal: Mayo Clinic proceedings 20051201
Title: [Heart failure after myocardial infarction. Increased risk, poorer treatment].
Journal: MMW Fortschritte der Medizin 20051201
Title: [Efficient improvement of prognosis after myocardial infarct? Additional aldosterone inhibition is required].
Journal: MMW Fortschritte der Medizin 20051201
Title: The genetic basis for altered blood vessel function in disease: large artery stiffening.
Journal: Vascular health and risk management 20051201
Title: Eplerenone inhibits atherosclerosis in nonhuman primates.
Journal: Hypertension (Dallas, Tex. : 1979) 20051101
Title: Eplerenone antagonizes atherosclerosis, but what is the agonist?
Journal: Hypertension (Dallas, Tex. : 1979) 20051101
Title: Mineralocorticoid-receptor blockade, hypertension and heart failure.
Journal: Nature clinical practice. Endocrinology & metabolism 20051101
Title: Mineralocorticoid receptor blocker increases angiotensin-converting enzyme 2 activity in congestive heart failure patients.
Journal: Circulation research 20051028
Title: Aldosterone stimulates collagen gene expression and synthesis via activation of ERK1/2 in rat renal fibroblasts.
Journal: Hypertension (Dallas, Tex. : 1979) 20051001
Title: Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation.
Journal: Hypertension (Dallas, Tex. : 1979) 20051001
Title: Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II.
Journal: Hypertension (Dallas, Tex. : 1979) 20051001
Title: c-Src-dependent nongenomic signaling responses to aldosterone are increased in vascular myocytes from spontaneously hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20051001
Title: Sudden death in patients with myocardial infarction.
Journal: The New England journal of medicine 20050922
Title: Effects of eplerenone versus losartan in patients with low-renin hypertension.
Journal: American heart journal 20050901
Title: Beneficial cardiovascular actions of eplerenone in the spontaneously hypertensive rat.
Journal: Journal of cardiovascular pharmacology and therapeutics 20050901
Title: Is eplerenone a cost-effective therapy for heart failure patients after myocardial infarction?
Journal: Nature clinical practice. Cardiovascular medicine 20050901
Title: Eplerenone appears cost-effective for people with heart failure after acute myocardial infarction. Commentary 1.
Journal: Evidence-based cardiovascular medicine 20050901
Title: Eplerenone appears cost-effective for people with heart failure after acute myocardial infarction. Commentary 2.
Journal: Evidence-based cardiovascular medicine 20050901
Title: Eplerenone reduces mortality 30 days after randomization following acute myocardial infarction in patients with left ventricular systolic dysfunction and heart failure.
Journal: Journal of the American College of Cardiology 20050802
Title: Letter regarding article by Weintraub et al, 'Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure'.
Journal: Circulation 20050802
Title: The risks and benefits of aldosterone antagonists.
Journal: Current heart failure reports 20050801
Title: Molecular mechanisms of mineralocorticoid receptor antagonism by eplerenone.
Journal: Mini reviews in medicinal chemistry 20050801
Title: Heart failure after acute ST-segment elevation myocardial infarction: what should we do about it?
Journal: Clinical cardiology 20050801
Title: New aldosteron receptor inhibitors in heart failure.
Journal: Minerva cardioangiologica 20050801
Title: Aldosterone receptor antagonism in heart failure.
Journal: Pharmacotherapy 20050801
Title: [Roll of aldosterone in pathogenesis of kidney disorders].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050710
Title: [Heart failure after acute myocardial infarct. Early aldosterone blockade increases survival rate].
Journal: MMW Fortschritte der Medizin 20050707
Title: [Neurohumoral systems escape control. Heart failure symptoms even once--long-term high risk prognosis].
Journal: MMW Fortschritte der Medizin 20050707
Title: Additive amelioration of left ventricular remodeling and molecular alterations by combined aldosterone and angiotensin receptor blockade after myocardial infarction.
Journal: Cardiovascular research 20050701
Title: Pharmacokinetics of eplerenone after single and multiple dosing in subjects with and without renal impairment.
Journal: Journal of clinical pharmacology 20050701
Title: Role of cardiovascular aldosterone in hypertension.
Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20050701
Title: [Explanation on indications and cost-efficiency of Inspra].
Journal: Lakartidningen 20050701
Title: [Inspra and the drug benefits board: What is the role of the drug committees?].
Journal: Lakartidningen 20050701
Title: The ligand-dependent interaction of mineralocorticoid receptor with coactivator and corepressor peptides suggests multiple activation mechanisms.
Journal: Molecular endocrinology (Baltimore, Md.) 20050601
Title: Participation of aldosterone in the vascular inflammatory response of spontaneously hypertensive rats: role of the NFkappaB/IkappaB system.
Journal: Journal of hypertension 20050601
Title: Aldosterone antagonism: an emerging strategy for effective blood pressure lowering.
Journal: Current hypertension reports 20050601
Title: Aldosterone receptor antagonists: biology and novel therapeutic applications.
Journal: Current hypertension reports 20050601
Title: [An addition concerning spironolactone and eplerenone (Inspra) in heart failure].
Journal: Lakartidningen 20050601
Title: [Recent insights into the role of aldosterone in physiology, pathology and therapy].
Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050601
Title: The Met852 residue is a key organizer of the ligand-binding cavity of the human mineralocorticoid receptor.
Journal: Molecular pharmacology 20050501
Title: Treatments that improve outcome in the patient with heart failure, left ventricular systolic dysfunction, or both after acute myocardial infarction.
Journal: Heart (British Cardiac Society) 20050501
Title: [The AREA IN-CHF trial (antiremodeling effect of aldosterone receptors blockade with canrenone in mild chronic heart failure): rationale and design].
Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20050501
Title: [LFN's evaluation of Inspra illustrates the need of drug committees!].
Journal: Lakartidningen 20050501
Title: [The role of aldosterone-antagonists in the treatment of congestive heart failure].
Journal: Orvosi hetilap 20050403
Title: Involvement of aldosterone and mineralocorticoid receptors in rat mesangial cell proliferation and deformability.
Journal: Hypertension (Dallas, Tex. : 1979) 20050401
Title: Aldosterone activates vascular p38MAP kinase and NADPH oxidase via c-Src.
Journal: Hypertension (Dallas, Tex. : 1979) 20050401
Title: Eplerenone shows renoprotective effect by reducing LOX-1-mediated adhesion molecule, PKCepsilon-MAPK-p90RSK, and Rho-kinase pathway.
Journal: Hypertension (Dallas, Tex. : 1979) 20050401
Title: Aldosterone as a cardiovascular risk factor.
Journal: Trends in endocrinology and metabolism: TEM 20050401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050401
Title: Implantable cardioverter-defibrillator therapy after myocardial infarction.
Journal: The New England journal of medicine 20050310
Title: Cost-effectiveness of eplerenone compared with placebo in patients with myocardial infarction complicated by left ventricular dysfunction and heart failure.
Journal: Circulation 20050308
Title: Eplerenone blocks nongenomic effects of aldosterone on the Na+/H+ exchanger, intracellular Ca2+ levels, and vasoconstriction in mesenteric resistance vessels.
Journal: Endocrinology 20050301
Title: [Aldosterone and aldosterone antagonists. Eplerenone in cardiac insufficiency after myocardial infarction].
Journal: Medizinische Monatsschrift fur Pharmazeuten 20050301
Title: [Eplerenone Post-AMI Heart Failure Efficacy and survival study (EPHESUS)].
Journal: Nihon rinsho. Japanese journal of clinical medicine 20050301
Title: [Aldosterone antagonist therapy for chronic heart failure].
Journal: Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20050210
Title: Effects of eplerenone, a selective aldosterone blocker, on the progression of left ventricular dysfunction and remodeling in rats with dilated cardiomyopathy.
Journal: Pharmacology 20050201
Title: Mineralocorticoid receptor inhibition ameliorates the transition to myocardial failure and decreases oxidative stress and inflammation in mice with chronic pressure overload.
Journal: Circulation 20050201
Title: [Aldosterone and magnesium].
Journal: Clinical calcium 20050201
Title: 2004 drug approval highlights: FDA update.
Journal: The Nurse practitioner 20050201
Title: RALES, EPHESUS and redox.
Journal: The Journal of steroid biochemistry and molecular biology 20050201
Title: Eplerenone: a selective aldosterone receptor antagonist for patients with heart failure.
Journal: The Annals of pharmacotherapy 20050101
Title: Eplerenone: a review of its use in essential hypertension.
Journal: American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101
Title: A new selective aldosterone antagonist. Inspra's role in hypertension and post-MI heart failure.
Journal: Advance for nurse practitioners 20050101
Title: Management of heart failure and left ventricular systolic dysfunction following acute myocardial infarction.
Journal: Clinical cardiology 20050101
Title: Interactions of high salt intake and the response of the cardiovascular system to aldosterone.
Journal: Cardiology in review 20050101
Title: Pharmacokinetics and pharmacodynamics of mineralocorticoid blocking agents and their effects on potassium homeostasis.
Journal: Heart failure reviews 20050101
Title: Effect of MR blockade on collagen formation and cardiovascular disease with a specific emphasis on heart failure.
Journal: Heart failure reviews 20050101
Title: The role of aldosterone blockade in patients with heart failure.
Journal: Heart failure reviews 20050101
Title: Antihypertensive therapy: role of aldosterone antagonists.
Journal: Current pharmaceutical design 20050101
Title: Vitamin A deficiency alters the pulmonary parenchymal elastic modulus and elastic fiber concentration in rats.
Journal: Respiratory research 20050101
Title: Eplerenone reduces oxidative stress and enhances eNOS in SHR: vascular functional and structural consequences.
Journal: Antioxidants & redox signaling 20050101
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20050101
Title: [The place of aldosterone receptor blockers in the treatment of chronic heart failure].
Journal: Kardiologiia 20050101
Title: Eplerenone : a pharmacoeconomic review of its use in patients with post-myocardial infarction heart failure.
Journal: PharmacoEconomics 20050101
Title: Cardioprotection by aldosterone receptor antagonism in heart failure. Part I. The role of aldosterone in heart failure.
Journal: Fiziologiia cheloveka 20050101
Title: Aldosterone in heart and kidney diseases.
Journal: Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 20050101
Title: [Novel action of aldosterone in CsA nephrotoxicity].
Journal: Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion 20050101
Title: Eplerenone: the evidence for its place in the treatment of heart failure after myocardial infarction.
Journal: Core evidence 20050101
Title: Eplerenone in hypertension.
Journal: Expert opinion on pharmacotherapy 20041201
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20041201
Title: The use of aldosterone receptor blockers in the treatment of hypertension.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20041101
Title: New pharmacological strategies in chronic heart failure.
Journal: Cardiovascular drugs and therapy 20041101
Title: Pleiotropic actions of aldosterone and the effects of eplerenone, a selective mineralocorticoid receptor antagonist.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20041101
Title: [Therapy of heart failure after myocardial infarction. With eplerenone a new course].
Journal: MMW Fortschritte der Medizin 20041021
Title: [More benefit in hypertension and high-grade reduction of the pump performance. Earlier beginning of therapy maximizes the benefit].
Journal: MMW Fortschritte der Medizin 20041021
Title: Mineralocorticoid receptor antagonism and cardiac remodeling in ischemic heart failure.
Journal: Current medicinal chemistry. Cardiovascular and hematological agents 20041001
Title: The use of selective aldosterone antagonists.
Journal: Current hypertension reports 20041001
Title: Eplerenone, a selective aldosterone blocker, improves diastolic function in aged rats with small-to-moderate myocardial infarction.
Journal: Journal of cardiac failure 20041001
Title: Differences in the determinants of eplerenone, spironolactone and aldosterone binding to the mineralocorticoid receptor.
Journal: Clinical and experimental pharmacology & physiology 20041001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20041001
Title: Aldosterone and anti-aldosterone effects in cardiovascular diseases and diabetic nephropathy.
Journal: Diabetes & metabolism 20040901
Title: Aldosterone blockade in heart failure.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20040901
Title: Reassessing guidelines for heart failure.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20040901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040901
Title: Prognostic value of health status in patients with heart failure after acute myocardial infarction.
Journal: Circulation 20040803
Title: Mineralocorticoid receptor antagonists and hypertension: is there a rationale?
Journal: Current hypertension reports 20040801
Title: Aldosterone-receptor antagonism and end-stage renal disease.
Journal: Current hypertension reports 20040801
Title: [Additive improvement of left ventricular remodeling by aldosterone receptor blockade with eplerenone and angiotensin II type 1 receptor antagonist in rats with myocardial infarction].
Journal: Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040801
Title: The clinical implications of aldosterone escape in congestive heart failure.
Journal: European journal of heart failure 20040801
Title: [Aldosterone].
Journal: Rinsho byori. The Japanese journal of clinical pathology 20040801
Title: Eplerenone, but not steroid withdrawal, reverses cardiac fibrosis in deoxycorticosterone/salt-treated rats.
Journal: Endocrinology 20040701
Title: Eplerenone: will it have a role in the treatment of acute coronary syndromes?
Journal: Current cardiology reports 20040701
Title: Aldosterone in the development and progression of renal injury.
Journal: Kidney international 20040701
Title: Aldosterone antagonism and congestive heart failure: a new look at an old therapy.
Journal: Current opinion in cardiology 20040701
Title: Inspra improves survival for CHF patients.
Journal: The Nurse practitioner 20040701
Title: Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20040601
Title: Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy.
Journal: Hypertension (Dallas, Tex. : 1979) 20040601
Title: Aldosterone and aldosterone antagonism in systemic hypertension.
Journal: Current hypertension reports 20040601
Title: Distinguishing the antihypertensive and electrolyte effects of eplerenone.
Journal: The Journal of clinical endocrinology and metabolism 20040601
Title: Eplerenone: a new selective aldosterone receptor antagonist.
Journal: Drugs of today (Barcelona, Spain : 1998) 20040601
Title: Aldosterone administration to mice stimulates macrophage NADPH oxidase and increases atherosclerosis development: a possible role for angiotensin-converting enzyme and the receptors for angiotensin II and aldosterone.
Journal: Circulation 20040511
Title: [Primary prevention of sudden cardiac death].
Journal: Deutsche medizinische Wochenschrift (1946) 20040507
Title: Eplerenone in the treatment of chronic heart failure.
Journal: Expert review of cardiovascular therapy 20040501
Title: Role of aldosterone blockade in managing heart failure: new and emerging treatment options. Introduction.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040501
Title: Pathophysiologic role of the renin-angiotensin-aldosterone and sympathetic nervous systems in heart failure.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040501
Title: Integrating traditional and emerging treatment options in heart failure.
Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040501
Title: Aldosterone-induced organ damage: plasma aldosterone level and inappropriate salt status.
Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20040501
Title: Efficacy of eplerenone versus enalapril as monotherapy in systemic hypertension.
Journal: The American journal of cardiology 20040415
Title: Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats.
Journal: Hypertension (Dallas, Tex. : 1979) 20040401
Title: Efficacy and safety of the selective aldosterone blocker eplerenone in Japanese patients with hypertension: a randomized, double-blind, placebo-controlled, dose-ranging study.
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20040401
Title: Evolving role of aldosterone blockers alone and in combination with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers in hypertension management: a review of mechanistic and clinical data.
Journal: American heart journal 20040401
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040401
Title: Eplerenone (Inspra), a new aldosterone antagonist for the treatment of systemic hypertension and heart failure.
Journal: Proceedings (Baylor University. Medical Center) 20040401
Title: The discovery, isolation and identification of aldosterone: reflections on emerging regulation and function.
Journal: Molecular and cellular endocrinology 20040331
Title: The evolution of aldosterone antagonists.
Journal: Molecular and cellular endocrinology 20040331
Title: The 45-year story of the development of an anti-aldosterone more specific than spironolactone.
Journal: Molecular and cellular endocrinology 20040331
Title: Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies.
Journal: Molecular and cellular endocrinology 20040331
Title: Towards selectively modulating mineralocorticoid receptor function: lessons from other systems.
Journal: Molecular and cellular endocrinology 20040331
Title: Aldosterone target organ protection by eplerenone.
Journal: Molecular and cellular endocrinology 20040331
Title: Review of aldosterone- and angiotensin II-induced target organ damage and prevention.
Journal: Cardiovascular research 20040301
Title: [Significance of aldosterone antagonist therapy].
Journal: Der Internist 20040301
Title: The resurrection of spironolactone on its golden anniversary.
Journal: American journal of critical care : an official publication, American Association of Critical-Care Nurses 20040301
Title: New therapies for heart failure.
Journal: RN 20040301
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20040301
Title: Role of the selective aldosterone receptor blockers in arterial hypertension.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20040301
Title: Ask the doctors. I read about a new drug for heart failure called eplerenone. How does it work? Is it safe?
Journal: Heart advisor 20040301
Title: The association between congestive heart failure and chronic renal disease.
Journal: Current opinion in nephrology and hypertension 20040301
Title: Prediction of in vivo drug interactions with eplerenone in man from in vitro metabolic inhibition data.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20040301
Title: Trial suggests that combining eplerenone and enalapril reduces left ventricular hypertrophy in hypertension more effectively than either treatment alone.
Journal: Evidence-based cardiovascular medicine 20040301
Title: Eplerenone (Inspra) for hypertension.
Journal: American family physician 20040215
Title: Aldosterone antagonism and arterial stiffness.
Journal: Hypertension (Dallas, Tex. : 1979) 20040201
Title: Role of a selective aldosterone blocker in mice with chronic heart failure.
Journal: Journal of cardiac failure 20040201
Title: Aldosterone antagonism attenuates obesity-induced hypertension and glomerular hyperfiltration.
Journal: Hypertension (Dallas, Tex. : 1979) 20040101
Title: Effects of eplerenone on heart and kidney in two-kidney, one-clip rats.
Journal: American journal of nephrology 20040101
Title: Aldosterone antagonism ameliorates proteinuria and nephrosclerosis independent of glomerular dynamics in L-NAME/SHR model.
Journal: American journal of nephrology 20040101
Title: The role of aldosterone in heart failure and the clinical benefits of aldosterone blockade.
Journal: Expert review of cardiovascular therapy 20040101
Title: New drugs of 2003.
Journal: Journal of the American Pharmacists Association : JAPhA 20040101
Title: The role of aldosterone and aldosterone-receptor antagonists in heart failure.
Journal: Reviews in cardiovascular medicine 20040101
Title: Eplerenone: selective aldosterone antagonism in management of cardiovascular and renal disease.
Journal: Journal of the American Pharmacists Association : JAPhA 20040101
Title: New treatment option for heart failure patients: eplerenone.
Journal: The Journal of cardiovascular nursing 20040101
Title: Eplerenone : a review of its use in left ventricular systolic dysfunction and heart failure after acute myocardial infarction.
Journal: Drugs 20040101
Title: The role of mineralocorticoid receptor antagonists in the treatment of cardiac failure.
Journal: Expert opinion on investigational drugs 20031201
Title: [Aldosterone receptor antagonists in heart failure. Rightly brought back from retirement].
Journal: MMW Fortschritte der Medizin 20031120
Title: Additive improvement of left ventricular remodeling and neurohormonal activation by aldosterone receptor blockade with eplerenone and ACE inhibition in rats with myocardial infarction.
Journal: Journal of the American College of Cardiology 20031105
Title: Aldosterone antagonism and myocardial infarction: from animals to man and back.
Journal: Journal of the American College of Cardiology 20031105
Title: Can renin status predict the antihypertensive efficacy of eplerenone add-on therapy?
Journal: Journal of clinical pharmacology 20031101
Title: Pharmacokinetics and metabolism of [14C]eplerenone after oral administration to humans.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101
Title: The cardiovascular effects of eplerenone, a selective aldosterone-receptor antagonist.
Journal: Clinical therapeutics 20031101
Title: Avoid the risks of mixed medications. How to minimize dangerous interactions with cardiovascular drugs.
Journal: Heart advisor 20031101
Title: [Selective aldosterone blocking in heart failure. Eplerenone reduces the risk after infarction].
Journal: MMW Fortschritte der Medizin 20031030
Title: Effects of eplerenone, enalapril, and eplerenone/enalapril in patients with essential hypertension and left ventricular hypertrophy: the 4E-left ventricular hypertrophy study.
Journal: Circulation 20031014
Title: Aldosterone blockade in patients with systolic left ventricular dysfunction.
Journal: Circulation 20031014
Title: Two better than one.
Journal: Circulation 20031014
Title: RAAS escape: a real clinical entity that may be important in the progression of cardiovascular and renal disease.
Journal: Current hypertension reports 20031001
Title: Aldosterone receptor blockade and the role of eplerenone: evolving perspectives.
Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20031001
Title: Ask the doctor. I am a 50-year-old man with congestive heart failure. My doctor has me on all the usual drugs, and a couple of years ago added spironolactone. I did okay with it for a while, but then began to notice that my breasts were getting bigger and began to hurt. My doctor agreed that I should stop taking spironolactone, but I wonder if I am missing out on something.
Journal: Harvard heart letter : from Harvard Medical School 20031001
Title: Inspra.
Journal: Discovery medicine 20031001
Title: Aldosterone blockade after myocardial infarction.
Journal: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20030902
Title: Should the aldosterone-receptor antagonist - eplerenone - be used after acute myocardial infarction with left ventricular dysfunction?
Journal: Expert opinion on pharmacotherapy 20030901
Title: New developments in the management of hypertension.
Journal: American family physician 20030901
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030901
Title: Long-term safety and efficacy of the selective aldosterone blocker eplerenone in patients with essential hypertension.
Journal: Clinical therapeutics 20030901
Title: Mineralocorticoid receptor blockade: new insights into the mechanism of action in patients with cardiovascular disease.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20030901
Title: Aldosterone blockade and vascular calcification in hemodialysis patients.
Journal: The American journal of medicine 20030815
Title: Selective aldosterone blockade with eplerenone in patients with congestive heart failure.
Journal: Expert opinion on investigational drugs 20030801
Title: Primary aldosteronism - treatment options.
Journal: Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society 20030801
Title: Aldosterone receptor antagonists in the treatment of heart failure.
Journal: Connecticut medicine 20030801
Title: Aldosterone receptor antagonists: biology and novel therapeutical applications.
Journal: Journal of endocrinological investigation 20030801
Title: Symptoms and the distress they cause: comparison of an aldosterone antagonist and a calcium channel blocking agent in patients with systolic hypertension.
Journal: Archives of internal medicine 20030714
Title: Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure.
Journal: Circulation research 20030711
Title: Eplerenone in patients with left ventricular dysfunction.
Journal: The New England journal of medicine 20030703
Title: Eplerenone in patients with left ventricular dysfunction.
Journal: The New England journal of medicine 20030703
Title: Eplerenone in patients with left ventricular dysfunction.
Journal: The New England journal of medicine 20030703
Title: Assessment of the novel selective aldosterone blocker eplerenone using ambulatory and clinical blood pressure in patients with systemic hypertension.
Journal: The American journal of cardiology 20030701
Title: Effect of eplerenone, a selective aldosterone blocker, on blood pressure, serum and macrophage oxidative stress, and atherosclerosis in apolipoprotein E-deficient mice.
Journal: Journal of cardiovascular pharmacology 20030601
Title: Inhibition of platelet activation in congestive heart failure by aldosterone receptor antagonism and ACE inhibition.
Journal: Thrombosis and haemostasis 20030601
Title: Aldosterone resurgens--letter from EPHESUS.
Journal: The Journal of clinical endocrinology and metabolism 20030601
Title: Addition of the selective aldosterone receptor antagonist eplerenone to ACE inhibition in heart failure: effect on endothelial dysfunction.
Journal: Cardiovascular research 20030601
Title: Update of clinical trials from the American College of Cardiology 2003. EPHESUS, SPORTIF-III, ASCOT, COMPANION, UK-PACE and T-wave alternans.
Journal: European journal of heart failure 20030601
Title: Late breaking heart failure trials from the 2003 ACC meeting: EPHESUS and COMPANION.
Journal: Journal of cardiac failure 20030601
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20030601
Title: Aldosterone blockade in patients with acute myocardial infarction.
Journal: Circulation 20030527
Title: Eplerenone: cardiovascular protection.
Journal: Circulation 20030520
Title: Eplerenone (Inspra).
Journal: The Medical letter on drugs and therapeutics 20030512
Title: Aldosterone/salt induces renal inflammation and fibrosis in hypertensive rats.
Journal: Kidney international 20030501
Title: Effects of the selective aldosterone blocker eplerenone versus the calcium antagonist amlodipine in systolic hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20030501
Title: New developments in the pharmacological treatment of chronic heart failure.
Journal: Expert opinion on investigational drugs 20030501
Title: More hope for heart failure. Findings suggest expanded use of aldosterone-blockers.
Journal: Health news (Waltham, Mass.) 20030501
Title: Aldosterone antagonism and hypertension.
Journal: Clinical cardiology 20030501
Title: Development and validation of a liquid chromatography-tandem mass spectrometric assay for Eplerenone and its hydrolyzed metabolite in human plasma.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030425
Title: [Which patient needs an aldosterone antagonist?].
Journal: MMW Fortschritte der Medizin 20030417
Title: Aldosterone blockade and heart failure.
Journal: The New England journal of medicine 20030403
Title: Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction.
Journal: The New England journal of medicine 20030403
Title: Efficacy and tolerability of eplerenone and losartan in hypertensive black and white patients.
Journal: Journal of the American College of Cardiology 20030402
Title: Hypertension, angiotensin II, aldosterone, and race.
Journal: Journal of the American College of Cardiology 20030402
Title: Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels.
Journal: Endocrinology 20030401
Title: Amiloride reduces stroke and renalinjury in stroke-prone hypertensive rats.
Journal: American journal of hypertension 20030401
Title: New antihypertensive drug class.
Journal: The American journal of nursing 20030401
Title: Aldosterone antagonism in addition to angiotensin-converting enzyme inhibitors in heart failure.
Journal: Minerva cardioangiologica 20030401
Title: Early inflammatory responses in experimental cardiac hypertrophy and fibrosis: effects of 11 beta-hydroxysteroid dehydrogenase inactivation.
Journal: Endocrinology 20030301
Title: Aldo is back: recent advances and unresolved controversies in hyperaldosteronism.
Journal: Current opinion in nephrology and hypertension 20030301
Title: Eplerenone.
Journal: Nature reviews. Drug discovery 20030301
Title: Single- and repeated-dose pharmacokinetics of eplerenone, a selective aldosterone receptor blocker, in rats.
Journal: Xenobiotica; the fate of foreign compounds in biological systems 20030301
Title: Aldosterone as a target in congestive heart failure.
Journal: The Medical clinics of North America 20030301
Title: Eplerenone. Pharmacia.
Journal: Current opinion in investigational drugs (London, England : 2000) 20030301
Title: A validated SPE-LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine.
Journal: Journal of pharmaceutical and biomedical analysis 20030205
Title: [Aldosterone and its antagonists in heart failure].
Journal: Presse medicale (Paris, France : 1983) 20030118
Title: Aldosterone receptor antagonists: focus on eplerenone.
Journal: Progress in cardiovascular nursing 20030101
Title: Eplerenone, a new selective aldosterone blocker.
Journal: Current pharmaceutical design 20030101
Title: Aldosterone receptor blockade: a therapy resurrected.
Journal: Heart disease (Hagerstown, Md.) 20030101
Title: Aldosterone and aldosterone antagonism in cardiovascular disease: focus on eplerenone (Inspra).
Journal: Heart disease (Hagerstown, Md.) 20030101
Title: Eplerenone: a selective aldosterone blocker.
Journal: Cardiovascular drug reviews 20030101
Title: Hyperkalemia, congestive heart failure, and aldosterone receptor antagonism.
Journal: Congestive heart failure (Greenwich, Conn.) 20030101
Title: [Anti-angiogenic effects of aldosterone antagonists in the fibrin chamber in rats].
Journal: Archives des maladies du coeur et des vaisseaux 20030101
Title: Adjunctive treatment with eplerenone reduced morbidity and mortality in acute myocardial infarction.
Journal: ACP journal club 20030101
Title: Aldosterone receptor antagonists for hypertension: what do they offer?
Journal: Drugs 20030101
Title: [Efficacy of an aldosterone receptor blocker eplerenone in high risk survivors of acute myocardial infarction with signs of heart failure: results of EPHESUS].
Journal: Kardiologiia 20030101
Title: Eplerenone: a selective aldosterone receptor antagonist for hypertension and heart failure.
Journal: Heart disease (Hagerstown, Md.) 20030101
Title: New therapy update. Inspra (eplerenone tablets).
Journal: Congestive heart failure (Greenwich, Conn.) 20030101
Title: The European Society of Cardiology working group on heart failure: Heart Failure Update 2003.
Journal: Heart failure monitor 20030101
Title: Trends and treatment of heart failure developing after acute myocardial infarction.
Journal: The American heart hospital journal 20030101
Title: Effects of long-term monotherapy with eplerenone, a novel aldosterone blocker, on progression of left ventricular dysfunction and remodeling in dogs with heart failure.
Journal: Circulation 20021203
Title: Involvement of CYP3A in the metabolism of eplerenone in humans and dogs: differential metabolism by CYP3A4 and CYP3A5.
Journal: Drug metabolism and disposition: the biological fate of chemicals 20021201
Title: Selective aldosterone blockade prevents angiotensin II/salt-induced vascular inflammation in the rat heart.
Journal: Endocrinology 20021201
Title: Do diuretics and aldosterone receptor antagonists improve ventricular remodeling?
Journal: Journal of cardiac failure 20021201
Title: Increased carotid wall elastic modulus and fibronectin in aldosterone-salt-treated rats: effects of eplerenone.
Journal: Circulation 20021126
Title: Aldosterone induces a vascular inflammatory phenotype in the rat heart.
Journal: American journal of physiology. Heart and circulatory physiology 20021101
Title: New biology of aldosterone, and experimental studies on the selective aldosterone blocker eplerenone.
Journal: American heart journal 20021101
Title: Clinical implications of aldosterone blockade.
Journal: American heart journal 20021101
Title: Eplerenone--a novel selective aldosterone blocker.
Journal: The Annals of pharmacotherapy 20021001
Title: The role of aldosterone receptor blockade in the management of cardiovascular disease.
Journal: Current opinion in investigational drugs (London, England : 2000) 20021001
Title: Gateways to clinical trials.
Journal: Methods and findings in experimental and clinical pharmacology 20021001
Title: [Selective aldosterone blocker for hypertension and heart failure. Better tolerance than previous drugs].
Journal: MMW Fortschritte der Medizin 20020926
Title: The pathophysiology of aldosterone in the cardiovascular system.
Journal: Annals of the New York Academy of Sciences 20020901
Title: Gateways to Clinical Trials.
Journal: Methods and findings in experimental and clinical pharmacology 20020901
Title: Efficacy of eplerenone added to renin-angiotensin blockade in hypertensive patients.
Journal: Hypertension (Dallas, Tex. : 1979) 20020801
Title: Mineralocorticoid and angiotensin receptor antagonism during hyperaldosteronemia.
Journal: Hypertension (Dallas, Tex. : 1979) 20020801
Title: Eplerenone, a selective aldosterone blocker, in mild-to-moderate hypertension.
Journal: American journal of hypertension 20020801
Title: Results from late-breaking clinical trial sessions at the American College of Cardiology 51st Annual Scientific Session.
Journal: Journal of the American College of Cardiology 20020703
Title: Interconversion pharmacokinetics of eplerenone, a selective aldosterone blocker, and its lactone-ring open form.
Journal: Journal of pharmaceutical sciences 20020601
Title: Mineralocorticoid receptor antagonism in experimental atherosclerosis.
Journal: Circulation 20020507
Title: Expanding the outcomes in clinical trials of heart failure: the quality of life and economic components of EPHESUS (EPlerenone's neuroHormonal Efficacy and SUrvival Study).
Journal: American heart journal 20020401
Title: Atypical dose-route-dependent food effects of eplerenone in the dog: presence of food effects following intravenous dosing and lack of food effects of following oral dosing.
Journal: Journal of pharmaceutical sciences 20020301
Title: Cardiac damage prevention by eplerenone: comparison with low sodium diet or potassium loading.
Journal: Hypertension (Dallas, Tex. : 1979) 20020201
Title: Aldosterone as a mediator in cardiovascular injury.
Journal: Cardiology in review 20020101
Title: Eplerenone: a new aldosterone receptor antagonist--are the FDAs restrictions appropriate?
Journal: Journal of clinical hypertension (Greenwich, Conn.) 20020101
Title: Aldosterone 2001.
Journal: Trends in endocrinology and metabolism: TEM 20011001
Title: Effect of a selective aldosterone receptor antagonist in myocardial infarction.
Journal: American journal of physiology. Heart and circulatory physiology 20010801
Title: Exciting new drugs on the horizon - eplerenone, a selective aldosterone receptor antagonist (SARA).
Journal: International journal of cardiology 20010801
Title: Eplerenone suppresses constrictive remodeling and collagen accumulation after angioplasty in porcine coronary arteries.
Journal: Circulation 20010724
Title: Aldosterone as a mediator of progressive renal disease: pathogenetic and clinical implications.
Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20010401
Title: Eplerenone (GD Searle & Co).
Journal: Current opinion in investigational drugs (London, England : 2000) 20010401
Title: Recent studies with eplerenone, a novel selective aldosterone receptor antagonist.
Journal: Current opinion in pharmacology 20010401
Title: Aldosterone receptor antagonism normalizes vascular function in liquorice-induced hypertension.
Journal: Hypertension (Dallas, Tex. : 1979) 20010201
Title: New treasures from old? EPHESUS. Eplerenome Post-AHI Heart Failure Efficacy and Survival Study.
Journal: Cardiovascular drugs and therapy 20010101
Title: The EPHESUS trial: eplerenone in patients with heart failure due to systolic dysfunction complicating acute myocardial infarction. Eplerenone Post-AMI Heart Failure Efficacy and Survival Study.
Journal: Cardiovascular drugs and therapy 20010101
Title: Eplerenone: a selective aldosterone receptor antagonist (SARA).
Journal: Cardiovascular drug reviews 20010101
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