Title: 17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Journal: Toxicology letters 20150105
Title: A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome.
Journal: Cell metabolism 20141104
Title: Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation.
Journal: Neuroscience 20140131
Title: Unusual increase in lumbar network excitability of the rat spinal cord evoked by the PARP-1 inhibitor PJ-34 through inhibition of glutamate uptake.
Journal: Neuropharmacology 20120901
Title: Contribution of PARP to endothelial dysfunction and hypertension in a rat model of pre-eclampsia.
Journal: British journal of pharmacology 20120801
Title: Treatment with the PARP-inhibitor PJ34 causes enhanced doxorubicin-mediated cell death in HeLa cells.
Journal: Anti-cancer drugs 20120701
Title: Mild activation of poly(ADP-ribose) polymerase (PARP) is neuroprotective in rat hippocampal slice models of ischemic tolerance.
Journal: The European journal of neuroscience 20120701
Title: Synthesis and SAR optimization of quinazolin-4(3H)-ones as poly(ADP-ribose)polymerase-1 inhibitors.
Journal: European journal of medicinal chemistry 20120401
Title: Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20120201
Title: Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation.
Journal: PloS one 20120101
Title: Tempol reduces podocyte apoptosis via PARP signaling pathway in experimental diabetes mellitus.
Journal: Nephron. Experimental nephrology 20120101
Title: Protective effect of the poly(ADP-ribose) polymerase inhibitor PJ34 on mitochondrial depolarization-mediated cell death in hepatocellular carcinoma cells involves attenuation of c-Jun N-terminal kinase-2 and protein kinase B/Akt activation.
Journal: Molecular cancer 20120101
Title: Fibroblast growth factor regulates human neuroectoderm specification through ERK1/2-PARP-1 pathway.
Journal: Stem cells (Dayton, Ohio) 20111201
Title: Minocycline reduces plaque size in diet induced atherosclerosis via p27(Kip1).
Journal: Atherosclerosis 20111101
Title: Inhibition of poly(ADP-ribose) polymerase (PARP) induces apoptosis in lung cancer cell lines.
Journal: Cancer investigation 20111101
Title: Poly(ADP-ribose)-dependent regulation of Snail1 protein stability.
Journal: Oncogene 20111020
Title: The PARP inhibitor PJ34 causes a PARP1-independent, p21 dependent mitotic arrest.
Journal: DNA repair 20111010
Title: SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells.
Journal: Cell cycle (Georgetown, Tex.) 20110915
Title: PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1.
Journal: Biochemical and biophysical research communications 20110826
Title: PARP-1 inhibition prevents CNS migration of dendritic cells during EAE, suppressing the encephalitogenic response and relapse severity.
Journal: Multiple sclerosis (Houndmills, Basingstoke, England) 20110701
Title: Studies of locomotor network neuroprotection by the selective poly(ADP-ribose) polymerase-1 inhibitor PJ-34 against excitotoxic injury to the rat spinal cord in vitro.
Journal: The European journal of neuroscience 20110601
Title: Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis.
Journal: Biology of reproduction 20110501
Title: N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Journal: Neuro-oncology 20110501
Title: p38γ mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose)-polymerase-1 inhibition in breast cancer.
Journal: Neoplasia (New York, N.Y.) 20110501
Title: 5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl)isoquinolin-1-ones as isoform-selective inhibitors of poly(ADP-ribose) polymerase 2 (PARP-2).
Journal: Journal of medicinal chemistry 20110414
Title: Effect of the PARP-1 inhibitor PJ 34 on excitotoxic damage evoked by kainate on rat spinal cord organotypic slices.
Journal: Cellular and molecular neurobiology 20110401
Title: Poly(ADP-ribose) polymerase 1 is involved in glucose toxicity through SIRT1 modulation in HepG2 hepatocytes.
Journal: Journal of cellular biochemistry 20110101
Title: A phenanthrene derived PARP inhibitor is an extra-centrosomes de-clustering agent exclusively eradicating human cancer cells.
Journal: BMC cancer 20110101
Title: Poly(ADP-ribose) polymerase 1 is indispensable for transforming growth factor-β Induced Smad3 activation in vascular smooth muscle cell.
Journal: PloS one 20110101
Title: Regulation of MKP-1 expression and MAPK activation by PARP-1 in oxidative stress: a new mechanism for the cytoplasmic effect of PARP-1 activation.
Journal: Free radical biology & medicine 20101215
Title: Identification by high-throughput screening of inhibitors of Schistosoma mansoni NAD(+) catabolizing enzyme.
Journal: Bioorganic & medicinal chemistry 20101115
Title: Inhibition of ADP ribosylation prevents and cures helicobacter-induced gastric preneoplasia.
Journal: Cancer research 20100715
Title: The role of PARP activation in glutamate-induced necroptosis in HT-22 cells.
Journal: Brain research 20100709
Title: Postischemic poly (ADP-ribose) polymerase (PARP) inhibition reduces ischemia reperfusion injury in a hind-limb ischemia model.
Journal: Surgery 20100701
Title: [Researched of PJ34 which is protective effect on the glutamate-induced HT-22 cell damage].
Journal: Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20100701
Title: Inhibition of PARP activity by PJ-34 leads to growth impairment and cell death associated with aberrant mitotic pattern and nucleolar actin accumulation in M14 melanoma cell line.
Journal: Journal of cellular physiology 20100201
Title: Pulmonary and renal protection: targeting PARP to ventilator-induced lung and kidney injury?
Journal: Critical care (London, England) 20100101
Title: Inhibition of matrix metalloproteinase-2 by PARP inhibitors.
Journal: Biochemical and biophysical research communications 20091002
Title: PolyADP-ribosylation is required for long-term memory formation in mammals.
Journal: Journal of neurochemistry 20091001
Title: Aldosterone-induced endothelial dysfunction of rat aorta: role of poly(ADP-ribose) activation.
Journal: Journal of the renin-angiotensin-aldosterone system : JRAAS 20090901
Title: Poly-(ADP-ribose) polymerase-1 is necessary for long-term facilitation in Aplysia.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20090729
Title: A comparative evaluation of the response to peroxynitrite by a brain endothelial cell line and control of the effects by drug targeting.
Journal: Cellular and molecular neurobiology 20090701
Title: Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury.
Journal: Journal of neurotrauma 20090701
Title: Roles of inhibitors of poly(ADP-ribose) polymerase in protecting rat RINm5F cell line against free fatty acid-induced apoptosis.
Journal: Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 20090601
Title: Inhibitors of poly ADP-ribose polymerase (PARP) induce apoptosis of myeloid leukemic cells: potential for therapy of myeloid leukemia and myelodysplastic syndromes.
Journal: Haematologica 20090501
Title: Inhibition of poly(ADP-ribose) polymerase suppresses inflammation and promotes recovery after ischemic injury.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20090401
Title: Selective blockade of CaMKII-alpha inhibits NMDA-induced caspase-3-dependent cell death but does not arrest PARP-1 activation or loss of plasma membrane selectivity in rat retinal neurons.
Journal: Brain research 20090223
Title: Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Journal: Journal of medicinal chemistry 20090212
Title: PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPAR gamma in cardiac fibroblasts.
Journal: Cardiovascular research 20090101
Title: Effect of PJ34 on spinal cord tissue viability and gene expression in a murine model of thoracic aortic reperfusion injury.
Journal: Vascular and endovascular surgery 20090101
Title: Upregulation of Salmonella-induced IL-6 production in Caco-2 cells by PJ-34, PARP-1 inhibitor: involvement of PI3K, p38 MAPK, ERK, JNK, and NF-kappaB.
Journal: Mediators of inflammation 20090101
Title: Poly(ADP-ribosyl)ation is implicated in the G0-G1 transition of resting cells.
Journal: Oncogene 20081016
Title: Sulfasalazine blocks the development of tactile allodynia in diabetic rats.
Journal: Diabetes 20081001
Title: PJ34, an inhibitor of PARP-1, suppresses cell growth and enhances the suppressive effects of cisplatin in liver cancer cells.
Journal: Oncology reports 20080901
Title: Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation.
Journal: Journal of neurochemistry 20080701
Title: Inhibition of angiogenesis by the poly(ADP-ribose) polymerase inhibitor PJ-34.
Journal: International journal of molecular medicine 20080701
Title: Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice.
Journal: European journal of pharmacology 20080624
Title: [Methods of increasing ischemic tolerance in liver surgery].
Journal: Magyar sebeszet 20080601
Title: Zinc triggers microglial activation.
Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20080528
Title: PJ34, a poly adenosine diphosphate-ribose polymerase inhibitor, attenuates chromate-induced nephrotoxicity.
Journal: Basic & clinical pharmacology & toxicology 20080501
Title: PARP1 is required for adhesion molecule expression in atherogenesis.
Journal: Cardiovascular research 20080401
Title: PARP-1 inhibition prevents oxidative and nitrosative stress-induced endothelial cell death via transactivation of the VEGF receptor 2.
Journal: Arteriosclerosis, thrombosis, and vascular biology 20080401
Title: Poly(ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury.
Journal: Critical care medicine 20080201
Title: Poly (ADP-ribose) polymerase as a potential target for the treatment of acute renal injury caused by lipopolysaccharide.
Journal: Renal failure 20080101
Title: Flavone as PARP-1 inhibitor: its effect on lipopolysaccharide induced gene-expression.
Journal: European journal of pharmacology 20071114
Title: Oxidant-induced cardiomyocyte injury: identification of the cytoprotective effect of a dopamine 1 receptor agonist using a cell-based high-throughput assay.
Journal: International journal of molecular medicine 20071101
Title: Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells.
Journal: The Journal of nutrition 20071001
Title: Poly(ADP-ribose) polymerase-1 is involved in the neuronal death induced by quinolinic acid in rats.
Journal: Neuroscience letters 20070920
Title: Effect of PJ-34 PARP-inhibitor on rat liver microcirculation and antioxidant status.
Journal: The Journal of surgical research 20070901
Title: Therapeutic treatment with poly(ADP-ribose) polymerase inhibitors attenuates the severity of acute pancreatitis and associated liver and lung injury.
Journal: British journal of pharmacology 20070801
Title: Contribution of poly(ADP-ribose) polymerase to postischemic blood-brain barrier damage in rats.
Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20070701
Title: Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.
Journal: Biochemical and biophysical research communications 20070608
Title: The role of poly(ADP-ribose) polymerase (PARP) in the autonomous proliferative response of endothelial cells to hypoxia.
Journal: Cardiovascular research 20070201
Title: Use of a poly(ADP-ribose) polymerase inhibitor to suppress inflammation and neuronal death after cerebral ischemia-reperfusion.
Journal: Stroke 20070201
Title: Homocysteine-induced changes in vascular reactivity of guinea-pig pulmonary arteries: role of the oxidative stress and poly (ADP-ribose) polymerase activation.
Journal: Pulmonary pharmacology & therapeutics 20070101
Title: Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.
Journal: Microvascular research 20070101
Title: Txk, a member of the non-receptor tyrosine kinase of the Tec family, forms a complex with poly(ADP-ribose) polymerase 1 and elongation factor 1alpha and regulates interferon-gamma gene transcription in Th1 cells.
Journal: Clinical and experimental immunology 20070101
Title: Protective effects of the PARP-1 inhibitor PJ34 in hypoxic-reoxygenated cardiomyoblasts.
Journal: Cellular and molecular life sciences : CMLS 20061201
Title: Pharmacological inhibition of poly(ADP-ribose) polymerase inhibits angiogenesis.
Journal: Biochemical and biophysical research communications 20061117
Title: Poly(ADP-ribose) polymerase inhibitors ameliorate nephropathy of type 2 diabetic Leprdb/db mice.
Journal: Diabetes 20061101
Title: Local administration of the Poly ADP-Ribose Polymerase (PARP) inhibitor, PJ34 during hindlimb ischemia modulates skeletal muscle reperfusion injury.
Journal: The Journal of surgical research 20061001
Title: Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice.
Journal: British journal of pharmacology 20060901
Title: Blockade of PARP activity attenuates poly(ADP-ribosyl)ation but offers only partial neuroprotection against NMDA-induced cell death in the rat retina.
Journal: Journal of neurochemistry 20060901
Title: Poly adenosine diphosphate-ribose polymerase inhibitor PJ34 abolishes systemic proinflammatory responses to thoracic aortic ischemia and reperfusion.
Journal: Journal of the American College of Surgeons 20060701
Title: Oxygen radicals induce poly(ADP-ribose) polymerase-dependent cell death in cytotoxic lymphocytes.
Journal: Journal of immunology (Baltimore, Md. : 1950) 20060615
Title: MafA expression and insulin promoter activity are induced by nicotinamide and related compounds in INS-1 pancreatic beta-cells.
Journal: Diabetes 20060301
Title: Pneumonia-induced sepsis and gut injury: effects of a poly-(ADP-ribose) polymerase inhibitor.
Journal: The Journal of surgical research 20051201
Title: 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors.
Journal: Bioorganic & medicinal chemistry letters 20051001
Title: Inhibition of poly(ADP-ribose) polymerase attenuates the severity of acute pancreatitis and associated lung injury.
Journal: Laboratory investigation; a journal of technical methods and pathology 20051001
Title: Targeting poly(ADP-ribosyl)ation: a promising approach in cancer therapy.
Journal: Trends in molecular medicine 20051001
Title: Gallotannin inhibits the expression of chemokines and inflammatory cytokines in A549 cells.
Journal: Molecular pharmacology 20050901
Title: PJ34, a poly-ADP-ribose polymerase inhibitor, modulates renal injury after thoracic aortic ischemia/reperfusion.
Journal: Surgery 20050801
Title: Synthesis and in vivo evaluation of [11C]PJ34, a potential radiotracer for imaging the role of PARP-1 in necrosis.
Journal: Nuclear medicine and biology 20050701
Title: Poly(ADP-ribose) polymerase inhibitor PJ-34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest.
Journal: American journal of physiology. Heart and circulatory physiology 20050601
Title: Inhibition of poly(ADP-ribose) polymerase prevents vascular hyporesponsiveness induced by lipopolysaccharide in isolated rat aorta.
Journal: Pharmacological research 20050601
Title: Beneficial effects of PJ34 and INO-1001, two novel water-soluble poly(ADP-ribose) polymerase inhibitors, on the consequences of traumatic brain injury in rat.
Journal: Brain research 20050418
Title: Polyadenosine diphosphate-ribose polymerase inhibition modulates skeletal muscle injury following ischemia reperfusion.
Journal: Archives of surgery (Chicago, Ill. : 1960) 20050401
Title: Poly(ADP-ribose) polymerase regulates myocardial calcium handling in doxorubicin-induced heart failure.
Journal: Biochemical pharmacology 20050301
Title: Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa.
Journal: The Biochemical journal 20050201
Title: Poly(adenosine diphosphate ribose) polymerase inhibition modulates spinal cord dysfunction after thoracoabdominal aortic ischemia-reperfusion.
Journal: Journal of vascular surgery 20050101
Title: Interaction between inducible nitric oxide synthase and poly(ADP-ribose) polymerase in focal ischemic brain injury.
Journal: Stroke 20041201
Title: Poly(ADP-ribose) polymerase inhibition prevents homocysteine-induced endothelial dysfunction in the isolated rat aorta.
Journal: Pharmacology 20041001
Title: The therapeutic effects of PJ34 [N-(6-oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide.HCl], a selective inhibitor of poly(ADP-ribose) polymerase, in experimental allergic encephalomyelitis are associated with immunomodulation.
Journal: The Journal of pharmacology and experimental therapeutics 20040901
Title: Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery.
Journal: American journal of physiology. Heart and circulatory physiology 20040801
Title: Peroxynitrite decomposition catalyst, FP15, and poly(ADP-ribose) polymerase inhibitor, PJ34, inhibit leukocyte entrapment in the retinal microcirculation of diabetic rats.
Journal: Current eye research 20040701
Title: Suppression of intestinal polyposis in Apcmin/+ mice by targeting the nitric oxide or poly(ADP-ribose) pathways.
Journal: Mutation research 20040414
Title: Evaluation of orally active poly(ADP-ribose) polymerase inhibitor in streptozotocin-diabetic rat model of early peripheral neuropathy.
Journal: Diabetologia 20040401
Title: PARP-1, PARP-2, and the cellular response to low doses of ionizing radiation.
Journal: International journal of radiation oncology, biology, physics 20040201
Title: Role of the activation of the nuclear enzyme poly(ADP-ribose) polymerase in the pathogenesis of periodontitis.
Journal: Journal of dental research 20031201
Title: Poly (ADP-ribose) polymerase inhibition prevents spontaneous and recurrent autoimmune diabetes in NOD mice by inducing apoptosis of islet-infiltrating leukocytes.
Journal: Diabetes 20030701
Title: Systemic and hepatosplanchnic hemodynamic and metabolic effects of the PARP inhibitor PJ34 during hyperdynamic porcine endotoxemia.
Journal: Shock (Augusta, Ga.) 20030501
Title: Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock.
Journal: Biochemical pharmacology 20030415
Title: Role of poly(ADP-ribose) polymerase activation in endotoxin-induced cardiac collapse in rodents.
Journal: Biochemical pharmacology 20021215
Title: Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.
Journal: Journal of the American College of Cardiology 20020904
Title: Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.
Journal: Critical care medicine 20020501
Title: Novel phenanthridinone inhibitors of poly (adenosine 5'-diphosphate-ribose) synthetase: potent cytoprotective and antishock agents.
Journal: Critical care medicine 20020501
Title: Development of novel, water-soluble inhibitors of poly (adenosine 5'-diphosphate ribose) synthetase activity for use in shock and ischemia-reperfusion injury.
Journal: Critical care medicine 20020501
Title: Activation of poly(ADP-ribose) polymerase contributes to development of doxorubicin-induced heart failure.
Journal: The Journal of pharmacology and experimental therapeutics 20020301
Title: Endothelial dysfunction in aging animals: the role of poly(ADP-ribose) polymerase activation.
Journal: British journal of pharmacology 20020301
Title: Myocardial protection by PJ34, a novel potent poly (ADP-ribose) synthetase inhibitor.
Journal: The Annals of thoracic surgery 20020201
Title: Poly(ADP-Ribose) polymerase inhibition reduces reperfusion injury after heart transplantation.
Journal: Circulation research 20020111
Title: Anti-inflammatory effects of a novel, potent inhibitor of poly (ADP-ribose) polymerase.
Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20011101
Title: Rapid reversal of the diabetic endothelial dysfunction by pharmacological inhibition of poly(ADP-ribose) polymerase.
Journal: Circulation research 20011012
Title: Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke.
Journal: International journal of molecular medicine 20010301
Title: Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2--(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph
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