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14484-47-0,MFCD00866106
Catalog No.:AA007K6Y

14484-47-0 | Deflazacort

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25mg
≥98%
in stock  
$46.00   $32.00
- +
50mg
>98%(HPLC)
in stock  
$75.00   $53.00
- +
100mg
>98%(HPLC)
in stock  
$124.00   $87.00
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250mg
≥98%
in stock  
$199.00   $139.00
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1g
>98.0%(HPLC)(N)
in stock  
$268.00   $188.00
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5g
>98.0%(HPLC)(N)
in stock  
$797.00   $558.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007K6Y
Chemical Name:
Deflazacort
CAS Number:
14484-47-0
Molecular Formula:
C25H31NO6
Molecular Weight:
441.5167
MDL Number:
MFCD00866106
SMILES:
CC(=O)OCC(=O)[C@@]12N=C(O[C@@H]1C[C@@H]1[C@]2(C)C[C@H](O)[C@H]2[C@H]1CCC1=CC(=O)C=C[C@]21C)C
Properties
Computed Properties
 
Complexity:
996  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2  

Literature

Title: Efficacy and safety of deflazacort vs prednisone and placebo for Duchenne muscular dystrophy.

Journal: Neurology 20161115

Title: [Pharmacokinetics of deflazacort tablets in healthy Chinese volunteers].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20140601

Title: Acute and chronic corticosteroid treatment of ten patients with paralytic form of Sydenham's chorea.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20120701

Title: [Influence of systemic corticosteroid administration in the prognosis of patients with community-acquired pneumonia].

Journal: Revista clinica espanola 20120701

Title: Early corticosteroid treatment in 4 Duchenne muscular dystrophy patients: 14-year follow-up.

Journal: Muscle & nerve 20120601

Title: Isolation and characterization of a degradation product of deflazacort.

Journal: Die Pharmazie 20120601

Title: Drug treatment of Duchenne muscular dystrophy: available evidence and perspectives.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20120501

Title: Old and new therapeutic developments in steroid treatment in Duchenne muscular dystrophy.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20120501

Title: The Canadian experience with long-term deflazacort treatment in Duchenne muscular dystrophy.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20120501

Title: Motor function measure scale, steroid therapy and patients with Duchenne muscular dystrophy.

Journal: Arquivos de neuro-psiquiatria 20120301

Title: Siliconosis: autoimmune/inflammatory syndrome induced by adjuvants (ASIA).

Journal: The Israel Medical Association journal : IMAJ 20120201

Title: [Sound therapy in sudden deafness].

Journal: Acta otorrinolaringologica espanola 20120101

Title: Eosinophilic esophagitis and pharyngitis presenting as mass lesion in a patient with inactive rheumatoid arthritis.

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20120101

Title: Central serous chorioretinopathy after renal transplantation.

Journal: Retina (Philadelphia, Pa.) 20111001

Title: Lupus relapse presented as frosted branch retinal angiitis: case report.

Journal: Ocular immunology and inflammation 20111001

Title: Functional changes in Duchenne muscular dystrophy: a 12-month longitudinal cohort study.

Journal: Neurology 20110719

Title: Impact of bisphosphonates on survival for patients with Duchenne muscular dystrophy.

Journal: Pediatrics 20110201

Title: A prospective randomized study comparing cyclosporine versus tacrolimus combined with daclizumab, mycophenolate mofetil, and steroids in heart transplantation.

Journal: Clinical transplantation 20110101

Title: [Toxic epidermal necrolysis with fatal ending due to the concurrent use of carbamazepine, cilostazol and omeprazol: a case report].

Journal: Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20110101

Title: An unusual case of annular bollous eruption of the inguinal folds.

Journal: La Clinica terapeutica 20110101

Title: Worsening of cardiomyopathy using deflazacort in an animal model rescued by gene therapy.

Journal: PloS one 20110101

Title: Comparison of motor strength and function in patients with Duchenne muscular dystrophy with or without steroid therapy.

Journal: Arquivos de neuro-psiquiatria 20101001

Title: Change in natural history of Duchenne muscular dystrophy with long-term corticosteroid treatment: implications for management.

Journal: Journal of child neurology 20100901

Title: Complete remission of non-HIV collapsing glomerulopathy with deflazacort and lisinopril in an adult patient.

Journal: Clinical and experimental nephrology 20100801

Title: Reversal of primary male infertility and testicular adrenal rest tumors in salt-wasting congenital adrenal hyperplasia.

Journal: The Journal of clinical endocrinology and metabolism 20100501

Title: A study on strategies for improving growth and body composition after renal transplantation.

Journal: Pediatric nephrology (Berlin, Germany) 20100401

Title: Primary Sjögren's syndrome with mesangial proliferative glomerulonephritis and IgA deposits in a child.

Journal: Pediatric nephrology (Berlin, Germany) 20100301

Title: Acute tubulointerstitial nephritis complicated by Salmonella enteritidis gastroenteritis.

Journal: Clinical nephrology 20100301

Title: Two siblings with limb-girdle muscular dystrophy type 2E responsive to deflazacort.

Journal: Neuromuscular disorders : NMD 20100201

Title: Quantitative assessment of the T2 relaxation time of the gluteus muscles in children with Duchenne muscular dystrophy: a comparative study before and after steroid treatment.

Journal: Korean journal of radiology 20100101

Title: Refractory otitis media as the first manifestation of Wegener's granulomatosis.

Journal: Brazilian journal of otorhinolaryngology 20100101

Title: Strongyloides stercoralis hyperinfection in a patient with rheumatoid arthritis and bronchial asthma: a case report.

Journal: Annals of clinical microbiology and antimicrobials 20100101

Title: Deflazacort: a possible alternative in corticosteroid allergy.

Journal: Journal of investigational allergology & clinical immunology 20100101

Title: Corticosteroid effects on blood gene expression in Duchenne muscular dystrophy.

Journal: The pharmacogenomics journal 20091201

Title: Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitis.

Journal: Clinical neurology and neurosurgery 20091201

Title: Treatment with an anti-inflammatory drug is detrimental for muscle regeneration at Bothrops jararacussu envenoming: an experimental study.

Journal: Toxicon : official journal of the International Society on Toxinology 20090901

Title: Long-term therapy with deflazacort decreases myocardial fibrosis in mdx mice.

Journal: Muscle & nerve 20090901

Title: A second cycle of tamsulosin in patients with distal ureteric stones: a prospective randomized trial.

Journal: BJU international 20090601

Title: Treatment of idiopathic retroperitoneal fibrosis with colchicine and steroids: a case series.

Journal: American journal of kidney diseases : the official journal of the National Kidney Foundation 20090401

Title: A scleroderma-like cutaneous syndrome associated with a marked Th2-type immune response occurring after a prosthetic joint implant.

Journal: Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 20090401

Title: Churg-Strauss syndrome in a child with IgA nephropathy.

Journal: Clinical nephrology 20090301

Title: Effect of deflazacort on cardiac and sternocleidomastoid muscles in Duchenne muscular dystrophy: a magnetic resonance imaging study.

Journal: European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20090101

Title: Bartonellosis causing bilateral Leber neuroretinitis: a case report.

Journal: European journal of ophthalmology 20090101

Title: Idiopathic transient osteoporosis of the pelvis in a non-pregnant young woman: a case study.

Journal: Hip international : the journal of clinical and experimental research on hip pathology and therapy 20090101

Title: A high-throughput liquid chromatography tandem mass spectrometry method for the comparative determination of fluticasone propionate by reversed-phase liquid chromatography and capillary electrophoresis methods in pharmaceutical nasal sprays.

Journal: European journal of mass spectrometry (Chichester, England) 20090101

Title: Deflazacort.

Journal: Journal of postgraduate medicine 20090101

Title: Idiopathic retroperitoneal fibrosis associated with Hashimoto's thyroiditis in an old-aged man.

Journal: Yonsei medical journal 20081231

Title: Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

Journal: Journal of medicinal chemistry 20081113

Title: [Streptococcus pneumoniae infection: cause or consequence of pulmonary alveolar proteinosis?].

Journal: Archivos de bronconeumologia 20081101

Title: Randomized prospective study of the evolution of renal function depending on the anticalcineurin used.

Journal: Transplantation proceedings 20081101

Title: Rapid periapical bone destruction during endodontic treatment of a patient with rheumatoid arthritis.

Journal: Journal of endodontics 20081001

Title: A comparative study of hydrocortisone versus deflazacort in drug-resistant epilepsy of childhood.

Journal: Epilepsy research 20080901

Title: Deflazacort use in Duchenne muscular dystrophy: an 8-year follow-up.

Journal: Pediatric neurology 20080301

Title: Rosacea with extensive extrafacial lesions.

Journal: International journal of dermatology 20080101

Title: [Recovery of total inmunoglobulin and immunoglobulin subclasses in nephrotic syndrome: deflazacort vs methylprednisone].

Journal: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20080101

Title: Deflazacort versus other glucocorticoids: a comparison.

Journal: Indian journal of dermatology 20080101

Title: Myth: nephrolithiasis and medical expulsive therapy.

Journal: CJEM 20071101

Title: An infant with bullous pemphigoid.

Journal: Dermatology online journal 20070713

Title: Deflazacort induced stronger immunosuppression than expected.

Journal: Clinical rheumatology 20070601

Title: Compared clinical efficacy and bone metabolic effects of low-dose deflazacort and methyl prednisolone in male inflammatory arthropathies: a 12-month open randomized pilot study.

Journal: Rheumatology (Oxford, England) 20070601

Title: Quantification of muscle strength and motor ability in patients with Duchenne muscular dystrophy on steroid therapy.

Journal: Arquivos de neuro-psiquiatria 20070601

Title: Effects of deflazacort vs. methylprednisone: a randomized study in kidney transplant patients.

Journal: Pediatric nephrology (Berlin, Germany) 20070501

Title: Physicochemical characterization of deflazacort: thermal analysis, crystallographic and spectroscopic study.

Journal: Steroids 20070301

Title: Deflazacort: a glucocorticoid with few metabolic adverse effects but important immunosuppressive activity.

Journal: Advances in therapy 20070101

Title: Not all ACE inhibitor related angioedema is always evident: a case which is misdiagnosed as panic attack and speech disorder.

Journal: Allergologia et immunopathologia 20070101

Title: Eosinophil recruiting chemokines are down-regulated in peripheral blood mononuclear cells of allergic patients treated with deflazacort or desloratadine.

Journal: International journal of immunopathology and pharmacology 20070101

Title: Cardiac treatment in neuro-muscular diseases.

Journal: Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology 20061201

Title: [Anesthetic management in immunoglobulin A deficiency syndrome associated with juvenile chronic arthritis].

Journal: Revista espanola de anestesiologia y reanimacion 20061101

Title: A process analytical technology approach based on near infrared spectroscopy: tablet hardness, content uniformity, and dissolution test measurements of intact tablets.

Journal: Journal of pharmaceutical sciences 20061001

Title: The glucocorticoid receptor N363S polymorphism and steroid response in Duchenne dystrophy.

Journal: Journal of neurology, neurosurgery, and psychiatry 20061001

Title: Corticosteroids and tamsulosin in the medical expulsive therapy for symptomatic distal ureter stones: single drug or association?

Journal: European urology 20060801

Title: Deflazacort for type-1 autoimmune hepatitis in a Korean girl.

Journal: Journal of Korean medical science 20060801

Title: Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells.

Journal: Bone 20060501

Title: Persistent and improved functional gain in mdx dystrophic mice after treatment with L-arginine and deflazacort.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060401

Title: Long-term benefits of deflazacort treatment for boys with Duchenne muscular dystrophy in their second decade.

Journal: Neuromuscular disorders : NMD 20060401

Title: [Blood viscosity profile in rapidly progressive sensorineural hearing loss with positive Western-blot].

Journal: Acta otorrinolaringologica espanola 20060201

Title: Granulomatous facial reaction to injected cosmetic fillers--a presentation of five cases.

Journal: Medicina oral, patologia oral y cirugia bucal 20060101

Title: Cutaneous Crohn's disease causing deformity of the penis and scrotum.

Journal: Acta dermato-venereologica 20060101

Title: [Parotid phlegmon with involvement of both lobes. Report of a case].

Journal: Anales otorrinolaringologicos ibero-americanos 20060101

Title: Corticosteroid treatment and functional improvement in Duchenne muscular dystrophy: long-term effect.

Journal: American journal of physical medicine & rehabilitation 20051101

Title: Deflazacort modulates the fibrinolytic pattern and reduces uPA-dependent chemioinvasion and proliferation in rheumatoid arthritis synoviocytes.

Journal: Rheumatology (Oxford, England) 20051001

Title: [Study of lymphocyte subpopulations in chronic autoimmune inflammatory rheumatic diseases. II. Polymyalgia rheumatica: behaviour of lymphocyte subpopulations during treatment with two different corticosteroids].

Journal: Minerva medica 20051001

Title: Medical-expulsive therapy for distal ureterolithiasis: randomized prospective study on role of corticosteroids used in combination with tamsulosin-simplified treatment regimen and health-related quality of life.

Journal: Urology 20051001

Title: [Spermatic cord mass as a manifestation of systemic vasculitis: a case report and review of the literature].

Journal: Actas urologicas espanolas 20050901

Title: Cutaneous adverse drug reactions to Fluticasone propionate and Deflazacort in an asthmatic patient.

Journal: Contact dermatitis 20050801

Title: [Choice of oral corticosteroids for asthma exacerbations].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20050301

Title: The role of upper endoscopy in identifying oesophageal involvement in patients with oral pemphigus vulgaris.

Journal: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver 20050301

Title: Alendronate in the treatment of low bone mass in steroid-treated boys with Duchennes muscular dystrophy.

Journal: Archives of physical medicine and rehabilitation 20050201

Title: [Statistical study and clinical results by comparison of two different protocols in the treatment of sudden hearing loss].

Journal: Acta otorrinolaringologica espanola 20050201

Title: CAPON expression in skeletal muscle is regulated by position, repair, NOS activity, and dystrophy.

Journal: Experimental cell research 20050115

Title: Practice parameter: corticosteroid treatment of Duchenne dystrophy: report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society.

Journal: Neurology 20050111

Title: Steroid therapy and cardiac function in Duchenne muscular dystrophy.

Journal: Pediatric cardiology 20050101

Title: [Treatment with nebulized lidocaine in steroid-dependent asthma].

Journal: Allergologia et immunopathologia 20050101

Title: Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20041201

Title: Aase-Smith syndrome type II.

Journal: Saudi medical journal 20041201

Title: Deflazacort in Duchenne muscular dystrophy: a comparison of two different protocols.

Journal: Neuromuscular disorders : NMD 20040901

Title: Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties.

Journal: European journal of endocrinology 20040901

Title: [Comparative efficacy of oral deflazacort versus oral prednisolone in children with moderate acute asthma].

Journal: Anales de pediatria (Barcelona, Spain : 2003) 20040901

Title: Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy.

Journal: Neurology 20040525

Title: Steroid treatment and the development of scoliosis in males with duchenne muscular dystrophy.

Journal: The Journal of bone and joint surgery. American volume 20040301

Title: Hydrocortisone and deflazacort induce different effects on vitamin D receptor level increase produced by 1,25-dihydroxyvitamin D3 in rat osteoblast-like UMR-106 cells.

Journal: The Journal of rheumatology 20040101

Title: Glucocorticoid corticosteroids for Duchenne muscular dystrophy.

Journal: The Cochrane database of systematic reviews 20040101

Title: Nifedipine versus tamsulosin for the management of lower ureteral stones.

Journal: International braz j urol : official journal of the Brazilian Society of Urology 20040101

Title: Efficacy of tamsulosin in the medical management of juxtavesical ureteral stones.

Journal: The Journal of urology 20031201

Title: Improvement of clinical and immunopathologic parameters in asthmatic children treated for concomitant chronic rhinosinusitis.

Journal: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20030701

Title: Correlated NOS-Imu and myf5 expression by satellite cells in mdx mouse muscle regeneration during NOS manipulation and deflazacort treatment.

Journal: Neuromuscular disorders : NMD 20030601

Title: Churg-Strauss syndrome in an HCV seropositive patient.

Journal: International journal of clinical practice 20030601

Title: [Rare opportunistic disease in a patient treated with immunosuppressive therapy for rheumatoid arthritis].

Journal: Anales de medicina interna (Madrid, Spain : 1984) 20030501

Title: Effects of deflazacort on left ventricular function in patients with Duchenne muscular dystrophy.

Journal: The American journal of cardiology 20030315

Title: [Septic arthritis due to Leclercia adecarboxylata of probable iatrogenic origin].

Journal: Enfermedades infecciosas y microbiologia clinica 20030301

Title: Alternative glucocorticoids for use in cases of adverse reaction to systemic glucocorticoids: a study on 10 patients.

Journal: The British journal of dermatology 20030101

Title: Morphea-like plaque in childhood.

Journal: Pediatric dermatology 20030101

Title: Nimesulide: is it only an anti-inflammatory, analgesic drug?

Journal: Clinical and experimental rheumatology 20030101

Title: [Polyarteritis nodosa cutanea: a case report].

Journal: Reumatismo 20030101

Title: Deflazacort for the treatment of Duchenne Dystrophy: a systematic review.

Journal: BMC neurology 20030101

Title: Deflazacort in giant cell arteritis.

Journal: The Journal of rheumatology 20021001

Title: Effects of deflazacort and cortisone on cellular proliferation in the rat thymus.

Journal: Life sciences 20020906

Title: Sonographically guided biopsy and sonographic monitoring in the diagnosis and follow-up of 2 cases of sarcoidosis with hepatic nodules and inconclusive thoracic findings.

Journal: Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 20020901

Title: Lichen sclerosus--a keratotic variant.

Journal: Journal of the European Academy of Dermatology and Venereology : JEADV 20020901

Title: Role of adjunctive medical therapy with nifedipine and deflazacort after extracorporeal shock wave lithotripsy of ureteral stones.

Journal: Urology 20020601

Title: [Mesenteric vasculitis and abdominal mass].

Journal: Medicina clinica 20020601

Title: Urticaria-angioedema by deflazacort.

Journal: Allergy 20020401

Title: Vertebral compression in Duchenne muscular dystrophy following deflazacort.

Journal: Neuromuscular disorders : NMD 20020301

Title: Corticosteroids in Duchenne muscular dystrophy: a reappraisal.

Journal: Journal of child neurology 20020301

Title: Effectiveness of nifedipine and deflazacort in the management of distal ureter stones.

Journal: The Journal of urology 20020201

Title: Duchenne muscular dystrophy.

Journal: The Journal of the American Academy of Orthopaedic Surgeons 20020101

Title: Multiple pulmonary arterial aneurysms in Behçet's disease: clinical and radiologic remission after cyclophosphamide and corticosteroid therapy.

Journal: Respiration; international review of thoracic diseases 20020101

Title: Pigmented and reticulated plaques of folds. A case of lichen planus pigmentosus-inversus?

Journal: European journal of dermatology : EJD 20020101

Title: Deflazacort treatment of cystoid macular edema in patients affected by Retinitis Pigmentosa: a pilot study.

Journal: European review for medical and pharmacological sciences 20020101

Title: Deflazacort increases osteoclast formation in mouse bone marrow culture and the ratio of RANKL/OPG mRNA expression in marrow stromal cells.

Journal: Journal of Korean medical science 20011201

Title: Risk of steroid withdrawal in pediatric renal transplant patients with suspected steroid toxicity.

Journal: Clinical nephrology 20011201

Title: Deflazacort versus prednisone in patients with giant cell arteritis: effects on bone mass loss.

Journal: The Journal of rheumatology 20011101

Title: Pharmacologic and genetic therapy for childhood muscular dystrophies.

Journal: Current neurology and neuroscience reports 20010301

Title: Metabolic shifts and myocyte hypertrophy in deflazacort treatment of mdx mouse cardiomyopathy.

Journal: Muscle & nerve 20010201

Title: Deflazacort treatment of Duchenne muscular dystrophy.

Journal: The Journal of pediatrics 20010101

Title: Effectiveness of nifedipine and deflazacort in the management of distal ureter stones.

Journal: Urology 20001001

Title: Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone.

Journal: Pharmaceutical research 19950701

Title: Prednisone versus deflazacort in the treatment of autoimmune thrombocytopenic purpura: evaluation of clinical response and immunological modifications.

Journal: Haematologica 19910101

Title: Differential binding in vitro to glucocorticoid receptors of deflazacort and prednisolone.

Journal: European journal of pharmacology 19811217

Title: Mollmann, H., et al., Pharmacokinetic/pharmacodynamic evaluation of deflazacort in comparison to methylprednisolone and prednisolone. Pharmaceutical research, 1995. 12(7): p. 1096-1100.

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Tags:14484-47-0 Molecular Formula|14484-47-0 MDL|14484-47-0 SMILES|14484-47-0 Deflazacort