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269390-77-4,MFCD18251410
Catalog No.:AA007MB5

269390-77-4 | AAL-993

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Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$105.00   $73.00
- +
5mg
≥95%
in stock  
$183.00   $128.00
- +
100mg
95%
in stock  
$336.00   $235.00
- +
250mg
95%
in stock  
$619.00   $433.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007MB5
Chemical Name:
AAL-993
CAS Number:
269390-77-4
Molecular Formula:
C20H16F3N3O
Molecular Weight:
371.3557
MDL Number:
MFCD18251410
SMILES:
O=C(c1ccccc1NCc1ccncc1)Nc1cccc(c1)C(F)(F)F
Properties
Computed Properties
 
Complexity:
480  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
4.6  

Literature

Title: Pharmacophore modeling and virtual screening studies for new VEGFR-2 kinase inhibitors.

Journal: European journal of medicinal chemistry 20101101

Title: (1,2,3-Triazol-4-yl)benzenamines: synthesis and activity against VEGF receptors 1 and 2.

Journal: Bioorganic & medicinal chemistry letters 20090301

Title: 3,4-Disubstituted isothiazoles: novel potent inhibitors of VEGF receptors 1 and 2.

Journal: Bioorganic & medicinal chemistry letters 20090215

Title: Conformation-activity relationship on novel 4-pyridylmethylthio derivatives with antiangiogenic activity.

Journal: Bioorganic & medicinal chemistry letters 20080501

Title: ortho-Substituted azoles as selective and dual inhibitors of VEGF receptors 1 and 2.

Journal: Bioorganic & medicinal chemistry letters 20070301

Title: Synthesis and biological evaluation of benzamides and benzamidines as selective inhibitors of VEGFR tyrosine kinases.

Journal: Bioorganic & medicinal chemistry letters 20061001

Title: Rational design of inhibitors that bind to inactive kinase conformations.

Journal: Nature chemical biology 20060701

Title: Inhibitors of VEGF receptors-1 and -2 based on the 2-((pyridin-4-yl)ethyl)pyridine template.

Journal: Bioorganic & medicinal chemistry letters 20060401

Title: 2-((1H-Azol-1-yl)methyl)-N-arylbenzamides: novel dual inhibitors of VEGFR-1/2 kinases.

Journal: Bioorganic & medicinal chemistry letters 20060315

Title: Hetaryl imidazoles: a novel dual inhibitors of VEGF receptors I and II.

Journal: Bioorganic & medicinal chemistry letters 20060301

Title: N-(Aryl)-4-(azolylethyl)thiazole-5-carboxamides: novel potent inhibitors of VEGF receptors I and II.

Journal: Bioorganic & medicinal chemistry letters 20060201

Title: Anthranilic acid amides: a novel class of antiangiogenic VEGF receptor kinase inhibitors.

Journal: Journal of medicinal chemistry 20021219

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