Title: Raf-1/CK2 and RhoA/ROCK signaling promote TNF-α-mediated endothelial apoptosis via regulating vimentin cytoskeleton.
Journal: Toxicology 20170815
Title: The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.
Journal: Journal of medicinal chemistry 20130808
Title: LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: suppression by curcumin.
Journal: Neurobiology of disease 20120901
Title: Raf-1, a potential therapeutic target, mediates early steps in endometriosis lesion development by endometrial epithelial and stromal cells.
Journal: Endocrinology 20120801
Title: The Raf-1 inhibitor GW5074 and the ERK1/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine.
Journal: Die Pharmazie 20120801
Title: Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease.
Journal: Science translational medicine 20120704
Title: Pentoxifylline inhibits hepatic stellate cells proliferation via the Raf/ERK pathway.
Journal: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica 20120701
Title: Analgesic potential of intrathecal farnesyl thiosalicylic acid and GW 5074 in vincristine-induced neuropathic pain in rats.
Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120501
Title: Biochemical and structural characterization of Plasmodium falciparum glutamate dehydrogenase 2.
Journal: Molecular and biochemical parasitology 20120501
Title: Secondhand smoke exposure causes bronchial hyperreactivity via transcriptionally upregulated endothelin and 5-hydroxytryptamine 2A receptors.
Journal: PloS one 20120101
Title: Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models.
Journal: Human molecular genetics 20111015
Title: Signaling cascades mediate astrocyte death induced by zinc.
Journal: Toxicology letters 20110728
Title: A new approach to Parkinson's disease: inhibition of leucine-rich repeat kinase-2.
Journal: Expert opinion on investigational drugs 20110401
Title: Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation.
Journal: Nature chemical biology 20110201
Title: Polygonatum cyrtonema lectin induces murine fibrosarcoma L929 cell apoptosis and autophagy via blocking Ras-Raf and PI3K-Akt signaling pathways.
Journal: Biochimie 20101201
Title: Identification of specific inhibitors for a trypanosomatid RNA editing reaction.
Journal: RNA (New York, N.Y.) 20101201
Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
Journal: Bioorganic & medicinal chemistry letters 20101101
Title: RAF associates with phosphorylated nuclear BubR1 during endoreduplication induced by JAK inhibition.
Journal: Cell cycle (Georgetown, Tex.) 20100815
Title: Raf-1 kinase regulates smooth muscle contraction in the rat mesenteric arteries.
Journal: Journal of vascular research 20100801
Title: Regulation of (pro)renin receptor expression by glucose-induced mitogen-activated protein kinase, nuclear factor-kappaB, and activator protein-1 signaling pathways.
Journal: Endocrinology 20100701
Title: Acute insulin signaling in pancreatic beta-cells is mediated by multiple Raf-1 dependent pathways.
Journal: Endocrinology 20100201
Title: C-Raf is associated with disease progression and cell proliferation in a subset of melanomas.
Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20090915
Title: Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.
Journal: The Journal of pharmacology and experimental therapeutics 20090901
Title: Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics.
Journal: The Journal of biological chemistry 20090821
Title: Enhanced clonogenic survival induced by protein tyrosine phosphatase (PTP) inhibition after Cr(VI) exposure is mediated by c-Raf and Ras activity.
Journal: Cellular signalling 20090501
Title: Simvastatin inhibits induction of matrix metalloproteinase-9 in rat alveolar macrophages exposed to cigarette smoke extract.
Journal: Experimental & molecular medicine 20090430
Title: Raf-1: a novel cardiac troponin T kinase.
Journal: Journal of muscle research and cell motility 20090101
Title: Effect of taurine on advanced glycation end products-induced hypertrophy in renal tubular epithelial cells.
Journal: Toxicology and applied pharmacology 20081201
Title: Raf inhibition protects cortical cells against beta-amyloid toxicity.
Journal: Neuroscience letters 20081017
Title: Characterization of pharmacologically active compounds that inhibit poliovirus and enterovirus 71 infectivity.
Journal: The Journal of general virology 20081001
Title: Inhibition of ATF-3 expression by B-Raf mediates the neuroprotective action of GW5074.
Journal: Journal of neurochemistry 20080501
Title: Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501
Title: Sustained morphine treatment augments basal CGRP release from cultured primary sensory neurons in a Raf-1 dependent manner.
Journal: European journal of pharmacology 20080428
Title: The Raf-1 inhibitor GW5074 and dexamethasone suppress sidestream smoke-induced airway hyperresponsiveness in mice.
Journal: Respiratory research 20080101
Title: Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells.
Journal: Journal of pharmacological sciences 20070901
Title: Carnosol, a component of rosemary (Rosmarinus officinalis L.) protects nigral dopaminergic neuronal cells.
Journal: Neuroreport 20061106
Title: Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway.
Journal: Journal of pharmacological sciences 20061101
Title: Chronic morphine-mediated adenylyl cyclase superactivation is attenuated by the Raf-1 inhibitor, GW5074.
Journal: European journal of pharmacology 20060701
Title: Combined inhibition of the phosphatidylinositol 3-kinase/Akt and Ras/mitogen-activated protein kinase pathways results in synergistic effects in glioblastoma cells.
Journal: Molecular cancer therapeutics 20060301
Title: Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways.
Journal: Journal of cellular biochemistry 20060201
Title: Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells.
Journal: Reproductive biology and endocrinology : RB&E 20060101
Title: Structural model of the Plasmodium CDK, Pfmrk, a novel target for malaria therapeutics.
Journal: Journal of molecular graphics & modelling 20050901
Title: Brain chemotherapy from the bench to the clinic: targeting neuronal survival with small molecule inhibitors of apoptosis.
Journal: Frontiers in bioscience : a journal and virtual library 20050101
Title: The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism.
Journal: Journal of neurochemistry 20040801
Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.
Journal: The Journal of biological chemistry 20020419
Title: Chin PC, et al. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. J Neurochem, 2004, 90(3), 595-608.
Title: Lei Y, et al. The Raf-1 inhibitor GW5074 and NSC 34521 suppress sidestream smoke-induced airway hyperresponsiveness in mice. Respir Res, 2008, 9(1), 71.
