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21416-53-5,MFCD00868514
Catalog No.:AA007QI7

21416-53-5 | Picrotin

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25mg
≥98%
in stock  
$46.00   $32.00
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50mg
≥98%
in stock  
$82.00   $57.00
- +
100mg
≥98%
in stock  
$140.00   $98.00
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250mg
≥98%
in stock  
$242.00   $169.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA007QI7
Chemical Name:
Picrotin
CAS Number:
21416-53-5
Molecular Formula:
C15H18O7
Molecular Weight:
310.2992
MDL Number:
MFCD00868514
SMILES:
O=C1OC2C(C1C1(O)CC3C4(C1(C2OC4=O)C)O3)C(O)(C)C
Properties
Computed Properties
 
Complexity:
644  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
8  
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
1  
XLogP3:
-0.8  

Literature

Title: Gating effects on picrotin block of glycine receptors.

Journal: Neuroreport 20121205

Title: Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.

Journal: Bioorganic & medicinal chemistry 20121115

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: Two-photon uncaging of gamma-aminobutyric acid in intact brain tissue.

Journal: Nature chemical biology 20100401

Title: A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore.

Journal: Journal of neurochemistry 20071001

Title: Mechanisms for picrotoxinin and picrotin blocks of alpha2 homomeric glycine receptors.

Journal: The Journal of biological chemistry 20070601

Title: NOESY on neurotoxins: NMR and conformational assignments of picrotoxins.

Journal: Phytochemical analysis : PCA 20010101

Title: Subunit-specific action of an anticonvulsant thiobutyrolactone on recombinant glycine receptors involves a residue in the M2 membrane-spanning region.

Journal: Molecular pharmacology 20000701

Title: Li P, et al. Gating effects on picrotin block of glycine receptors. Neuroreport. 2012 Dec 5;23(17):1017-20.

Title: Yang Z, et al. A proposed structural basis for picrotoxinin and picrotin binding in the glycine receptor pore. J Neurochem. 2007 Oct;103(2):580-9.

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