194804-75-6,MFCD08141853
Catalog No.:AA007RCX

194804-75-6 | Ganefloxacin

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Purity
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5mg
≥98%
in stock  
$158.00   $110.00
- +
10mg
≥98%
in stock  
$236.00   $165.00
- +
25mg
≥98%
in stock  
$503.00   $352.00
- +
50mg
≥98%
in stock  
$975.00   $683.00
- +
100mg
≥98%
in stock  
$1,707.00   $1,195.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007RCX
Chemical Name:
Ganefloxacin
CAS Number:
194804-75-6
Molecular Formula:
C23H20F2N2O4
Molecular Weight:
426.4127
MDL Number:
MFCD08141853
SMILES:
FC(Oc1c(ccc2c1n(cc(c2=O)C(=O)O)C1CC1)c1ccc2c(c1)CN[C@@H]2C)F
Properties
Computed Properties
 
Complexity:
771  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
XLogP3:
2.1  

Downstream Synthesis Route

[1]Hayashi,Kazuya;Takahata,Masahiro;Kawamura,Yasuhito;Todo,Yozo[Arzneimittel-Forschung/DrugResearch,2002,vol.52,#12,p.903-913]

173435-78-4    194804-75-6   
CASUnavailable 

[1]Peek,James;Koirala,Bimal;Brady,SeanF.[BioorganicandMedicinalChemistryLetters,2022,vol.57]

[2]Peek,James;Koirala,Bimal;Brady,SeanF.[BioorganicandMedicinalChemistryLetters,2022,vol.57]

Literature

Title: In vitro antichlamydial activity of garenoxacin against Chlamydia trachomatis.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120801

Title: Inhibitory activity of garenoxacin against DNA gyrase of Mycoplasma pneumoniae.

Journal: The Journal of antimicrobial chemotherapy 20120801

Title: In vitro pharmacodynamic evaluation of garenoxacin against quinolone-resistant Streptococcus pneumoniae.

Journal: International journal of antimicrobial agents 20120201

Title: Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation.

Journal: European journal of clinical pharmacology 20120101

Title: Anaphylaxis due to intravenous levofloxacin with tolerance to garenoxacin.

Journal: Internal medicine (Tokyo, Japan) 20120101

Title: Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells.

Journal: European journal of pharmacology 20111001

Title: In vitro and in vivo antibacterial activities of garenoxacin against group G Streptococcus dysgalactiae subsp. equisimilis.

Journal: International journal of antimicrobial agents 20110901

Title: Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110801

Title: Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20110401

Title: [Mutant prevention concentrations of garenoxacin against Streptococcus pneumoniae isolates from otorhinolaryngological infections].

Journal: The Japanese journal of antibiotics 20100801

Title: Pharmacokinetics of garenoxacin in elderly patients with respiratory tract infections.

Journal: International journal of antimicrobial agents 20100601

Title: Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

Journal: Clinical and experimental nephrology 20100401

Title: Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.

Journal: Bioorganic & medicinal chemistry 20091001

Title: [Antimicrobial susceptibility surveillance of recent isolates from otorhinolaryngological infections to garenoxacin and other antimicrobial drugs].

Journal: The Japanese journal of antibiotics 20090401

Title: Quinolones with enhanced bactericidal activity induce autolysis in Streptococcus pneumoniae.

Journal: Chemotherapy 20090101

Title: Clinical studies of garenoxacin.

Journal: International journal of antimicrobial agents 20081201

Title: Comparative pharmacodynamics of garenoxacin, gemifloxacin, and moxifloxacin in community-acquired pneumonia caused by Streptococcus pneumoniae: a Monte Carlo simulation analysis.

Journal: Clinical therapeutics 20071201

Title: Potency and spectrum of garenoxacin tested against an international collection of skin and soft tissue infection pathogens: report from the SENTRY antimicrobial surveillance program (1999-2004).

Journal: Diagnostic microbiology and infectious disease 20070501

Title: In vitro activity of garenoxacin tested against a worldwide collection of ciprofloxacin-susceptible and ciprofloxacin-resistant Enterobacteriaceae strains (1999-2004).

Journal: Diagnostic microbiology and infectious disease 20070501

Title: The effect of omeprazole on the bioavailability and safety of garenoxacin in healthy volunteers.

Journal: Journal of clinical pharmacology 20070501

Title: Activity of garenoxacin, an investigational des-F(6)-quinolone, tested against pathogens from community-acquired respiratory tract infections, including those with elevated or resistant-level fluoroquinolone MIC values.

Journal: Diagnostic microbiology and infectious disease 20070501

Title: Garenoxacin activity against isolates form patients hospitalized with community-acquired pneumonia and multidrug-resistant Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease 20070501

Title: Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection.

Journal: Journal of pharmaceutical and biomedical analysis 20070411

Title: Garenoxacin pharmacokinetics in subjects with renal impairment.

Journal: Current medical research and opinion 20070301

Title: [In-vitro and in-vivo activities of moxifloxacin and garenoxacin against Mycobacterium leprae].

Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20070201

Title: 3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

Journal: Journal of medicinal chemistry 20061102

Title: Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae.

Journal: The Journal of antimicrobial chemotherapy 20060701

Title: Intravitreal toxicity of garenoxacin.

Journal: Retina (Philadelphia, Pa.) 20060201

Title: Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients.

Journal: The Journal of antimicrobial chemotherapy 20051101

Title: In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867.

Journal: Antimicrobial agents and chemotherapy 20051001

Title: Comparison of the minimum inhibitory, mutant prevention and minimum bactericidal concentrations of ciprofloxacin, levofloxacin and garenoxacin against enteric Gram-negative urinary tract infection pathogens.

Journal: Journal of chemotherapy (Florence, Italy) 20051001

Title: Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.

Journal: The Journal of antimicrobial chemotherapy 20050401

Title: Bactericidal activity of garenoxacin tested by kill-curve methodology against wild type and QRDR mutant strains of Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease 20041101

Title: Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

Journal: Antimicrobial agents and chemotherapy 20040401

Title: Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats.

Journal: Archives of toxicology 20040201

Title: Comparisons of the in vitro susceptibility testing results for garenoxacin using six different national methods: report from the garenoxacin international bridging study.

Journal: The Journal of antimicrobial chemotherapy 20040201

Title: Comparative activity of garenoxacin and other agents by susceptibility and time-kill testing against Staphylococcus aureus, Streptococcus pyogenes and respiratory pathogens.

Journal: The Journal of antimicrobial chemotherapy 20031101

Title: Metabolism and disposition of novel des-fluoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20031101

Title: Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.

Journal: The Journal of antimicrobial chemotherapy 20031001

Title: [Comparative in vitro activity of garenoxacin (BMS-284756). Sentry program, Spain (1999-2000)].

Journal: Enfermedades infecciosas y microbiologia clinica 20031001

Title: Ultrastructural changes induced by the des-F(6)-quinolone garenoxacin (BMS-284756) and two fluoroquinolones in Achilles tendon from immature rats.

Journal: Archives of toxicology 20030901

Title: In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniae.

Journal: International journal of antimicrobial agents 20030601

Title: Re-evaluation of quality control guidelines for gatifloxacin and garenoxacin (BMS284756) when susceptibility testing Haemophilus influenzae and Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease 20030601

Title: Comparative activity of garenoxacin (BMS 284756), a novel desfluoroquinolone, tested against 8,331 isolates from community-acquired respiratory tract infections: North American results from the SENTRY Antimicrobial Surveillance Program (1999-2001).

Journal: Diagnostic microbiology and infectious disease 20030401

Title: Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.

Journal: The Journal of toxicological sciences 20030201

Title: Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci.

Journal: Antimicrobial agents and chemotherapy 20030101

Title: Antimicrobial activity of a novel des-fluoro (6) quinolone, garenoxacin (BMS-284756), compared to other quinolones, against clinical isolates from cancer patients.

Journal: Diagnostic microbiology and infectious disease 20021001

Title: Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20020901

Title: Comparative in vitro activity of garenoxacin against Chlamydia spp.

Journal: The Journal of antimicrobial chemotherapy 20020901

Title: Geographic variations in garenoxacin (BMS284756) activity tested against pathogens associated with skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (2000).

Journal: Diagnostic microbiology and infectious disease 20020801

Title: Comparative articular toxicity of garenoxacin, a novel quinolone antimicrobial agent, in juvenile beagle dogs.

Journal: The Journal of toxicological sciences 20020801

Title: Synergistic activity of the novel des-fluoro(6) quinolone, garenoxacin (BMS-284756), in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species.

Journal: International journal of antimicrobial agents 20020701

Title: Comparative antimicrobial spectrum and activity of the desfluoroquinolone BMS284756 (T-3811) tested against non-fermentative Gram-negative bacilli.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20020601

Title: Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20020601

Title: BMS284756 (formerly T-3811, a des-fluoroquinolone) potency and spectrum tested against over 10,000 bacterial bloodstream infection isolates from the SENTRY antimicrobial surveillance programme (2000).

Journal: The Journal of antimicrobial chemotherapy 20020501

Title: In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates.

Journal: Antimicrobial agents and chemotherapy 20020301

Title: Increased in vitro activity of the novel des-fluoro(6) quinolone BMS-284756 against genetically defined clinical isolates of Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy 20020201

Title: Antimicrobial resistance trends in community-acquired respiratory tract pathogens in the Western Pacific Region and South Africa: report from the SENTRY antimicrobial surveillance program, (1998-1999) including an in vitro evaluation of BMS284756.

Journal: International journal of antimicrobial agents 20020201

Title: Comparative antimicrobial spectrum and activity of BMS284756 (T-3811; a desfluoroquinolone) tested against an international collection of staphylococci and enterococci, including in vitro test development and intermethod comparisons.

Journal: Journal of chemotherapy (Florence, Italy) 20020201

Title: The in vitro activity of BMS-284756, a new des-fluorinated quinolone.

Journal: The Journal of antimicrobial chemotherapy 20020101

Title: Comparison of the bactericidal activities and post-antibiotic effects of the Des-F(6)-quinolone BMS-284756, levofloxacin, and ciprofloxacin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20020101

Title: Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids. Discovery of the novel des-F(6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756).

Journal: Arzneimittel-Forschung 20020101

Title: Determination of BMS-284756, a new quinolone, in mouse serum by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20011205

Title: BMS-284756 (T-3811ME) a new fluoroquinolone: in vitro activity against Legionella, efficacy in a guinea pig model of L. pneumophila pneumonia and pharmacokinetics in guinea pigs.

Journal: The Journal of antimicrobial chemotherapy 20011101

Title: Activity of the novel des-fluoro(6) quinolone BMS-284756 against methicillin-susceptible and -resistant staphylococci.

Journal: The Journal of antimicrobial chemotherapy 20011101

Title: Antimicrobial activity of BMS 284756 (T-3811) against Neisseria gonorrhoeae tested by three methods.

Journal: International journal of antimicrobial agents 20011101

Title: Comparison of the in vitro activities of BMS-284756 and four fluoroquinolones against Streptococcus pneumoniae.

Journal: The Journal of antimicrobial chemotherapy 20010901

Title: The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues.

Journal: The Journal of antimicrobial chemotherapy 20010801

Title: Comparative antimicrobial spectrum and activity of BMS284756 (T-3811, a desfluoroquinolone) tested against 656 Enterobacteriaceae, including preliminary in vitro susceptibility test comparisons and development.

Journal: International journal of antimicrobial agents 20010801

Title: Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and beta-lactams.

Journal: International journal of antimicrobial agents 20010701

Title: Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States.

Journal: Diagnostic microbiology and infectious disease 20010401

Title: Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci.

Journal: Diagnostic microbiology and infectious disease 20010201

Title: Activity of BMS284756 (T-3811) tested against anaerobic bacteria, Campylobacter jejuni, Helicobacter pylori and Legionella spp.

Journal: Diagnostic microbiology and infectious disease 20010101

Title: In vitro susceptibility study of BMS-284756 against Legionella species.

Journal: Diagnostic microbiology and infectious disease 20010101

Title: Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.

Journal: Antimicrobial agents and chemotherapy 20001201

Title: In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.

Journal: Antimicrobial agents and chemotherapy 19990501

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Related Products of 194804-75-6
Tags:194804-75-6 Molecular Formula|194804-75-6 MDL|194804-75-6 SMILES|194804-75-6 Ganefloxacin
Catalog No.: AA007RCX
194804-75-6,MFCD08141853
194804-75-6 | Ganefloxacin
Pack Size: 5mg
Purity: ≥98%
in stock
$158.00 $110.00
Pack Size: 10mg
Purity: ≥98%
in stock
$236.00 $165.00
Pack Size: 25mg
Purity: ≥98%
in stock
$503.00 $352.00
Pack Size: 50mg
Purity: ≥98%
in stock
$975.00 $683.00
Pack Size: 100mg
Purity: ≥98%
in stock
$1,707.00 $1,195.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA007RCX
Chemical Name: Ganefloxacin
CAS Number: 194804-75-6
Molecular Formula: C23H20F2N2O4
Molecular Weight: 426.4127
MDL Number: MFCD08141853
SMILES: FC(Oc1c(ccc2c1n(cc(c2=O)C(=O)O)C1CC1)c1ccc2c(c1)CN[C@@H]2C)F
Properties
Complexity: 771  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 31  
Hydrogen Bond Acceptor Count: 8  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 5  
XLogP3: 2.1  
Downstream Synthesis Route
194805-14-6    194804-75-6 

[1]Hayashi,Kazuya;Takahata,Masahiro;Kawamura,Yasuhito;Todo,Yozo[Arzneimittel-Forschung/DrugResearch,2002,vol.52,#12,p.903-913]

173435-78-4    194804-75-6   
CASUnavailable 

[1]Peek,James;Koirala,Bimal;Brady,SeanF.[BioorganicandMedicinalChemistryLetters,2022,vol.57]

[2]Peek,James;Koirala,Bimal;Brady,SeanF.[BioorganicandMedicinalChemistryLetters,2022,vol.57]

Literature fold

Title: In vitro antichlamydial activity of garenoxacin against Chlamydia trachomatis.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20120801

Title: Inhibitory activity of garenoxacin against DNA gyrase of Mycoplasma pneumoniae.

Journal: The Journal of antimicrobial chemotherapy20120801

Title: In vitro pharmacodynamic evaluation of garenoxacin against quinolone-resistant Streptococcus pneumoniae.

Journal: International journal of antimicrobial agents20120201

Title: Optimal dose finding of garenoxacin based on population pharmacokinetics/pharmacodynamics and Monte Carlo simulation.

Journal: European journal of clinical pharmacology20120101

Title: Anaphylaxis due to intravenous levofloxacin with tolerance to garenoxacin.

Journal: Internal medicine (Tokyo, Japan)20120101

Title: Anti-inflammatory effects of garenoxacin on IL-8 production and ERK1/2 activation induced by lipopolysaccharides in A549 and THP-1 cells.

Journal: European journal of pharmacology20111001

Title: In vitro and in vivo antibacterial activities of garenoxacin against group G Streptococcus dysgalactiae subsp. equisimilis.

Journal: International journal of antimicrobial agents20110901

Title: Pulmonary nocardiosis caused by Nocardia exalbida complicating Pneumocystis pneumonia in an HIV-infected patient.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20110801

Title: Garenoxacin-induced increase of CD11b expression on human polymorphonuclear neutrophils does not affect phagocytosis and killing of Staphylococcus aureus.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy20110401

Title: [Mutant prevention concentrations of garenoxacin against Streptococcus pneumoniae isolates from otorhinolaryngological infections].

Journal: The Japanese journal of antibiotics20100801

Title: Pharmacokinetics of garenoxacin in elderly patients with respiratory tract infections.

Journal: International journal of antimicrobial agents20100601

Title: Torsades de Pointes induced by a combination of garenoxacin and disopyramide and other cytochrome P450, family 3, subfamily A polypeptide-4-influencing drugs during hypokalemia due to licorice.

Journal: Clinical and experimental nephrology20100401

Title: Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria.

Journal: Bioorganic & medicinal chemistry20091001

Title: [Antimicrobial susceptibility surveillance of recent isolates from otorhinolaryngological infections to garenoxacin and other antimicrobial drugs].

Journal: The Japanese journal of antibiotics20090401

Title: Quinolones with enhanced bactericidal activity induce autolysis in Streptococcus pneumoniae.

Journal: Chemotherapy20090101

Title: Clinical studies of garenoxacin.

Journal: International journal of antimicrobial agents20081201

Title: Comparative pharmacodynamics of garenoxacin, gemifloxacin, and moxifloxacin in community-acquired pneumonia caused by Streptococcus pneumoniae: a Monte Carlo simulation analysis.

Journal: Clinical therapeutics20071201

Title: Potency and spectrum of garenoxacin tested against an international collection of skin and soft tissue infection pathogens: report from the SENTRY antimicrobial surveillance program (1999-2004).

Journal: Diagnostic microbiology and infectious disease20070501

Title: In vitro activity of garenoxacin tested against a worldwide collection of ciprofloxacin-susceptible and ciprofloxacin-resistant Enterobacteriaceae strains (1999-2004).

Journal: Diagnostic microbiology and infectious disease20070501

Title: The effect of omeprazole on the bioavailability and safety of garenoxacin in healthy volunteers.

Journal: Journal of clinical pharmacology20070501

Title: Activity of garenoxacin, an investigational des-F(6)-quinolone, tested against pathogens from community-acquired respiratory tract infections, including those with elevated or resistant-level fluoroquinolone MIC values.

Journal: Diagnostic microbiology and infectious disease20070501

Title: Garenoxacin activity against isolates form patients hospitalized with community-acquired pneumonia and multidrug-resistant Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease20070501

Title: Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection.

Journal: Journal of pharmaceutical and biomedical analysis20070411

Title: Garenoxacin pharmacokinetics in subjects with renal impairment.

Journal: Current medical research and opinion20070301

Title: [In-vitro and in-vivo activities of moxifloxacin and garenoxacin against Mycobacterium leprae].

Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association20070201

Title: 3-aminoquinazolinediones as a new class of antibacterial agents demonstrating excellent antibacterial activity against wild-type and multidrug resistant organisms.

Journal: Journal of medicinal chemistry20061102

Title: Pharmacodynamic activity of garenoxacin against ciprofloxacin-resistant Streptococcus pneumoniae.

Journal: The Journal of antimicrobial chemotherapy20060701

Title: Intravitreal toxicity of garenoxacin.

Journal: Retina (Philadelphia, Pa.)20060201

Title: Comparative in vitro antimicrobial activity of a novel quinolone, garenoxacin, against aerobic and anaerobic microbial isolates recovered from general, vascular, cardiothoracic and otolaryngologic surgical patients.

Journal: The Journal of antimicrobial chemotherapy20051101

Title: In vitro susceptibility of Mycobacterium tuberculosis clinical isolates to garenoxacin and DA-7867.

Journal: Antimicrobial agents and chemotherapy20051001

Title: Comparison of the minimum inhibitory, mutant prevention and minimum bactericidal concentrations of ciprofloxacin, levofloxacin and garenoxacin against enteric Gram-negative urinary tract infection pathogens.

Journal: Journal of chemotherapy (Florence, Italy)20051001

Title: Comparative activity of quinolones (ciprofloxacin, levofloxacin, moxifloxacin and garenoxacin) against extracellular and intracellular infection by Listeria monocytogenes and Staphylococcus aureus in J774 macrophages.

Journal: The Journal of antimicrobial chemotherapy20050401

Title: Bactericidal activity of garenoxacin tested by kill-curve methodology against wild type and QRDR mutant strains of Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease20041101

Title: Mycobacterium tuberculosis DNA gyrase: interaction with quinolones and correlation with antimycobacterial drug activity.

Journal: Antimicrobial agents and chemotherapy20040401

Title: Concentrations of the des-F(6)-quinolone garenoxacin in plasma and joint cartilage of immature rats.

Journal: Archives of toxicology20040201

Title: Comparisons of the in vitro susceptibility testing results for garenoxacin using six different national methods: report from the garenoxacin international bridging study.

Journal: The Journal of antimicrobial chemotherapy20040201

Title: Comparative activity of garenoxacin and other agents by susceptibility and time-kill testing against Staphylococcus aureus, Streptococcus pyogenes and respiratory pathogens.

Journal: The Journal of antimicrobial chemotherapy20031101

Title: Metabolism and disposition of novel des-fluoro quinolone garenoxacin in experimental animals and an interspecies scaling of pharmacokinetic parameters.

Journal: Drug metabolism and disposition: the biological fate of chemicals20031101

Title: Accumulation of garenoxacin by Bacteroides fragilis compared with that of five fluoroquinolones.

Journal: The Journal of antimicrobial chemotherapy20031001

Title: [Comparative in vitro activity of garenoxacin (BMS-284756). Sentry program, Spain (1999-2000)].

Journal: Enfermedades infecciosas y microbiologia clinica20031001

Title: Ultrastructural changes induced by the des-F(6)-quinolone garenoxacin (BMS-284756) and two fluoroquinolones in Achilles tendon from immature rats.

Journal: Archives of toxicology20030901

Title: In vitro activity of garenoxacin against recent clinical isolates of Chlamydia pneumoniae.

Journal: International journal of antimicrobial agents20030601

Title: Re-evaluation of quality control guidelines for gatifloxacin and garenoxacin (BMS284756) when susceptibility testing Haemophilus influenzae and Streptococcus pneumoniae.

Journal: Diagnostic microbiology and infectious disease20030601

Title: Comparative activity of garenoxacin (BMS 284756), a novel desfluoroquinolone, tested against 8,331 isolates from community-acquired respiratory tract infections: North American results from the SENTRY Antimicrobial Surveillance Program (1999-2001).

Journal: Diagnostic microbiology and infectious disease20030401

Title: Pharmacological evaluation of garenoxacin, a novel des-F(6)-quinolone antimicrobial agent: effects on the central nervous system.

Journal: The Journal of toxicological sciences20030201

Title: Garenoxacin (BMS-284756) and moxifloxacin in experimental meningitis caused by vancomycin-tolerant pneumococci.

Journal: Antimicrobial agents and chemotherapy20030101

Title: Antimicrobial activity of a novel des-fluoro (6) quinolone, garenoxacin (BMS-284756), compared to other quinolones, against clinical isolates from cancer patients.

Journal: Diagnostic microbiology and infectious disease20021001

Title: Intra-abdominal anaerobic infections: bacteriology and therapeutic potential of newer antimicrobial carbapenem, fluoroquinolone, and desfluoroquinolone therapeutic agents.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America20020901

Title: Comparative in vitro activity of garenoxacin against Chlamydia spp.

Journal: The Journal of antimicrobial chemotherapy20020901

Title: Geographic variations in garenoxacin (BMS284756) activity tested against pathogens associated with skin and soft tissue infections: report from the SENTRY Antimicrobial Surveillance Program (2000).

Journal: Diagnostic microbiology and infectious disease20020801

Title: Comparative articular toxicity of garenoxacin, a novel quinolone antimicrobial agent, in juvenile beagle dogs.

Journal: The Journal of toxicological sciences20020801

Title: Synergistic activity of the novel des-fluoro(6) quinolone, garenoxacin (BMS-284756), in combination with other antimicrobial agents against Pseudomonas aeruginosa and related species.

Journal: International journal of antimicrobial agents20020701

Title: Comparative antimicrobial spectrum and activity of the desfluoroquinolone BMS284756 (T-3811) tested against non-fermentative Gram-negative bacilli.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases20020601

Title: Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases20020601

Title: BMS284756 (formerly T-3811, a des-fluoroquinolone) potency and spectrum tested against over 10,000 bacterial bloodstream infection isolates from the SENTRY antimicrobial surveillance programme (2000).

Journal: The Journal of antimicrobial chemotherapy20020501

Title: In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates.

Journal: Antimicrobial agents and chemotherapy20020301

Title: Increased in vitro activity of the novel des-fluoro(6) quinolone BMS-284756 against genetically defined clinical isolates of Staphylococcus aureus.

Journal: The Journal of antimicrobial chemotherapy20020201

Title: Antimicrobial resistance trends in community-acquired respiratory tract pathogens in the Western Pacific Region and South Africa: report from the SENTRY antimicrobial surveillance program, (1998-1999) including an in vitro evaluation of BMS284756.

Journal: International journal of antimicrobial agents20020201

Title: Comparative antimicrobial spectrum and activity of BMS284756 (T-3811; a desfluoroquinolone) tested against an international collection of staphylococci and enterococci, including in vitro test development and intermethod comparisons.

Journal: Journal of chemotherapy (Florence, Italy)20020201

Title: The in vitro activity of BMS-284756, a new des-fluorinated quinolone.

Journal: The Journal of antimicrobial chemotherapy20020101

Title: Comparison of the bactericidal activities and post-antibiotic effects of the Des-F(6)-quinolone BMS-284756, levofloxacin, and ciprofloxacin against methicillin-susceptible and methicillin-resistant Staphylococcus aureus.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology20020101

Title: Synthesis, antibacterial activity, and toxicity of 7-(isoindolin-5-yl)-4-oxoquinoline-3-carboxylic acids. Discovery of the novel des-F(6)-quinolone antibacterial agent garenoxacin (T-3811 or BMS-284756).

Journal: Arzneimittel-Forschung20020101

Title: Determination of BMS-284756, a new quinolone, in mouse serum by high-performance liquid chromatography with fluorescence detection.

Journal: Journal of chromatography. B, Biomedical sciences and applications20011205

Title: BMS-284756 (T-3811ME) a new fluoroquinolone: in vitro activity against Legionella, efficacy in a guinea pig model of L. pneumophila pneumonia and pharmacokinetics in guinea pigs.

Journal: The Journal of antimicrobial chemotherapy20011101

Title: Activity of the novel des-fluoro(6) quinolone BMS-284756 against methicillin-susceptible and -resistant staphylococci.

Journal: The Journal of antimicrobial chemotherapy20011101

Title: Antimicrobial activity of BMS 284756 (T-3811) against Neisseria gonorrhoeae tested by three methods.

Journal: International journal of antimicrobial agents20011101

Title: Comparison of the in vitro activities of BMS-284756 and four fluoroquinolones against Streptococcus pneumoniae.

Journal: The Journal of antimicrobial chemotherapy20010901

Title: The inhibition and selectivity of bacterial topoisomerases by BMS-284756 and its analogues.

Journal: The Journal of antimicrobial chemotherapy20010801

Title: Comparative antimicrobial spectrum and activity of BMS284756 (T-3811, a desfluoroquinolone) tested against 656 Enterobacteriaceae, including preliminary in vitro susceptibility test comparisons and development.

Journal: International journal of antimicrobial agents20010801

Title: Comparative killing kinetics of the novel des-fluoro(6) quinolone BMS-284756, fluoroquinolones, vancomycin and beta-lactams.

Journal: International journal of antimicrobial agents20010701

Title: Activity of BMS284756 against 2,681 recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis: Report from The SENTRY Antimicrobial Surveillance Program (2000) in Europe, Canada and the United States.

Journal: Diagnostic microbiology and infectious disease20010401

Title: Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci.

Journal: Diagnostic microbiology and infectious disease20010201

Title: Activity of BMS284756 (T-3811) tested against anaerobic bacteria, Campylobacter jejuni, Helicobacter pylori and Legionella spp.

Journal: Diagnostic microbiology and infectious disease20010101

Title: In vitro susceptibility study of BMS-284756 against Legionella species.

Journal: Diagnostic microbiology and infectious disease20010101

Title: Antibacterial spectrum of a novel des-fluoro(6) quinolone, BMS-284756.

Journal: Antimicrobial agents and chemotherapy20001201

Title: In vitro and in vivo antimicrobial activities of T-3811ME, a novel des-F(6)-quinolone.

Journal: Antimicrobial agents and chemotherapy19990501

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