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Home Other Building Blocks 1045792-66-2
1045792-66-2,MFCD17010286
Catalog No.:AA007XO8

1045792-66-2 | CAY10603

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$56.00   $39.00
- +
5mg
≥95%
in stock  
$252.00   $176.00
- +
10mg
≥95%
in stock  
$463.00   $324.00
- +
25mg
≥95%
in stock  
$826.00   $578.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA007XO8
Chemical Name:
CAY10603
CAS Number:
1045792-66-2
Molecular Formula:
C22H30N4O6
Molecular Weight:
446.4968
MDL Number:
MFCD17010286
SMILES:
ONC(=O)CCCCCCNC(=O)c1noc(c1)c1ccc(cc1)NC(=O)OC(C)(C)C
Properties
Computed Properties
 
Complexity:
616  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
12  
XLogP3:
2.6  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2008,vol.51,#15,p.4370-4373

Literature

Title: An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.

Journal: The Journal of pharmacology and experimental therapeutics 20170101

Title: Development and therapeutic implications of selective histone deacetylase 6 inhibitors.

Journal: Journal of medicinal chemistry 20130822

Title: Identification of potent Yes1 kinase inhibitors using a library screening approach.

Journal: Bioorganic & medicinal chemistry letters 20130801

Title: Inhibitors selective for HDAC6 in enzymes and cells.

Journal: Bioorganic & medicinal chemistry letters 20101201

Title: Use of the nitrile oxide cycloaddition (NOC) reaction for molecular probe generation: a new class of enzyme selective histone deacetylase inhibitors (HDACIs) showing picomolar activity at HDAC6.

Journal: Journal of medicinal chemistry 20080814

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Tags:1045792-66-2 Molecular Formula|1045792-66-2 MDL|1045792-66-2 SMILES|1045792-66-2 CAY10603