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153190-29-5,MFCD01074991
Catalog No.:AA007Y5O

153190-29-5 | U-74389G

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50mg
≥99%
in stock  
$103.00   $72.00
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100mg
≥99%
in stock  
$165.00   $115.00
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250mg
≥99%
in stock  
$380.00   $266.00
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  • Technical Information
  • Properties
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Technical Information
Catalog Number:
AA007Y5O
Chemical Name:
U-74389G
CAS Number:
153190-29-5
Molecular Formula:
C41H54N6O6
Molecular Weight:
726.9041
MDL Number:
MFCD01074991
SMILES:
O=C1C=C[C@]2(C(=C1)CC[C@@H]1C2=CC[C@]2([C@H]1CC[C@@H]2C(=O)CN1CCN(CC1)c1cc(nc(n1)N1CCCC1)N1CCCC1)C)C.OC(=O)C=CC(=O)O
Properties
Computed Properties
 
Complexity:
1380  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
5  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
53  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
8  

Literature

Title: Effects of lazaroids on intestinal ischemia and reperfusion injury in experimental models.

Journal: The Journal of surgical research 20110401

Title: The effects of lazaroid U-74389G in a rat sepsis model.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20110101

Title: U74389F, a 21-aminosteroid antioxidant, improves neoendothelial morphology, but not neointimal thickening after balloon catheter injury.

Journal: Canadian journal of physiology and pharmacology 20091201

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The effect of U-74389G on liver recovery after acute liver ischemia-reperfusion injury in a swine model.

Journal: The Journal of surgical research 20090101

Title: Contribution of xanthine oxidase-derived superoxide to chronic hypoxic pulmonary hypertension in neonatal rats.

Journal: American journal of physiology. Lung cellular and molecular physiology 20080201

Title: Antioxidant U74389G improves glycerol-induced acute renal failure without affecting PPARgamma gene.

Journal: Renal failure 20070101

Title: In vitro efficacy of three lazaroids in a model of acute chemical neuronal hypoxia.

Journal: Neuroscience letters 20061023

Title: Biochemical activity of reactive oxygen species scavengers do not predict retinal ganglion cell survival.

Journal: Investigative ophthalmology & visual science 20060901

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Neuroprotection with methylaminochroman and lazaroid of embryonic ventral mesencephalic tegmental dopaminergic neurons in cold storage.

Journal: Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20060501

Title: The 21-aminosteroid U74389G prevents the down-regulation and decrease in activity of CYP1A1, 1A2 and 3A6 induced by an inflammatory reaction.

Journal: Biochemical pharmacology 20060112

Title: Effects of lazaroid U-74389G on acute necrotizing pancreatitis in rats.

Journal: European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes 20060101

Title: Effects of Carolina rinse solution, dimethyl sulfoxide, and the 21-aminosteroid, U-74389G, on microvascular permeability and morphology of the equine jejunum after low-flow ischemia and reperfusion.

Journal: American journal of veterinary research 20050301

Title: [Effects of U74389G on pulmonary macrophage influx and lung development in 95% O2 exposed newborn rats].

Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics 20040201

Title: Evaluation of the potential protective effect of 21-aminosteroid U-74389G on liver injury induced by reduced and prolonged partial hepatic ischaemia reperfusion in rats.

Journal: Pharmacology & toxicology 20031101

Title: Effect of U-74389G (21-lazaroid) on intestinal recovery after acute mesenteric ischemia and reperfusion in rats.

Journal: In vivo (Athens, Greece) 20030101

Title: Effect of lazaroid pretreatment on dopamine-induced impairment of the rat nigrostriatal system.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020501

Title: Role of mitochondrial complexes I and II, reactive oxygen species and arachidonic acid metabolism in deoxycholate-induced apoptosis.

Journal: Cancer letters 20020328

Title: Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.

Journal: Hepatology (Baltimore, Md.) 20011101

Title: Increased tyrosine nitration of the brain in chronic renal insufficiency: reversal by antioxidant therapy and angiotensin-converting enzyme inhibition.

Journal: Journal of the American Society of Nephrology : JASN 20010901

Title: Cellular basis of steroid neuroprotection in the wobbler mouse, a genetic model of motoneuron disease.

Journal: Cellular and molecular neurobiology 20010601

Title: Protective effect of lipophilic antioxidants on phorbol-induced acute lung injury in rats.

Journal: Critical care medicine 20010401

Title: In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G.

Journal: Life sciences 20010209

Title: Tirilazad mesylate improve water immersion stress induced decrease in erythrocyte deformability in the rats.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20010101

Title: Effect of lazaroid U-74389G on pulmonary ischemia-reperfusion injury in dogs.

Journal: Journal of investigative surgery : the official journal of the Academy of Surgical Research 20010101

Title: Cardiotoxicity of doxorubicin: effects of 21-aminosteroids.

Journal: Life sciences 19980101

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