142720-24-9,MFCD00467704
Catalog No.:AA007Z8I

142720-24-9 | FGIN-1-27

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Purity
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Price(USD)
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5mg
≥98%
in stock  
$53.00   $37.00
- +
10mg
≥98%
in stock  
$98.00   $68.00
- +
25mg
≥98%
in stock  
$155.00   $108.00
- +
50mg
≥98%
in stock  
$279.00   $195.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA007Z8I
Chemical Name:
FGIN-1-27
CAS Number:
142720-24-9
Molecular Formula:
C28H37FN2O
Molecular Weight:
436.6046
MDL Number:
MFCD00467704
SMILES:
CCCCCCN(C(=O)Cc1c([nH]c2c1cccc2)c1ccc(cc1)F)CCCCCC
Properties
Computed Properties
 
Complexity:
522  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
32  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0  
Rotatable Bond Count:
13  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
7.9  

Literature

Title: The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide.

Journal: Biochimica et biophysica acta 20111201

Title: On the path from chemistry to neuroscience: early explorations in chemical medicine under the mentorship of Dr. Erminio Costa, a neuroscientist with a big brain and a bigger heart.

Journal: Pharmacological research 20111001

Title: Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Journal: Toxicology letters 20110425

Title: Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor).

Journal: The Journal of biological chemistry 20110114

Title: Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.

Journal: Psychopharmacology 20110101

Title: Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology 20091001

Title: The translocator protein (18 kDa): central nervous system disease and drug design.

Journal: Journal of medicinal chemistry 20090212

Title: Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.

Journal: Reproduction (Cambridge, England) 20090101

Title: The 18-kDa translocator protein, formerly known as the peripheral-type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line.

Journal: Pharmacogenetics and genomics 20081101

Title: Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.

Journal: Bioorganic & medicinal chemistry 20080601

Title: The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells.

Journal: Haematologica 20071201

Title: Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.

Journal: Organic letters 20060928

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells.

Journal: Biochemical and biophysical research communications 20050708

Title: A cDNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in Helicoverpa armigera: molecular characterization and expression analysis associated with pupal diapause.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20050601

Title: In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.

Journal: Psychopharmacology 20050301

Title: Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.

Journal: Biochemical pharmacology 20050301

Title: Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1.

Journal: Journal of hepatology 20041101

Title: GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A.

Journal: Biochemical pharmacology 20041001

Title: Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.

Journal: Biochemical pharmacology 20040501

Title: Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.

Journal: Bioorganic & medicinal chemistry 20040115

Title: Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.

Journal: British journal of cancer 20030804

Title: Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters.

Journal: Journal of neuroendocrinology 20030701

Title: Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area.

Journal: Neuroendocrinology 20030101

Title: Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo.

Journal: Reproductive toxicology (Elmsford, N.Y.) 20030101

Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.

Journal: International journal of cancer 20021201

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.

Journal: European journal of pharmacology 20011207

Title: Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43.

Journal: The Journal of pharmacy and pharmacology 20011101

Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.

Journal: British journal of cancer 20011101

Title: Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents.

Journal: Brain research 20010413

Title: Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.

Journal: The Journal of pharmacology and experimental therapeutics 19940701

Title: 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

Journal: The Journal of pharmacology and experimental therapeutics 19920901

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SDS
Related Products of 142720-24-9
Tags:142720-24-9 Molecular Formula|142720-24-9 MDL|142720-24-9 SMILES|142720-24-9 FGIN-1-27
Catalog No.: AA007Z8I
142720-24-9,MFCD00467704
142720-24-9 | FGIN-1-27
Pack Size: 5mg
Purity: ≥98%
in stock
$53.00 $37.00
Pack Size: 10mg
Purity: ≥98%
in stock
$98.00 $68.00
Pack Size: 25mg
Purity: ≥98%
in stock
$155.00 $108.00
Pack Size: 50mg
Purity: ≥98%
in stock
$279.00 $195.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA007Z8I
Chemical Name: FGIN-1-27
CAS Number: 142720-24-9
Molecular Formula: C28H37FN2O
Molecular Weight: 436.6046
MDL Number: MFCD00467704
SMILES: CCCCCCN(C(=O)Cc1c([nH]c2c1cccc2)c1ccc(cc1)F)CCCCCC
Properties
Complexity: 522  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 32  
Hydrogen Bond Acceptor Count: 2  
Hydrogen Bond Donor Count: 1  
Isotope Atom Count: 0  
Rotatable Bond Count: 13  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 7.9  
Literature fold

Title: The translocator protein (peripheral benzodiazepine receptor) mediates rat-selective activation of the mitochondrial permeability transition by norbormide.

Journal: Biochimica et biophysica acta20111201

Title: On the path from chemistry to neuroscience: early explorations in chemical medicine under the mentorship of Dr. Erminio Costa, a neuroscientist with a big brain and a bigger heart.

Journal: Pharmacological research20111001

Title: Modulation of constitutive androstane receptor (CAR) and pregnane X receptor (PXR) by 6-arylpyrrolo[2,1-d][1,5]benzothiazepine derivatives, ligands of peripheral benzodiazepine receptor (PBR).

Journal: Toxicology letters20110425

Title: Regulation of the inner membrane mitochondrial permeability transition by the outer membrane translocator protein (peripheral benzodiazepine receptor).

Journal: The Journal of biological chemistry20110114

Title: Effects of neurosteroid actions at N-methyl-D-aspartate and GABA A receptors in the midbrain ventral tegmental area for anxiety-like and mating behavior of female rats.

Journal: Psychopharmacology20110101

Title: Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience20101215

Title: Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Journal: Nature chemical biology20091001

Title: The translocator protein (18 kDa): central nervous system disease and drug design.

Journal: Journal of medicinal chemistry20090212

Title: Increasing 3alpha,5alpha-THP following inhibition of neurosteroid biosynthesis in the ventral tegmental area reinstates anti-anxiety, social, and sexual behavior of naturally receptive rats.

Journal: Reproduction (Cambridge, England)20090101

Title: The 18-kDa translocator protein, formerly known as the peripheral-type benzodiazepine receptor, confers proapoptotic and antineoplastic effects in a human colorectal cancer cell line.

Journal: Pharmacogenetics and genomics20081101

Title: Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor.

Journal: Bioorganic & medicinal chemistry20080601

Title: The potential anticancer agent PK11195 induces apoptosis irrespective of p53 and ATM status in chronic lymphocytic leukemia cells.

Journal: Haematologica20071201

Title: Preparation of indoles from alpha-aminonitriles: A short synthesis of FGIN-1-27.

Journal: Organic letters20060928

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Mechanisms of mitochondrial apoptosis induced by peripheral benzodiazepine receptor ligands in human colorectal cancer cells.

Journal: Biochemical and biophysical research communications20050708

Title: A cDNA encoding diazepam-binding inhibitor/acyl-CoA-binding protein in Helicoverpa armigera: molecular characterization and expression analysis associated with pupal diapause.

Journal: Comparative biochemistry and physiology. Toxicology & pharmacology : CBP20050601

Title: In the ventral tegmental area picrotoxin blocks FGIN 1-27-induced increases in sexual behavior of rats and hamsters.

Journal: Psychopharmacology20050301

Title: Peripheral benzodiazepine receptor (PBR) ligand cytotoxicity unrelated to PBR expression.

Journal: Biochemical pharmacology20050301

Title: Peripheral benzodiazepine receptor ligands induce apoptosis and cell cycle arrest in human hepatocellular carcinoma cells and enhance chemosensitivity to paclitaxel, docetaxel, doxorubicin and the Bcl-2 inhibitor HA14-1.

Journal: Journal of hepatology20041101

Title: GABA(A)/central benzodiazepine receptor and peripheral benzodiazepine receptor ligands as inducers of phenobarbital-inducible CYP2B and CYP3A.

Journal: Biochemical pharmacology20041001

Title: Enhancement of peripheral benzodiazepine receptor ligand-induced apoptosis and cell cycle arrest of esophageal cancer cells by simultaneous inhibition of MAPK/ERK kinase.

Journal: Biochemical pharmacology20040501

Title: Design, synthesis and structure-affinity relationships of aryloxyanilide derivatives as novel peripheral benzodiazepine receptor ligands.

Journal: Bioorganic & medicinal chemistry20040115

Title: Ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in oesophageal cancer cells: involvement of the p38MAPK signalling pathway.

Journal: British journal of cancer20030804

Title: Mitochondrial benzodiazepine receptors in the ventral tegmental area modulate sexual behaviour of cycling or hormone-primed hamsters.

Journal: Journal of neuroendocrinology20030701

Title: Lordosis of rats is modified by neurosteroidogenic effects of membrane benzodiazepine receptors in the ventral tegmental area.

Journal: Neuroendocrinology20030101

Title: Mitochondrial benzodiazepine receptors regulate oxygen homeostasis in the early mouse embryo.

Journal: Reproductive toxicology (Elmsford, N.Y.)20030101

Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human esophageal cancer cells.

Journal: International journal of cancer20021201

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes.

Journal: European journal of pharmacology20011207

Title: Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1-27 and FGIN-1-43.

Journal: The Journal of pharmacy and pharmacology20011101

Title: Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells.

Journal: British journal of cancer20011101

Title: Cataleptic effect of neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice: modulation by serotonergic agents.

Journal: Brain research20010413

Title: Mitochondrial diazepam-binding inhibitor receptor complex agonists antagonize dizocilpine amnesia: putative role for allopregnanolone.

Journal: The Journal of pharmacology and experimental therapeutics19940701

Title: 2-Aryl-3-indoleacetamides (FGIN-1): a new class of potent and specific ligands for the mitochondrial DBI receptor (MDR).

Journal: The Journal of pharmacology and experimental therapeutics19920901

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