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118081-34-8,MFCD00864918
Catalog No.:AA00819J

118081-34-8 | Ceftibuten dihydrate

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Purity
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Price(USD)
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25mg
98%
in stock  
$48.00   $34.00
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100mg
98%
in stock  
$129.00   $90.00
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA00819J
Chemical Name:
Ceftibuten dihydrate
CAS Number:
118081-34-8
Molecular Formula:
C15H18N4O8S2
Molecular Weight:
446.4554
MDL Number:
MFCD00864918
SMILES:
OC(=O)CC=C(C(=O)NC1C(=O)N2C1SCC=C2C(=O)O)c1csc(n1)N.O.O
Properties
Computed Properties
 
Complexity:
755  
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
12  
Hydrogen Bond Donor Count:
6  
Rotatable Bond Count:
6  

Literature

Title: Ceftibuten versus trimethoprim-sulfamethoxazole for oral treatment of febrile urinary tract infection in children.

Journal: Pediatric nephrology (Berlin, Germany) 20090301

Title: Randomised trial of oral versus sequential intravenous/oral cephalosporins in children with pyelonephritis.

Journal: European journal of pediatrics 20080901

Title: Inhibitory effect of zinc on the absorption of beta-lactam antibiotic ceftibuten via the peptide transporters in rats.

Journal: Drug metabolism and pharmacokinetics 20080101

Title: Recognition of 2-aminothiazole-4-acetic acid derivatives by the peptide transporters PEPT1 and PEPT2.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070901

Title: In vitro selection and characterization of mutants in TEM-1-producing Escherichia coli by ceftazidime and ceftibuten.

Journal: Journal of chemotherapy (Florence, Italy) 20070401

Title: In vitro activity of ceftibuten at sub-inhibitory concentrations in comparison with other antibiotics against respiratory and urinary tract pathogens.

Journal: Journal of chemotherapy (Florence, Italy) 20070401

Title: Burkholderia cepacia complex nasal isolation in immunocompetent patients with sinonasal polyposis not associated with cystic fibrosis.

Journal: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20070101

Title: Purification by p-aminobenzoic acid (PABA)-affinity chromatography and the functional reconstitution of the nateglinide/H+ cotransport system in the rat intestinal brush-border membrane.

Journal: Biochemical and biophysical research communications 20060217

Title: Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.

Journal: Chemotherapy 20060101

Title: A case of selective IgE-mediated hypersensitivity to ceftibuten.

Journal: Allergy 20051101

Title: Nateglinide uptake by a ceftibuten transporter in the rat kidney brush-border membrane.

Journal: Biochimica et biophysica acta 20050830

Title: Computational modelling of H+-coupled peptide transport via human PEPT1.

Journal: The Journal of physiology 20050601

Title: Increased protein level of PEPT1 intestinal H+-peptide cotransporter upregulates absorption of glycylsarcosine and ceftibuten in 5/6 nephrectomized rats.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20050401

Title: H+-dependent transport mechanism of nateglinide in the brush-border membrane of the rat intestine.

Journal: The Journal of pharmacology and experimental therapeutics 20050101

Title: Efflux properties of basolateral peptide transporter in human intestinal cell line Caco-2.

Journal: Pflugers Archiv : European journal of physiology 20041101

Title: [Treatment mostly not in line with current knowledge. New guidelines for sinusitis therapy].

Journal: MMW Fortschritte der Medizin 20040610

Title: Antibiotic use profile at paediatric clinics in two transitional countries.

Journal: Pharmacoepidemiology and drug safety 20040301

Title: Altered diurnal rhythm of intestinal peptide transporter by fasting and its effects on the pharmacokinetics of ceftibuten.

Journal: The Journal of pharmacology and experimental therapeutics 20031101

Title: Comparison of ceftibuten transport across Caco-2 cells and rat jejunum mounted on modified Ussing chambers.

Journal: Biopharmaceutics & drug disposition 20031001

Title: Urinary tract infections in South Croatia: aetiology and antimicrobial resistance.

Journal: International journal of antimicrobial agents 20031001

Title: Inhibitory effect of zinc on PEPT1-mediated transport of glycylsarcosine and beta-lactam antibiotics in human intestinal cell line Caco-2.

Journal: Pharmaceutical research 20030901

Title: [Our experience with cedax (ceftibuten) in the obstetrical and gynecological practice].

Journal: Akusherstvo i ginekologiia 20030101

Title: Transporters involved in apical and basolateral uptake of ceftibuten into Caco-2 cells.

Journal: Biopharmaceutics & drug disposition 20021101

Title: [Treatment of obstetric and gynecologic diseases with anti-inflammatory drug cedax].

Journal: Akusherstvo i ginekologiia 20020101

Title: [Therapeutic recommendation in acute suppurative sinusitis. Antibiotic plus topical steroid].

Journal: MMW Fortschritte der Medizin 20011206

Title: [Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201

Title: The changing pattern of multi-drug resistant enteric fever--a physician's dilemma.

Journal: The Journal of the Association of Physicians of India 20011001

Title: Comparative study of ceftibuten and cefixime in the treatment of complicated urinary tract infections.

Journal: Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20010901

Title: [Five days ceftibuten versus 10 days penicillin in the treatment of 2099 patients with A-streptococcal tonsillopharyngitis].

Journal: Fortschritte der Medizin. Originalien 20010719

Title: Interpretive criteria of ceftibuten disk diffusion susceptibility tests according to the DIN 58 940 method.

Journal: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20010601

Title: [Patient adherence in respiratory tract infections: ceftibuten versus other antibiotics (PARTICULAR study)].

Journal: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20010601

Title: Oral ceftibuten switch therapy for acute pyelonephritis in children.

Journal: Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20010601

Title: [Treatment of group A streptococcal tonsillopharyngitis. 5 days cephalosporin is as effective as 10 days penicillin].

Journal: MMW Fortschritte der Medizin 20010503

Title: Ceftibuten stability to active-site serine and metallo-beta-lactamases.

Journal: International journal of antimicrobial agents 20010101

Title: Fewer bacterial relapses after oral treatment with norfloxacin than with ceftibuten in acute pyelonephritis initially treated with intravenous cefuroxime.

Journal: Scandinavian journal of infectious diseases 20010101

Title: Significance of substrate hydrophobicity for recognition by an oligopeptide transporter (PEPT1).

Journal: Bioconjugate chemistry 20010101

Title: [Comparative clinical efficacy and tolerance of cefuroxime axetil (zinnat) and ceftibuten (cedex) in patients with acute sinusitis].

Journal: Vestnik otorinolaringologii 20010101

Title: [Treatment with cedax in asymptomatic bacteriuria in the first trimester of pregnancy].

Journal: Akusherstvo i ginekologiia 20010101

Title: Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.

Journal: The American journal of physiology 19971101

Title: Identification of the histidine residues involved in substrate recognition by a rat H+/peptide cotransporter, PEPT1.

Journal: FEBS letters 19960930

Title: Kearns GL, et al. Single-dose pharmacokinetics of ceftibuten (SCH 39720) in infants and children. Antimicrob Agents Chemother. 1991;35(10):2078-2084.

Title: Shawar R, et al. Comparative in vitro activity of ceftibuten (Sch 39720) against bacterial enteropathogens. Antimicrob Agents Chemother. 1989;33(5):781-784.

Title: Tamai I, et al. Functional expression of intestinal dipeptide/beta-lactam antibiotic transporter in Xenopus laevis oocytes. Biochem Pharmacol. 1994;48(5):881-888.

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