Name: Name:4-(4-Trifluoromethylphenyl)thiazol-2-ylamine
Brand: AABLOCKS
SKU: AA0084OD
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA0084OD

Chemical Name: 4-(4-Trifluoromethylphenyl)thiazol-2-ylamine

CAS Number: 105512-79-6

Molecular Formula: C10H7F3N2S

Molecular Weight: 244.2362

MDL Number: MFCD03094298

SMILES: FC(c1ccc(cc1)c1csc(n1)N)(F)F

Properties

Complexity: 239

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 16

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 1

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 3.2

Downstream Synthesis Route

383-53-9

17356-08-0

105512-79-6

[1]CurrentPatentAssignee:IRMLLC-WO2007/89557,2007,A2Locationinpatent:Page/Pagecolumn24

[2]CurrentPatentAssignee:IRMLLC-WO2007/56496,2007,A1Locationinpatent:Page/Pagecolumn23

[3]Dai,Weiyang;Samanta,Soma;Xue,Ding;Petrunak,ElyseM.;Stuckey,JeanneA.;Han,Yanyan;Sun,Duxin;Wu,Yong;Neamati,Nouri[JournalofMedicinalChemistry,2019,vol.62,#6,p.3068-3087]

[4]Hanke,Thomas;Dehm,Friederike;Liening,Stefanie;Popella,Sven-Desiderius;MacZewsky,Jonas;Pillong,Max;Kunze,Jens;Weinigel,Christina;Barz,Dagmar;Kaiser,Astrid;Wurglics,Mario;Lämmerhofer,Michael;Schneider,Gisbert;Sautebin,Lidia;Schubert-Zsilavecz,Manfred;Werz,Oliver[JournalofMedicinalChemistry,2013,vol.56,#22,p.9031-9044]

[5]Gawali,Rakhi;Trivedi,Jay;Bhansali,Sujit;Bhosale,Raghunath;Sarkar,Dhiman;Mitra,Debashis[EuropeanJournalofMedicinalChemistry,2018,vol.157,p.310-319]

[6]Hu,XiaoLong;Long,Huan;Shi,Wei;Wang,Hao;Wang,Quan[BioorganicandMedicinalChemistryLetters,2022,vol.69]

[7]Hu,XiaoLong;Long,Huan;Shi,Wei;Wang,Hao;Wang,Quan[BioorganicandMedicinalChemistryLetters,2022,vol.69]

[8]Locationinpatent:experimentalpartXu,Qinyuan;Huang,Li;Liu,Juan;Ma,Liang;Chen,Tao;Chen,Jinying;Peng,Fei;Cao,Dong;Yang,Zhuang;Qiu,Neng;Qiu,Jingxiang;Wang,Guangcheng;Liang,Xiaolin;Peng,Aihua;Xiang,Mingli;Wei,Yuquan;Chen,Lijuan[EuropeanJournalofMedicinalChemistry,2012,vol.52,p.70-81]

[9]Ma,Liang;Wang,Taijin;Shi,Min;Ye,Haoyu[DrugDesign,DevelopmentandTherapy,2016,vol.10,p.1807-1815]

936711-74-9

105512-79-6

2-methyl-2-(2-methyl-4-{2-4-(4-trifluoromethyl-phenyl)-thiazol-2-ylamino-ethoxy}-phenoxy)-propionicacidmethylester

[1]CurrentPatentAssignee:IRMLLC-WO2007/56496,2007,A1Locationinpatent:Page/Pagecolumn37-38

2-(4-chlorosulfonyl-2-methyl-phenoxy)-2-methyl-propionicacidmethylester

105512-79-6

2-methyl-2-{2-methyl-4-4-(4-trifluoromethyl-phenyl)-thiazol-2-ylsulfamoyl-phenoxy}-propionicacidmethylester

[1]CurrentPatentAssignee:IRMLLC-WO2007/56496,2007,A1Locationinpatent:Page/Pagecolumn39

936712-23-1

105512-79-6

2-(2,5-dimethyl-4-4-(4-trifluoromethyl-phenyl)-thiazol-2-ylamino-methyl}-phenoxy)-2-methyl-propionicacidmethylester

[1]CurrentPatentAssignee:IRMLLC-WO2007/56496,2007,A1Locationinpatent:Page/Pagecolumn40

105512-79-6 | 4-(4-Trifluoromethylphenyl)thiazol-2-ylamine