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894804-07-0,MFCD19690908
Catalog No.:AA0087P0

894804-07-0 | JNK Inhibitor VIII

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$145.00   $101.00
- +
10mg
≥98%
in stock  
$275.00   $192.00
- +
25mg
≥98%
in stock  
$542.00   $379.00
- +
50mg
≥98%
in stock  
$650.00   $455.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA0087P0
Chemical Name:
JNK Inhibitor VIII
CAS Number:
894804-07-0
Molecular Formula:
C18H20N4O4
Molecular Weight:
356.3758
MDL Number:
MFCD19690908
SMILES:
CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(c1C#N)N
Properties
Computed Properties
 
Complexity:
509  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
7  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
2.2  

Literature

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal 20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology 20111101

Title: Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics 20100401

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America 20071218

Title: Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Journal: Journal of medicinal chemistry 20060615

Title: Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.

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SDS
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Tags:894804-07-0 Molecular Formula|894804-07-0 MDL|894804-07-0 SMILES|894804-07-0 JNK Inhibitor VIII
Catalog No.: AA0087P0
894804-07-0,MFCD19690908
894804-07-0 | JNK Inhibitor VIII
Pack Size： 5mg
Purity： ≥98%
in stock
$145.00 $101.00
Pack Size： 10mg
Purity： ≥98%
in stock
$275.00 $192.00
Pack Size： 25mg
Purity： ≥98%
in stock
$542.00 $379.00
Pack Size： 50mg
Purity： ≥98%
in stock
$650.00 $455.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA0087P0
Chemical Name: JNK Inhibitor VIII
CAS Number: 894804-07-0
Molecular Formula: C18H20N4O4
Molecular Weight: 356.3758
MDL Number: MFCD19690908
SMILES: CCOc1nc(NC(=O)Cc2cc(OC)ccc2OC)cc(c1C#N)N
Properties
Complexity: 509  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 26  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 7  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 2.2  
Literature fold

Title: A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.

Journal: The Biochemical journal20130415

Title: Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity.

Journal: Nature biotechnology20111101

Title: Mitogen-activated protein kinase phosphatase-1 negatively regulates the expression of interleukin-6, interleukin-8, and cyclooxygenase-2 in A549 human lung epithelial cells.

Journal: The Journal of pharmacology and experimental therapeutics20100401

Title: A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

Journal: Proceedings of the National Academy of Sciences of the United States of America20071218

Title: Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity.

Journal: Journal of medicinal chemistry20060615

Title: Szczepankiewicz BG, et al. Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J Med Chem. 2006 Jun 15;49(12):3563-80.

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