874902-19-9,MFCD08703123
Catalog No.:AA008C5F

874902-19-9 | LY2183240

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$133.00   $93.00
- +
5mg
98% by HPLC
in stock  
$148.00   $104.00
- +
10mg
≥98%
in stock  
$199.00   $139.00
- +
25mg
98% by HPLC
in stock  
$364.00   $255.00
- +
50mg
98% by HPLC
in stock  
$575.00   $403.00
- +
100mg
98% by HPLC
in stock  
$949.00   $664.00
- +
500mg
98% by HPLC
in stock  
$2,920.00   $2,044.00
- +
1000mg
98% by HPLC
in stock  
$4,634.00   $3,244.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008C5F
Chemical Name:
LY2183240
CAS Number:
874902-19-9
Molecular Formula:
C17H17N5O
Molecular Weight:
307.3498
MDL Number:
MFCD08703123
SMILES:
CN(C(=O)n1nnnc1Cc1ccc(cc1)c1ccccc1)C
Properties
Computed Properties
 
Complexity:
388  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
4  
Rotatable Bond Count:
3  
XLogP3:
3  

Literature

Title: The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Journal: Bioorganic & medicinal chemistry letters 20110815

Title: Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference.

Journal: Psychopharmacology 20101201

Title: Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.

Journal: Journal of medicinal chemistry 20091210

Title: Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.

Journal: Journal of medicinal chemistry 20091126

Title: Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.

Journal: Journal of medicinal chemistry 20090108

Title: The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein.

Journal: European journal of pharmacology 20090105

Title: Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.

Journal: Journal of medicinal chemistry 20081211

Title: Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.

Journal: European journal of medicinal chemistry 20080101

Title: The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.

Journal: Journal of the American Chemical Society 20060802

Title: Moore SA, et al. Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc Natl Acad Sci U S A. 2005;102(49):17852-17857.

Title: Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.

Title: Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc. 2006 Aug 2;128(30):9699-704.

Title: Maione S, et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008 Nov;155(5):775-82.

Title: Pelorosso FG, et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. Eur J Pharmacol. 2009 Jan 5;602(1):176-9.

Title: Powers MS, et al. Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Psychopharmacology (Berl). 2010 Dec;212(4):571-83.

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Tags:874902-19-9 Molecular Formula|874902-19-9 MDL|874902-19-9 SMILES|874902-19-9 LY2183240
Catalog No.: AA008C5F
874902-19-9,MFCD08703123
874902-19-9 | LY2183240
Pack Size: 1mg
Purity: ≥98%
in stock
$133.00 $93.00
Pack Size: 5mg
Purity: 98% by HPLC
in stock
$148.00 $104.00
Pack Size: 10mg
Purity: ≥98%
in stock
$199.00 $139.00
Pack Size: 25mg
Purity: 98% by HPLC
in stock
$364.00 $255.00
Pack Size: 50mg
Purity: 98% by HPLC
in stock
$575.00 $403.00
Pack Size: 100mg
Purity: 98% by HPLC
in stock
$949.00 $664.00
Pack Size: 500mg
Purity: 98% by HPLC
in stock
$2,920.00 $2,044.00
Pack Size: 1000mg
Purity: 98% by HPLC
in stock
$4,634.00 $3,244.00
Quantity
- +
Add to Card
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bulk Quotation Request
Technical Information
Catalog Number: AA008C5F
Chemical Name: LY2183240
CAS Number: 874902-19-9
Molecular Formula: C17H17N5O
Molecular Weight: 307.3498
MDL Number: MFCD08703123
SMILES: CN(C(=O)n1nnnc1Cc1ccc(cc1)c1ccccc1)C
Properties
Complexity: 388  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 23  
Hydrogen Bond Acceptor Count: 4  
Rotatable Bond Count: 3  
XLogP3: 3  
Literature fold

Title: The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH).

Journal: Bioorganic & medicinal chemistry letters20110815

Title: Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference.

Journal: Psychopharmacology20101201

Title: Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors.

Journal: Journal of medicinal chemistry20091210

Title: Bis(dialkylaminethiocarbonyl)disulfides as potent and selective monoglyceride lipase inhibitors.

Journal: Journal of medicinal chemistry20091126

Title: Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.

Journal: Journal of medicinal chemistry20090108

Title: The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein.

Journal: European journal of pharmacology20090105

Title: Discovery and development of fatty acid amide hydrolase (FAAH) inhibitors.

Journal: Journal of medicinal chemistry20081211

Title: Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: a critical revisitation.

Journal: European journal of medicinal chemistry20080101

Title: The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases.

Journal: Journal of the American Chemical Society20060802

Title: Moore SA, et al. Identification of a high-affinity binding site involved in the transport of endocannabinoids. Proc Natl Acad Sci U S A. 2005;102(49):17852-17857.

Title: Sun L, et al. Endocannabinoid activation of CB1 receptors contributes to long-lasting reversal of neuropathic pain by repetitive spinal cord stimulation. Eur J Pain. 2017 May;21(5):804-814.

Title: Alexander JP, Cravatt BF. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc. 2006 Aug 2;128(30):9699-704.

Title: Maione S, et al. Antinociceptive effects of tetrazole inhibitors of endocannabinoid inactivation: cannabinoid and non-cannabinoid receptor-mediated mechanisms. Br J Pharmacol. 2008 Nov;155(5):775-82.

Title: Pelorosso FG, et al. The endocannabinoid anandamide inhibits kinin B1 receptor sensitization through cannabinoid CB1 receptor stimulation in human umbilical vein. Eur J Pharmacol. 2009 Jan 5;602(1):176-9.

Title: Powers MS, et al. Effects of the novel endocannabinoid uptake inhibitor, LY2183240, on fear-potentiated startle and alcohol-seeking behaviors in mice selectively bred for high alcohol preference. Psychopharmacology (Berl). 2010 Dec;212(4):571-83.

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