Name: Name:Trofinetide
Brand: AABLOCKS
SKU: AA008FJO
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008FJO

Chemical Name: Trofinetide

CAS Number: 853400-76-7

Molecular Formula: C13H21N3O6

Molecular Weight: 315.3223

MDL Number: MFCD28502204

SMILES: NCC(=O)N1CCC[C@@]1(C)C(=O)N[C@H](C(=O)O)CCC(=O)O

Properties

Complexity: 480

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 2

Heavy Atom Count: 22

Hydrogen Bond Acceptor Count: 7

Hydrogen Bond Donor Count: 4

Rotatable Bond Count: 7

XLogP3: -3.9

Literature fold

Title: NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism20091201

Title: NNZ-2566: a Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke.

Journal: Journal of the neurological sciences20090315

Title: NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.

Journal: Journal of neurotrauma20090101

Title: NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats.

Journal: Journal of neuroinflammation20090101

Title: The neuroprotective activity of GPE tripeptide analogues does not correlate with glutamate receptor binding affinity.

Journal: Bioorganic & medicinal chemistry letters20060701

Title: Analogues of the neuroprotective tripeptide Gly-Pro-Glu (GPE): synthesis and structure-activity relationships.

Journal: Bioorganic & medicinal chemistry letters20050502

Title: Wei HH, et al. NNZ-2566 treatment inhibits neuroinflammation and pro-inflammatory cytokine expression induced by experimental penetrating ballistic-like brain injury in rats. J Neuroinflammation. 2009 Aug 5;6:19.

Title: Lu XC, et al. NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats. J Cereb Blood Flow Metab. 2009 Dec;29(12):1924-32.

Title: Cartagena CM, Phillips KL, Williams GL, et al. Mechanism of action for NNZ-2566 anti-inflammatory effects following PBBI involves upregulation of immunomodulator ATF3. Neuromolecular Med. 2013;15(3):504-514.

853400-76-7 | Trofinetide