Home Bromides 83-67-0
83-67-0,MFCD00022830
Catalog No.:AA008IJ0

83-67-0 | Theobromine

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Purity
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Price(USD)
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1g
98%
in stock  
$28.00   $19.00
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5g
98%
in stock  
$29.00   $20.00
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25g
≥98%
in stock  
$46.00   $32.00
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50g
≥98%
in stock  
$88.00   $61.00
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100g
99 - 101% (Assay)
in stock  
$116.00   $81.00
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250g
99 - 101% (Assay)
in stock  
$196.00   $137.00
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500g
>98.0%(T)(HPLC)
in stock  
$387.00   $271.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008IJ0
Chemical Name:
Theobromine
CAS Number:
83-67-0
Molecular Formula:
C7H8N4O2
Molecular Weight:
180.1640
MDL Number:
MFCD00022830
SMILES:
Cn1cnc2c1c(=O)[nH]c(=O)n2C
FEMA Number:
3591
Properties
Computed Properties
 
Complexity:
267  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
XLogP3:
-0.8  

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Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20120601

Title: Measurement of CYP1A2 activity: a focus on caffeine as a probe.

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Title: Modification of ginseng flavors by bitter compounds found in chocolate and coffee.

Journal: Journal of food science 20120601

Title: Guarana: Paullinia cupana, P. sorbilis; also known as Brazilian cocoa and 'zoom'.

Journal: Journal of primary health care 20120601

Title: Functional analysis of the relative growth rate, chemical composition, construction and maintenance costs, and the payback time of Coffea arabica L. leaves in response to light and water availability.

Journal: Journal of experimental botany 20120501

Title: The effects of maternal caffeine and chocolate intake on fetal heart rate.

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Journal: European journal of public health 20120401

Title: A randomized, double-blind, placebo-controlled study of the safety and tolerance of regadenoson in subjects with stage 3 or 4 chronic kidney disease.

Journal: Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20120401

Title: Characterization of swellable molecularly imprinted polymer particles by surface plasmon resonance spectroscopy.

Journal: Applied spectroscopy 20120401

Title: Anti-obesity and anti-diabetic effects of Yerba Mate (Ilex paraguariensis) in C57BL/6J mice fed a high-fat diet.

Journal: Laboratory animal research 20120301

Title: Histopathology of incidental findings in beagles used in toxicity studies.

Journal: Journal of toxicologic pathology 20120301

Title: Development of a chromatographic low pressure flow injection system: application to the analysis of methylxanthines in coffee.

Journal: Analytica chimica acta 20120217

Title: Caffeine as an indicator for the quantification of untreated wastewater in karst systems.

Journal: Water research 20120201

Title: Simultaneous determination of polyphenols and major purine alkaloids in Greek Sideritis species, herbal extracts, green tea, black tea, and coffee by high-performance liquid chromatography-diode array detection.

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Title: Analysis of Camellia sinensis green and black teas via ultra high performance liquid chromatography assisted by liquid-liquid partition and two-dimensional liquid chromatography (size exclusion × reversed phase).

Journal: Journal of chromatography. A 20120127

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Journal: Neuroscience 20120110

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Journal: Molecular nutrition & food research 20120101

Title: A combination of ischemic preconditioning and allopurinol protects against ischemic injury through a nitric oxide-dependent mechanism.

Journal: Nitric oxide : biology and chemistry 20120101

Title: Physiology, biochemistry and possible applications of microbial caffeine degradation.

Journal: Applied microbiology and biotechnology 20120101

Title: Equine poisoning by coffee husk (Coffea arabica L.).

Journal: BMC veterinary research 20120101

Title: Development of an innovative nutraceutical fermented beverage from herbal mate (Ilex paraguariensis A.St.-Hil.) extract.

Journal: International journal of molecular sciences 20120101

Title: Effects of a caffeine-containing energy drink on simulated soccer performance.

Journal: PloS one 20120101

Title: A novel HPLC method for the concurrent analysis and quantitation of seven water-soluble vitamins in biological fluids (plasma and urine): a validation study and application.

Journal: TheScientificWorldJournal 20120101

Title: Pan-pathway based interaction profiling of FDA-approved nucleoside and nucleobase analogs with enzymes of the human nucleotide metabolism.

Journal: PloS one 20120101

Title: Antimicrobial and Anti-Inflammatory Activities of Pterygota macrocarpa and Cola gigantea (Sterculiaceae).

Journal: Evidence-based complementary and alternative medicine : eCAM 20120101

Title: Evaluation of human enamel surfaces treated with theobromine: a pilot study.

Journal: Oral health & preventive dentistry 20120101

Title: Differential contributions of theobromine and caffeine on mood, psychomotor performance and blood pressure.

Journal: Physiology & behavior 20111024

Title: Structure of 2,4-diaminopyrimidine-theobromine alternate base pairs.

Journal: The journal of physical chemistry. A 20111020

Title: Cocrystals of quercetin with improved solubility and oral bioavailability.

Journal: Molecular pharmaceutics 20111003

Title: Effect of prolonged status epilepticus as a result of intoxication on epileptogenesis in a UK canine population.

Journal: The Veterinary record 20111001

Title: Comparison of the chemical constituents of aged pu-erh tea, ripened pu-erh tea, and other teas using HPLC-DAD-ESI-MSn.

Journal: Journal of agricultural and food chemistry 20110824

Title: Flavanols and methylxanthines in commercially available dark chocolate: a study of the correlation with nonfat cocoa solids.

Journal: Journal of agricultural and food chemistry 20110810

Title: Producing low-caffeine tea through post-transcriptional silencing of caffeine synthase mRNA.

Journal: Plant molecular biology 20110801

Title: Agrobacterium-mediated silencing of caffeine synthesis through root transformation in Camellia sinensis L.

Journal: Molecular biotechnology 20110701

Title: Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats.

Journal: Xenobiotica; the fate of foreign compounds in biological systems 20110701

Title: Effect of source variation on drug release from HPMC tablets: linear regression modeling for prediction of drug release.

Journal: International journal of pharmaceutics 20110615

Title: Rapid methods to determine procyanidins, anthocyanins, theobromine and caffeine in rat tissues by liquid chromatography-tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110601

Title: The potentiality of medicinal plants as the source of new contraceptive principles in males.

Journal: North American journal of medical sciences 20110601

Title: Evaluation of the reproductive and developmental risks of caffeine.

Journal: Birth defects research. Part B, Developmental and reproductive toxicology 20110401

Title: Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

Journal: PLoS genetics 20110401

Title: Adenosine modulates the excitability of layer II stellate neurons in entorhinal cortex through A1 receptors.

Journal: Hippocampus 20110301

Title: Blood levels of vitamin D in teens and young adults with myopia.

Journal: Optometry and vision science : official publication of the American Academy of Optometry 20110301

Title: Pharmacologic modulation of experimentally induced allergic asthma.

Journal: Interdisciplinary toxicology 20110301

Title: Adenosine reduces GABAergic IPSC frequency via presynaptic A₁ receptors in hypothalamic paraventricular neurons projecting to rostral ventrolateral medulla.

Journal: Neuroscience letters 20110218

Title: Characterization of a broad-specificity non-haem iron N-demethylase from Pseudomonas putida CBB5 capable of utilizing several purine alkaloids as sole carbon and nitrogen source.

Journal: Microbiology (Reading, England) 20110201

Title: Chocolate is no sweetener for concerns!

Journal: Journal of perioperative practice 20110201

Title: Interactions between minimum run time, modifier concentration, and efficiency parameters in a high performance liquid chromatography separation.

Journal: Journal of chromatography. A 20110114

Title: Comparative pharmacokinetics and metabolisms of caffeine in sheep breeds.

Journal: The Journal of veterinary medical science 20110101

Title: Distribution, biosynthesis and catabolism of methylxanthines in plants.

Journal: Handbook of experimental pharmacology 20110101

Title: Pharmacokinetics and metabolism of natural methylxanthines in animal and man.

Journal: Handbook of experimental pharmacology 20110101

Title: Theobromine and the pharmacology of cocoa.

Journal: Handbook of experimental pharmacology 20110101

Title: Deep sequencing of the Camellia sinensis transcriptome revealed candidate genes for major metabolic pathways of tea-specific compounds.

Journal: BMC genomics 20110101

Title: The influence of the PDE inhibitors on cough reflex in guinea pigs.

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Title: Effects of rutaecarpine on the metabolism and urinary excretion of caffeine in rats.

Journal: Archives of pharmacal research 20110101

Title: The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols.

Journal: BMC biochemistry 20110101

Title: Reproducibility and relative validity of a food frequency questionnaire developed for female adolescents in Suihua, North China.

Journal: PloS one 20110101

Title: Agrobacterium-mediated genetic transformation of Coffea arabica (L.) is greatly enhanced by using established embryogenic callus cultures.

Journal: BMC plant biology 20110101

Title: Potential activity of the purine compounds caffeine and aminophylline on bacteria.

Journal: Journal of global infectious diseases 20110101

Title: Large-scale assessment of the zebrafish embryo as a possible predictive model in toxicity testing.

Journal: PloS one 20110101

Title: Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars.

Journal: PloS one 20110101

Title: Effects of caffeinated and decaffeinated coffee on biological risk factors for type 2 diabetes: a randomized controlled trial.

Journal: Nutrition journal 20110101

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Journal: Indian journal of urology : IJU : journal of the Urological Society of India 20110101

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Journal: Frontiers in neuroscience 20110101

Title: Effect of caffeine on the intraocular pressure in patients with primary open angle glaucoma.

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Title: Simultaneous determination of methylxanthines in different types of tea by a newly developed and validated TLC method.

Journal: Journal of separation science 20101201

Title: Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.

Journal: Healthcare informatics research 20101201

Title: Atrial fibrillation associated with chocolate intake abuse and chronic salbutamol inhalation abuse.

Journal: International journal of cardiology 20101119

Title: Effects on peripheral and central blood pressure of cocoa with natural or high-dose theobromine: a randomized, double-blind crossover trial.

Journal: Hypertension (Dallas, Tex. : 1979) 20101101

Title: Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.

Journal: Bioorganic & medicinal chemistry letters 20101101

Title: The interaction of lysozyme with caffeine, theophylline and theobromine in solution.

Journal: Molecular biology reports 20101001

Title: Pentoxifylline in preterm neonates: a systematic review.

Journal: Paediatric drugs 20101001

Title: Guaraná's Journey from Regional Tonic to Aphrodisiac and Global Energy Drink.

Journal: Evidence-based complementary and alternative medicine : eCAM 20100901

Title: Novel N-methylated 8-oxoisoguanines from Pacific sponges with diverse neuroactivities.

Journal: Journal of medicinal chemistry 20100826

Title: Coffee intake can promote activity of antioxidant enzymes with increasing MDA level and decreasing HDL-cholesterol in physically trained rats.

Journal: Nutrition research and practice 20100801

Title: Chocolate consumption, blood pressure, and cardiovascular risk.

Journal: European heart journal 20100701

Title: A brief history of asthma and its mechanisms to modern concepts of disease pathogenesis.

Journal: Allergy, asthma & immunology research 20100701

Title: Effects of paraxanthine and caffeine on sleep, locomotor activity, and body temperature in orexin/ataxin-3 transgenic narcoleptic mice.

Journal: Sleep 20100701

Title: Rapid determination of methylxanthines in real samples by high-performance liquid chromatography using the new FastGradient narrow-bore monolithic column.

Journal: Talanta 20100615

Title: Energy drinks: a review of use and safety for athletes.

Journal: The Physician and sportsmedicine 20100601

Title: Molecularly imprinted polymers for ochratoxin a extraction and analysis.

Journal: Toxins 20100601

Title: Natural cocoa as diet-mediated antimalarial prophylaxis.

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Title: Predicting stoichiometry and structure of solvates.

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Title: Phenolic acids and methylxanthines composition and antioxidant properties of mate (Ilex paraguariensis) residue.

Journal: Journal of food science 20100401

Title: Zirconia based monoliths used in hydrophilic-interaction chromatography for original selectivity of xanthines.

Journal: Journal of chromatography. A 20100226

Title: Methylxanthines and phenolics content extracted during the consumption of mate (Ilex paraguariensis St. Hil) beverages.

Journal: Journal of agricultural and food chemistry 20100224

Title: Quantification of theobromine and caffeine in saliva, plasma and urine via liquid chromatography-tandem mass spectrometry: a single analytical protocol applicable to cocoa intervention studies.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100201

Title: Production and characterization of a genetically engineered anti-caffeine camelid antibody and its use in immunoaffinity chromatography.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20100115

Title: Inhibition of CTP synthase from Escherichia coli by xanthines and uric acids.

Journal: Bioorganic & medicinal chemistry letters 20100101

Title: International society of sports nutrition position stand: caffeine and performance.

Journal: Journal of the International Society of Sports Nutrition 20100101

Title: Oxidative stress in lens in vivo: inhibitory effect of caffeine. A preliminary report.

Journal: Molecular vision 20100101

Title: Beneficial effects of green tea: a literature review.

Journal: Chinese medicine 20100101

Title: Expression for caffeine biosynthesis and related enzymes in Camellia sinensis.

Journal: Zeitschrift fur Naturforschung. C, Journal of biosciences 20100101

Title: Synergistic properties of methylxanthine with cadmium and mercury on dermatophytes.

Journal: Journal of global infectious diseases 20100101

Title: Natural compounds in the human diet and their ability to bind mutagens prevents DNA-mutagen intercalation.

Journal: Journal of toxicology and environmental health. Part A 20100101

Title: Synthesis of phenolics and flavonoids in ginger (Zingiber officinale Roscoe) and their effects on photosynthesis rate.

Journal: International journal of molecular sciences 20100101

Title: Caffeine's Vascular Mechanisms of Action.

Journal: International journal of vascular medicine 20100101

Title: Comparison of the effects of dietary factors in the management and prophylaxis of migraine.

Journal: Journal of pain research 20100101

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Journal: Ayu 20100101

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Journal: Clinical pharmacology : advances and applications 20100101

Title: [Rapid determination of theophylline, theobromine and caffeine in dietary supplements containing guarana by ultra-performance liquid chromatography].

Journal: Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan 20091201

Title: Design of a new cartridge for selective solid phase extraction using molecularly imprinted polymers: selective extraction of theophylline from human serum samples.

Journal: Biosensors & bioelectronics 20091115

Title: Grafting of molecularly imprinted polymers on iniferter-modified carbon nanotube.

Journal: Biosensors & bioelectronics 20091115

Title: Influence of xanthine derivatives on cough and airway reactivity in guinea pigs.

Journal: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20091101

Title: A theobromine derived silver N-heterocyclic carbene: synthesis, characterization, and antimicrobial efficacy studies on cystic fibrosis relevant pathogens.

Journal: Dalton transactions (Cambridge, England : 2003) 20090921

Title: Maternal serum theobromine and the development of preeclampsia.

Journal: Epidemiology (Cambridge, Mass.) 20090901

Title: Some food toxic for pets.

Journal: Interdisciplinary toxicology 20090901

Title: Rapid determination of phenolic compounds and alkaloids of carob flour by improved liquid chromatography tandem mass spectrometry.

Journal: Journal of agricultural and food chemistry 20090826

Title: Safety assessment of kola nut extract as a food ingredient.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20090801

Title: Chemical diversity and defence metabolism: how plants cope with pathogens and ozone pollution.

Journal: International journal of molecular sciences 20090801

Title: Hapten-induced dimerization of a single-domain VHH camelid antibody.

Journal: Biochemistry 20090728

Title: Antihypertensive effect of a polyphenol-rich cocoa powder industrially processed to preserve the original flavonoids of the cocoa beans.

Journal: Journal of agricultural and food chemistry 20090722

Title: The role of the basal forebrain adenosine receptors in sleep homeostasis.

Journal: Neuroreport 20090715

Title: Identification of paraxanthine as the most potent caffeine-derived inhibitor of connective tissue growth factor expression in liver parenchymal cells.

Journal: Liver international : official journal of the International Association for the Study of the Liver 20090701

Title: Two distinct pathways for metabolism of theophylline and caffeine are coexpressed in Pseudomonas putida CBB5.

Journal: Journal of bacteriology 20090701

Title: Functional interaction between purinergic system and opioid withdrawal: in vitro evidence.

Journal: Current drug safety 20090501

Title: Effect of cocoa tea (Camellia ptilophylla) co-administrated with green tea on ambulatory behaviors.

Journal: Bioscience, biotechnology, and biochemistry 20090423

Title: Direct injection liquid chromatography/electrospray ionization mass spectrometric horse urine analysis for the quantification and confirmation of threshold substances for doping control. II. Determination of theobromine.

Journal: Rapid communications in mass spectrometry : RCM 20090401

Title: Analysis of group I intron splicing in the presence of naturally occurring methylxanthines.

Journal: Clinica chimica acta; international journal of clinical chemistry 20090201

Title: Occurrence of theobromine synthase genes in purine alkaloid-free species of Camellia plants.

Journal: Planta 20090201

Title: Liquid chromatography coupled with ultraviolet absorbance detection, electrospray ionization, collision-induced dissociation and tandem mass spectrometry on a triple quadrupole for the on-line characterization of polyphenols and methylxanthines in green coffee beans.

Journal: Rapid communications in mass spectrometry : RCM 20090201

Title: Correlation analysis of cocoa consumption data with worldwide incidence rates of testicular cancer and hypospadias.

Journal: International journal of environmental research and public health 20090201

Title: Phenolic and theobromine contents of commercial dark, milk and white chocolates on the Malaysian market.

Journal: Molecules (Basel, Switzerland) 20090105

Title: Microbial transformation of hydroxy metabolites of 1-oxohexyl derivatives of theobromine by Cunninghamella echinulata NRRL 1384.

Journal: Letters in applied microbiology 20090101

Title: Quantitative capillary electrophoresis and its application in analysis of alkaloids in tea, coffee, coca cola, and theophylline tablets.

Journal: Journal of separation science 20090101

Title: Validity and reproducibility of a self-administered semi-quantitative food-frequency questionnaire for estimating usual daily fat, fibre, alcohol, caffeine and theobromine intakes among Belgian post-menopausal women.

Journal: International journal of environmental research and public health 20090101

Title: Long-term functional side-effects of stimulants and sedatives in Drosophila melanogaster.

Journal: PloS one 20090101

Title: Does long-term coffee intake reduce type 2 diabetes mellitus risk?

Journal: Diabetology & metabolic syndrome 20090101

Title: Altered expression of the caffeine synthase gene in a naturally caffeine-free mutant of Coffea arabica.

Journal: Genetics and molecular biology 20090101

Title: Effects of maté tea intake on ex vivo LDL peroxidation induced by three different pathways.

Journal: Nutrients 20090101

Title: Effects of common antitussive drugs on the hERG potassium channel current.

Journal: Journal of cardiovascular pharmacology 20081201

Title: Systemic 7-methylxanthine in retarding axial eye growth and myopia progression: a 36-month pilot study.

Journal: Journal of ocular biology, diseases, and informatics 20081201

Title: Evaluation of anti-tussive activity of Chamaedorea tepejilote.

Journal: Journal of ethnopharmacology 20081120

Title: [Coffee and cancer].

Journal: Medicina clinica 20081108

Title: MDA-MB-231 produces ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human lymphatic endothelial cells.

Journal: American journal of physiology. Cell physiology 20081101

Title: Effects of chronic administration of caffeine and stress on feeding behavior of rats.

Journal: Physiology & behavior 20081020

Title: Analysis of total caffeine and other xanthines in specialty coffees using mixed mode solid-phase extraction and liquid chromatography-diode-array detection after microwave digestion.

Journal: Journal of analytical toxicology 20081001

Title: Quantitation of methylxanthinic alkaloids and phenolic compounds in mate (Ilex paraguariensis) and their effects on blood vessel formation in chick embryos.

Journal: Journal of agricultural and food chemistry 20080924

Title: Protection of human HepG2 cells against oxidative stress by cocoa phenolic extract.

Journal: Journal of agricultural and food chemistry 20080910

Title: Pressurized liquid extraction of mate tea leaves.

Journal: Analytica chimica acta 20080905

Title: Cocoa procyanidins suppress transformation by inhibiting mitogen-activated protein kinase kinase.

Journal: The Journal of biological chemistry 20080725

Title: Comparative diffusion of drugs through bronchial tissue.

Journal: International journal of pharmaceutics 20080605

Title: Interactions of beta- and hydroxypropyl-beta-cyclodextrin with some purine alkaloids: thermodynamic study.

Journal: Current drug discovery technologies 20080601

Title: Non-standard base pairing and stacked structures in methyl xanthine clusters.

Journal: Physical chemistry chemical physics : PCCP 20080521

Title: Chocolate consumption in pregnancy and reduced likelihood of preeclampsia.

Journal: Epidemiology (Cambridge, Mass.) 20080501

Title: Hypotensive effects of intravenously administered uridine and cytidine in conscious rats: involvement of adenosine receptors.

Journal: European journal of pharmacology 20080414

Title: Caffeine markedly sensitizes human mesothelioma cell lines to pemetrexed.

Journal: Cancer chemotherapy and pharmacology 20080401

Title: Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans.

Journal: Neuropsychiatric disease and treatment 20080401

Title: Dimerization of N-methyltransferases involved in caffeine biosynthesis.

Journal: Biochimie 20080301

Title: Prenatal caffeine assessment: fetal and maternal biomarkers or self-reported intake?

Journal: Annals of epidemiology 20080301

Title: Increases in cerebrospinal fluid caffeine concentration are associated with favorable outcome after severe traumatic brain injury in humans.

Journal: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20080201

Title: Determination of caffeine and associated compounds in food, beverages, natural products, pharmaceuticals, and cosmetics by micellar electrokinetic capillary chromatography.

Journal: Journal of chromatographic science 20080201

Title: Simultaneous HPLC determination of caffeine, theobromine, and theophylline in food, drinks, and herbal products.

Journal: Journal of chromatographic science 20080201

Title: Predictive relationship between polyphenol and nonfat cocoa solids content of chocolate.

Journal: Journal of agricultural and food chemistry 20080109

Title: Riboflavin-binding protein is a novel bitter inhibitor.

Journal: Chemical senses 20080101

Title: Prediction of elution bandwidth for purine compounds by a retention model in reversed-phase HPLC with linear-gradient elution.

Journal: Journal of separation science 20080101

Title: Distribution of adenosine receptors in human sclera fibroblasts.

Journal: Molecular vision 20080101

Title: Maternal caffeine intake during pregnancy and risk of fetal growth restriction: a large prospective observational study.

Journal: BMJ (Clinical research ed.) 20080101

Title: Simultaneous determination of theobromine, (+)-catechin, caffeine, and (-)-epicatechin in standard reference material baking chocolate 2384, cocoa, cocoa beans, and cocoa butter.

Journal: Journal of chromatographic science 20080101

Title: Protective effect of adenosine in diabetic neuropathic pain is mediated through adenosine A1-receptors.

Journal: Indian journal of physiology and pharmacology 20080101

Title: Inelastic neutron scattering study of methyl groups rotation in some methylxanthines.

Journal: The Journal of chemical physics 20071207

Title: Microbial and dietary factors associated with the 8-prenylnaringenin producer phenotype: a dietary intervention trial with fifty healthy post-menopausal Caucasian women.

Journal: The British journal of nutrition 20071101

Title: Effect of drug solubility on release behavior of calcium polysaccharide gel-coated pellets.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071101

Title: Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance.

Journal: American journal of physiology. Heart and circulatory physiology 20071001

Title: Sodium intake determines the role of adenosine A2 receptors in control of renal medullary perfusion in the rat.

Journal: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20071001

Title: Adenosine A2 receptor activation attenuates afferent arteriolar autoregulation during adenosine receptor saturation in rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20071001

Title: Determination of caffeine in coffee products by dynamic complexation with 3,4-dimethoxycinnamate and separation by CZE.

Journal: Electrophoresis 20071001

Title: Selective liquid CO2 extraction of purine alkaloids in different Ilex paraguariensis progenies grown under environmental influences.

Journal: Journal of agricultural and food chemistry 20070822

Title: Powder X-ray diffraction as an emerging method to structurally characterize organic solids.

Journal: Organic letters 20070802

Title: Effect of acute administration of hydroalcohol extract of Ilex paraguariensis St Hilaire (Aquifoliaceae) in animal models of Parkinson's disease.

Journal: Phytotherapy research : PTR 20070801

Title: Effect of the adenosine A2a receptor antagonist 3,7-dimethyl-propargylxanthine on anxiety-like and depression-like behavior and alcohol consumption in Wistar Rats.

Journal: Alcoholism, clinical and experimental research 20070801

Title: Development of in-tube solid-phase microextraction coupled to pressure-assisted CEC and its application to the analysis of propranolol enantiomers in human urine.

Journal: Electrophoresis 20070801

Title: Degradation kinetics of caffeine and related methylxanthines by induced cells of Pseudomonas sp.

Journal: Current microbiology 20070701

Title: Influence of peptone source on sporulation of Clostridium perfringens type A.

Journal: Journal of food protection 20070701

Title: Simultaneous analysis of catechins, gallic acid, strictinin, and purine alkaloids in green tea by using catechol as an internal standard.

Journal: Journal of agricultural and food chemistry 20070627

Title: Molecular structures and vibrational frequencies of xanthine and its methyl derivatives (caffeine and theobromine) by ab initio Hartree-Fock and density functional theory calculations.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070601

Title: The structure of two N-methyltransferases from the caffeine biosynthetic pathway.

Journal: Plant physiology 20070601

Title: Death by chocolate: a fatal problem for an inquisitive wild parrot.

Journal: New Zealand veterinary journal 20070601

Title: Transdermal and buccal delivery of methylxanthines through human tissue in vitro.

Journal: Drug development and industrial pharmacy 20070501

Title: Characterization of the potency, selectivity, and pharmacokinetic profile for six adenosine A2A receptor antagonists.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20070401

Title: Cloning, expression, crystallization and preliminary X-ray analysis of the XMT and DXMT N-methyltransferases from Coffea canephora (robusta).

Journal: Acta crystallographica. Section F, Structural biology and crystallization communications 20070401

Title: Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro.

Journal: Molecular immunology 20070301

Title: Neonatal withdrawal syndrome after chronic maternal drinking of mate.

Journal: Therapeutic drug monitoring 20070201

Title: Development of a biosensor for caffeine.

Journal: Analytica chimica acta 20070123

Title: The use of ultrasound in the extraction of Ilex paraguariensis leaves: a comparison with maceration.

Journal: Ultrasonics sonochemistry 20070101

Title: A double-blind, placebo-controlled, multi-dose evaluation of the acute behavioural effects of guaraná in humans.

Journal: Journal of psychopharmacology (Oxford, England) 20070101

Title: Overview of antibacterial, antitoxin, antiviral, and antifungal activities of tea flavonoids and teas.

Journal: Molecular nutrition & food research 20070101

Title: Topical application of plant extracts containing xanthine derivatives can prevent UV-induced wrinkle formation in hairless mice.

Journal: Photodermatology, photoimmunology & photomedicine 20070101

Title: Determination of theobromine, theophylline, and caffeine in by-products of cupuacu and cacao seeds by high-performance liquid chromatography.

Journal: Journal of chromatographic science 20070101

Title: Evaluation of the stimulant content of dietary supplements marketed as 'ephedra-free'.

Journal: Journal of herbal pharmacotherapy 20070101

Title: [Biologically active substances in grated cocoa and cocoa butter].

Journal: Voprosy pitaniia 20070101

Title: Determination of caffeine and caffeine-related metabolites in ephedra-containing standard reference materials using liquid chromatography with absorbance detection and tandem mass spectrometry.

Journal: Journal of AOAC International 20070101

Title: Metabolic responses to the acute ingestion of two commercially available carbonated beverages: A pilot study.

Journal: Journal of the International Society of Sports Nutrition 20070101

Title: Theacrine, a special purine alkaloid with sedative and hypnotic properties from Cammelia assamica var. kucha in mice.

Journal: Journal of Asian natural products research 20070101

Title: Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity.

Journal: Folia histochemica et cytobiologica 20070101

Title: Chocolate as a cough suppressant: rationale and justification for an upcoming clinical trial.

Journal: Supportive cancer therapy 20070101

Title: Intrahepatic adenosine-mediated activation of hepatorenal reflex is via A1 receptors in rats.

Journal: Canadian journal of physiology and pharmacology 20061101

Title: Computationally-assisted approach to the vibrational spectra of molecular crystals: study of hydrogen-bonding and pseudo-polymorphism.

Journal: Chemphyschem : a European journal of chemical physics and physical chemistry 20061013

Title: Contribution of hepatic adenosine A1 receptors to renal dysfunction associated with acute liver injury in rats.

Journal: Hepatology (Baltimore, Md.) 20061001

Title: Caffeine metabolites are inhibitors of the nuclear enzyme poly(ADP-ribose)polymerase-1 at physiological concentrations.

Journal: Biochemical pharmacology 20060928

Title: A taste receptor required for the caffeine response in vivo.

Journal: Current biology : CB 20060919

Title: Suppression of VLDL associated triacylglycerol secretion by both alpha- and beta-adrenoceptor agonists in isolated rat hepatocytes.

Journal: European journal of pharmacology 20060918

Title: Metabolism and ecology of purine alkaloids.

Journal: Frontiers in bioscience : a journal and virtual library 20060901

Title: Evaluation of cerebrospinal fluid concentration and plasma free concentration as a surrogate measurement for brain free concentration.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20060901

Title: Adenosine is upregulated during peritonitis and is involved in downregulation of inflammation.

Journal: Kidney international 20060801

Title: Inhibitory responses to exogenous adenosine in murine proximal and distal colon.

Journal: British journal of pharmacology 20060801

Title: [Action of AMP579 and adenosine on potassium or sodium ionic channels in isolated rat and guinea pig ventricular myocytes].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060801

Title: Urinary excretion of dietary contaminants in horses.

Journal: Equine veterinary journal. Supplement 20060801

Title: Molecular definition of the taste of roasted cocoa nibs (Theobroma cacao) by means of quantitative studies and sensory experiments.

Journal: Journal of agricultural and food chemistry 20060726

Title: Towards the design of highly selective recognition sites into molecular imprinting polymers: a computational approach.

Journal: Biosensors & bioelectronics 20060715

Title: In vitro transdermal delivery of caffeine, theobromine, theophylline and catechin from extract of Guarana, Paullinia Cupana.

Journal: International journal of pharmaceutics 20060706

Title: Caffeine metabolites in umbilical cord blood, cytochrome P-450 1A2 activity, and intrauterine growth restriction.

Journal: American journal of epidemiology 20060601

Title: Characterization of calcium alginate beads containing structurally similar drugs.

Journal: Drug development and industrial pharmacy 20060601

Title: Danger to dogs from cocoa bean mulch put into perspective.

Journal: Journal of the American Veterinary Medical Association 20060601

Title: Fluid bed drying of guarana (Paullinia cupana HBK) extract: effect of process factors on caffeine content.

Journal: AAPS PharmSciTech 20060601

Title: Sol-gel molecular imprinted ormosil for solid-phase extraction of methylxanthines.

Journal: Journal of chromatography. A 20060512

Title: Caffeine biosynthesis and adenine metabolism in transgenic Coffea canephora plants with reduced expression of N-methyltransferase genes.

Journal: Phytochemistry 20060501

Title: Regulation of the body fat percentage in developmental-stage rats by methylxanthine derivatives in a high-fat diet.

Journal: Bioscience, biotechnology, and biochemistry 20060501

Title: Involvement of adenosine A1 and A2A receptors in (-)-linalool-induced antinociception.

Journal: Life sciences 20060418

Title: Induction of neutral endopeptidase (NEP) activity of SK-N-SH cells by natural compounds from green tea.

Journal: The Journal of pharmacy and pharmacology 20060401

Title: Substrate specificity of N-methyltransferase involved in purine alkaloids synthesis is dependent upon one amino acid residue of the enzyme.

Journal: Molecular genetics and genomics : MGG 20060201

Title: Antimicrobial activities of tea catechins and theaflavins and tea extracts against Bacillus cereus.

Journal: Journal of food protection 20060201

Title: [Simultaneous determination of ephedrine and chlorpheniramine in human plasma by a highly sensitive liquid chromatography-tandem mass spectrometric method].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20060201

Title: Involvement of adenosine in the effect of fluoxetine on isolated guinea-pig atria.

Journal: Pharmacological research 20060101

Title: Morphometric and functional abnormalities of kidneys in the progeny of mice fed chocolate during pregnancy and lactation.

Journal: Folia histochemica et cytobiologica 20060101

Title: Poly(lactide-co-glycolide)-methoxy-poly(ethylene glycol) nanoparticles: drug loading and release properties.

Journal: Journal of nanoscience and nanotechnology 20060101

Title: Adenosine receptor antagonists intensify the benzodiazepine withdrawal signs in mice.

Journal: Pharmacological reports : PR 20060101

Title: Lumenal adenosine and AMP rapidly increase glucose transport by intact small intestine.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20051201

Title: Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.

Journal: Drug metabolism and disposition: the biological fate of chemicals 20051201

Title: Sleep disturbances, psychiatric disorders, and psychotropic drugs.

Journal: Dialogues in clinical neuroscience 20051201

Title: Multivariate optimisation of the experimental conditions for determination of three methylxanthines by reversed-phase high-performance liquid chromatography.

Journal: Talanta 20051031

Title: Polyphenol levels in human urine after intake of six different polyphenol-rich beverages.

Journal: The British journal of nutrition 20051001

Title: Study for luminescence performance of three methyl xanthine derivatives.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050901

Title: Comment on vibrational spectral investigation on xanthine and its derivatives-theophylline, caffeine and theobromine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050901

Title: Structure-affinity relationship in the interactions of human organic anion transporter 1 with caffeine, theophylline, theobromine and their metabolites.

Journal: Biochimica et biophysica acta 20050815

Title: Reinforcing effects of caffeine and theobromine as found in chocolate.

Journal: Psychopharmacology 20050801

Title: Sensory-guided decomposition of roasted cocoa nibs (Theobroma cacao) and structure determination of taste-active polyphenols.

Journal: Journal of agricultural and food chemistry 20050629

Title: Use of a physiologically based pharmacokinetic model to study the time to reach brain equilibrium: an experimental analysis of the role of blood-brain barrier permeability, plasma protein binding, and brain tissue binding.

Journal: The Journal of pharmacology and experimental therapeutics 20050601

Title: Preformed and induced chemical resistance of tea leaf against Exobasidium vexans infection.

Journal: Journal of chemical ecology 20050601

Title: Simultaneous determination of 16 purine derivatives in urinary calculi by gradient reversed-phase high-performance liquid chromatography with UV detection.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050525

Title: Evaluation of cocoa- and coffee-derived methylxanthines as toxicants for the control of pest coyotes.

Journal: Journal of agricultural and food chemistry 20050518

Title: Inhibition of HIV-1 replication by caffeine and caffeine-related methylxanthines.

Journal: Virology 20050510

Title: Raman spectroscopic characterisations and analytical discrimination between caffeine and demethylated analogues of pharmaceutical relevance.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050501

Title: Solid-phase ultraviolet sensing system for determination of methylxanthines.

Journal: Analytical and bioanalytical chemistry 20050501

Title: Adenosine receptor ligands and dizocilpine-induced antinociception in mice.

Journal: The International journal of neuroscience 20050401

Title: Non-human primate SPECT model for determining cerebral perfusion effects of cerebrovasoactive drugs acting via multiple modes of pharmacological action.

Journal: Journal of the neurological sciences 20050315

Title: Development and validation of a high-performance liquid chromatography-mass spectrometry assay for methylxanthines and taurine in dietary supplements.

Journal: Journal of pharmaceutical and biomedical analysis 20050309

Title: Biochemical changes during the development of witches' broom: the most important disease of cocoa in Brazil caused by Crinipellis perniciosa.

Journal: Journal of experimental botany 20050301

Title: PCB exposure and in vivo CYP1A2 activity among Native Americans.

Journal: Environmental health perspectives 20050301

Title: Classification of Ilex species based on metabolomic fingerprinting using nuclear magnetic resonance and multivariate data analysis.

Journal: Journal of agricultural and food chemistry 20050223

Title: Aqueous extract of Ilex paraguariensis decreases nucleotide hydrolysis in rat blood serum.

Journal: Journal of ethnopharmacology 20050210

Title: Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI.

Journal: Synapse (New York, N.Y.) 20050201

Title: Theobromine inhibits sensory nerve activation and cough.

Journal: FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050201

Title: Vibrational spectral investigation on xanthine and its derivatives--theophylline, caffeine and theobromine.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20050101

Title: Protective effect of adenosine and purine nucleos(t)ides against the death by hydrogen peroxide and glucose deprivation in rat primary astrocytes.

Journal: Neuroscience research 20050101

Title: Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine.

Journal: Basic & clinical pharmacology & toxicology 20050101

Title: Look what I found! Poison hunting on eBay.

Journal: Clinical toxicology (Philadelphia, Pa.) 20050101

Title: Molecular recognition and crystal energy landscapes: an X-ray and computational study of caffeine and other methylxanthines.

Journal: Chemistry (Weinheim an der Bergstrasse, Germany) 20041217

Title: Determination of methylxanthines in urine by liquid chromatography with diode array UV detection.

Journal: Journal of pharmaceutical and biomedical analysis 20041115

Title: Methylxanthines are the psycho-pharmacologically active constituents of chocolate.

Journal: Psychopharmacology 20041101

Title: The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices.

Journal: Anesthesia and analgesia 20041001

Title: Simultaneous determination of caffeine, theophylline and theobromine in human plasma by on-line solid-phase extraction coupled to reversed-phase chromatography.

Journal: Biomedical chromatography : BMC 20041001

Title: Adenosine A1-receptor modulation of glutamate-induced calcium influx in rat retinal ganglion cells.

Journal: Investigative ophthalmology & visual science 20041001

Title: Modified micellar electrokinetic chromatography in the analysis of catechins and xanthines in chocolate.

Journal: Electrophoresis 20041001

Title: Separation, pre-concentration, and HPLC analysis of methylxanthines in urine samples.

Journal: Journal of separation science 20041001

Title: Development of a validated HPLC method for the determination of B-complex vitamins in pharmaceuticals and biological fluids after solid phase extraction.

Journal: Journal of separation science 20041001

Title: Urinary methylxanthine and autistic disorder: absence of previously reported correlation.

Journal: Nucleosides, nucleotides & nucleic acids 20041001

Title: Ethanol operant self-administration in rats is regulated by adenosine A2 receptors.

Journal: Alcoholism, clinical and experimental research 20040901

Title: Plant biochemistry: a naturally decaffeinated arabica coffee.

Journal: Nature 20040624

Title: Roles of adenosine receptors in the regulation of kainic acid-induced neurotoxic responses in mice.

Journal: Brain research. Molecular brain research 20040618

Title: Determination of caffeine, theobromine, and theophylline in standard reference material 2384, baking chocolate, using reversed-phase liquid chromatography.

Journal: Journal of agricultural and food chemistry 20040602

Title: Dietary sources of nutrients among US adults, 1994 to 1996.

Journal: Journal of the American Dietetic Association 20040601

Title: HPLC-MSn analysis of phenolic compounds and purine alkaloids in green and black tea.

Journal: Journal of agricultural and food chemistry 20040519

Title: The role of intraspinal adenosine A1 receptors in sympathetic regulation.

Journal: European journal of pharmacology 20040510

Title: Catabolism of caffeine in plants and microorganisms.

Journal: Frontiers in bioscience : a journal and virtual library 20040501

Title: Influence of agronomic variables on the composition of mate tea leaves (Ilex paraguariensis) extracts obtained from CO2 extraction at 30 degrees C and 175 bar.

Journal: Journal of agricultural and food chemistry 20040407

Title: Serum metabolite/caffeine ratios as a test for liver function.

Journal: Journal of clinical pharmacology 20040401

Title: Biosynthesis, accumulation and degradation of theobromine in developing Theobroma cacao fruits.

Journal: Journal of plant physiology 20040401

Title: Application of RNAi to confirm theobromine as the major intermediate for caffeine biosynthesis in coffee plants with potential for construction of decaffeinated varieties.

Journal: Plant molecular biology 20040401

Title: Automated sample preparation based on the sequential injection principle. Solid-phase extraction on a molecularly imprinted polymer coupled on-line to high-performance liquid chromatography.

Journal: Journal of chromatography. A 20040319

Title: Metabolite profiling using (1)H NMR spectroscopy for quality assessment of green tea, Camellia sinensis (L.).

Journal: Journal of agricultural and food chemistry 20040225

Title: Simultaneous analysis of theanine, chlorogenic acid, purine alkaloids and catechins in tea samples with the help of multi-dimension information of on-line high performance liquid chromatography/electrospray-mass spectrometry.

Journal: Journal of pharmaceutical and biomedical analysis 20040218

Title: Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke.

Journal: The Cochrane database of systematic reviews 20040101

Title: Electrospray ionization mass spectrometric characterization and quantitation of xanthine derivatives using isotopically labelled analogues: an application for equine doping control analysis.

Journal: Rapid communications in mass spectrometry : RCM 20040101

Title: Multiple effects of theobromine on fetus development and postnatal status of the immune system.

Journal: International journal of tissue reactions 20040101

Title: Effects of coffee components on the response of GABA(A) receptors expressed in Xenopus oocytes.

Journal: Journal of agricultural and food chemistry 20031217

Title: Carbon nanotubes as separation carrier in capillary electrophoresis.

Journal: Electrophoresis 20031201

Title: Adenosinergic protection of dopaminergic and GABAergic neurons against mitochondrial inhibition through receptors located in the substantia nigra and striatum, respectively.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20031126

Title: Inhibition of caffeine biosynthesis in tea (Camellia sinensis) and coffee (Coffea arabica) plants by ribavirin.

Journal: FEBS letters 20031120

Title: Adenosine kinase inhibitors. 3. Synthesis, SAR, and antiinflammatory activity of a series of l-lyxofuranosyl nucleosides.

Journal: Journal of medicinal chemistry 20031023

Title: Purine alkaloids in Paullinia.

Journal: Phytochemistry 20031001

Title: Study on inclusion complex of cyclodextrin with methyl xanthine derivatives by fluorimetry.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20031001

Title: Antioxidant and prooxidant properties of caffeine, theobromine and xanthine.

Journal: Medical science monitor : international medical journal of experimental and clinical research 20030901

Title: Polydeoxyribonucleotide (PDRN) promotes human osteoblast proliferation: a new proposal for bone tissue repair.

Journal: Life sciences 20030829

Title: Producing decaffeinated coffee plants.

Journal: Nature 20030619

Title: Antinociceptive mechanisms of orally administered decursinol in the mouse.

Journal: Life sciences 20030613

Title: Intraspinal adenosine induces spinal cord norepinephrine release in spinal nerve-ligated rats but not in normal or sham controls.

Journal: Anesthesiology 20030601

Title: Adenosine A1 receptor activation reduces myocardial reperfusion effects on intrinsic cardiac nervous system.

Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20030501

Title: Study on the paper substrate room temperature phosphorescence of theobromine, caffeine and theophylline and analytical application.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20030501

Title: Molecular cloning and functional characterization of three distinct N-methyltransferases involved in the caffeine biosynthetic pathway in coffee plants.

Journal: Plant physiology 20030501

Title: Effect of naturally occurring plant phenolics on the induction of drug metabolizing enzymes by o-toluidine.

Journal: Toxicology 20030415

Title: De-intercalation of ethidium bromide and acridine orange by xanthine derivatives and their modulatory effect on anticancer agents: a study of DNA-directed toxicity enlightened by time correlated single photon counting.

Journal: Journal of biomolecular structure & dynamics 20030401

Title: RNA binding efficacy of theophylline, theobromine and caffeine.

Journal: Journal of biomolecular structure & dynamics 20030401

Title: Endogenous adenosine prevents post-tetanic release facilitation mediated by alpha3beta2 nicotinic autoreceptors.

Journal: European journal of pharmacology 20030319

Title: Antagonism of adenosine receptors by caffeine and caffeine metabolites in equine forebrain tissues.

Journal: American journal of veterinary research 20030201

Title: Regional differences in the adenosine A(2) receptor-mediated modulation of contractions in rat vas deferens.

Journal: European journal of pharmacology 20030124

Title: Isolation of a new dual-functional caffeine synthase gene encoding an enzyme for the conversion of 7-methylxanthine to caffeine from coffee (Coffea arabica L.).

Journal: FEBS letters 20030116

Title: Researching on new species of 'Mate': Ilex brevicuspis: phytochemical and pharmacology study.

Journal: European journal of nutrition 20030101

Title: Chocolate feeding of pregnant mice influences length of limbs of their progeny.

Journal: Polish journal of veterinary sciences 20030101

Title: [Study of the cardiovascular properties of some new methyl-xanthine derivatives].

Journal: Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi 20030101

Title: Uric acid or 1-methyl uric acid in the urinary bladder increases serum glucose, insulin, true triglyceride, and total cholesterol levels in Wistar rats.

Journal: TheScientificWorldJournal 20030101

Title: Value assignment of nutrient concentrations in standard reference material 2384 baking chocolate.

Journal: Journal of agricultural and food chemistry 20021120

Title: Glucose-induced islet blood flow increase in rats: interaction between nervous and metabolic mediators.

Journal: American journal of physiology. Endocrinology and metabolism 20020901

Title: Role of extracellular ATP metabolism in regulation of platelet reactivity.

Journal: The Journal of laboratory and clinical medicine 20020901

Title: Extraction of methylxanthines from guaraná seeds, maté leaves, and cocoa beans using supercritical carbon dioxide and ethanol.

Journal: Journal of agricultural and food chemistry 20020814

Title: Caffeine potentiates the discriminative-stimulus effects of nicotine in rats.

Journal: Psychopharmacology 20020801

Title: Cacao usage by the earliest Maya civilization.

Journal: Nature 20020718

Title: Inhibition of vaccinia virus replication by adenosine in BSC-40 cells: involvement of A(2) receptor-mediated PKA activation.

Journal: Archives of virology 20020701

Title: Electronic structure of some adenosine receptor antagonists. III. Quantitative investigation of the electronic absorption spectra of alkyl xanthines.

Journal: Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020701

Title: The involvement of nitric oxide on the adenosine A(2) receptor-induced cardiovascular inhibitory responses in the posterior hypothalamus of rats.

Journal: Neuroscience letters 20020621

Title: Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.

Journal: The American journal of pathology 20020601

Title: Pharmacology of ephedra alkaloids and caffeine after single-dose dietary supplement use.

Journal: Clinical pharmacology and therapeutics 20020601

Title: Enhanced analysis of purine and pyrimidine bases by the use of double-strand polyaniline coatings in micellar electrokinetic capillary chromatography.

Journal: Electrophoresis 20020601

Title: Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells.

Journal: International journal of cancer 20020520

Title: Theacrine (1,3,7,9-tetramethyluric acid) synthesis in leaves of a Chinese tea, kucha (Camellia assamica var. kucha).

Journal: Phytochemistry 20020501

Title: Spinal noradrenergic activation mediates allodynia reduction from an allosteric adenosine modulator in a rat model of neuropathic pain.

Journal: Pain 20020501

Title: Adenosine inhibits calcium channel currents via A1 receptors on salamander retinal ganglion cells in a mini-slice preparation.

Journal: Journal of neurochemistry 20020501

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: Salt effects on caffeine solubility, distribution, and self-association.

Journal: Journal of pharmaceutical sciences 20020401

Title: Study of catechin and xanthine tea profiles as geographical tracers.

Journal: Journal of agricultural and food chemistry 20020327

Title: Selective solid-phase extraction sorbent for caffeine made by molecular imprinting.

Journal: Journal of chromatography. A 20020301

Title: Platinum complexes of oxopurines: cis-bis(theophyllinato-N7)bis(triphenylphosphine)platinum(II) and cis-chloro(theobrominato-N1)bis(triphenylphosphine)platinum(II) ethanol hemisolvate.

Journal: Acta crystallographica. Section C, Crystal structure communications 20020201

Title: Activation of adenosine A2a receptor pathway reduces leukocyte infiltration but enhances edema formation in rat caerulein pancreatitis.

Journal: Pancreas 20020101

Title: Cocaine withdrawal severity and urine toxicology results from treatment entry predict outcome in medication trials for cocaine dependence.

Journal: Addictive behaviors 20020101

Title: Simultaneous determination of caffeine, theobromine, and theophylline by high-performance liquid chromatography.

Journal: Journal of chromatographic science 20020101

Title: Glucan stimulates human dermal fibroblast collagen biosynthesis through a nuclear factor-1 dependent mechanism.

Journal: Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 20020101

Title: High-performance capillary electrophoresis analysis of mate infusions prepared from stems and leaves of Ilex paraguariensis using automated micellar electrokinetic capillary chromatography.

Journal: Phytochemical analysis : PCA 20020101

Title: Determination of theophylline by HPLC and GC-IDMS, the effect of chemically similar xanthine derivatives on the specificity of the method and the possibility of paracetamol as interfering substance.

Journal: Clinical laboratory 20020101

Title: Group I aptazymes as genetic regulatory switches.

Journal: BMC biotechnology 20020101

Title: Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange.

Journal: Journal of medicinal chemistry 20011220

Title: Simultaneous determination of artificial sweeteners, preservatives, caffeine, theobromine and theophylline in food and pharmaceutical preparations by ion chromatography.

Journal: Journal of chromatography. A 20011207

Title: Regulation of K(+) current in human airway epithelial cells by exogenous and autocrine adenosine.

Journal: American journal of physiology. Cell physiology 20011201

Title: Adenosine modulates Mg(2+) uptake in distal convoluted tubule cells via A(1) and A(2) purinoceptors.

Journal: American journal of physiology. Renal physiology 20011201

Title: Evidence for the presence of A(1) adenosine receptors in the aorta of spontaneously hypertensive rats.

Journal: British journal of pharmacology 20011201

Title: Effect of methylxanthine derivatives on doxorubicin transport and antitumor activity.

Journal: Current drug metabolism 20011201

Title: Minoxidil-induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil.

Journal: The Journal of investigative dermatology 20011201

Title: Continuous measurement of caffeine and two metabolites in blood and skeletal muscle of unrestrained adult horses by semi-automated in vivo microdialysis.

Journal: Journal of veterinary pharmacology and therapeutics 20011201

Title: In vivo effects of adenosine A(2) receptor agonist and antagonist on neuronal and astrocytic intermediary metabolism studied with ex vivo (13)C MR spectroscopy.

Journal: Journal of neurochemistry 20011101

Title: A novel analgesic compound OT-7100 attenuates nociceptive responses in animal models of inflammatory and neuropathic hyperalgesia: a possible involvement of adenosinergic anti-nociception.

Journal: Japanese journal of pharmacology 20011101

Title: Developmental variation of sugars, carboxylic acids, purine alkaloids, fatty acids, and endoproteinase activity during maturation of Theobroma cacao L. seeds.

Journal: Journal of agricultural and food chemistry 20011001

Title: Nanoparticles in plant extracts--factors which influence the formation of nanoparticles in black tea infusions.

Journal: Die Pharmazie 20011001

Title: Role of adenosine in renal protection induced by a brief episode of ischemic preconditioning in rats.

Journal: Japanese journal of pharmacology 20011001

Title: Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.

Journal: Journal of immunology (Baltimore, Md. : 1950) 20010901

Title: The plasma protein extravasation induced by adenosine and its analogues in the rat dorsal skin: evidence for the involvement of capsaicin sensitive primary afferent neurones and mast cells.

Journal: British journal of pharmacology 20010901

Title: Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia.

Journal: British journal of pharmacology 20010901

Title: Synergism between A(2A)-adenosine receptor activation and vasoactive intestinal peptide to facilitate [3H]-acetylcholine release from the rat motor nerve terminals.

Journal: Neuroscience letters 20010824

Title: Use of novel solid-phase extraction sorbent materials for high-performance liquid chromatography quantitation of caffeine metabolism products methylxanthines and methyluric acids in samples of biological origin.

Journal: Journal of chromatography. B, Biomedical sciences and applications 20010815

Title: Adenosine A(1) receptors mediate plasma exudation from the oral mucosa.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20010801

Title: Improved high-performance liquid chromatography method to determine theobromine and caffeine in cocoa and cocoa products.

Journal: Journal of agricultural and food chemistry 20010801

Title: Suppressive effect of coffee on lipopolysaccharide-induced hepatitis in D-galactosamine-sensitized rats.

Journal: Bioscience, biotechnology, and biochemistry 20010801

Title: Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine.

Journal: Life sciences 20010706

Title: Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010701

Title: Uncertainty factors for chemical risk assessment. human variability in the pharmacokinetics of CYP1A2 probe substrates.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010701

Title: A new caffeine biosynthetic pathway in tea leaves: utilisation of adenosine released from the S-adenosyl-L-methionine cycle.

Journal: FEBS letters 20010615

Title: Sparks and puffs in oligodendrocyte progenitors: cross talk between ryanodine receptors and inositol trisphosphate receptors.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010601

Title: Weight loss and delayed gastric emptying following a South American herbal preparation in overweight patients.

Journal: Journal of human nutrition and dietetics : the official journal of the British Dietetic Association 20010601

Title: Caffeine-induced cardiac arrhythmia: an unrecognised danger of healthfood products.

Journal: The Medical journal of Australia 20010521

Title: Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

Journal: The Journal of neuroscience : the official journal of the Society for Neuroscience 20010515

Title: Drug diffusion mechanism through pH-sensitive hydrophobic/polyelectrolyte hydrogel membranes.

Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20010501

Title: Seizure activity and unresponsiveness after hydroxycut ingestion.

Journal: Pharmacotherapy 20010501

Title: Adenosine inhibits neutrophil vascular endothelial growth factor release and transendothelial migration via A2B receptor activation.

Journal: Shock (Augusta, Ga.) 20010401

Title: Theobromine intoxication in a red fox and a European badger in Sweden.

Journal: Journal of wildlife diseases 20010401

Title: Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue. Its potential role in alcohol-promoted mammary cancer.

Journal: Toxicology 20010307

Title: An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial.

Journal: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 20010301

Title: [Simultaneous determination of various food additives by high performance liquid chromatography].

Journal: Se pu = Chinese journal of chromatography 20010301

Title: Comparison of the potency of adenosine as an agonist at human adenosine receptors expressed in Chinese hamster ovary cells.

Journal: Biochemical pharmacology 20010215

Title: [Cerebral infarction in a patient consuming MaHuang extract and guarana].

Journal: Presse medicale (Paris, France : 1983) 20010203

Title: Caffeine metabolism before and after liver transplantation.

Journal: International journal of clinical pharmacology and therapeutics 20010201

Title: Suspected caffeine and ephedrine toxicosis resulting from ingestion of an herbal supplement containing guarana and ma huang in dogs: 47 cases (1997-1999).

Journal: Journal of the American Veterinary Medical Association 20010115

Title: Efferent arteriole tubuloglomerular feedback in the renal nephron.

Journal: Kidney international 20010101

Title: Caffeine metabolism in a group of 67 patients with primary biliary cirrhosis.

Journal: International journal of clinical pharmacology and therapeutics 20010101

Title: Rat ventral prostate xanthine oxidase bioactivation of ethanol to acetaldehyde and 1-hydroxyethyl free radicals: analysis of its potential role in heavy alcohol drinking tumor-promoting effects.

Journal: Teratogenesis, carcinogenesis, and mutagenesis 20010101

Title: Protection by aspirin of indomethacin-induced small intestinal damage in rats: mediation by salicylic acid.

Journal: Journal of physiology, Paris 20010101

Title: Medicinal and ethnoveterinary remedies of hunters in Trinidad.

Journal: BMC complementary and alternative medicine 20010101

Title: Effect of adenosine A1 and A2 receptor stimulation on hypoxia-induced convulsions in adult mice.

Journal: Polish journal of pharmacology 20010101

Title: A TLC visualisation reagent for dimethylamphetamine and other abused tertiary amines.

Journal: Science & justice : journal of the Forensic Science Society 20010101

Title: Effects of caffeine and its reactive metabolites theophylline and theobromine on the differentiating testis.

Journal: Reproduction, fertility, and development 20010101

Title: Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver.

Journal: Polish journal of pharmacology 20010101

Title: Purification and partial characterization of caffeine oxidase--A novel enzyme from a mixed culture consortium.

Journal: Biochemical and biophysical research communications 19990924

Title: Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism.

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Tags:83-67-0 Molecular Formula|83-67-0 MDL|83-67-0 SMILES|83-67-0 Theobromine