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81840-15-5,MFCD00867124
Catalog No.:AA008LBJ

81840-15-5 | Vesnarinone

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1mg
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5mg
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$199.00   $139.00
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10mg
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25mg
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  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008LBJ
Chemical Name:
Vesnarinone
CAS Number:
81840-15-5
Molecular Formula:
C22H25N3O4
Molecular Weight:
395.4516
MDL Number:
MFCD00867124
SMILES:
COc1ccc(cc1OC)C(=O)N1CCN(CC1)c1ccc2c(c1)CCC(=O)N2
Properties
Computed Properties
 
Complexity:
593  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.1  

Downstream Synthesis Route

[1]ChemicalandPharmaceuticalBulletin,1984,vol.32,p.2100-2110

[1]CurrentPatentAssignee:OTSUKAHOLDINGSCOLTD-US4760064,1988,A

CASUnavailable 
  81839-45-4    22246-13-5    81840-15-5 

[1]CurrentPatentAssignee:OTSUKAHOLDINGSCOLTD-US4415572,1983,A

CASUnavailable 
  81840-15-5 

[1]CurrentPatentAssignee:OTSUKAHOLDINGSCOLTD-US4415572,1983,A

[1]CurrentPatentAssignee:OTSUKAHOLDINGSCOLTD-US4415572,1983,A

Literature

Title: Animal models of cardiorenal syndrome: a review.

Journal: Heart failure reviews 20120501

Title: Enhanced interleukin-1 activity contributes to exercise intolerance in patients with systolic heart failure.

Journal: PloS one 20120101

Title: Red cell distribution width: a novel marker of activity in inflammatory bowel disease.

Journal: Gut and liver 20111201

Title: Are there differences in acute phase inflammation markers regarding the type of heart failure?

Journal: Heart international 20110929

Title: New predictive models of heart failure mortality using time-series measurements and ensemble models.

Journal: Circulation. Heart failure 20110701

Title: Effect of exercise training on interleukin-6, tumour necrosis factor alpha and functional capacity in heart failure.

Journal: Cardiology research and practice 20110101

Title: Design, synthesis and biological evaluation of 6-(benzyloxy)-4-methylquinolin-2(1H)-one derivatives as PDE3 inhibitors.

Journal: Bioorganic & medicinal chemistry 20100115

Title: Effect of levosimendan in experimental verapamil-induced myocardial depression.

Journal: Scandinavian journal of trauma, resuscitation and emergency medicine 20100101

Title: β-Adrenoceptor activation depresses brain inflammation and is neuroprotective in lipopolysaccharide-induced sensitization to oxygen-glucose deprivation in organotypic hippocampal slices.

Journal: Journal of neuroinflammation 20100101

Title: A novel approach to improve cardiac performance: cardiac myosin activators.

Journal: Heart failure reviews 20091201

Title: Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials.

Journal: European heart journal 20091201

Title: Agents with inotropic properties for the management of acute heart failure syndromes. Traditional agents and beyond.

Journal: Heart failure reviews 20091201

Title: Glutathione deficiency in cardiac patients is related to the functional status and structural cardiac abnormalities.

Journal: PloS one 20090101

Title: Vesnarinone represses the fibrotic changes in murine lung injury induced by bleomycin.

Journal: International journal of biological sciences 20090101

Title: Comparative value of simple inflammatory markers in the prediction of left ventricular systolic dysfunction in postacute coronary syndrome patients.

Journal: Mediators of inflammation 20090101

Title: Leukocyte redistribution: effects of beta blockers in patients with chronic heart failure.

Journal: PloS one 20090101

Title: Vesnarinone downregulates CXCR4 expression via upregulation of Krüppel-like factor 2 in oral cancer cells.

Journal: Molecular cancer 20090101

Title: Elevated plasma levels of TNF-alpha and interleukin-6 in patients with diastolic dysfunction and glucose metabolism disorders.

Journal: Cardiovascular diabetology 20090101

Title: In silico risk assessment for drug-induction of cardiac arrhythmia.

Journal: Progress in biophysics and molecular biology 20080901

Title: Placebo effect-adjusted assessment of quality of life in placebo-controlled clinical trials.

Journal: Statistics in medicine 20080430

Title: Bunched, the Drosophila homolog of the mammalian tumor suppressor TSC-22, promotes cellular growth.

Journal: BMC developmental biology 20080101

Title: Frequency-dependent effects of various IKr blockers on cardiac action potential duration in a human atrial model.

Journal: American journal of physiology. Heart and circulatory physiology 20070701

Title: Associations of gender and etiology with outcomes in heart failure with systolic dysfunction: a pooled analysis of 5 randomized control trials.

Journal: Journal of the American College of Cardiology 20070403

Title: Effects of phosphodiesterase (PDE) inhibitors on human ether-a-go-go related gene (hERG) channel activity.

Journal: Journal of applied toxicology : JAT 20070101

Title: Effects of promyelocytic leukemia zinc finger protein on the proliferation of cultured human corneal endothelial cells.

Journal: Molecular vision 20070101

Title: Association of cytokines with endothelium dependent flow mediated vasodilation (FMD) of systemic arteries in patients with non-ischemic cardiomyopathy.

Journal: Cardiovascular ultrasound 20070101

Title: Differentiation-inducing therapy for solid tumors.

Journal: Current pharmaceutical design 20060101

Title: Chronic Obstructive Pulmonary Disease, inflammation and co-morbidity--a common inflammatory phenotype?

Journal: Respiratory research 20060101

Title: Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8.

Journal: International journal of oncology 20051201

Title: A comparison of the covalent binding of clozapine, procainamide, and vesnarinone to human neutrophils in vitro and rat tissues in vitro and in vivo.

Journal: Chemical research in toxicology 20050901

Title: Treating critical illness: the importance of first doing no harm.

Journal: PLoS medicine 20050601

Title: Myocardial dysfunction in rheumatoid arthritis: epidemiology and pathogenesis.

Journal: Arthritis research & therapy 20050101

Title: Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma.

Journal: British journal of cancer 20040913

Title: TSC-22 (TGF-beta stimulated clone-22): a novel molecular target for differentiation-inducing therapy in salivary gland cancer.

Journal: Current cancer drug targets 20040901

Title: Comparison of kinetic properties of quinidine and dofetilide block of HERG channels.

Journal: European journal of pharmacology 20040616

Title: New positive inotropic agents in the treatment of left ventricular dysfunction.

Journal: Italian heart journal : official journal of the Italian Federation of Cardiology 20040601

Title: Models of dilated cardiomyopathy in small animals and novel positive inotropic therapies.

Journal: Annals of the New York Academy of Sciences 20040501

Title: The best of times, the worst of times: the wealth and poverty of heart failure pharmacotherapies: is there a role for vesnarinone?

Journal: Drug safety 20040101

Title: Clinical characteristics of vesnarinone.

Journal: Drug safety 20040101

Title: Precautions for use and adverse effects of vesnarinone: potential mechanisms and future therapies.

Journal: Drug safety 20040101

Title: Optimising outcomes in end-stage heart failure: differences in therapeutic responses between diverse ethnic groups.

Journal: Drug safety 20040101

Title: Vesnarinone-mediated alterations of gene expression in cardiac fibroblasts from aortic regurgitant hearts.

Journal: American journal of therapeutics 20040101

Title: Extended application of an LC-MS/MS method for the analysis of vesnarinone and its metabolites in human urine and dialysate fluid.

Journal: Journal of pharmaceutical and biomedical analysis 20031124

Title: Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods.

Journal: Bioorganic & medicinal chemistry letters 20030818

Title: Vesnarinone: a differentiation-inducing anti-cancer drug.

Journal: Anti-cancer drugs 20030701

Title: Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain.

Journal: Molecular pharmacology 20030501

Title: [Inotropic agents].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20030501

Title: Role of nonglycosidic inotropic agents: indications, ethics, and limitations.

Journal: The Medical clinics of North America 20030301

Title: Transcriptional activation of cyclin-dependent kinase inhibitor, p21waf1 gene by treatment with a differentiation inducing agent, vesnarinone in a human salivary gland cancer cell line.

Journal: Journal of experimental & clinical cancer research : CR 20030301

Title: Management of congestive heart failure: a gender gap may still exist. Observations from a contemporary cohort.

Journal: BMC cardiovascular disorders 20030101

Title: Vesnarinone, a differentiation inducing drug, directly activates p21(waf1) gene promoter via Sp1 sites in a human salivary gland cancer cell line.

Journal: British journal of cancer 20021021

Title: Inotropic agents and immune modulation.

Journal: Cardiovascular drugs and therapy 20020501

Title: Vesnarinone causes oxidative damage by inhibiting catalase function through ceramide action in myeloid cell apoptosis.

Journal: Molecular pharmacology 20020301

Title: Interferon-alpha 2b and vesnarinone influence levels of tumor necrosis factor-alpha, apoptosis, or interleukin 6 in ESKOL, a hairy cell leukemic cell line. A potential cytokine and oncogene relationship regulating apoptosis is suggested.

Journal: Leukemia research 20020201

Title: Item response models for joint analysis of quality of life and survival.

Journal: Statistics in medicine 20020115

Title: Induction of apoptosis in human choriocarcinoma cell lines by treatment with 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)-quinolinone (vesnarinone).

Journal: Oncology reports 20020101

Title: Open channel block of HERG K(+) channels by vesnarinone.

Journal: Molecular pharmacology 20010801

Title: Effects of vesnarinone on peripheral circulating levels of cytokines and cytokine receptors in patients with heart failure: a report from the Vesnarinone Trial.

Journal: Chest 20010801

Title: The underreporting of results and possible mechanisms of 'negative' drug trials in patients with chronic heart failure.

Journal: International journal of cardiology 20010801

Title: Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST).

Journal: Circulation 20010424

Title: Carvedilol and vesnarinone: new antiarrhythmic approach in heart failure therapy.

Journal: Acta pharmacologica Sinica 20010301

Title: OPC-8212, a quinoline derivative, counteracts the reduction in type III collagen mRNA due to lipopolysaccharides in cultured rat cardiac fibroblasts.

Journal: Japanese heart journal 20010101

Title: Investigation on SCH00013, a novel cardiotonic agent with Ca++ sensitizing action. 4th communication: influence on experimentally induced ventricular arrhythmia in dogs.

Journal: Arzneimittel-Forschung 19990501

Title: Differential modulation of cytokine production by drugs: implications for therapy in heart failure.

Journal: Journal of molecular and cellular cardiology 19961201

Title: Vesnarinone inhibits production of HIV-1 in cultured cells.

Journal: Biochemical and biophysical research communications 19930930

Title: Inhibitors of cyclic AMP phosphodiesterase. 2. Structural variations of N-cyclohexyl-N-methyl-4-[(1,2,3,5-tetrahydro- 2-oxoimidazo[2,1-b]quinazolin-7-yl)-oxy]butyramide (RS-82856).

Journal: Journal of medicinal chemistry 19870201

Title: In vitro and in vivo studies of 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-2(1H)- quinolinone (OPC-8212), a novel positive inotropic drug, in various animals.

Journal: Arzneimittel-Forschung 19840101

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