79558-09-1,MFCD04974501
Catalog No.:AA008LU7

79558-09-1 | Aceticacid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-

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10mg
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008LU7
Chemical Name:
Aceticacid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
CAS Number:
79558-09-1
Molecular Formula:
C22H26O7
Molecular Weight:
402.4376
MDL Number:
MFCD04974501
SMILES:
CCCc1c(OCCCOc2ccc(cc2)OCC(=O)O)ccc(c1O)C(=O)C
Properties
Computed Properties
 
Complexity:
501  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0  
Defined Bond Stereocenter Count:
0  
Formal Charge:
0  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0  
Rotatable Bond Count:
12  
Undefined Atom Stereocenter Count:
0  
Undefined Bond Stereocenter Count:
0  
XLogP3:
4.7  

Literature

Title: Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices.

Journal: PloS one 20140101

Title: The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.

Journal: Journal of cellular biochemistry 20120601

Title: Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity.

Journal: The Journal of biological chemistry 20120413

Title: Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.

Journal: Bioorganic & medicinal chemistry letters 20120401

Title: Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.

Journal: Journal of medicinal chemistry 20120112

Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Journal: Environmental health perspectives 20110801

Title: Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20110801

Title: Peroxisome proliferator-activated receptor δ downregulates the expression of the receptor for advanced glycation end products and pro-inflammatory cytokines in the kidney of streptozotocin-induced diabetic mice.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110518

Title: AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.

Journal: Experimental dermatology 20110501

Title: Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?

Journal: The British journal of dermatology 20110101

Title: PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; inhibition in naïve, untreated cells and enhancement in LPS-stimulated cells.

Journal: Journal of neurochemistry 20101001

Title: Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.

Journal: Immunology 20100801

Title: Advanced glycation end products-induced apoptosis attenuated by PPARdelta activation and epigallocatechin gallate through NF-kappaB pathway in human embryonic kidney cells and human mesangial cells.

Journal: Diabetes/metabolism research and reviews 20100701

Title: Porcine peroxisome proliferator-activated receptor delta mediates the lipolytic effects of dietary fish oil to reduce body fat deposition.

Journal: Journal of animal science 20100601

Title: Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.

Journal: The Journal of pharmacology and experimental therapeutics 20100201

Title: Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism.

Journal: PPAR research 20100101

Title: PPARdelta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice.

Journal: European journal of pharmacology 20091110

Title: Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.

Journal: Cell proliferation 20091001

Title: Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.

Journal: Molecular pharmacology 20090801

Title: Role of PPAR-beta in hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells.

Journal: Atherosclerosis 20090601

Title: PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair.

Journal: Journal of hepatology 20090601

Title: Enhancement of PPAR-beta activity by repetitive low-grade H(2)O(2) stress protects human umbilical vein endothelial cells from subsequent oxidative stress-induced apoptosis.

Journal: Free radical biology & medicine 20090301

Title: PPARdelta agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/beta-catenin.

Journal: Cell cycle (Georgetown, Tex.) 20090215

Title: PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle.

Journal: Atherosclerosis 20090201

Title: Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxisome proliferator-activated receptor-delta transcriptional pathway.

Journal: Molecular pharmacology 20081101

Title: The role of peroxisome proliferator-activated receptor-beta/delta in epidermal growth factor-induced HaCaT cell proliferation.

Journal: Experimental cell research 20081015

Title: Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.

Journal: Molecular pharmacology 20081001

Title: Effects of PPAR agonists on proliferation and differentiation in human urothelium.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080901

Title: Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes.

Journal: The FEBS journal 20080801

Title: Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.

Journal: Endocrinology 20080301

Title: Ectopic expression of porcine peroxisome proliferator-activated receptor delta regulates adipogenesis in mouse myoblasts.

Journal: Journal of animal science 20080101

Title: A novel bioluminescent protease assay using engineered firefly luciferase.

Journal: Current chemical genomics 20080101

Title: Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.

Journal: Pflugers Archiv : European journal of physiology 20071201

Title: Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.

Journal: American journal of physiology. Endocrinology and metabolism 20071101

Title: Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids.

Journal: Endocrinology 20070801

Title: Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.

Journal: Bioorganic & medicinal chemistry 20070801

Title: Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes.

Journal: Biochemical and biophysical research communications 20070525

Title: The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

Journal: Journal of hepatology 20070501

Title: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

Journal: Cellular and molecular life sciences : CMLS 20070501

Title: Stimulation of embryo hatching and implantation by prostacyclin and peroxisome proliferator-activated receptor delta activation: implication in IVF.

Journal: Human reproduction (Oxford, England) 20070301

Title: Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics 20070301

Title: Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties.

Journal: Arteriosclerosis, thrombosis, and vascular biology 20070301

Title: PPAR agonists modulate human osteoclast formation and activity in vitro.

Journal: Bone 20070101

Title: Studies towards the conception of new selective PPARbeta/delta ligands.

Journal: Bioorganic & medicinal chemistry letters 20060901

Title: Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR.

Journal: Molecular and cellular endocrinology 20060815

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

Title: Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure.

Journal: Journal of the American Society of Nephrology : JASN 20050801

Title: Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells.

Journal: Biochimica et biophysica acta 20050501

Title: Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes.

Journal: Cardiovascular research 20050301

Title: Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands.

Journal: The Journal of pharmacology and experimental therapeutics 20041101

Title: PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.

Journal: Journal of lipid research 20030201

Title: Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

Journal: Gastroenterology 20030101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry 20020419

Title: PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.

Journal: European journal of pharmacology 20020125

Title: Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

Journal: Biochemical and biophysical research communications 20020111

Title: The PPARs: from orphan receptors to drug discovery.

Journal: Journal of medicinal chemistry 20000224

Title: Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures.

Journal: The Journal of biological chemistry 19991210

Title: Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.

Journal: The Journal of biological chemistry 19990305

Title: Berger J, et al. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25.

Title: Park, Jin-Hee., et al. The PPARδ ligand L-165041 inhibits vegf-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. Journal of Cellular Biochemistry (2012), 113(6), 1947-1954.

Title: Lim, Hyun-Joung., et al. PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice. European Journal of Pharmacology (2009), 622(1-3), 45-51.

Title: Lim, Hyun-Joung., et al. PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Atherosclerosis (Amsterdam, Netherlands) (2009), 202(2), 446-454.

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Related Products of 79558-09-1
Tags:79558-09-1 Molecular Formula|79558-09-1 MDL|79558-09-1 SMILES|79558-09-1 Aceticacid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
Catalog No.: AA008LU7
79558-09-1,MFCD04974501
79558-09-1 | Aceticacid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
Pack Size: 5mg
Purity: ≥98%
in stock
$123.00 $86.00
Pack Size: 10mg
Purity: ≥98%
in stock
$185.00 $129.00
Pack Size: 25mg
Purity: ≥98%
in stock
$423.00 $296.00
Pack Size: 50mg
Purity: ≥98%
in stock
$758.00 $530.00
Quantity
- +
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Technical Information
Catalog Number: AA008LU7
Chemical Name: Aceticacid, 2-[4-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]phenoxy]-
CAS Number: 79558-09-1
Molecular Formula: C22H26O7
Molecular Weight: 402.4376
MDL Number: MFCD04974501
SMILES: CCCc1c(OCCCOc2ccc(cc2)OCC(=O)O)ccc(c1O)C(=O)C
Properties
Complexity: 501  
Covalently-Bonded Unit Count: 1  
Defined Atom Stereocenter Count: 0  
Defined Bond Stereocenter Count: 0  
Formal Charge: 0  
Heavy Atom Count: 29  
Hydrogen Bond Acceptor Count: 7  
Hydrogen Bond Donor Count: 2  
Isotope Atom Count: 0  
Rotatable Bond Count: 12  
Undefined Atom Stereocenter Count: 0  
Undefined Bond Stereocenter Count: 0  
XLogP3: 4.7  
Literature fold

Title: Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices.

Journal: PloS one20140101

Title: The PPARδ ligand L-165041 inhibits VEGF-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ.

Journal: Journal of cellular biochemistry20120601

Title: Peroxisome proliferator-activated receptor β/δ induces myogenesis by modulating myostatin activity.

Journal: The Journal of biological chemistry20120413

Title: Anti-inflammatory and PPAR transactivational effects of secondary metabolites from the roots of Asarum sieboldii.

Journal: Bioorganic & medicinal chemistry letters20120401

Title: Synthesis, characterization and biological evaluation of ureidofibrate-like derivatives endowed with peroxisome proliferator-activated receptor activity.

Journal: Journal of medicinal chemistry20120112

Title: Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Journal: Environmental health perspectives20110801

Title: Pharmacological activation of peroxisome proliferator-activated receptor δ improves insulin resistance and hepatic steatosis in high fat diet-induced diabetic mice.

Journal: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme20110801

Title: Peroxisome proliferator-activated receptor δ downregulates the expression of the receptor for advanced glycation end products and pro-inflammatory cytokines in the kidney of streptozotocin-induced diabetic mice.

Journal: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences20110518

Title: AP1-dependent repression of TGFα-mediated MMP9 upregulation by PPARδ agonists in keratinocytes.

Journal: Experimental dermatology20110501

Title: Peroxisome proliferator-activated receptor activators protect sebocytes from apoptosis: a new treatment modality for acne?

Journal: The British journal of dermatology20110101

Title: PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; inhibition in naïve, untreated cells and enhancement in LPS-stimulated cells.

Journal: Journal of neurochemistry20101001

Title: Peroxisome proliferator-activated receptor delta agonists inhibit T helper type 1 (Th1) and Th17 responses in experimental allergic encephalomyelitis.

Journal: Immunology20100801

Title: Advanced glycation end products-induced apoptosis attenuated by PPARdelta activation and epigallocatechin gallate through NF-kappaB pathway in human embryonic kidney cells and human mesangial cells.

Journal: Diabetes/metabolism research and reviews20100701

Title: Porcine peroxisome proliferator-activated receptor delta mediates the lipolytic effects of dietary fish oil to reduce body fat deposition.

Journal: Journal of animal science20100601

Title: Endothelium-dependent vasodilator effects of peroxisome proliferator-activated receptor beta agonists via the phosphatidyl-inositol-3 kinase-Akt pathway.

Journal: The Journal of pharmacology and experimental therapeutics20100201

Title: Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism.

Journal: PPAR research20100101

Title: PPARdelta ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice.

Journal: European journal of pharmacology20091110

Title: Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channels.

Journal: Cell proliferation20091001

Title: Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels.

Journal: Molecular pharmacology20090801

Title: Role of PPAR-beta in hydrogen peroxide-induced apoptosis in human umbilical vein endothelial cells.

Journal: Atherosclerosis20090601

Title: PPARdelta agonist attenuates alcohol-induced hepatic insulin resistance and improves liver injury and repair.

Journal: Journal of hepatology20090601

Title: Enhancement of PPAR-beta activity by repetitive low-grade H(2)O(2) stress protects human umbilical vein endothelial cells from subsequent oxidative stress-induced apoptosis.

Journal: Free radical biology & medicine20090301

Title: PPARdelta agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/beta-catenin.

Journal: Cell cycle (Georgetown, Tex.)20090215

Title: PPAR delta agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle.

Journal: Atherosclerosis20090201

Title: Nonsteroidal anti-inflammatory drugs induced endothelial apoptosis by perturbing peroxisome proliferator-activated receptor-delta transcriptional pathway.

Journal: Molecular pharmacology20081101

Title: The role of peroxisome proliferator-activated receptor-beta/delta in epidermal growth factor-induced HaCaT cell proliferation.

Journal: Experimental cell research20081015

Title: Keratinocyte-derived vascular endothelial growth factor biosynthesis represents a pleiotropic side effect of peroxisome proliferator-activated receptor-gamma agonist troglitazone but not rosiglitazone and involves activation of p38 mitogen-activated protein kinase: implications for diabetes-impaired skin repair.

Journal: Molecular pharmacology20081001

Title: Effects of PPAR agonists on proliferation and differentiation in human urothelium.

Journal: Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie20080901

Title: Role of ceramide kinase in peroxisome proliferator-activated receptor beta-induced cell survival of mouse keratinocytes.

Journal: The FEBS journal20080801

Title: Nuclear receptor agonists improve insulin responsiveness in cultured cardiomyocytes through enhanced signaling and preserved cytoskeletal architecture.

Journal: Endocrinology20080301

Title: Ectopic expression of porcine peroxisome proliferator-activated receptor delta regulates adipogenesis in mouse myoblasts.

Journal: Journal of animal science20080101

Title: A novel bioluminescent protease assay using engineered firefly luciferase.

Journal: Current chemical genomics20080101

Title: Inactivation of peroxisome proliferator-activated receptor isoforms alpha, beta/delta, and gamma mediate distinct facets of hypertrophic transformation of adult cardiac myocytes.

Journal: Pflugers Archiv : European journal of physiology20071201

Title: Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes.

Journal: American journal of physiology. Endocrinology and metabolism20071101

Title: Differential 3,5,3'-triiodothyronine-mediated regulation of uncoupling protein 3 transcription: role of Fatty acids.

Journal: Endocrinology20070801

Title: Design, synthesis, and evaluation of potent, structurally novel peroxisome proliferator-activated receptor (PPAR) delta-selective agonists.

Journal: Bioorganic & medicinal chemistry20070801

Title: Effect of PPAR-delta agonist on the expression of visfatin, adiponectin, and resistin in rat adipose tissue and 3T3-L1 adipocytes.

Journal: Biochemical and biophysical research communications20070525

Title: The Interleukin-1 receptor antagonist is a direct target gene of PPARalpha in liver.

Journal: Journal of hepatology20070501

Title: Glycogen synthase 2 is a novel target gene of peroxisome proliferator-activated receptors.

Journal: Cellular and molecular life sciences : CMLS20070501

Title: Stimulation of embryo hatching and implantation by prostacyclin and peroxisome proliferator-activated receptor delta activation: implication in IVF.

Journal: Human reproduction (Oxford, England)20070301

Title: Neuroprotective efficacy of the peroxisome proliferator-activated receptor delta-selective agonists in vitro and in vivo.

Journal: The Journal of pharmacology and experimental therapeutics20070301

Title: Tetradecylselenoacetic acid, a PPAR ligand with antioxidant, antiinflammatory, and hypolipidemic properties.

Journal: Arteriosclerosis, thrombosis, and vascular biology20070301

Title: PPAR agonists modulate human osteoclast formation and activity in vitro.

Journal: Bone20070101

Title: Studies towards the conception of new selective PPARbeta/delta ligands.

Journal: Bioorganic & medicinal chemistry letters20060901

Title: Ligand-activated PPARbeta efficiently represses the induction of LXR-dependent promoter activity through competition with RXR.

Journal: Molecular and cellular endocrinology20060815

Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology20060501

Title: Peroxisome proliferator-activated receptor beta/delta exerts a strong protection from ischemic acute renal failure.

Journal: Journal of the American Society of Nephrology : JASN20050801

Title: Agonist-induced activation releases peroxisome proliferator-activated receptor beta/delta from its inhibition by palmitate-induced nuclear factor-kappaB in skeletal muscle cells.

Journal: Biochimica et biophysica acta20050501

Title: Peroxisome proliferator-activated receptor beta/delta activation inhibits hypertrophy in neonatal rat cardiomyocytes.

Journal: Cardiovascular research20050301

Title: Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands.

Journal: The Journal of pharmacology and experimental therapeutics20041101

Title: PPARbeta regulates vitamin A metabolism-related gene expression in hepatic stellate cells undergoing activation.

Journal: Journal of lipid research20030201

Title: Peroxisome proliferator-activated receptor-beta signaling contributes to enhanced proliferation of hepatic stellate cells.

Journal: Gastroenterology20030101

Title: Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.

Journal: The Journal of biological chemistry20020419

Title: PPARalpha and PPARdelta activators inhibit cytokine-induced nuclear translocation of NF-kappaB and expression of VCAM-1 in EAhy926 endothelial cells.

Journal: European journal of pharmacology20020125

Title: Fibrate and statin synergistically increase the transcriptional activities of PPARalpha/RXRalpha and decrease the transactivation of NFkappaB.

Journal: Biochemical and biophysical research communications20020111

Title: The PPARs: from orphan receptors to drug discovery.

Journal: Journal of medicinal chemistry20000224

Title: Peroxisome proliferator-activated receptor beta regulates acyl-CoA synthetase 2 in reaggregated rat brain cell cultures.

Journal: The Journal of biological chemistry19991210

Title: Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects.

Journal: The Journal of biological chemistry19990305

Title: Berger J, et al. Novel peroxisome proliferator-activated receptor (PPAR) gamma and PPARdelta ligands produce distinct biological effects. J Biol Chem. 1999 Mar 5;274(10):6718-25.

Title: Park, Jin-Hee., et al. The PPARδ ligand L-165041 inhibits vegf-induced angiogenesis, but the antiangiogenic effect is not related to PPARδ. Journal of Cellular Biochemistry (2012), 113(6), 1947-1954.

Title: Lim, Hyun-Joung., et al. PPARδ ligand L-165041 ameliorates Western diet-induced hepatic lipid accumulation and inflammation in LDLR-/- mice. European Journal of Pharmacology (2009), 622(1-3), 45-51.

Title: Lim, Hyun-Joung., et al. PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle. Atherosclerosis (Amsterdam, Netherlands) (2009), 202(2), 446-454.

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