[1]Patent:US2016/151506,2016,A1,.Locationinpatent:Paragraph0416-0420
[1]JournalofMedicinalChemistry,2010,vol.53,#21,p.7879-7882
[2]Patent:CN107176942,2017,A,.Locationinpatent:Paragraph0067;0068;0069
[3]Patent:CN108440274,2018,A,.Locationinpatent:Paragraph0076;0077;0078;0079;0080
[1]Patent:CN106699559,2017,A,.Locationinpatent:Paragraph0116-0118
[1]JournalofMedicinalChemistry,2010,vol.53,p.7879-7882
[2]Patent:CN107176942,2017,A.Locationinpatent:Paragraph0067;0068;0069
[3]Patent:CN109776300,2019,A.Locationinpatent:Paragraph0048;0050;0056;0061-0062
[4]Patent:CN108440274,2018,A.Locationinpatent:Paragraph0076;0077;0078;0079;0080
[5]Patent:CN109809987,2019,A.Locationinpatent:Paragraph0008;0011
[6]Patent:CN109111360,2019,A.Locationinpatent:Paragraph0034-0041
[1]Patent:US2016/151506,2016,A1.Locationinpatent:Paragraph0416-0420
[1]Patent:CN106699559,2017,A
[1]Patent:CN106699559,2017,A
[2]Patent:CN108440274,2018,A
[3]Patent:CN109809987,2019,A
[4]Patent:CN109776300,2019,A
[1]Patent:CN109134261,2019,A.Locationinpatent:Paragraph0036;0037;0039;0045
Title: Short-term administration of diclofenac sodium affects renal function after laparoscopic radical nephrectomy in elderly patients.
Journal: Japanese journal of clinical oncology 20121101
Title: Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascularization in age-related macular degeneration.
Journal: European journal of ophthalmology 20120101
Title: New therapeutic strategy for amino acid medicine: prophylactic and healing promoting effect of monosodium glutamate against NSAID-induced enteropathy.
Journal: Journal of pharmacological sciences 20120101
Title: Heart failure assocated with pregabalin.
Journal: Pain physician 20120101
Title: Synthesis and biological evaluation of loxoprofen derivatives.
Journal: Bioorganic & medicinal chemistry 20110601
Title: Protective effect of geranylgeranylacetone against loxoprofen sodium-induced small intestinal lesions in rats.
Journal: European journal of pharmacology 20110210
Title: Unilateral eyelid angioedema with congestion of the right bulbar conjunctiva due to loxoprofen sodium.
Journal: Cutis 20110101
Title: Influence of nonsteroidal anti-inflammatory drugs on the antiplatelet effects of aspirin in rats.
Journal: Biological & pharmaceutical bulletin 20110101
Title: Antipyretic and analgesic effects of zaltoprofen for the treatment of acute upper respiratory tract infection: verification of a noninferiority hypothesis using loxoprofen sodium.
Journal: Pharmacology 20110101
Title: Epiploic appendagitis in a 27-year-old man.
Journal: Medical science monitor : international medical journal of experimental and clinical research 20110101
Title: Vulnerable sites and changes in mucin in the rat small intestine after non-steroidal anti-inflammatory drugs administration.
Journal: Digestive diseases and sciences 20101201
Title: Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities.
Journal: Journal of medicinal chemistry 20101111
Title: High molecular weight hyaluronic acid relieved joint pain and prevented the progression of cartilage degeneration in a rabbit osteoarthritis model after onset of arthritis.
Journal: Modern rheumatology 20101001
Title: Lafutidine prevents low-dose aspirin and loxoprofen induced gastric injury: a randomized, double-blinded, placebo controlled study.
Journal: Journal of gastroenterology and hepatology 20101001
Title: Protective effect of lafutidine, a histamine H2 receptor antagonist, against loxoprofen-induced small intestinal lesions in rats.
Journal: Journal of gastroenterology and hepatology 20100501
Title: Evaluation of correlation between dissolution rates of loxoprofen tablets and their surface morphology observed by scanning electron microscope and atomic force microscope.
Journal: Chemical & pharmaceutical bulletin 20100101
Title: Low direct cytotoxicity of loxoprofen on gastric mucosal cells.
Journal: Biological & pharmaceutical bulletin 20100101
Title: Case of Chlamydia-associated arthritis.
Journal: Nihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology 20091201
Title: Efficacy and safety of rabeprazole in non-steroidal anti-inflammatory drug-induced ulcer in Japan.
Journal: World journal of gastroenterology 20091028
Title: [Tendencies of prescriptions for neuralgic pain in National Suruga Sanatorium (leprosy), Japan during last 11 years].
Journal: Nihon Hansenbyo Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association 20090901
Title: Liquid chromatography-tandem mass spectrometry method of loxoprofen in human plasma.
Journal: Biomedical chromatography : BMC 20090701
Title: The importance of brain PGE2 inhibition versus paw PGE2 inhibition as a mechanism for the separation of analgesic and antipyretic effects of lornoxicam in rats with paw inflammation.
Journal: The Journal of pharmacy and pharmacology 20090501
Title: Synthesis of the active form of loxoprofen by using allylic substitutions in two steps.
Journal: Organic letters 20090305
Title: Effects of non-steroidal anti-inflammatory drugs (NSAIDs) on serum allergen levels after wheat ingestion.
Journal: Journal of dermatological science 20090301
Title: Herbal medicine Shakuyaku-kanzo-to reduces paclitaxel-induced painful peripheral neuropathy in mice.
Journal: European journal of pain (London, England) 20090101
Title: A clinical investigation of the mechanism of loxoprofen, a non-steroidal anti-inflammatory drug, for patients with nocturia.
Journal: Acta medica Okayama 20081201
Title: Prolonged intrahepatic cholestasis after exposure to loxoprofen.
Journal: Clinical therapeutics 20081201
Title: Identification of degradation products in loxoprofen sodium adhesive tapes by liquid chromatography-mass spectrometry and dynamic pressurized liquid extraction-solid-phase extraction coupled to liquid chromatography-nuclear magnetic resonance spectroscopy.
Journal: Journal of chromatography. A 20081024
Title: Long-lasting breaches in the bladder epithelium lead to storage dysfunction with increase in bladder PGE2 levels in the rat.
Journal: American journal of physiology. Regulatory, integrative and comparative physiology 20080801
Title: Loxoprofen sodium treatment for elderly men with refractory nocturia: effect on night-time urine production.
Journal: International journal of urology : official journal of the Japanese Urological Association 20080501
Title: Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model.
Journal: BMC musculoskeletal disorders 20080101
Title: NSAID loxoprofen inhibits high threshold or wide dynamic range neuronal responses in the rat at different time-courses.
Journal: Pharmacological reports : PR 20080101
Title: Micro-CT imaging analysis for the effect of celecoxib, a cyclooxygenase-2 inhibitor, on inflammatory bone destruction in adjuvant arthritis rats.
Journal: Journal of bone and mineral metabolism 20080101
Title: Short-term effect of COX-2 selective inhibitor as an adjunct for the treatment of periodontal disease: a clinical double-blind study in humans.
Journal: Brazilian dental journal 20080101
Title: Massive myelinolytic leukoencephalopathy in a patient medicated with low-dose oral methotrexate for rheumatoid arthritis: an autopsy report.
Journal: Acta neuropathologica 20071001
Title: [Case of loxoprofen sodium-induced eosinophilic pneumonia that occurred ipsilaterally after VATS lobectomy for lung cancer].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20071001
Title: Education and Imaging. Gastrointestinal: ileal ulcers induced by non-steroidal anti-inflammatory drugs.
Journal: Journal of gastroenterology and hepatology 20070801
Title: Skin irritation in transdermal drug delivery systems: a strategy for its reduction.
Journal: Pharmaceutical research 20070201
Title: Influence of loxoprofen use on recovery from naturally acquired upper respiratory tract infections: a randomized controlled trial.
Journal: Internal medicine (Tokyo, Japan) 20070101
Title: Pharmacokinetics and bioequivalence study of two brands of loxoprofen tablets in healthy volunteers.
Journal: Arzneimittel-Forschung 20070101
Title: Study on the mechanism of photosensitive dermatitis caused by ketoprofen in the guinea pig.
Journal: Archives of toxicology 20060701
Title: Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery.
Journal: International journal of oral and maxillofacial surgery 20060701
Title: Direct and simultaneous analysis of loxoprofen and its diastereometric alcohol metabolites in human serum by on-line column switching liquid chromatography and its application to a pharmacokinetic study.
Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501
Title: Microsphere-based protease assays and screening application for lethal factor and factor Xa.
Journal: Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Title: Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats.
Journal: Biomedical research (Tokyo, Japan) 20060401
Title: Anti-inflammatory activity of 4,4'-dihydroxy-alpha-truxillic acid.
Journal: Biological & pharmaceutical bulletin 20060301
Title: [A case of takotsubo cardiomyopathy provoked by taking a new quinolone antibiotic drug and a non-steroidal anti-inflammatory drug].
Journal: Kaku igaku. The Japanese journal of nuclear medicine 20060201
Title: Pseudogout attack induced during etidronate disodium therapy.
Journal: Modern rheumatology 20060101
Title: Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites.
Journal: Biological & pharmaceutical bulletin 20051101
Title: Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism.
Journal: Journal of pharmaceutical sciences 20051001
Title: Effectiveness of an anti-inflammatory drug, loxoprofen, for patients with nocturia.
Journal: International journal of urology : official journal of the Japanese Urological Association 20050801
Title: Retroperitoneal fibrosis with periaortic and pericardial involvement.
Journal: Circulation journal : official journal of the Japanese Circulation Society 20050601
Title: Effect of celecoxib, a cyclooxygenase-2 inhibitor, on the pathophysiology of adjuvant arthritis in rat.
Journal: European journal of pharmacology 20050425
Title: Loxoprofen inhibits facilitated micturition reflex induced by acetic acid urinary bladder infusion of the rats.
Journal: Biomedical research (Tokyo, Japan) 20050201
Title: Implication of prostaglandin E(2) in TNF-alpha-induced release of m-calpain from HCS-2/8 chondrocytes. Inhibition of m-calpain release by NSAIDs.
Journal: Osteoarthritis and cartilage 20041101
Title: Methotrexate-loxoprofen interaction: involvement of human organic anion transporters hOAT1 and hOAT3.
Journal: Drug metabolism and pharmacokinetics 20041001
Title: Parvovirus B19 infection and myofasciitis.
Journal: Clinical rheumatology 20040401
Title: Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2.
Journal: Bioorganic & medicinal chemistry letters 20040308
Title: Loxoprofen sodium and survival in older people with advanced non-small cell lung cancer.
Journal: Journal of the American Geriatrics Society 20040301
Title: Effectiveness of a nonsteroidal anti-inflammatory drug for nocturia on patients with benign prostatic hyperplasia: a prospective non-randomized study of loxoprofen sodium 60 mg once daily before sleeping.
Journal: Acta medica Okayama 20040201
Title: [A case of loxoprofen sodium-induced bronchiolitis obliterans organizing pneumonia (BOOP)].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20031201
Title: Effects of orally administered OP-1206 alpha-CD with loxoprofen-Na on walking dysfunction in the rat neuropathic intermittent claudication model.
Journal: Prostaglandins, leukotrienes, and essential fatty acids 20031001
Title: [The analysis of prescription frequency and the factors on adverse reactions of NSAIDs for post-operative pain in orthopedic patients].
Journal: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20030701
Title: Evaluation of gastric acid secretion in two patients (each aged over 90 years) with Helicobacter pylori-negative nonsteroidal anti-inflammatory drug-caused duodenal ulcers.
Journal: Journal of gastroenterology 20030101
Title: Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor.
Journal: Acta oncologica (Stockholm, Sweden) 20030101
Title: [A study of logotherapy for chronic low back pain patients].
Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20030101
Title: Cognitive decline in administration of the nonsteroidal antiinflammatory drug loxoprofen with misoprostol in a 91-year-old Japanese woman.
Journal: Journal of the American Geriatrics Society 20021001
Title: Altered metabolism of orally administered loxoprofen in human subjects after an oral administration of loxoprofen for three consecutive days followed by a seven-day washout.
Journal: Journal of pharmaceutical sciences 20020401
Title: Stereospecific analysis of loxoprofen in plasma by chiral column liquid chromatography with a circular dichroism-based detector.
Journal: Journal of chromatography. A 20020301
Title: [A case of loxoprofen-induced pneumonitis pathologically resembling hypersensitivity pneumonitis].
Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20020201
Title: The combination therapy of Ephedra herb and Loxoprofen caused gastric lesions in mice.
Journal: The American journal of Chinese medicine 20020101
Title: Anti-inflammatory, analgesic and antipyretic activities of loxoprofen sodium given intramuscularly in animals.
Journal: Archives of pharmacal research 20011201
Title: Simultaneous determination of loxoprofen and its diastereomeric alcohol metabolites in human plasma and urine by a simple HPLC-UV detection method.
Journal: Journal of pharmaceutical and biomedical analysis 20010601
Title: An autopsy case of giant cell myocarditis probably due to a non-steroidal anti-inflammatory drug.
Journal: Pathology international 20010201
Title: Direct superoxide scavenging activity of nonsteroidal anti-inflammatory drugs: determination by electron spin resonance using the spin trap method.
Journal: Headache 20010201
Title: NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions.
Journal: General pharmacology 19930101
Title: Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.
Journal: Journal of medicinal chemistry 19840201
Title: Riendeau D, et al. Evaluation of loxoprofen and its alcohol metabolites for potency and selectivity of inhibition of cyclooxygenase-2. Bioorg Med Chem Lett. 2004;14(5):1201-1203.
Title: Paudel S, et al. Assessing Drug Interaction and Pharmacokinetics of Loxoprofen in Mice Treated with CYP3A Modulators. Pharmaceutics. 2019;11(9):479. Published 2019 Sep 16.
Title: Hamaguchi M, et al. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation. J Clin Biochem Nutr. 2010 Sep;47(2):138-47.
Title: Kanda A, et al. Loxoprofen sodium suppresses mouse tumor growth by inhibiting vascular endothelial growth factor. Acta Oncol. 2003;42(1):62-70.
