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1180-95-6,MFCD00003671
Catalog No.:AA008R0N

1180-95-6 | Taurodeoxycholic acid sodium salt

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1g
95%
in stock  
$13.00   $9.00
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5g
95%
in stock  
$61.00   $43.00
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100g
95%
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$797.00   $558.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008R0N
Chemical Name:
Taurodeoxycholic acid sodium salt
CAS Number:
1180-95-6
Molecular Formula:
C26H44NNaO6S
Molecular Weight:
521.6854
MDL Number:
MFCD00003671
SMILES:
O[C@@H]1CC[C@]2(C(C1)CCC1C2C[C@H](O)[C@]2(C1CC[C@@H]2[C@@H](CCC(=O)NCCS(=O)(=O)[O-])C)C)C.[Na+]
Properties
Computed Properties
 
Complexity:
864  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
10  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
7  

Literature

Title: Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates.

Journal: Toxicology in vitro : an international journal published in association with BIBRA 20140301

Title: Bile salts increase epithelial cell proliferation through HuR-induced c-Myc expression.

Journal: The Journal of surgical research 20121101

Title: Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.

Journal: Diabetes 20120601

Title: Muscarinic receptor agonists stimulate matrix metalloproteinase 1-dependent invasion of human colon cancer cells.

Journal: Biochemical and biophysical research communications 20111118

Title: Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in mice.

Journal: European journal of pharmacology 20111116

Title: Determination of perfluorinated compounds in human plasma and serum Standard Reference Materials using independent analytical methods.

Journal: Analytical and bioanalytical chemistry 20111101

Title: Study on improvement of extracellular production of recombinant Thermobifida fusca cutinase by Escherichia coli.

Journal: Applied biochemistry and biotechnology 20110901

Title: Bile salt supplementation acts via the farnesoid X receptor to alleviate lipopolysaccharide-induced intestinal injury.

Journal: Surgery 20110901

Title: Carica papaya lipase: a naturally immobilized enzyme with interesting biochemical properties.

Journal: Plant foods for human nutrition (Dordrecht, Netherlands) 20110301

Title: X-ray characterization of self-assembled long-chain phosphatidylcholine/bile salt/silica mesostructured films with nanoscale homogeneity.

Journal: Chemical communications (Cambridge, England) 20110214

Title: Identification of components of grape powder with anti-apoptotic effects.

Journal: Toxicology and industrial health 20110201

Title: [Evaluation on hepatotoxicity caused by Dioscorea bulbifera based on analysis of bile acids].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20110101

Title: Polyamine catabolism in relation to trypsin activation and apoptosis in experimental acute pancreatitis.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20110101

Title: Association between remote organ injury and tissue polyamine homeostasis in acute experimental pancreatitis - treatment with a polyamine analogue bismethylspermine.

Journal: Pharmacological reports : PR 20110101

Title: Highly sensitive chiral analysis of amino acids by in-line single drop microextraction and capillary electrophoresis with laser-induced fluorescence detection.

Journal: Analytica chimica acta 20100910

Title: Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis.

Journal: World journal of gastroenterology 20100721

Title: Dietary bile acid supplementation improves intestinal integrity and survival in a murine model.

Journal: Journal of pediatric surgery 20100601

Title: Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20100501

Title: Increased affinity to canalicular P-gp via formation of lipophilic ion-pair complexes with endogenous bile salts is associated with mw threshold in hepatobiliary excretion of quaternary ammonium compounds.

Journal: Pharmaceutical research 20100501

Title: Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma.

Journal: Gut 20100201

Title: Bile acid reflux contributes to development of esophageal adenocarcinoma via activation of phosphatidylinositol-specific phospholipase Cgamma2 and NADPH oxidase NOX5-S.

Journal: Cancer research 20100201

Title: A photophysical study on the role of bile salt hydrophobicity in solubilizing amphotericin B aggregates.

Journal: Journal of pharmaceutical sciences 20091101

Title: Freeze-dried grape powder attenuates mitochondria- and oxidative stress-mediated apoptosis in liver cells.

Journal: Journal of agricultural and food chemistry 20091014

Title: Apoptosis and modulation of cell cycle control by bile acids in human leukemia T cells.

Journal: Annals of the New York Academy of Sciences 20090801

Title: An analytical method for the determination of perfluorinated compounds in whole blood using acetonitrile and solid phase extraction methods.

Journal: Journal of chromatography. A 20090619

Title: Trp-107 and trp-253 account for the increased steady state fluorescence that accompanies the conformational change in human pancreatic triglyceride lipase induced by tetrahydrolipstatin and bile salt.

Journal: The Journal of biological chemistry 20090522

Title: [Epicatechin abolished TDCA-induced apoptosis in Huh7 cell by inhibiting Bax, p38 MAPK and ROS production].

Journal: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090501

Title: A small component of the endoplasmic reticulum is required for store-operated Ca2+ channel activation in liver cells: evidence from studies using TRPV1 and taurodeoxycholic acid.

Journal: The Biochemical journal 20090315

Title: Akt-dependent NF-kappaB activation is required for bile acids to rescue colon cancer cells from stress-induced apoptosis.

Journal: Experimental cell research 20090201

Title: Effect of cell-penetrating peptides on the nasal absorption of insulin.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20090119

Title: Taurodeoxycholate-induced intestinal injury is modulated by oxidative stress-dependent pre-conditioning like mechanisms.

Journal: Toxicology letters 20081110

Title: Study of thermodynamic parameters for solubilization of plant sterol and stanol in bile salt micelles.

Journal: Chemistry and physics of lipids 20080801

Title: A polyamine analog bismethylspermine ameliorates severe pancreatitis induced by intraductal infusion of taurodeoxycholate.

Journal: Surgery 20080701

Title: Deoxycholyltaurine rescues human colon cancer cells from apoptosis by activating EGFR-dependent PI3K/Akt signaling.

Journal: Journal of cellular physiology 20080501

Title: Store-operated Ca(2+) channels and Stromal Interaction Molecule 1 (STIM1) are targets for the actions of bile acids on liver cells.

Journal: Biochimica et biophysica acta 20080501

Title: Bile salt-phospholipid aggregation at submicellar concentrations.

Journal: Colloids and surfaces. B, Biointerfaces 20080401

Title: Polyamine levels in the pancreas and the blood change according to the severity of pancreatitis.

Journal: Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20080101

Title: Effect of ion-pair formation with bile salts on the in vitro cellular transport of berberine.

Journal: Archives of pharmacal research 20080101

Title: Initiation of acute pancreatitis by heparan sulphate in the rat.

Journal: Scandinavian journal of gastroenterology 20080101

Title: Protective effects of erythropoietin against acute lung injury in a rat model of acute necrotizing pancreatitis.

Journal: World journal of gastroenterology 20071214

Title: Role of protein kinase C-delta in the age-dependent secretagogue action of bile acids in mammalian colon.

Journal: American journal of physiology. Cell physiology 20071201

Title: Proteolytic cleavage of ostrich and turkey pancreatic lipases: production of an active N-terminal domain.

Journal: Pancreas 20071001

Title: Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis.

Journal: Pancreas 20071001

Title: Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells.

Journal: Journal of lipid research 20070701

Title: Potential effects of PKC or protease inhibitors on acute pancreatitis-induced tissue injury in rats.

Journal: Vascular pharmacology 20070601

Title: Taurodeoxycholate modulates apical Cl-/OH- exchange activity in Caco2 cells.

Journal: Digestive diseases and sciences 20070501

Title: Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.

Journal: Molecular pharmacology 20070401

Title: Matrix metalloproteinase-7-catalyzed release of HB-EGF mediates deoxycholyltaurine-induced proliferation of a human colon cancer cell line.

Journal: Biochemical pharmacology 20070401

Title: Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1alpha.

Journal: The Biochemical journal 20070215

Title: [Impairment of humoral regulation of exocrine pancreatic function in chronic pancreatitis].

Journal: Terapevticheskii arkhiv 20070101

Title: Taurocholate and taurodeoxycholate: gel formation and protonation constants.

Journal: Annali di chimica 20070101

Title: Bile acid salt binding with colesevelam HCl is not affected by suspension in common beverages.

Journal: Journal of pharmaceutical sciences 20061201

Title: Effect of bile acid on the cell membrane functionality of lactic acid bacteria for oral administration.

Journal: Research in microbiology 20061001

Title: Role of enteral nutrition supplemented with ebselen and EHEC in pancreatitis-associated multiple organ dysfunction in rats.

Journal: Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20061001

Title: [Bile salts induce differentiation in cultured human normal esophageal mucosal epithelial cells].

Journal: Zhonghua yi xue za zhi 20060912

Title: The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice.

Journal: Journal of lipid research 20060901

Title: Micelle formation of bile salts and zwitterionic derivative as studied by two-dimensional NMR spectroscopy.

Journal: Chemistry and physics of lipids 20060701

Title: Chiral capillary electrophoretic separation of amino acids derivatized with 9-fluorenylmethylchloroformate using mixed chiral selectors of beta-cyclodextrin and sodium taurodeoxycholate.

Journal: Electrophoresis 20060701

Title: Polymorphic behavior in protein-surfactant mixtures: the water-bovine serum albumin-sodium taurodeoxycholate system.

Journal: The journal of physical chemistry. B 20060622

Title: Effect of acid, pepsin, and bile acid on the stenotic progression of traumatized subglottis.

Journal: The American journal of gastroenterology 20060601

Title: Single-step analysis of individual conjugated bile acids in human bile using 1H NMR spectroscopy.

Journal: Lipids 20060601

Title: Protein kinase C modulates the pulmonary inflammatory response in acute pancreatitis.

Journal: Respiratory physiology & neurobiology 20060501

Title: A novel 'reverse screening' to identify refolding additives for activin-A.

Journal: Protein expression and purification 20060501

Title: Indomethacin disrupts the protective effect of phosphatidylcholine against bile salt-induced ileal mucosa injury.

Journal: European journal of clinical investigation 20060201

Title: Effect of tamoxifen and raloxifene on the conjugation of bile acids with taurine and glycine in ovariectomized rats.

Journal: Pharmacological reports : PR 20060101

Title: Adsorption of bile acid by chitosan salts prepared with cinnamic acid and analogue compounds.

Journal: Journal of biomaterials science. Polymer edition 20060101

Title: Conjugated bile acids promote ERK1/2 and AKT activation via a pertussis toxin-sensitive mechanism in murine and human hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20051201

Title: Structures and biological properties of DNA adducts derived from N-nitroso bile acid conjugates.

Journal: Chemical research in toxicology 20051001

Title: Enhanced intestinal absorption of salmon calcitonin (sCT) from proliposomes containing bile salts.

Journal: Journal of controlled release : official journal of the Controlled Release Society 20050902

Title: Microemulsion electrokinetic chromatography of corticosteroids. Effect of surfactants and cyclodextrins on the separation selectivity.

Journal: Journal of chromatography. A 20050715

Title: Analysis of ecdysteroids by micellar electrokinetic chromatography with on-line preconcentration.

Journal: Journal of chromatography. A 20050715

Title: Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M(3) receptor-dependent.

Journal: European journal of pharmacology 20050704

Title: Severity of pancreatitis-associated gut barrier dysfunction is reduced following treatment with the PAF inhibitor lexipafant.

Journal: Biochemical pharmacology 20050501

Title: Bile acid induced gene expression in LT97 colonic adenoma cells.

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050101

Title: Isolation of cholesterol-lowering lactic acid bacteria from human intestine for probiotic use.

Journal: Journal of veterinary science 20041201

Title: Bile acids induce mitochondrial ROS, which promote activation of receptor tyrosine kinases and signaling pathways in rat hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20041001

Title: Taurodeoxycholate stimulates intestinal cell proliferation and protects against apoptotic cell death through activation of NF-kappaB.

Journal: Digestive diseases and sciences 20041001

Title: Measurement of bile acid in serum and bile with arylamine-glass-bound 3alpha-hydroxysteroid dehydrogenase and diaphorase.

Journal: Analytical biochemistry 20040901

Title: Physiological concentrations of bile salts inhibit recovery of ischemic-injured porcine ileum.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040801

Title: Chemotactic response of Helicobacter pylori to human plasma and bile.

Journal: Journal of medical microbiology 20040801

Title: Effect of membrane perturbants on the activity and phase distribution of inositol phosphorylceramide synthase; development of a novel assay.

Journal: Biochemistry 20040706

Title: Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim.

Journal: The Journal of biological chemistry 20040625

Title: Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3.

Journal: The Journal of biological chemistry 20040625

Title: Differential effects of deoxycholic acid and taurodeoxycholic acid on NF-kappa B signal transduction and IL-8 gene expression in colonic epithelial cells.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20040601

Title: Taurodeoxycholate increases intestinal epithelial cell proliferation through c-myc expression.

Journal: Surgery 20040201

Title: Trafficking of the bile salt export pump from the Golgi to the canalicular membrane is regulated by the p38 MAP kinase.

Journal: Gastroenterology 20040201

Title: Effects of nitric oxide synthase inhibitors on retrograde bile salt-induced pancreatitis rats.

Journal: Journal of the Chinese Medical Association : JCMA 20040101

Title: Unique inhibition of bile salt-induced apoptosis by lecithins and cytoprotective bile salts in immortalized mouse cholangiocytes.

Journal: Digestive diseases and sciences 20031201

Title: Effect of drugs on cholesterol crystallization in an artificial bile model and relation of this effect to drug binding to albumin.

Journal: Fundamental & clinical pharmacology 20030601

Title: [Effect of Tauroursodeoxycholic acid on cytochrome C-mediated apoptosis in HepG2 cells].

Journal: Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20030501

Title: NF-kappaB regulates intestinal epithelial cell and bile salt-induced migration after injury.

Journal: Annals of surgery 20030401

Title: Contribution of ion-pair complexation with bile salts to the transport of organic cations across LLC-PK1 cell monolayers.

Journal: Pharmaceutical research 20030401

Title: In vitro cellular interaction and absorption of dispersed cubic particles.

Journal: International journal of pharmaceutics 20030306

Title: Repetitive short-term bile duct obstruction and relief causes reproducible and reversible bile acid regurgitation.

Journal: The Journal of surgical research 20030301

Title: Effects of bile acids on biliary epithelial cells: proliferation, cytotoxicity, and cytokine secretion.

Journal: Life sciences 20030207

Title: Taurohyodeoxycholate- and tauroursodeoxycholate-induced hypercholeresis is augmented in bile duct ligated rats.

Journal: Journal of hepatology 20030201

Title: Vesicle formation and other structures in aqueous dispersions of monoolein and sodium oleate.

Journal: Journal of colloid and interface science 20030115

Title: Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies.

Journal: International journal of pharmaceutics 20030102

Title: Basolateral Ca2+-dependent K+-channels play a key role in Cl- secretion induced by taurodeoxycholate from colon mucosa.

Journal: Biology of the cell 20030101

Title: Bile acids for primary sclerosing cholangitis.

Journal: The Cochrane database of systematic reviews 20030101

Title: Effects of bile acids on dog pancreatic duct epithelial cell secretion and monolayer resistance.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20021101

Title: Surface fluorescence resonance energy transfer studies on interfacial adsorption of Thermomyces (humicola) lanuginosa lipase, using monomolecular films of cis-parinaric acid.

Journal: Biopolymers 20021015

Title: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia.

Journal: The Journal of pharmacology and experimental therapeutics 20021001

Title: Effects of hydrophobic and hydrophilic bile salt mixtures on cholesterol crystallization in model biles.

Journal: Biochimica et biophysica acta 20020711

Title: Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20020601

Title: Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner.

Journal: Gastroenterology 20020501

Title: Activation of the Raf-1/MEK/ERK cascade by bile acids occurs via the epidermal growth factor receptor in primary rat hepatocytes.

Journal: Hepatology (Baltimore, Md.) 20020201

Title: Role of mast cells in the development of pancreatitis-induced multiple organ dysfunction.

Journal: The British journal of surgery 20020201

Title: Comparison of three different anionic surfactants for the separation of hydrophobic compounds by nonaqueous capillary electrophoresis.

Journal: Electrophoresis 20020201

Title: Comparative cytotoxic and cytoprotective effects of taurohyodeoxycholic acid (THDCA) and tauroursodeoxycholic acid (TUDCA) in HepG2 cell line.

Journal: Biochimica et biophysica acta 20020130

Title: Indirect evidence that intestinal bile salt absorption in rats and hamsters is under positive feedback control.

Journal: Zeitschrift fur Gastroenterologie 20011101

Title: Pericentral hepatocytes translocate hydrophilic bile acids more rapidly than hydrophobic ones.

Journal: Digestive diseases and sciences 20011001

Title: Effect of chronic administration of tauro-hyodeoxycholic acid on biliary bile acid composition and on biliary lipid secretion in humans.

Journal: Scandinavian journal of gastroenterology 20010901

Title: DSC studies of Fusarium solani pisi cutinase: consequences for stability in the presence of surfactants.

Journal: Biophysical chemistry 20010830

Title: Effects of gum arabic on lipase interfacial binding and activity.

Journal: Analytical biochemistry 20010701

Title: Colchicine inhibits taurodeoxycholate transport in pericentral but not in periportal hepatocytes.

Journal: Biochimica et biophysica acta 20010620

Title: The bile acid-activated phosphatidylinositol 3-kinase pathway inhibits Fas apoptosis upstream of bid in rodent hepatocytes.

Journal: Gastroenterology 20010601

Title: Bile salt stimulates intestinal epithelial cell migration through TGFbeta after wounding.

Journal: The Journal of surgical research 20010501

Title: Effects of deoxycholic acid and its epimers on lipid peroxidation in isolated rat hepatocytes.

Journal: Journal of biochemistry 20010501

Title: Colipase residues Glu64 and Arg65 are essential for normal lipase-mediated fat digestion in the presence of bile salt micelles.

Journal: The Journal of biological chemistry 20010420

Title: Differences in Ca(2+) signaling underlie age-specific effects of secretagogues on colonic Cl(-) transport.

Journal: American journal of physiology. Cell physiology 20010301

Title: The mechanism of bile salt-induced hemolysis.

Journal: Cellular & molecular biology letters 20010101

Title: Villavicencio-Queijeiro A, et al. The fully-active and structurally-stable form of the mitochondrial ATP synthase of Polytomella sp. is dimeric. J Bioenerg Biomembr. 2009 Feb;41(1):1-13.

Title: Kispal G,et al. Isolation and characterization of 3-hydroxyacyl coenzyme A dehydrogenase-binding protein from pig heart inner mitochondrial membrane. J Biol Chem. 1986 Oct 25;261(30):14209-13.

Title: Choi HJ, et al. Evaluation of acute and subacute toxicity of sodium taurodeoxycholate in rats. Drug Chem Toxicol. 2019 Jun 19:1-9.

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