Home Other Building Blocks 119673-08-4
119673-08-4,MFCD14635404
Catalog No.:AA008RKM

119673-08-4 | BMS 181176

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1mg
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008RKM
Chemical Name:
BMS 181176
CAS Number:
119673-08-4
Molecular Formula:
C33H34Cl2N4O7
Molecular Weight:
669.5517
MDL Number:
MFCD14635404
SMILES:
CCN(CCn1c(=O)c2c(c1=O)c1c(c3c2c2cccc(c2[nH]3)Cl)n(c2c1cccc2Cl)[C@@H]1O[C@H](CO)[C@H]([C@@H]([C@H]1O)O)OC)CC
Properties
Computed Properties
 
Complexity:
1150  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
46  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
8  
XLogP3:
3.6  

Literature

Title: A phase I study of rebeccamycin analog in combination with oxaliplatin in patients with refractory solid tumors.

Journal: Investigational new drugs 20110201

Title: Phase II and pharmacokinetic trial of rebeccamycin analog in advanced biliary cancers.

Journal: Cancer chemotherapy and pharmacology 20091201

Title: Becatecarin (rebeccamycin analog, NSC 655649) is a transport substrate and induces expression of the ATP-binding cassette transporter, ABCG2, in lung carcinoma cells.

Journal: Cancer chemotherapy and pharmacology 20090801

Title: Phase 1 study of XL119, a rebeccamycin analog, in patients with refractory hematologic malignancies.

Journal: Cancer 20080715

Title: A phase II trial of rebeccamycin analogue (NSC #655649) in children with solid tumors: a Children's Oncology Group study.

Journal: Pediatric blood & cancer 20080301

Title: Phase I and pharmacokinetic study of sequences of the rebeccamycin analogue NSC 655649 and cisplatin in patients with advanced solid tumors.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20051215

Title: Becatecarin (Helsinn Healthcare).

Journal: IDrugs : the investigational drugs journal 20051001

Title: A phase II study of rebeccamycin analog (NSC-655649) in metastatic renal cell cancer.

Journal: Investigational new drugs 20031101

Title: Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.

Journal: Bioorganic & medicinal chemistry 20030815

Title: Phase I trial of rebeccamycin analog (NSC #655649) in children with refractory solid tumors: a pediatric oncology group study.

Journal: Journal of pediatric hematology/oncology 20030701

Title: A phase II study of rebeccamycin analog NSC 655649 in patients with metastatic colorectal cancer.

Journal: Investigational new drugs 20030201

Title: Phase I clinical and pharmacokinetic study of NSC 655649, a rebeccamycin analogue, given in both single-dose and multiple-dose formats.

Journal: Clinical cancer research : an official journal of the American Association for Cancer Research 20020701

Title: Discovery of antitumor indolocarbazoles: rebeccamycin, NSC 655649, and fluoroindolocarbazoles.

Journal: Current medicinal chemistry. Anti-cancer agents 20020301

Title: Phase I and pharmacokinetic study of NSC 655649, a rebeccamycin analog with topoisomerase inhibitory properties.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010601

Title: Phase I clinical and pharmacokinetic study of rebeccamycin analog NSC 655649 given daily for five consecutive days.

Journal: Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20010415

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