Name: Name:FKGK 11
Brand: AABLOCKS
SKU: AA008SP2
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008SP2

Chemical Name: FKGK 11

CAS Number: 1071000-98-0

Molecular Formula: C13H13F5O

Molecular Weight: 280.2337

MDL Number: MFCD18382097

SMILES: O=C(C(C(F)(F)F)(F)F)CCCCc1ccccc1

Properties

Complexity: 292

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 0

Formal Charge: 0

Heavy Atom Count: 19

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 0

Isotope Atom Count: 0

Rotatable Bond Count: 6

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.5

Literature fold

Title: Group VIA phospholipase A2 is a target for vasopressin signaling in the thick ascending limb.

Journal: American journal of physiology. Renal physiology20120401

Title: Combination therapy of an inhibitor of group VIA phospholipase A2 with paclitaxel is highly effective in blocking ovarian cancer development.

Journal: The American journal of pathology20110701

Title: Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2.

Journal: Journal of medicinal chemistry20100513

Title: Synthesis of polyfluoro ketones for selective inhibition of human phospholipase A2 enzymes.

Journal: Journal of medicinal chemistry20081225

Title: Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury.

Journal: Brain : a journal of neurology20081001

Title: Kokotos G, et al. Potent and selective fluoroketone inhibitors of group VIA calcium-independent phospholipase A2. J Med Chem. 2010 May 13;53(9):3602-10.

Title: Yan Xu, et al. Abstract 3525: Targeting Group VIA phospholipase A2 using small molecules for ovarian cancer treatment. Cancer Res (2011) 71 (8_Supplement): 3525.

Title: López-Vales R, et al. Intracellular phospholipase A(2) group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury. Brain. 2008 Oct;131(Pt 10):2620-31.

1071000-98-0 | FKGK 11