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1105698-15-4,MFCD12912446
Catalog No.:AA008SPP

1105698-15-4 | Salermide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$7.00   $5.00
- +
5mg
98%
in stock  
$12.00   $8.00
- +
10mg
98%
in stock  
$17.00   $12.00
- +
25mg
98%
in stock  
$28.00   $20.00
- +
50mg
98%
in stock  
$46.00   $32.00
- +
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Upstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008SPP
Chemical Name:
Salermide
CAS Number:
1105698-15-4
Molecular Formula:
C26H22N2O2
Molecular Weight:
394.4651
MDL Number:
MFCD12912446
SMILES:
O=C(C(c1ccccc1)C)Nc1cccc(c1)NC=C1C(=O)C=Cc2c1cccc2
Properties
Computed Properties
 
Complexity:
586  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
30  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
5  
Undefined Atom Stereocenter Count:
1  
XLogP3:
5.5  

Upstream Synthesis Route

[1]JournalofMedicinalChemistry,2012,vol.55,#24,p.10937-10947

[1]JournalofMedicinalChemistry,2012,vol.55,#24,p.10937-10947

Literature

Title: Antiasthmatic effects of resveratrol in ovalbumin-induced asthma model mice involved in the upregulation of PTEN.

Journal: Biological & pharmaceutical bulletin 20150101

Title: Resveratrol reverses monocrotaline-induced pulmonary vascular and cardiac dysfunction: a potential role for atrogin-1 in smooth muscle.

Journal: Vascular pharmacology 20120101

Title: SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2.

Journal: Molecular cancer therapeutics 20100401

Title: Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

Journal: Oncogene 20090212

Title: Lara E, et al. Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect. Oncogene. 2009 Feb 12;28(6):781-91.

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SDS
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