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1135695-98-5,MFCD08669741
Catalog No.:AA008SQ2

1135695-98-5 | Q-VD-Oph

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1mg
97%
in stock  
$25.00   $18.00
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10mg
97%
in stock  
$93.00   $65.00
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25mg
97%
in stock  
$156.00   $110.00
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50mg
97%
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$248.00   $174.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008SQ2
Chemical Name:
Q-VD-Oph
CAS Number:
1135695-98-5
Molecular Formula:
C26H25F2N3O6
Molecular Weight:
513.4900
MDL Number:
MFCD08669741
SMILES:
OC(=O)CC(C(=O)COc1c(F)cccc1F)NC(=O)C(C(C)C)NC(=O)c1ccc2c(n1)cccc2
Properties
Computed Properties
 
Complexity:
818  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
11  
XLogP3:
3.7  

Literature

Title: The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques.

Journal: The Journal of clinical investigation 20180402

Title: 3-Monochloro-1,2-propanediol (3-MCPD) induces apoptosis via mitochondrial oxidative phosphorylation system impairment and the caspase cascade pathway.

Journal: Toxicology 20161130

Title: An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death.

Journal: The Journal of biological chemistry 20150821

Title: Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.

Journal: Breast cancer research and treatment 20130101

Title: Differential effects of the autophagy inhibitors 3-methyladenine and chloroquine on spontaneous and TNF-α-induced neutrophil apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20121001

Title: The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

Journal: Leukemia research 20120701

Title: Calpain activation is involved in acute manganese neurotoxicity in the rat striatum in vivo.

Journal: Experimental neurology 20120101

Title: Radiolabeled isatin binding to caspase-3 activation induced by anti-Fas antibody.

Journal: Nuclear medicine and biology 20120101

Title: Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes.

Journal: Journal of cellular biochemistry 20111101

Title: Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway.

Journal: Cancer letters 20111001

Title: Multiple caspases mediate acute renal cell apoptosis induced by bacterial cell wall components.

Journal: Renal failure 20110101

Title: Caspase activation is not required for villous cytotrophoblast fusion into syncytiotrophoblasts.

Journal: Placenta 20101101

Title: Mitochondrial remodeling following fission inhibition by 15d-PGJ2 involves molecular changes in mitochondrial fusion protein OPA1.

Journal: Biochemical and biophysical research communications 20100903

Title: Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines.

Journal: Toxicology and applied pharmacology 20100501

Title: Macrophage response to apoptotic cells varies with the apoptotic trigger and is not altered by a deficiency in LRP expression.

Journal: Journal of innate immunity 20100401

Title: The small 11 kDa nonstructural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells.

Journal: Blood 20100204

Title: Contractile response of norepinephrine is modulated by caspase-3 in adult rat ventricular myocytes isolated from septic rat heart.

Journal: Pharmacological research 20091001

Title: Sex differences in caspase activation after stroke.

Journal: Stroke 20090501

Title: Modulation of caspase-independent cell death leads to resensitization of imatinib mesylate-resistant cells.

Journal: Cancer research 20090401

Title: Small-molecule activation of neuronal cell fate.

Journal: Nature chemical biology 20080701

Title: Enteropathogenic E. coli-induced barrier function alteration is not a consequence of host cell apoptosis.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20080501

Title: Straw blood cell count, growth, inhibition and comparison to apoptotic bodies.

Journal: BMC cell biology 20080101

Title: Influence of pan-caspase inhibitors on coxsackievirus B3-infected CD19+ B lymphocytes.

Journal: Apoptosis : an international journal on programmed cell death 20070901

Title: Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury.

Journal: Journal of applied physiology (Bethesda, Md. : 1985) 20070701

Title: Novel molecular imaging of cell death in experimental cerebral stroke.

Journal: Brain research 20070504

Title: Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia.

Journal: Cell death and differentiation 20070401

Title: Broad-spectrum caspase inhibitors: from myth to reality?

Journal: Cell death and differentiation 20070201

Title: Caspase inhibition blocks cell death and results in cell cycle arrest in cytokine-deprived hematopoietic cells.

Journal: The Journal of biological chemistry 20070126

Title: Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action.

Journal: Experimental eye research 20061101

Title: 7-Bromoindirubin-3'-oxime induces caspase-independent cell death.

Journal: Oncogene 20061012

Title: Caspases and calpain are independent mediators of cisplatin-induced endothelial cell necrosis.

Journal: American journal of physiology. Renal physiology 20060901

Title: Copper-induced stimulation of extracellular signal-regulated kinase in trout hepatocytes: the role of reactive oxygen species, Ca2+, and cell energetics and the impact of extracellular signal-regulated kinase signaling on apoptosis and necrosis.

Journal: Toxicological sciences : an official journal of the Society of Toxicology 20060801

Title: Motexafin gadolinium induces mitochondrially-mediated caspase-dependent apoptosis.

Journal: Apoptosis : an international journal on programmed cell death 20051001

Title: Functional role of caspases in heat-induced testicular germ cell apoptosis.

Journal: Biology of reproduction 20050301

Title: A novel systemically active caspase inhibitor attenuates the toxicities of MPTP, malonate, and 3NP in vivo.

Journal: Neurobiology of disease 20041101

Title: Q-VD-OPh, next generation caspase inhibitor.

Journal: Advances in experimental medicine and biology 20040101

Title: Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties.

Journal: Apoptosis : an international journal on programmed cell death 20030801

Title: Neutrophil-independent mechanisms of caspase-1- and IL-18-mediated ischemic acute tubular necrosis in mice.

Journal: The Journal of clinical investigation 20021015

Title: Rohn TT, et al. Caspase activation in transgenic mice with Alzheimer-like pathology: results from a pilot study utilizing the caspase inhibitor, Q-VD-OPh. Int J Clin Exp Med. 2009 Nov 5;2(4):300-8.

Title: Kuzelová K, et al. Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes. J Cell Biochem. 2011 Nov;112(11):3334-42.

Title: Caserta TM, et al. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis. 2003 Aug;8(4):345-52.

Title: Chen-Deutsch X, et al. Leuk Res. 2012 Jul;36(7):884-8.The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells.

Title: Laforge M, et al. The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-infected rhesus macaques. J Clin Invest. 2018 Apr 2;128(4):1627-1640.

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