Title: INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis.
Journal: Biochemical and biophysical research communications 20180903
Title: TGR5, Not Only a Metabolic Regulator.
Journal: Frontiers in physiology 20160101
Title: Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells.
Journal: Biochemical and biophysical research communications 20121026
Title: TGR5 potentiates GLP-1 secretion in response to anionic exchange resins.
Journal: Scientific reports 20120101
Title: TGR5 activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading.
Journal: Cell metabolism 20111207
Title: Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO⁻₃ output.
Journal: Hepatology (Baltimore, Md.) 20111001
Title: The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
Journal: Molecular endocrinology (Baltimore, Md.) 20110601
Title: Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity.
Journal: Journal of medicinal chemistry 20091224
Title: TGR5-mediated bile acid sensing controls glucose homeostasis.
Journal: Cell metabolism 20090901
Title: Pellicciari R, et al. Discovery of 6alpha-ethyl-23(S)-methylcholic acid (S-EMCA, INT-777) as a potent and selective agonist for the TGR5 receptor, a novel target for diabesity. J Med Chem. 2009 Dec 24;52(24):7958-61.
Title: Thomas C, et al. TGR5-mediated bile acid sensing controls glucose homeostasis. Cell Metab. 2009 Sep;10(3):167-77.
Title: Duboc H, et al.Reduction of epithelial secretion in male rat distal colonic mucosa by bile acid receptor TGR5 agonist, INT-777: role of submucosal neurons. Neurogastroenterol Motil. 2016 Jun 3. doi: 10.1111/nmo.
Title: Baiqiang Li, et al. INT-777, a bile acid receptor agonist, extenuates pancreatic acinar cells necrosis in a mouse model of acute pancreatitis. Biochem Biophys Res Commun. 2018 Sep 3;503(1):38-44.
