103878-84-8,MFCD20488051
Catalog No.:AA008SQE

103878-84-8 | LAZABEMIDE

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5mg
≥95%
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10mg
≥95%
in stock  
$89.00   $62.00
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50mg
≥95%
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$363.00   $254.00
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  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008SQE
Chemical Name:
LAZABEMIDE
CAS Number:
103878-84-8
Molecular Formula:
C8H10ClN3O
Molecular Weight:
199.6375
MDL Number:
MFCD20488051
SMILES:
NCCNC(=O)c1ccc(cn1)Cl
Properties
Computed Properties
 
Complexity:
177  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
3  
XLogP3:
0.2  

Literature

Title: Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.

Journal: Journal of medicinal chemistry 20111208

Title: Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20111201

Title: Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.

Journal: Brain research 20110125

Title: Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.

Journal: European journal of pharmacology 20100710

Title: Molecular dynamics, flexible docking, virtual screening, ADMET predictions, and molecular interaction field studies to design novel potential MAO-B inhibitors.

Journal: Journal of biomolecular structure & dynamics 20080201

Title: Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.

Journal: Journal of neurochemistry 20060301

Title: Effect of co-administration of subchronic lithium pretreatment and acute MAO inhibitors on extracellular monoamine levels and the expression of contextual conditioned fear in rats.

Journal: European journal of pharmacology 20060227

Title: Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.

Journal: Bioorganic & medicinal chemistry letters 20051015

Title: Characterisation of imidazoline I2 binding sites in pig brain.

Journal: European journal of pharmacology 20050905

Title: High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.

Journal: European journal of pharmacology 20050822

Title: Monoamine oxidase B inhibitors for early Parkinson's disease.

Journal: The Cochrane database of systematic reviews 20050720

Title: Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei.

Journal: Brain research 20050510

Title: Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.

Journal: British journal of pharmacology 20041201

Title: Clinical trials of neuroprotection for Parkinson's disease.

Journal: Neurology 20041012

Title: SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.

Journal: The Journal of pharmacology and experimental therapeutics 20040901

Title: Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex.

Journal: Life sciences 20030711

Title: Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression.

Journal: Journal of psychiatric research 20030101

Title: Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation.

Journal: Addiction (Abingdon, England) 20021001

Title: Lifestyle drug market booming.

Journal: Nature medicine 20020901

Title: Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO).

Journal: Journal of neural transmission (Vienna, Austria : 1996) 20020301

Title: Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.

Journal: European journal of pharmacology 20010518

Title: Antioxidant activity of the monoamine oxidase B inhibitor lazabemide.

Journal: Biochemical pharmacology 20000901

Title: Safety study of lazabemide (Ro19-6327), a new MAO-B inhibitor, on cardiac arrhythmias and blood pressure of patients with Parkinson's disease.

Journal: Clinical neuropharmacology 19990101

Title: Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy.

Journal: Journal of neurochemistry 19970301

Title: Effect of lazabemide on the progression of disability in early Parkinson's disease. The Parkinson Study Group.

Journal: Annals of neurology 19960701

Title: Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry.

Journal: Neuroscience 19960201

Title: Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.

Journal: Neuroscience 19940901

Title: Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings.

Journal: Journal of neural transmission. Supplementum 19940101

Title: Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327.

Journal: Neurology 19931001

Title: Ro 19-6327, a reversible and highly selective monoamine, oxidase B inhibitor: a novel tool to explore the MAO-B function in humans.

Journal: Advances in neurology 19900101

Title: Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J Neurosci. 1992 May;12(5):1977-99.

Title: Bondiolotti GP, et al. In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem Pharmacol. 1995 Jun 29;50(1):97-102.

Title: Guimaraes J, et al. The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998;62(8):727-37.

Title: Suzuki T, et al. MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Pharmacology. 1995 Jun;50(6):357-62.

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SDS
Tags:103878-84-8 Molecular Formula|103878-84-8 MDL|103878-84-8 SMILES|103878-84-8 LAZABEMIDE
Catalog No.: AA008SQE
103878-84-8,MFCD20488051
103878-84-8 | LAZABEMIDE
Pack Size: 5mg
Purity: ≥95%
in stock
$48.00 $33.00
Pack Size: 10mg
Purity: ≥95%
in stock
$89.00 $62.00
Pack Size: 50mg
Purity: ≥95%
in stock
$363.00 $254.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008SQE
Chemical Name: LAZABEMIDE
CAS Number: 103878-84-8
Molecular Formula: C8H10ClN3O
Molecular Weight: 199.6375
MDL Number: MFCD20488051
SMILES: NCCNC(=O)c1ccc(cn1)Cl
Properties
Complexity: 177  
Covalently-Bonded Unit Count: 1  
Heavy Atom Count: 13  
Hydrogen Bond Acceptor Count: 3  
Hydrogen Bond Donor Count: 2  
Rotatable Bond Count: 3  
XLogP3: 0.2  
Literature fold

Title: Novel reversible monoamine oxidase A inhibitors: highly potent and selective 3-(1H-pyrrol-3-yl)-2-oxazolidinones.

Journal: Journal of medicinal chemistry20111208

Title: Pharmacological characterization of MRZ-8676, a novel negative allosteric modulator of subtype 5 metabotropic glutamate receptors (mGluR5): focus on L: -DOPA-induced dyskinesia.

Journal: Journal of neural transmission (Vienna, Austria : 1996)20111201

Title: Up-regulation of the isoenzymes MAO-A and MAO-B in the human basal ganglia and pons in Huntington's disease revealed by quantitative enzyme radioautography.

Journal: Brain research20110125

Title: Combined treatment with MAO-A inhibitor and MAO-B inhibitor increases extracellular noradrenaline levels more than MAO-A inhibitor alone through increases in beta-phenylethylamine.

Journal: European journal of pharmacology20100710

Title: Molecular dynamics, flexible docking, virtual screening, ADMET predictions, and molecular interaction field studies to design novel potential MAO-B inhibitors.

Journal: Journal of biomolecular structure & dynamics20080201

Title: Autoradiographical distribution of imidazoline binding sites in monoamine oxidase A deficient mice.

Journal: Journal of neurochemistry20060301

Title: Effect of co-administration of subchronic lithium pretreatment and acute MAO inhibitors on extracellular monoamine levels and the expression of contextual conditioned fear in rats.

Journal: European journal of pharmacology20060227

Title: Docking studies on monoamine oxidase-B inhibitors: estimation of inhibition constants (K(i)) of a series of experimentally tested compounds.

Journal: Bioorganic & medicinal chemistry letters20051015

Title: Characterisation of imidazoline I2 binding sites in pig brain.

Journal: European journal of pharmacology20050905

Title: High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain.

Journal: European journal of pharmacology20050822

Title: Monoamine oxidase B inhibitors for early Parkinson's disease.

Journal: The Cochrane database of systematic reviews20050720

Title: Effects of depression, cigarette smoking, and age on monoamine oxidase B in amygdaloid nuclei.

Journal: Brain research20050510

Title: Locomotor effects of imidazoline I2-site-specific ligands and monoamine oxidase inhibitors in rats with a unilateral 6-hydroxydopamine lesion of the nigrostriatal pathway.

Journal: British journal of pharmacology20041201

Title: Clinical trials of neuroprotection for Parkinson's disease.

Journal: Neurology20041012

Title: SL25.1131 [3(S),3a(S)-3-methoxymethyl-7-[4,4,4-trifluorobutoxy]-3,3a,4,5-tetrahydro-1,3-oxazolo[3,4-a]quinolin-1-one], a new, reversible, and mixed inhibitor of monoamine oxidase-A and monoamine oxidase-B: biochemical and behavioral profile.

Journal: The Journal of pharmacology and experimental therapeutics20040901

Title: Differential substrate specificity of monoamine oxidase in the rat heart and renal cortex.

Journal: Life sciences20030711

Title: Serotonin transporter and MAO-B levels in monoamine nuclei of the human brainstem are normal in major depression.

Journal: Journal of psychiatric research20030101

Title: Lazabemide, a selective, reversible monoamine oxidase B inhibitor, as an aid to smoking cessation.

Journal: Addiction (Abingdon, England)20021001

Title: Lifestyle drug market booming.

Journal: Nature medicine20020901

Title: Inhibition of monoamine oxidase modulates the behaviour of semicarbazide-sensitive amine oxidase (SSAO).

Journal: Journal of neural transmission (Vienna, Austria : 1996)20020301

Title: Anxiolytic effects of aniracetam in three different mouse models of anxiety and the underlying mechanism.

Journal: European journal of pharmacology20010518

Title: Antioxidant activity of the monoamine oxidase B inhibitor lazabemide.

Journal: Biochemical pharmacology20000901

Title: Safety study of lazabemide (Ro19-6327), a new MAO-B inhibitor, on cardiac arrhythmias and blood pressure of patients with Parkinson's disease.

Journal: Clinical neuropharmacology19990101

Title: Increased density of catalytic sites and expression of brain monoamine oxidase A in humans with hepatic encephalopathy.

Journal: Journal of neurochemistry19970301

Title: Effect of lazabemide on the progression of disability in early Parkinson's disease. The Parkinson Study Group.

Journal: Annals of neurology19960701

Title: Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry.

Journal: Neuroscience19960201

Title: Increased monoamine oxidase B activity in plaque-associated astrocytes of Alzheimer brains revealed by quantitative enzyme radioautography.

Journal: Neuroscience19940901

Title: Lazabemide (Ro 19-6327), a reversible and highly sensitive MAO-B inhibitor: preclinical and clinical findings.

Journal: Journal of neural transmission. Supplementum19940101

Title: Monoamine oxidase B (MAO B) inhibitor therapy in Parkinson's disease: the degree and reversibility of human brain MAO B inhibition by Ro 19 6327.

Journal: Neurology19931001

Title: Ro 19-6327, a reversible and highly selective monoamine, oxidase B inhibitor: a novel tool to explore the MAO-B function in humans.

Journal: Advances in neurology19900101

Title: Saura J, et al. Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19-6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain. J Neurosci. 1992 May;12(5):1977-99.

Title: Bondiolotti GP, et al. In vitro effects on monoamine uptake and release by the reversible monoamine oxidase-B inhibitors lazabemide and N-(2-aminoethyl)-p-chlorobenzamide: a comparison with L-deprenyl. Biochem Pharmacol. 1995 Jun 29;50(1):97-102.

Title: Guimaraes J, et al. The activity of MAO A and B in rat renal cells and tubules. Life Sci. 1998;62(8):727-37.

Title: Suzuki T, et al. MAO inhibitors, clorgyline and lazabemide, prevent hydroxyl radical generation caused by brain ischemia/reperfusion in mice. Pharmacology. 1995 Jun;50(6):357-62.

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