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1035227-43-0,MFCD28044083
Catalog No.:AA008TAV

1035227-43-0 | AZ505

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$79.00   $55.00
- +
5mg
≥95%
in stock  
$282.00   $197.00
- +
10mg
>98% (or refer to the Certificate of Analysis)
in stock  
$504.00   $353.00
- +
25mg
>98% (or refer to the Certificate of Analysis)
in stock  
$1,040.00   $728.00
- +
50mg
>98% (or refer to the Certificate of Analysis)
in stock  
$1,754.00   $1,228.00
- +
100mg
>98% (or refer to the Certificate of Analysis)
in stock  
$3,004.00   $2,103.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TAV
Chemical Name:
AZ505
CAS Number:
1035227-43-0
Molecular Formula:
C29H38Cl2N4O4
Molecular Weight:
577.5424
MDL Number:
MFCD28044083
SMILES:
O=C1COc2c(N1)c(O)ccc2CCNCCN(C(=O)CCNCCc1ccc(c(c1)Cl)Cl)C1CCCCC1
Properties
Computed Properties
 
Complexity:
772  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
13  
XLogP3:
4.4  

Literature

Title: Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2.

Journal: Journal of medicinal chemistry 20160526

Title: Oncoepigenomics: making histone lysine methylation count.

Journal: European journal of medicinal chemistry 20121001

Title: Structural basis of substrate methylation and inhibition of SMYD2.

Journal: Structure (London, England : 1993) 20110907

Title: Komatsu S, et al. Overexpression of SMYD2 contributes to malignant outcome in gastric cancer. Br J Cancer. 2015 Jan 20;112(2):357-64.

Title: Ferguson AD, et al. Structural basis of substrate methylation and inhibition of SMYD2. Structure. 2011 Sep 7;19(9):1262-73.

Title: Li LX, et al. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. J Clin Invest. 2017 Jun 30;127(7):2751-2764.

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