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1174043-16-3,MFCD24386811
Catalog No.:AA008TAY

1174043-16-3 | AZD2461

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98+%
in stock  
$17.00   $12.00
- +
5mg
98+%
in stock  
$44.00   $31.00
- +
10mg
98+%
in stock  
$61.00   $43.00
- +
25mg
98+%
in stock  
$102.00   $71.00
- +
50mg
98+%
in stock  
$143.00   $100.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TAY
Chemical Name:
AZD2461
CAS Number:
1174043-16-3
Molecular Formula:
C22H22FN3O3
Molecular Weight:
395.4268
MDL Number:
MFCD24386811
SMILES:
COC1CCN(CC1)C(=O)c1cc(ccc1F)Cc1n[nH]c(=O)c2c1cccc2
Properties
Computed Properties
 
Complexity:
647  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  
XLogP3:
2.6  

Literature

Title: Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors.

Journal: Cancer discovery 20130101

Title: Clinical perspectives of PARP inhibitors.

Journal: Pharmacological research 20050701

Title: Oplustil O'Connor L, et al. The PARP Inhibitor AZD2461 Provides Insights into the Role of PARP3 Inhibition for Both Synthetic Lethality and Tolerability with Chemotherapy in Preclinical Models. Cancer Res. 2016 Oct 15;76(20):6084-6094. Epub 2016 Aug 22.

Title: Węsierska-Gądek J, et al. Differential Potential of Pharmacological PARP Inhibitors for Inhibiting Cell Proliferation and Inducing Apoptosis in Human Breast Cancer Cells. J Cell Biochem. 2015 Dec;116(12):2824-39.

Title: Jaspers JE, et al. Loss of 53BP1 causes PARP inhibitor resistance in Brca1-mutated mouse mammary tumors. Cancer Discov. 2013 Jan;3(1):68-81.

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