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1198300-79-6,MFCD28167811
Catalog No.:AA008TC9

1198300-79-6 | Cerdulatinib

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$16.00   $11.00
- +
5mg
98%
in stock  
$41.00   $29.00
- +
10mg
98%
in stock  
$61.00   $43.00
- +
50mg
98%
in stock  
$161.00   $113.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TC9
Chemical Name:
Cerdulatinib
CAS Number:
1198300-79-6
Molecular Formula:
C20H27N7O3S
Molecular Weight:
445.5385
MDL Number:
MFCD28167811
SMILES:
CCS(=O)(=O)N1CCN(CC1)c1ccc(cc1)Nc1ncc(c(n1)NC1CC1)C(=O)N
Properties
Computed Properties
 
Complexity:
711  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
31  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
8  
XLogP3:
1.9  

Downstream Synthesis Route

[1]Patent:WO2019/213606,2019,A2

611400-14-7   
C9H12N4OS 
  1198300-79-6 

[1]Patent:WO2019/213606,2019,A2.Locationinpatent:Page/Pagecolumn0414;0417-0422

1198300-79-6   
4-(cyclopropylamino)-2-({4-4-(ethylsulfonyl)piperazin-1-ylphenyl}amino)pyrimidine-5-carboxamidehydrochloride 

[1]Patent:WO2019/213606,2019,A2.Locationinpatent:Paragraph0414;0423;0431;0448

1198300-79-6   
C20H27N7O3S*1.5ClH 

[1]Patent:WO2019/213606,2019,A2.Locationinpatent:Paragraph0414;0425

Literature

Title: The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer.

Journal: The Journal of pharmacology and experimental therapeutics 20141201

Title: Guo A, et al. Dual SYK/JAK inhibition overcomes ibrutinib resistance in chronic lymphocytic leukemia: Cerdulatinib, but not ibrutinib, induces apoptosis of tumor cells protected by the microenvironment. Oncotarget. 2017 Feb 21;8(8):12953-12967.

Title: Coffey G, et al. The novel kinase inhibitor PRT062070 (Cerdulatinib) demonstrates efficacy in models of autoimmunity and B-cell cancer. J Pharmacol Exp Ther. 2014 Dec;351(3):538-48.

Title: Ma J, et al. Cerdulatinib, a novel dual SYK/JAK kinase inhibitor, has broad anti-tumor activity in both ABC and GCB types of diffuse large B cell lymphoma. Oncotarget. 2015 Dec 22;6(41):43881-96.

Title: Blunt MD, et al. The Dual Syk/JAK Inhibitor Cerdulatinib Antagonizes B-cell Receptor and Microenvironmental Signaling in Chronic Lymphocytic Leukemia. Clin Cancer Res. 2017 May 1;23(9):2313-2324.

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