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Home Fluorides 1181770-72-8
1181770-72-8,MFCD25541743
Catalog No.:AA008TCZ

1181770-72-8 | N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$80.00   $56.00
- +
5mg
≥98%
in stock  
$345.00   $241.00
- +
10mg
≥98%
in stock  
$613.00   $429.00
- +
25mg
≥98%
in stock  
$1,338.00   $936.00
- +
50mg
98%
in stock  
$1,541.00   $1,079.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TCZ
Chemical Name:
N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide
CAS Number:
1181770-72-8
Molecular Formula:
C18H18F2N2O4
Molecular Weight:
364.3433
MDL Number:
MFCD25541743
SMILES:
CCc1c(ccc(c1C)O)C(=O)NNC(=O)C(c1cc(F)cc(c1)F)O
Properties
Computed Properties
 
Complexity:
498  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
4  
Undefined Atom Stereocenter Count:
1  
XLogP3:
2.8  

Downstream Synthesis Route

[1]Patent:US2011/60050,2011,A1

[1]Patent:US2011/60050,2011,A1

[1]Patent:US2011/60050,2011,A1

[1]Patent:US2011/60050,2011,A1

[1]Patent:US2011/60050,2011,A1.Locationinpatent:Page/Pagecolumn3

Literature

Title: Ackermann TF, et al. EMD638683, a novel SGK inhibitor with antihypertensive potency. Cell Physiol Biochem. 2011;28(1):137-46.

Title: Towhid ST, et al. Inhibition of colonic tumor growth by the selective SGK inhibitor EMD638683. Cell Physiol Biochem. 2013;32(4):838-48.

Title: Xi X, et al. Serum-glucocorticoid regulated kinase 1 regulates macrophage recruitment and activation contributing to monocrotaline-induced pulmonary arterial hypertension. Cardiovasc Toxicol. 2014 Dec;14(4):368-78.

Title: Zhou H, et al. Inhibition of serum- and glucocorticoid-inducible kinase 1 enhances TLR-mediated inflammation and promotes endotoxin-driven organ failure. FASEB J. 2015 Sep;29(9):3737-49.

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SDS
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Tags:1181770-72-8 Molecular Formula|1181770-72-8 MDL|1181770-72-8 SMILES|1181770-72-8 N'-(2-(3,5-difluorophenyl)-2-hydroxyacetyl)-2-ethyl-4-hydroxy-3-methylbenzohydrazide