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1186486-62-3,MFCD23105886
Catalog No.:AA008TDD

1186486-62-3 | Evacetrapib (LY2484595)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
98%
in stock  
$17.00   $12.00
- +
5mg
98%
in stock  
$42.00   $29.00
- +
10mg
98%
in stock  
$63.00   $44.00
- +
100mg
98%
in stock  
$585.00   $409.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TDD
Chemical Name:
Evacetrapib (LY2484595)
CAS Number:
1186486-62-3
Molecular Formula:
C32H37F6N5O2
Molecular Weight:
637.6589
MDL Number:
MFCD23105886
SMILES:
OC(=O)[C@@H]1CC[C@H](CC1)CN1CCC[C@@H](c2c1c(C)cc(c2)C)C(c1nnn(n1)C)Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F
Properties
Computed Properties
 
Complexity:
973  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
7  
XLogP3:
7.7  

Downstream Synthesis Route
C32H38F6N6O2 
  1186486-62-3    1587704-15-1 

[1]OrganicProcessResearchandDevelopment,2014,vol.18,p.546-551

Literature

Title: Recent advances in pharmacotherapy for hypertriglyceridemia.

Journal: Progress in lipid research 20141001

Title: Future of cholesteryl ester transfer protein inhibitors.

Journal: Annual review of medicine 20140101

Title: Rationale for cholesteryl ester transfer protein inhibition.

Journal: Current opinion in lipidology 20120801

Title: Evacetrapib.

Journal: Current cardiology reports 20120601

Title: Design, synthesis and structure-activity-relationship of 1,5-tetrahydronaphthyridines as CETP inhibitors.

Journal: Bioorganic & medicinal chemistry letters 20120501

Title: New focus on raising HDL 'good' cholesterol. But the value of this is not entirely clear.

Journal: DukeMedicine healthnews 20120201

Title: Cholesteryl ester transfer protein inhibitors for dyslipidemia: focus on dalcetrapib.

Journal: Drug design, development and therapy 20120101

Title: [Secondary coronary heart disease prevention. Will CEPT inhibitors be the next breakthrough?].

Journal: MMW Fortschritte der Medizin 20111208

Title: Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure.

Journal: Journal of lipid research 20111201

Title: Effects of the CETP inhibitor evacetrapib administered as monotherapy or in combination with statins on HDL and LDL cholesterol: a randomized controlled trial.

Journal: JAMA 20111116

Title: High-density lipoprotein cholesterol as the Holy Grail.

Journal: JAMA 20111116

Title: Cao G, et al. Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressure. J Lipid Res. 2011 Dec;52(12):2169-76.

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