+1 858-523-8231
Login | Register
menu
AA Blocks, Building Blocks, Catalysts, Inhibitors
Login | Register
1038915-73-9,MFCD28167748
Catalog No.:AA008TFC

1038915-73-9 | Mk-4827 (tosylate)

Pack Size
Purity
Availability
Price(USD)
Quantity
  
5mg
≥98%
in stock  
$66.00   $46.00
- +
10mg
≥98%
in stock  
$119.00   $83.00
- +
25mg
≥98%
in stock  
$213.00   $149.00
- +
50mg
≥98%
in stock  
$362.00   $253.00
- +
100mg
99%
in stock  
$600.00   $420.00
- +
250mg
99%
in stock  
$1,281.00   $897.00
- +
1g
99%
in stock  
$4,456.00   $3,119.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
Technical Information
Catalog Number:
AA008TFC
Chemical Name:
Mk-4827 (tosylate)
CAS Number:
1038915-73-9
Molecular Formula:
C26H28N4O4S
Molecular Weight:
492.5899
MDL Number:
MFCD28167748
SMILES:
NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1.Cc1ccc(cc1)S(=O)(=O)O
Properties
Computed Properties
 
Complexity:
655  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
4  

Literature

Title: Jones P, et al. Discovery of 2-{4-[(3S)-piperidin-3-ylphenyl}-2H-indazole-7-carboxamide (MK-4827): a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors. J Med Chem. 2009 Nov 26;52(22):7170-85.

Title: Bridges KA, et al. Niraparib (MK-4827), a novel poly(ADP-Ribose) polymerase inhibitor, radiosensitizes human lung and breast cancer cells. Oncotarget. 2014 Jul 15;5(13):5076-86.

Title: Wang L, et al. MK-4827, a PARP-1/-2 inhibitor, strongly enhances response of human lung and breast cancer xenografts to radiation. Invest New Drugs. 2012 Dec;30(6):2113-20.

Title: Mirza MR, et al. Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer. N Engl J Med. 2016 Dec 1;375(22):2154-2164.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
Submit
SDS
Related Products of 1038915-73-9
1613220-15-7

1613220-15-7

 1038915-60-4

1038915-60-4

 1038915-58-0

1038915-58-0

 1476777-06-6

1476777-06-6

 1038915-64-8

1038915-64-8

 1038915-75-1

1038915-75-1
Building Blocks
More >
Tags:1038915-73-9 Molecular Formula|1038915-73-9 MDL|1038915-73-9 SMILES|1038915-73-9 Mk-4827 (tosylate)
Catalog No.: AA008TFC
1038915-73-9,MFCD28167748
1038915-73-9 | Mk-4827 (tosylate)
Pack Size： 5mg
Purity： ≥98%
in stock
$66.00 $46.00
Pack Size： 10mg
Purity： ≥98%
in stock
$119.00 $83.00
Pack Size： 25mg
Purity： ≥98%
in stock
$213.00 $149.00
Pack Size： 50mg
Purity： ≥98%
in stock
$362.00 $253.00
Pack Size： 100mg
Purity： 99%
in stock
$600.00 $420.00
Pack Size： 250mg
Purity： 99%
in stock
$1,281.00 $897.00
Pack Size： 1g
Purity： 99%
in stock
$4,456.00 $3,119.00
Quantity
- +
Add to Card
Order Now
bulk Quotation Request
Technical Information
Catalog Number: AA008TFC
Chemical Name: Mk-4827 (tosylate)
CAS Number: 1038915-73-9
Molecular Formula: C26H28N4O4S
Molecular Weight: 492.5899
MDL Number: MFCD28167748
SMILES: NC(=O)c1cccc2c1nn(c2)c1ccc(cc1)[C@@H]1CCCNC1.Cc1ccc(cc1)S(=O)(=O)O
Properties
Complexity: 655  
Covalently-Bonded Unit Count: 2  
Defined Atom Stereocenter Count: 1  
Heavy Atom Count: 35  
Hydrogen Bond Acceptor Count: 6  
Hydrogen Bond Donor Count: 3  
Rotatable Bond Count: 4  
Related Products of of 1038915-73-9
1613220-15-7
1613220-15-7
1038915-60-4
1038915-60-4
1038915-58-0
1038915-58-0
1476777-06-6
1476777-06-6
1038915-64-8
1038915-64-8
1038915-75-1
1038915-75-1
Building Blocks More >
1160521-50-5
1160521-50-5
ITI214 free base
AA008TK3 | MFCD28385866
105093-21-8
105093-21-8
CIPROFLOXACIN PIPERAZINYL-N4-SULFATE
AA008TO8 | MFCD04973582
1029144-49-7
1029144-49-7
Thieno[3,2-d]pyrimidine-4-carboxylic acid
AA008TXX | MFCD17015875
1092961-03-9
1092961-03-9
4-(Bromomethyl)-1-methyl-1H-indazole
AA008U66 | MFCD11052619
1092352-46-9
1092352-46-9
3-Bromoimidazo[1,2-a]pyridin-7-amine
AA008UFU | MFCD11518906
1066-38-2
1066-38-2
Trimethyliodogermane
AA008UQV | MFCD00013700
103896-91-9
103896-91-9
2-(2,5-Dimethylphenoxy)acetohydrazide
AA008V0J | MFCD02288788
107890-32-4
107890-32-4
1-[4-(Trifluoromethyl)benzyl]piperazine
AA008V74 | MFCD03407490
112091-27-7
112091-27-7
Ethyl chloro[2-(4-chloro-2-nitrophenyl)hydrazono]acetate
AA008VB7 | MFCD06200942
1123169-25-4
1123169-25-4
6-Bromo-2-methyl-3(2h)-pyridazinone
AA008VHU | MFCD12198437
Submit
© 2017 AA BLOCKS, INC. All rights reserved.