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1041434-82-5,MFCD09837902
Catalog No.:AA008TG3

1041434-82-5 | Peramivir trihydrate

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10mg
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$7.00   $5.00
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50mg
98%
in stock  
$14.00   $10.00
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250mg
98%
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$22.00   $15.00
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1g
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  • Technical Information
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TG3
Chemical Name:
Peramivir trihydrate
CAS Number:
1041434-82-5
Molecular Formula:
C15H34N4O7
Molecular Weight:
382.4531
MDL Number:
MFCD09837902
SMILES:
CCC([C@@H]([C@H]1[C@H](NC(=N)N)C[C@@H]([C@H]1O)C(=O)O)NC(=O)C)CC.O.O.O
Properties
Computed Properties
 
Complexity:
460  
Covalently-Bonded Unit Count:
4  
Defined Atom Stereocenter Count:
5  
Heavy Atom Count:
26  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
8  
Rotatable Bond Count:
7  

Literature

Title: Absence of pharmacokinetic interaction between intravenous peramivir and oral oseltamivir or rimantadine in humans.

Journal: Journal of clinical pharmacology 20120901

Title: Recent advances in neuraminidase inhibitor development as anti-influenza drugs.

Journal: ChemMedChem 20120901

Title: Efficacy of a single intravenous dose of the neuraminidase inhibitor peramivir in the treatment of equine influenza.

Journal: Veterinary journal (London, England : 1997) 20120801

Title: In vitro neuraminidase inhibitory activities of four neuraminidase inhibitors against influenza viruses isolated in the 2010-2011 season in Japan.

Journal: Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20120801

Title: In vitro passaging of a pandemic H1N1/09 virus selects for viruses with neuraminidase mutations conferring high-level resistance to oseltamivir and peramivir, but not to zanamivir.

Journal: The Journal of antimicrobial chemotherapy 20120801

Title: Editorial commentary: What did we learn from the emergency use authorization of peramivir in 2009?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120701

Title: Emergency use authorization for intravenous peramivir: evaluation of safety in the treatment of hospitalized patients infected with 2009 H1N1 influenza A virus.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120701

Title: Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under emergency use authorization, October 2009-June 2010.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120701

Title: Neuropathology of H5N1 virus infection in ferrets.

Journal: Veterinary microbiology 20120504

Title: Combinations of favipiravir and peramivir for the treatment of pandemic influenza A/California/04/2009 (H1N1) virus infections in mice.

Journal: Antiviral research 20120401

Title: Peramivir for the treatment of influenza.

Journal: Expert review of anti-infective therapy 20120201

Title: Use of intravenous peramivir for treatment of severe influenza A(H1N1)pdm09.

Journal: PloS one 20120101

Title: Drugs: Lines of defence.

Journal: Nature 20111207

Title: The de-guanidinylated derivative of peramivir remains a potent inhibitor of influenza neuraminidase.

Journal: Bioorganic & medicinal chemistry letters 20111201

Title: Pharmacokinetic assessment of peramivir in a hospitalized adult undergoing continuous venovenous hemofiltration.

Journal: The Annals of pharmacotherapy 20111201

Title: [Clinical efficiency in children treated with intravenous drip infusion of peramivir].

Journal: The Japanese journal of antibiotics 20111201

Title: Influenza B viruses with mutation in the neuraminidase active site, North Carolina, USA, 2010-11.

Journal: Emerging infectious diseases 20111101

Title: Characterization of the binding affinities of peramivir and oseltamivir carboxylate to the neuraminidase enzyme.

Journal: Antiviral research 20110901

Title: Postpartum pharmacokinetics of peramivir in the treatment of 2009 H1N1 influenza.

Journal: Obstetrics and gynecology 20110801

Title: Use of intravenous neuraminidase inhibitors during the 2009 pandemic: results from population-based surveillance.

Journal: JAMA 20110713

Title: A single intramuscular injection of neuraminidase inhibitor peramivir demonstrates antiviral activity against novel pandemic A/California/04/2009 (H1N1) influenza virus infection in mice.

Journal: Antiviral research 20110401

Title: Clinical experience in adults and children treated with intravenous peramivir for 2009 influenza A (H1N1) under an Emergency IND program in the United States.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110315

Title: Peramivir: another tool for influenza treatment?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110315

Title: Successful salvage therapy with inhaled zanamivir in a patient with peramivir-resistant pandemic influenza A (H1N1) 2009 virus.

Journal: Scandinavian journal of infectious diseases 20110201

Title: The emergency use authorization of peramivir IV: a view from the manufacturer.

Journal: Clinical pharmacology and therapeutics 20110201

Title: Generation and characterization of recombinant pandemic influenza A(H1N1) viruses resistant to neuraminidase inhibitors.

Journal: The Journal of infectious diseases 20110101

Title: Economic model for emergency use authorization of intravenous peramivir.

Journal: The American journal of managed care 20110101

Title: Real time enzyme inhibition assays provide insights into differences in binding of neuraminidase inhibitors to wild type and mutant influenza viruses.

Journal: PloS one 20110101

Title: Synergistic effects in the designs of neuraminidase ligands: analysis from docking and molecular dynamics studies.

Journal: Journal of theoretical biology 20101207

Title: Combination of peramivir and rimantadine demonstrate synergistic antiviral effects in sub-lethal influenza A (H3N2) virus mouse model.

Journal: Antiviral research 20101201

Title: Early emergence of an H275Y mutation in a hematopoietic cell transplant recipient treated with intravenous peramivir.

Journal: Transplant infectious disease : an official journal of the Transplantation Society 20101201

Title: A fourth scale sensitive to the magnetic field; intermolecular frequency symmetry in a specific interaction between protein and low-molecular compound.

Journal: Chemical & pharmaceutical bulletin 20101201

Title: The role of clinical pharmacology in supporting the emergency use authorization of an unapproved anti-influenza drug, peramivir.

Journal: Clinical pharmacology and therapeutics 20101101

Title: Peramivir for severe influenza infection in a patient with diabetic nephropathy.

Journal: American journal of respiratory and critical care medicine 20101101

Title: Combinations of oseltamivir and peramivir for the treatment of influenza A (H1N1) virus infections in cell culture and in mice.

Journal: Antiviral research 20101001

Title: Peramivir pharmacokinetics in two critically ill adults with 2009 H1N1 influenza A concurrently receiving continuous renal replacement therapy.

Journal: Pharmacotherapy 20101001

Title: Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses.

Journal: Journal of medicinal chemistry 20100909

Title: [Current anti-influenza virus chemotherapy].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20100901

Title: Treatment options for H5N1: lessons learned from the H1N1 pandemic.

Journal: Postgraduate medicine 20100901

Title: Peramivir clearance in continuous renal replacement therapy.

Journal: Hemodialysis international. International Symposium on Home Hemodialysis 20100701

Title: Targeting pandemic influenza: a primer on influenza antivirals and drug resistance.

Journal: The Journal of antimicrobial chemotherapy 20100601

Title: Peramivir and its use in H1N1 influenza.

Journal: Drugs of today (Barcelona, Spain : 1998) 20100601

Title: Respiratory failure caused by 2009 novel influenza A/H1N1 in a hematopoietic stem-cell transplant recipient: Detection of extrapulmonary H1N1 RNA and use of intravenous peramivir.

Journal: Annals of internal medicine 20100504

Title: Rapid selection of oseltamivir- and peramivir-resistant pandemic H1N1 virus during therapy in 2 immunocompromised hosts.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20100501

Title: Losing the opportunity to study influenza drugs.

Journal: JAMA 20100303

Title: [Research progress of anti-influenza virus agents].

Journal: Yao xue xue bao = Acta pharmaceutica Sinica 20100301

Title: Host cell selection of influenza neuraminidase variants: implications for drug resistance monitoring in A(H1N1) viruses.

Journal: Antiviral research 20100201

Title: [Emergency admission of peramivir in the U.S.A].

Journal: Pharmazie in unserer Zeit 20100101

Title: Intravenous peramivir emergency use authorization 2009: update for the clinical nurse specialist.

Journal: Clinical nurse specialist CNS 20100101

Title: Peramivir: an intravenous neuraminidase inhibitor for the treatment of 2009 H1N1 influenza.

Journal: The Annals of pharmacotherapy 20100101

Title: Pandemic (H1N1) 2009-associated ARDS rescued by neuraminidase inhibitors with emergency use of extracorporeal membrane oxygenation.

Journal: Internal medicine (Tokyo, Japan) 20100101

Title: Fulminant fatal swine influenza (H1N1): Myocarditis, myocardial infarction, or severe influenza pneumonia?

Journal: Heart & lung : the journal of critical care 20100101

Title: Comprehensive assessment of 2009 pandemic influenza A (H1N1) virus drug susceptibility in vitro.

Journal: Antiviral therapy 20100101

Title: Successful management of fulminant influenza A subtype H1N1 myocarditis.

Journal: BMJ case reports 20100101

Title: Emergency-use authorization of peramivir.

Journal: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20091215

Title: The Emergency Use Authorization of peramivir for treatment of 2009 H1N1 influenza.

Journal: The New England journal of medicine 20091203

Title: Dynamic behavior of avian influenza A virus neuraminidase subtype H5N1 in complex with oseltamivir, zanamivir, peramivir, and their phosphonate analogues.

Journal: Journal of chemical information and modeling 20091001

Title: Emergence and spread of oseltamivir-resistant A(H1N1) influenza viruses in Oceania, South East Asia and South Africa.

Journal: Antiviral research 20090701

Title: Quantification of peramivir (a novel anti-influenza drug) in human plasma by hydrophilic interaction chromatography/tandem mass spectrometry.

Journal: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090401

Title: Developing new antiviral agents for influenza treatment: what does the future hold?

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20090101

Title: Development and validation of a high-throughput zwitterionic hydrophilic interaction liquid chromatography solid-phase extraction-liquid chromatography-tandem mass spectrometry method for determination of the anti-influenza drug peramivir in plasma.

Journal: Journal of chromatography. A 20081226

Title: Intramuscularly administered neuraminidase inhibitor peramivir is effective against lethal H5N1 influenza virus in mice.

Journal: Antiviral research 20081101

Title: Understanding of known drug-target interactions in the catalytic pocket of neuraminidase subtype N1.

Journal: Proteins 20080601

Title: Injectable peramivir mitigates disease and promotes survival in ferrets and mice infected with the highly virulent influenza virus, A/Vietnam/1203/04 (H5N1).

Journal: Virology 20080425

Title: Neuraminidase inhibitor resistance in influenza viruses.

Journal: Journal of medical virology 20071001

Title: Characterization of drug-resistant recombinant influenza A/H1N1 viruses selected in vitro with peramivir and zanamivir.

Journal: Antiviral research 20070501

Title: Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.

Journal: Antiviral research 20070301

Title: Characterization of multidrug-resistant influenza A/H3N2 viruses shed during 1 year by an immunocompromised child.

Journal: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20061215

Title: [Peramivir. A new and potent neuraminidase inhibitor for the treatment of influenza].

Journal: Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20061201

Title: Evaluation of methyl inosine monophosphate (MIMP) and peramivir activities in a murine model of lethal influenza A virus infection.

Journal: Antiviral research 20060801

Title: Anti-influenza virus activity of peramivir in mice with single intramuscular injection.

Journal: Antiviral research 20060101

Title: Impact of neuraminidase mutations conferring influenza resistance to neuraminidase inhibitors in the N1 and N2 genetic backgrounds.

Journal: Antiviral therapy 20060101

Title: Comparison of the anti-influenza virus activity of cyclopentane derivatives with oseltamivir and zanamivir in vivo.

Journal: Bioorganic & medicinal chemistry 20050602

Title: Efficacy and tolerability of the oral neuraminidase inhibitor peramivir in experimental human influenza: randomized, controlled trials for prophylaxis and treatment.

Journal: Antiviral therapy 20050101

Title: A reverse genetics study of resistance to neuraminidase inhibitors in an influenza A/H1N1 virus.

Journal: Antiviral therapy 20040801

Title: Identification of a human influenza type B strain with reduced sensitivity to neuraminidase inhibitor drugs.

Journal: Virus research 20040701

Title: Inhibition of influenza virus infections in immunosuppressed mice with orally administered peramivir (BCX-1812).

Journal: Antiviral research 20030901

Title: Stereoselective total synthesis of racemic BCX-1812 (RWJ-270201) for the development of neuraminidase inhibitors as anti-influenza agents.

Journal: The Journal of organic chemistry 20030822

Title: A point mutation in influenza B neuraminidase confers resistance to peramivir and loss of slow binding.

Journal: Antiviral research 20030601

Title: Population analysis of the pharmacokinetics and pharmacodynamics of RWJ-270201 (BCX-1812) in treating experimental influenza A and B virus in healthy volunteers.

Journal: AAPS pharmSci 20021201

Title: A release-competent influenza A virus mutant lacking the coding capacity for the neuraminidase active site.

Journal: The Journal of general virology 20021101

Title: Peramivir (BCX-1812, RWJ-270201): potential new therapy for influenza.

Journal: Expert opinion on investigational drugs 20020601

Title: Susceptibility of recent Canadian influenza A and B virus isolates to different neuraminidase inhibitors.

Journal: Antiviral research 20020601

Title: Structural studies of the resistance of influenza virus neuramindase to inhibitors.

Journal: Journal of medicinal chemistry 20020523

Title: Combination treatment of influenza A virus infections in cell culture and in mice with the cyclopentane neuraminidase inhibitor RWJ-270201 and ribavirin.

Journal: Chemotherapy 20020501

Title: Accumulation of defective neuraminidase (NA) genes by influenza A viruses in the presence of NA inhibitors as a marker of reduced dependence on NA.

Journal: The Journal of infectious diseases 20020301

Title: Detection of influenza virus resistance to neuraminidase inhibitors by an enzyme inhibition assay.

Journal: Antiviral research 20020101

Title: RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza.

Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences 20011229

Title: Systematic structure-based design and stereoselective synthesis of novel multisubstituted cyclopentane derivatives with potent antiinfluenza activity.

Journal: Journal of medicinal chemistry 20011206

Title: Characterization of an influenza A (H3N2) virus resistant to the cyclopentane neuraminidase inhibitor RWJ-270201.

Journal: Antiviral research 20011201

Title: Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants.

Journal: Antimicrobial agents and chemotherapy 20011201

Title: Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses.

Journal: Antimicrobial agents and chemotherapy 20011001

Title: Influence of virus strain, challenge dose, and time of therapy initiation on the in vivo influenza inhibitory effects of RWJ-270201.

Journal: Antiviral research 20010901

Title: Primary immune system effects of the orally administered cyclopentane neuraminidase inhibitor RWJ-270201 in influenza virus-infected mice.

Journal: International immunopharmacology 20010601

Title: Comparison of the anti-influenza virus activity of RWJ-270201 with those of oseltamivir and zanamivir.

Journal: Antimicrobial agents and chemotherapy 20010401

Title: Cyclopentane neuraminidase inhibitors with potent in vitro anti-influenza virus activities.

Journal: Antimicrobial agents and chemotherapy 20010301

Title: In vivo influenza virus-inhibitory effects of the cyclopentane neuraminidase inhibitor RJW-270201.

Journal: Antimicrobial agents and chemotherapy 20010301

Title: BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.

Journal: Journal of medicinal chemistry 20000921

Title: Babu YS, et al. BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design. J Med Chem. 2000 Sep 21;43(19):3482-6.

Title: Young D, et al. RWJ-270201 (BCX-1812): a novel neuraminidase inhibitor for influenza. Philos Trans R Soc Lond B Biol Sci. 2001 Dec 29;356(1416):1905-13.

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