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Home Other Building Blocks 1082744-20-4
1082744-20-4,MFCD22665724
Catalog No.:AA008TG4

1082744-20-4 | PF 04447943

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$52.00   $36.00
- +
5mg
≥98%
in stock  
$136.00   $95.00
- +
10mg
≥98%
in stock  
$246.00   $172.00
- +
25mg
≥98%
in stock  
$549.00   $384.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TG4
Chemical Name:
PF 04447943
CAS Number:
1082744-20-4
Molecular Formula:
C20H25N7O2
Molecular Weight:
395.4582
MDL Number:
MFCD22665724
SMILES:
C[C@@H]1CN(C[C@H]1c1nc(=O)c2c([nH]1)n(nc2)C1CCOCC1)Cc1ncccn1
Properties
Computed Properties
 
Complexity:
632  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
1  
Rotatable Bond Count:
4  

Downstream Synthesis Route
936643-80-0   
6-((3S,4S)-4-ethylpyrrolidin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo3,4-dpyrimidin-4(5H)-onehydrochloride 
  1082744-20-4 

[1]Patent:WO2008/139293,2008,A1.Locationinpatent:Page/Pagecolumn129-130

[1]Patent:US2009/30003,2009,A1.Locationinpatent:Page/Pagecolumn53

936643-80-0   
6-(3S,4S)-4-methylpyrrolidin-3-yl-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo3,4-dpyrimidin-4(5H)-onehydrogenchloride 
  1082744-20-4 

[1]JournalofMedicinalChemistry,2012,vol.55,p.9045-9054

[1]JournalofMedicinalChemistry,2012,vol.55,p.9045-9054

[1]JournalofMedicinalChemistry,2012,vol.55,p.9045-9054

Literature

Title: Kleiman RJ, et al. Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo. J Pharmacol Exp Ther. 2012 May;341(2):396-409.

Title: Hutson, P. H, et al. The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo,4-dpyrimidin-4-one) enhances synaptic plasticity and

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SDS
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Tags:1082744-20-4 Molecular Formula|1082744-20-4 MDL|1082744-20-4 SMILES|1082744-20-4 PF 04447943