Home Other Building Blocks 1062243-51-9
1062243-51-9,MFCD22665717
Catalog No.:AA008TGL

1062243-51-9 | Ro 3280

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Purity
Availability
Price(USD)
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1mg
≥98%
in stock  
$48.00   $33.00
- +
5mg
≥98%
in stock  
$196.00   $137.00
- +
10mg
≥98%
in stock  
$363.00   $254.00
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25mg
≥99%
in stock  
$754.00   $528.00
- +
50mg
≥99%
in stock  
$1,154.00   $808.00
- +
100mg
≥99%
in stock  
$1,843.00   $1,290.00
- +
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Downstream Synthesis Route
  • Literature
Technical Information
Catalog Number:
AA008TGL
Chemical Name:
Ro 3280
CAS Number:
1062243-51-9
Molecular Formula:
C27H35F2N7O3
Molecular Weight:
543.6087
MDL Number:
MFCD22665717
SMILES:
COc1cc(ccc1Nc1ncc2c(n1)N(CC(C(=O)N2C)(F)F)C1CCCC1)C(=O)NC1CCN(CC1)C
Properties
Computed Properties
 
Complexity:
868  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
3.5  

Downstream Synthesis Route

[1]BioorganicandMedicinalChemistryLetters,2012,vol.22,p.1247-1250

Literature

Title: Identification of novel, potent and selective inhibitors of Polo-like kinase 1.

Journal: Bioorganic & medicinal chemistry letters 20120115

Title: Wang NN, et al. Molecular targeting of the oncoprotein PLK1 in pediatric acute myeloid leukemia: RO3280, a novel PLK1 inhibitor, induces apoptosis in leukemia cells. Int J Mol Sci. 2015 Jan 7;16(1):1266-92.

Title: Chen S, et al. Identification of novel, potent and selective inhibitors of Polo-like kinase 1. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1247-50.

Title: Zhang Z, et al. Targeted inhibition of Polo-like kinase 1 by a novel small-molecule inhibitor induces mitotic catastrophe and apoptosis in human bladder cancer cells. J Cell Mol Med. 2017 Apr;21(4):758-767.

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SDS
Tags:1062243-51-9 Molecular Formula|1062243-51-9 MDL|1062243-51-9 SMILES|1062243-51-9 Ro 3280