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112457-95-1,MFCD01939743
Catalog No.:AA008TGS

112457-95-1 | SM 3997

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5mg
99%
in stock  
$202.00   $142.00
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10mg
99%
in stock  
$263.00   $184.00
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100mg
95%
in stock  
$295.00   $207.00
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250mg
95%
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$538.00   $377.00
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1g
95%
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$1,268.00   $888.00
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  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TGS
Chemical Name:
SM 3997
CAS Number:
112457-95-1
Molecular Formula:
C27H37N5O9
Molecular Weight:
575.6108
MDL Number:
MFCD01939743
SMILES:
O=C1N(CCCCN2CCN(CC2)c2ncccn2)C(=O)[C@@H]2[C@H]1[C@H]1CC[C@@H]2C1.OC(=O)CC(C(=O)O)(CC(=O)O)O
Properties
Computed Properties
 
Complexity:
799  
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
4  
Rotatable Bond Count:
11  

Literature

Title: Prevention of the phencyclidine-induced impairment in novel object recognition in female rats by co-administration of lurasidone or tandospirone, a 5-HT(1A) partial agonist.

Journal: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120901

Title: 5-HT1A and 5-HT7 receptors contribute to lurasidone-induced dopamine efflux.

Journal: Neuroreport 20120509

Title: Effect of transient blockade of N-methyl-D-aspartate receptors at neonatal stage on stress-induced lactate metabolism in the medial prefrontal cortex of adult rats: role of 5-HT1A receptor agonism.

Journal: Synapse (New York, N.Y.) 20120501

Title: The role of 5-HT1A receptors in phencyclidine (PCP)-induced novel object recognition (NOR) deficit in rats.

Journal: Psychopharmacology 20120501

Title: Differential effects of diazepam, tandospirone, and paroxetine on plasma brain-derived neurotrophic factor level under mental stress.

Journal: Human psychopharmacology 20120501

Title: [Efficacy and safety of tandospirone in the treatment of patients with anxiety disorder].

Journal: Zhonghua yi xue za zhi 20120403

Title: [First death case of serotonin syndrome in Japan induced by fluvoxamine and tandospirone].

Journal: Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology 20111201

Title: Determination of tandospirone in human plasma by a liquid chromatography-tandem mass spectrometry method.

Journal: Analytical and bioanalytical chemistry 20110701

Title: Efficacy of a 5-HT1a receptor agonist in atopic dermatitis.

Journal: Clinical and experimental dermatology 20101201

Title: Difference in the effects of tandospirone on ataxia in various types of spinocerebellar degeneration: an open-label study.

Journal: Cerebellum (London, England) 20101201

Title: Effect of tandospirone on mismatch negativity and cognitive performance in schizophrenia: a case report.

Journal: Journal of clinical psychopharmacology 20101201

Title: Effect of tandospirone, a serotonin-1A receptor partial agonist, on information processing and locomotion in dizocilpine-treated rats.

Journal: Psychopharmacology 20101001

Title: Inhibitory effects of antipsychotic and anxiolytic agents on stress-induced degranulation of mouse dermal mast cells.

Journal: Clinical and experimental dermatology 20100701

Title: The effects of acute treatment with tandospirone, diazepam, and placebo on driving performance and cognitive function in healthy volunteers.

Journal: Human psychopharmacology 20100401

Title: Efficacy of the 5-HT1A agonist tandospirone citrate in improving symptoms of patients with functional dyspepsia: a randomized controlled trial.

Journal: The American journal of gastroenterology 20091101

Title: Effects of tandospirone, a 5-HT1A agonistic anxiolytic agent, on haloperidol-induced catalepsy and forebrain Fos expression in mice.

Journal: Journal of pharmacological sciences 20090401

Title: Rebound insomnia induced by abrupt withdrawal of hypnotics in sleep-disturbed rats.

Journal: European journal of pharmacology 20081112

Title: Serotonin1A receptors in the pathophysiology of schizophrenia: development of novel cognition-enhancing therapeutics.

Journal: Advances in therapy 20081001

Title: Pharmacokinetic interaction between tandospirone and fluvoxamine in the rat contextual conditioned fear stress model and its functional consequence: Involvement of cytochrome P450 3A4.

Journal: Psychiatry and clinical neurosciences 20081001

Title: Evaluation of the antibradykinetic actions of 5-HT1A agonists using the mouse pole test.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20080701

Title: Effects of selective 5-HT1A agonist tandospirone on the rate and rhythmicity of binocular rivalry.

Journal: Psychopharmacology 20080601

Title: Opposite effects of SSRIs and tandospirone in the treatment of REM sleep behavior disorder.

Journal: Sleep medicine 20080301

Title: Successful treatment of blepharospasm with tandospirone, a 5-HT1A partial agonist: a case report.

Journal: Movement disorders : official journal of the Movement Disorder Society 20080101

Title: Synergistic effects of tandospirone and selective serotonin reuptake inhibitors on the contextual conditioned fear stress response in rats.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20071001

Title: Effect of buspirone, a serotonin1A partial agonist, on cognitive function in schizophrenia: a randomized, double-blind, placebo-controlled study.

Journal: Schizophrenia research 20070901

Title: Effect of tandospirone on sleep latency in rats placed on a grid suspended over water.

Journal: Journal of pharmacological sciences 20070901

Title: Effects of cytochrome P450 (CYP) 3A4 inhibitors on the anxiolytic action of tandospirone in rat contextual conditioned fear.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070509

Title: Effective adjunctive use of tandospirone with perospirone for enhancing verbal memory and quality of life in schizophrenia.

Journal: Progress in neuro-psychopharmacology & biological psychiatry 20070509

Title: A preliminary open-label study of 5-HT1A partial agonist tandospirone for behavioural and psychological symptoms associated with dementia.

Journal: The international journal of neuropsychopharmacology 20070401

Title: Paroxetine-induced bruxism effectively treated with tandospirone.

Journal: The Journal of neuropsychiatry and clinical neurosciences 20070101

Title: Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20070101

Title: Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.

Journal: European journal of drug metabolism and pharmacokinetics 20070101

Title: Use of a serotonin 1A receptor agonist to treat restless legs syndrome.

Journal: Journal of clinical psychopharmacology 20061201

Title: Tandospirone, a 5-HT1A agonist, ameliorates movement disorder via non-dopaminergic systems in rats with unilateral 6-hydroxydopamine-generated lesions.

Journal: Brain research 20060927

Title: The pharmacokinetics and pharmacodynamics of tandospirone in rats exposed to conditioned fear stress.

Journal: European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701

Title: Effects of itraconazole and tandospirone on the pharmacokinetics of perospirone.

Journal: Therapeutic drug monitoring 20060201

Title: Synthesis of some n-substituted derivatives of 1-(1h-pyrrole-1 -ylmethyl)- 10-oxa-4-azatricyclo [5.2.1.0(2,6)]dec-8-ene-3,5-dione with an expected anxiolytic activity.

Journal: Acta poloniae pharmaceutica 20060101

Title: Usefulness of famotidine in functional dyspepsia patient treatment: comparison among prokinetic, acid suppression and antianxiety therapies.

Journal: Alimentary pharmacology & therapeutics 20050601

Title: Effects of famotidine, mosapride and tandospirone for treatment of functional dyspepsia.

Journal: Alimentary pharmacology & therapeutics 20050601

Title: Tandospirone activates neuroendocrine and ERK (MAP kinase) signaling pathways specifically through 5-HT1A receptor mechanisms in vivo.

Journal: Naunyn-Schmiedeberg's archives of pharmacology 20050101

Title: Although antidepressants and anxiolytics are frequently used together to treat depression in the acute phase, how effective is the concomitant use of these drugs?

Journal: Journal of psychiatry & neuroscience : JPN 20041101

Title: Antianxiety and antidepressant-like effects of AC-5216, a novel mitochondrial benzodiazepine receptor ligand.

Journal: British journal of pharmacology 20040801

Title: Serotonin 1A receptors in memory function.

Journal: The American journal of psychiatry 20040801

Title: [Postherpetic neuralgia alleviated by an SSRI fluvoxamine: two cases of PHN accompanied with depression were treated with fluvoxamine].

Journal: Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20040401

Title: [Dementia induced by antianxiety drugs].

Journal: Nihon rinsho. Japanese journal of clinical medicine 20040101

Title: Effects of tandospirone on '5-HT1A receptor-associated symptoms' in patients with Machado-Josephe disease: an open-label study.

Journal: Clinical neuropharmacology 20040101

Title: Oral tandospirone and clonidine provide similar relief of preoperative anxiety.

Journal: Canadian journal of anaesthesia = Journal canadien d'anesthesie 20040101

Title: [Hippocampal serotonin 1A receptor and memory function].

Journal: Seishin shinkeigaku zasshi = Psychiatria et neurologia Japonica 20040101

Title: 'Drug holiday' effects of tandospirone in a patient with Machado-Joseph disease.

Journal: Psychiatry and clinical neurosciences 20031201

Title: Clinical efficacy of tandospirone augmentation in patients with major depressive disorder: a randomized controlled trial.

Journal: Psychiatry and clinical neurosciences 20030401

Title: Inhibitory effect of hippocampal 5-HT1A receptors on human explicit memory.

Journal: The American journal of psychiatry 20030201

Title: [Pharmacology of anxiolytics and their therapeutic use].

Journal: Ryoikibetsu shokogun shirizu 20030101

Title: [Organic anxiety disorder].

Journal: Ryoikibetsu shokogun shirizu 20030101

Title: In vivo drug action of tandospirone at 5-HT1A receptor examined using positron emission tomography and neuroendocrine response.

Journal: Psychopharmacology 20021201

Title: Prevention of nausea and vomiting with tandospirone in adults after tympanoplasty.

Journal: Anesthesia and analgesia 20021101

Title: Effects of serotonin 1A agonist on acute spinal cord injury.

Journal: Spinal cord 20021001

Title: [Serotonin syndrome caused by tandospirone citrate alone].

Journal: Rinsho shinkeigaku = Clinical neurology 20020901

Title: Effectiveness of serotonin (5-HT)1A receptor agonist in a patient with psychogenic apneusis.

Journal: Journal of clinical psychopharmacology 20020601

Title: Effect of serotonin 1A agonist tandospirone on depression symptoms in senile patients with dementia.

Journal: Human psychopharmacology 20020601

Title: Beneficial effects of tandospirone on ataxia of a patient with Machado-Joseph disease.

Journal: Psychiatry and clinical neurosciences 20020401

Title: [Tandospirone citrate, a selective 5-HT1A agonist, alleviates L-DOPA-induced dyskinesia in patients with Parkinson's disease].

Journal: No to shinkei = Brain and nerve 20020201

Title: [Clinical effectiveness of tandospirone citrate (5-HT1A agonist) on patients with progressive supranuclear palsy].

Journal: Rinsho shinkeigaku = Clinical neurology 20020101

Title: The anxiolytic effects of the 5-hydroxytryptamine-1A agonist tandospirone before otolaryngologic surgery.

Journal: Anesthesia and analgesia 20011101

Title: [Successful treatment of emotional disturbances following non-herpetic limbic encephalitis by serotonergic agents. A case report].

Journal: Rinsho shinkeigaku = Clinical neurology 20011101

Title: Enhancement of cognitive performance in schizophrenia by addition of tandospirone to neuroleptic treatment.

Journal: The American journal of psychiatry 20011001

Title: Inhibitory effects of tandospirone, a 5-HT1A agonist, on medial vestibular nucleus neurons responding to lateral roll tilt stimulation in rats.

Journal: Brain research 20010810

Title: Effects of tandospirone, a serotonin-1A agonist, on the hypothalamo-pituitary-gonadal axis of male patients.

Journal: Neuro endocrinology letters 20010801

Title: Conformational analysis of tandospirone in aqueous solution: lead evolution of potent dopamine D4 receptor ligands.

Journal: Bioorganic & medicinal chemistry letters 20010507

Title: Gynecomastia induced by treatment with tandospirone, a 5-HT1A agonist.

Journal: Journal of psychiatry & neuroscience : JPN 20010301

Title: Possible mild serotonin syndrome related to co-prescription of tandospirone and trazodone.

Journal: General hospital psychiatry 20010101

Title: Alpha 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse forced swimming.

Journal: Methods and findings in experimental and clinical pharmacology 20010101

Title: Amelioration of frozen gait by tandospirone, a serotonin 1A agonist, in a patient with pure akinesia developing resistance to L-threo-3,4-dihydroxyphenylserine.

Journal: Clinical neuropharmacology 20010101

Title: [A case of progressive supranuclear palsy improved with tandospirone citrate].

Journal: Rinsho shinkeigaku = Clinical neurology 20010101

Title: Different effects of anxiolytic agents, diazepam and 5-HT(1A) agonist tandospirone, on hippocampal long-term potentiation in vivo.

Journal: Pharmacology, biochemistry, and behavior 20010101

Title: Involvement of 5-hydroxytryptamine(1A) receptors in nicotine-induced tail tremor in rats.

Journal: European journal of pharmacology 20001110

Title: Hamik A, et al. Analysis of tandospirone (SM-3997) interactions with neurotransmitter receptor binding sites. Biol Psychiatry. 1990 Jul 15;28(2):99-109.

Title: Shimizu H, et al. Characterization of the putative anxiolytic SM-3997 recognition sites in rat brain. Life Sci. 1988;42(24):2419-27.

Title: Uehara T, et al. Chronic treatment with tandospirone, a 5-HT1A receptor partial agonist, suppresses footshock stress-induced lactate production in the prefrontal cortex of rats. Pharmacol Biochem Behav. 2013 Nov 15;113:1-6.

Title: Ohmura Y, et al. Tandospirone suppresses impulsive action by possible blockade of the 5-HT1A receptor. J Pharmacol Sci. 2013;122(2):84-92.

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