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1005780-62-0,MFCD23160045
Catalog No.:AA008TH0

1005780-62-0 | TAK-593

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
95%
1 week  
$108.00   $76.00
- +
5mg
95%
1 week  
$170.00   $119.00
- +
10mg
95%
1 week  
$254.00   $178.00
- +
25mg
95%
1 week  
$445.00   $312.00
- +
50mg
95%
1 week  
$658.00   $460.00
- +
100mg
95%
1 week  
$925.00   $648.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008TH0
Chemical Name:
TAK-593
CAS Number:
1005780-62-0
Molecular Formula:
C23H23N7O3
Molecular Weight:
445.4738
MDL Number:
MFCD23160045
SMILES:
Cc1cc(n(n1)C)C(=O)Nc1cc(ccc1C)Oc1ccc2n(n1)cc(n2)NC(=O)C1CC1
Properties
Computed Properties
 
Complexity:
735  
Covalently-Bonded Unit Count:
1  
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
2  
Rotatable Bond Count:
6  
XLogP3:
2.4  

Literature

Title: Vascular endothelial growth factor (VEGF) receptors: drugs and new inhibitors.

Journal: Journal of medicinal chemistry 20121227

Title: Biochemical characterization of TAK-593, a novel VEGFR/PDGFR inhibitor with a two-step slow binding mechanism.

Journal: Biochemistry 20110208

Title: Miyamoto N, et al. Discovery of N--({2-[(cyclopropylcarbonyl)aminoimidazo,2-bpyridazin-6-yl}oxy)-2-methylphenyl-1,3-dimethyl-1H-pyrazole-5-carboxamide (TAK-593), a highly potent VEGFR2 kinase inhibitor. Bioorg Med Chem. 2013 Apr 15;21(8):2333-2345.

Title: Awazu Y, et al. Anti-angiogenic and anti-tumor effects of TAK-593, a potent and selective inhibitor of vascular endothelial growth factor and platelet-derived growth factor receptor tyrosine kinase. Cancer Sci. 2013 Apr;104(4):486-94.

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