Name: Name:HO-3867
Brand: AABLOCKS
SKU: AA008TM9
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008TM9

Chemical Name: HO-3867

CAS Number: 1172133-28-6

Molecular Formula: C28H30F2N2O2

Molecular Weight: 464.5468

MDL Number: MFCD28143913

SMILES: Fc1ccc(cc1)/C=C/1\CN(C/C(=C\c2ccc(cc2)F)/C1=O)CC1=CC(N(C1(C)C)O)(C)C

Properties

Complexity: 816

Covalently-Bonded Unit Count: 1

Defined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 2

Formal Charge: 0

Heavy Atom Count: 34

Hydrogen Bond Acceptor Count: 6

Hydrogen Bond Donor Count: 1

Isotope Atom Count: 0

Rotatable Bond Count: 4

Undefined Atom Stereocenter Count: 0

Undefined Bond Stereocenter Count: 0

XLogP3: 4.1

Downstream Synthesis Route

1172133-28-6

1-(1-oxyl-2,2,5,5-tetramethyl-2,5-dihydro-1H-pyrrol-3-yl)methyl-(3E,5E)-3,5-bis(4-fluorobenzylidene)piperidin-4-onehydrochloride

[1]Patent:US8722707,2014,B1.Locationinpatent:Page/Pagecolumn8

Literature fold

Title: HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells.

Journal: Cancer biology & therapy20120701

Title: Amelioration of doxorubicin-induced cardiotoxicity by an anticancer-antioxidant dual-function compound, HO-3867.

Journal: The Journal of pharmacology and experimental therapeutics20111101

Title: HO-3867, a curcumin analog, sensitizes cisplatin-resistant ovarian carcinoma, leading to therapeutic synergy through STAT3 inhibition.

Journal: Cancer biology & therapy20111101

Title: Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.

Journal: Cancer biology & therapy20101115

Title: HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.

Journal: Molecular cancer research : MCR20100901

Title: Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.

Journal: Molecular cancer therapeutics20100501

Title: Inhibition of vascular smooth-muscle cell proliferation and arterial restenosis by HO-3867, a novel synthetic curcuminoid, through up-regulation of PTEN expression.

Journal: The Journal of pharmacology and experimental therapeutics20090601

Title: Rath KS et al. HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer. Cancer Res. 2014 Apr 15;74(8):2316-27.

Title: Hu Y, et al. A novel STAT3 inhibitor HO-3867 induces cell apoptosis by reactive oxygen species-dependent endoplasmic reticulum stress in human pancreatic cancer cells. Anticancer Drugs. 2017 Apr;28(4):392-400.

Title: Tierney BJ et al. HO-3867, a STAT3 inhibitor induces apoptosis by inactivation of STAT3 activity in BRCA1-mutated ovarian cancer cells. Cancer Biol Ther. 2012 Jul;13(9):766-75

1172133-28-6 | HO-3867