Name: Name:Mirin
Brand: AABLOCKS
SKU: AA008TMF
Rating: 90 (10 reviews)

Technical Information

Catalog Number: AA008TMF

Chemical Name: Mirin

CAS Number: 1198097-97-0

Molecular Formula: C10H8N2O2S

Molecular Weight: 220.2477

MDL Number: MFCD05885480

SMILES: O=C1NC(=N)S/C/1=C\c1ccc(cc1)O

Properties

Complexity: 330

Covalently-Bonded Unit Count: 1

Defined Bond Stereocenter Count: 1

Heavy Atom Count: 15

Hydrogen Bond Acceptor Count: 3

Hydrogen Bond Donor Count: 2

Rotatable Bond Count: 1

XLogP3: 1.5

Literature fold

Title: Mre11-dependent degradation of stalled DNA replication forks is prevented by BRCA2 and PARP1.

Journal: Cancer research20120601

Title: ATM regulates Mre11-dependent DNA end-degradation and microhomology-mediated end joining.

Journal: Cell cycle (Georgetown, Tex.)20100715

Title: FANCD2: A DNA binding protein regulated by MRE11-RAD50-NBS1.

Journal: Cell cycle (Georgetown, Tex.)20100115

Title: Discovery of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione, a readily available and orally active glitazone for the treatment of concanavalin A-induced acute liver injury of BALB/c mice.

Journal: Journal of medicinal chemistry20100114

Title: Role of Mre11 in chromosomal nonhomologous end joining in mammalian cells.

Journal: Nature structural & molecular biology20090801

Title: Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex.

Journal: Nature chemical biology20090301

Title: A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex.

Journal: Nature chemical biology20080201

Title: Small molecule versus DNA repair nanomachine.

Journal: Nature chemical biology20080201

Title: Rozier L, et al. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107.

Title: Lee JH, et al. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J Biol Chem. 2013 May 3;288(18):12840-51.

Title: Garner KM, et al. Corrected structure of Mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2009 Mar;5(3):129-30.

1198097-97-0 | Mirin