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1071992-99-8,MFCD22124467
Catalog No.:AA008WG6

1071992-99-8 | AT406

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥95%
in stock  
$82.00   $57.00
- +
25mg
98%
in stock  
$208.00   $146.00
- +
100mg
95%
in stock  
$693.00   $485.00
- +
1g
97%
in stock  
$6,064.00   $4,245.00
- +
  • Technical Information
  • Properties
  • Literature
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  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA008WG6
Chemical Name:
AT406
CAS Number:
1071992-99-8
Molecular Formula:
C32H43N5O4
Molecular Weight:
561.7149
MDL Number:
MFCD22124467
SMILES:
CN[C@H](C(=O)N[C@H]1CN(CC[C@@H]2N(C1=O)[C@@H](CC2)C(=O)NC(c1ccccc1)c1ccccc1)C(=O)CC(C)C)C
Properties
Computed Properties
 
Complexity:
896  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Rotatable Bond Count:
9  
XLogP3:
3.1  

Literature

Title: A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment.

Journal: Journal of medicinal chemistry 20110428

Title: Mechanisms of drug sensitization to TRA-8, an agonistic death receptor 5 antibody, involve modulation of the intrinsic apoptotic pathway in human breast cancer cells.

Journal: Molecular cancer research : MCR 20110401

Title: Cai Q, Sun H, Peng Y, et al. A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011;54(8):2714-2726.

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SDS
Tags:1071992-99-8 Molecular Formula|1071992-99-8 MDL|1071992-99-8 SMILES|1071992-99-8 AT406