Home Other Building Blocks 127060-75-7
127060-75-7,MFCD00133611
Catalog No.:AA009AB2

127060-75-7 | CGP 42112

Pack Size
Purity
Availability
Price(USD)
Quantity
  
1mg
≥98%
in stock  
$218.00   $152.00
- +
5mg
≥98%
in stock  
$959.00   $671.00
- +
10mg
≥98%
in stock  
$1,720.00   $1,204.00
- +
  • Technical Information
  • Properties
  • Literature
  • Request for Quotation
  • Download SDS
  • Technical Information
  • Properties
  • Literature
Technical Information
Catalog Number:
AA009AB2
Chemical Name:
CGP 42112
CAS Number:
127060-75-7
Molecular Formula:
C52H69N13O11
Molecular Weight:
1052.1848
MDL Number:
MFCD00133611
SMILES:
CC[C@@H]([C@@H](C(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)c1cccnc1)Cc1ccc(cc1)O)CCCCNC(=O)[C@@H](NC(=O)OCc1ccccc1)CCCNC(=N)N)Cc1nc[nH]c1)C
Properties
Computed Properties
 
Complexity:
1930  
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
7  
Heavy Atom Count:
76  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
11  
Rotatable Bond Count:
30  
XLogP3:
2.2  

Literature

Title: Angiotensin AT2 receptor stimulation inhibits activation of NADPH oxidase and ameliorates oxidative stress in rotenone model of Parkinson's disease in CATH.a cells.

Journal: Neurotoxicology and teratology 20150101

Title: Angiotensin II type 2 receptor-mediated inhibition of NaCl absorption is blunted in thick ascending limbs from Dahl salt-sensitive rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20120901

Title: Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.

Journal: Regulatory peptides 20120820

Title: Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.

Journal: Pharmacological research 20120701

Title: Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.

Journal: American journal of physiology. Heart and circulatory physiology 20120615

Title: Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.

Journal: Journal of hypertension 20120601

Title: Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.

Journal: Clinical science (London, England : 1979) 20111001

Title: Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats.

Journal: American journal of physiology. Heart and circulatory physiology 20111001

Title: Altered efficacy of AT1R-targeted treatment after spontaneous cancer cell-AT1R upregulation.

Journal: BMC cancer 20110101

Title: Inhibition of NAD(P)H oxidase potentiates AT2 receptor agonist-induced natriuresis in Sprague-Dawley rats.

Journal: American journal of physiology. Renal physiology 20101001

Title: Angiotensin III modulates the nociceptive control mediated by the periaqueductal gray matter.

Journal: Neuroscience 20091215

Title: Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats.

Journal: American journal of physiology. Heart and circulatory physiology 20090301

Title: Imbalance of angiotensin type 1 receptor and angiotensin II type 2 receptor in the rostral ventrolateral medulla: potential mechanism for sympathetic overactivity in heart failure.

Journal: Hypertension (Dallas, Tex. : 1979) 20081001

Title: Angiotensin II upregulates acyl-CoA:cholesterol acyltransferase-1 via the angiotensin II Type 1 receptor in human monocyte-macrophages.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20080901

Title: Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.

Journal: Journal of cardiovascular pharmacology 20080801

Title: Angiotensin (1-7) reduces intraocular pressure in the normotensive rabbit eye.

Journal: Investigative ophthalmology & visual science 20080601

Title: Vasopressin and angiotensin receptors of the medial septal area of the brain in the control of thirst and salt appetite induced by vasopressin in water-deprived and sodium-depleted rats.

Journal: Pharmacology, biochemistry, and behavior 20071001

Title: Angiotensin II type 2 receptor vasoactivity in internal mammary arteries of patients with coronary artery disease.

Journal: Journal of cardiovascular pharmacology 20071001

Title: Angiotensin II-induced neural differentiation via angiotensin II type 2 (AT2) receptor-MMS2 cascade involving interaction between AT2 receptor-interacting protein and Src homology 2 domain-containing protein-tyrosine phosphatase 1.

Journal: Molecular endocrinology (Baltimore, Md.) 20070201

Title: Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway.

Journal: American journal of physiology. Renal physiology 20060601

Title: Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20060601

Title: Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance.

Journal: Metabolism: clinical and experimental 20060401

Title: A non-radioactive method for angiotensin II receptor binding studies using the rat liver.

Journal: Journal of pharmacological and toxicological methods 20060101

Title: Dynamic expression of the angiotensin II type 2 receptor and duodenal mucosal alkaline secretion in the Sprague-Dawley rat.

Journal: Experimental physiology 20060101

Title: Opposing actions of angiotensin II type 1 and 2 receptors on plasma cholesterol levels in rats.

Journal: Journal of hypertension 20060101

Title: Interaction between arginine vasopressin and angiotensin II receptors in the central regulation of sodium balance.

Journal: Regulatory peptides 20051215

Title: Reversal of fructose-induced hypertension and insulin resistance by chronic losartan treatment is independent of AT2 receptor activation in rats.

Journal: Journal of hypertension 20051201

Title: Nitric oxide contributes to AT2 but not AT1 angiotensin II receptor-mediated vasodilatation of porcine pial arteries and arterioles.

Journal: European journal of pharmacology 20051121

Title: The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice.

Journal: Journal of cardiovascular pharmacology 20050901

Title: Angiotensin II infusion increases hepatic triglyceride production via its type 2 receptor in rats.

Journal: Journal of hypertension 20050801

Title: Angiotensin II increases human monocyte matrix metalloproteinase-1 through the AT2 receptor and prostaglandin E2: implications for atherosclerotic plaque rupture.

Journal: Journal of leukocyte biology 20050701

Title: Taurine may prevent diabetic rats from developing cardiomyopathy also by downregulating angiotensin II type2 receptor expression.

Journal: Cardiovascular drugs and therapy 20050301

Title: Renal angiotensin II type-2 receptors are upregulated and mediate the candesartan-induced natriuresis/diuresis in obese Zucker rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20050201

Title: A new role for the renin-angiotensin system in the rat periaqueductal gray matter: angiotensin receptor-mediated modulation of nociception.

Journal: Neuroscience 20050101

Title: Minocycline treatment attenuates microglia activation and non-angiotensin II [125I] CGP42112 binding in brainstem following nodose ganglionectomy.

Journal: Neuroscience 20050101

Title: AT2 receptor-mediated vasodilatation is unmasked by AT1 receptor blockade in conscious SHR.

Journal: British journal of pharmacology 20040701

Title: Effects of angiotensin and vasopressin V(1) receptors on water and sodium intake induced by injection of vasopressin into lateral septal area.

Journal: Regulatory peptides 20040515

Title: Influence of arginine vasopressin receptors and angiotensin receptor subtypes on the water intake and arterial blood pressure induced by vasopressin injected into the lateral septal area of the rat.

Journal: Autonomic neuroscience : basic & clinical 20040331

Title: Regulation of inhibitory protein-kappaB and monocyte chemoattractant protein-1 by angiotensin II type 2 receptor-activated Src homology protein tyrosine phosphatase-1 in fetal vascular smooth muscle cells.

Journal: Molecular endocrinology (Baltimore, Md.) 20040301

Title: Effects of subtypes of adrenergic and angiotensinergic antagonists on the water and sodium intake induced by adrenaline injected into the paraventricular nucleus.

Journal: Brain research 20031224

Title: Angiotensin II mediates Tyr-dephosphorylation in rat fetal kidney membranes.

Journal: Molecular and cellular biochemistry 20031201

Title: Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells.

Journal: Hypertension research : official journal of the Japanese Society of Hypertension 20031101

Title: Effects of V1 and angiotensin receptor subtypes of the paraventricular nucleus on the water intake induced by vasopressin injected into the lateral septal area.

Journal: Brain research bulletin 20030930

Title: Angiotensin II type 2 receptor inhibits vascular endothelial growth factor-induced migration and in vitro tube formation of human endothelial cells.

Journal: Circulation research 20030905

Title: Disparate roles of AT2 receptors in the renal cortical and medullary circulations of anesthetized rabbits.

Journal: Hypertension (Dallas, Tex. : 1979) 20030801

Title: Angiotensin II and III microinjections into the zona incerta influence drinking behavior.

Journal: Brain research 20030711

Title: Localization of AT(2) receptors in the nucleus of the solitary tract of spontaneously hypertensive and Wistar Kyoto rats using [125I] CGP42112: upregulation of a non-angiotensin II binding site following unilateral nodose ganglionectomy.

Journal: Brain research 20030404

Title: The angiotensin II receptor type 2 agonist CGP 42112A stimulates NO production in the porcine jejunal mucosa.

Journal: BMC pharmacology 20030101

Title: AT2 receptor-mediated relaxation is preserved after long-term AT1 receptor blockade.

Journal: Hypertension (Dallas, Tex. : 1979) 20021001

Title: Binding of KRH-594, an antagonist of the angiotensin II type 1 receptor, to cloned human and rat angiotensin II receptors.

Journal: Fundamental & clinical pharmacology 20020801

Title: Effects of angiotensin II microinjected into medial amygdala on male sexual behavior in rats.

Journal: Hormones and behavior 20020501

Title: Angiotensin II stimulation of Na+/K+ATPase activity and cell growth by calcium-independent pathway in MCF-7 breast cancer cells.

Journal: The Journal of endocrinology 20020501

Title: Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats.

Journal: Hypertension (Dallas, Tex. : 1979) 20011201

Title: Angiotensin II enhances noradrenaline release from sympathetic nerves of the rat prostate via a novel angiotensin receptor: implications for the pathophysiology of benign prostatic hyperplasia.

Journal: The Journal of endocrinology 20011001

Title: Differential regulation of thrombospondin-1 and fibronectin by angiotensin II receptor subtypes in cultured endothelial cells.

Journal: Cardiovascular research 20010901

Title: Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure.

Journal: Hypertension (Dallas, Tex. : 1979) 20010901

Title: Identification of angiotensin II type 2 (AT2) receptor domains mediating high-affinity CGP 42112A binding and receptor activation.

Journal: The Journal of pharmacology and experimental therapeutics 20010801

Title: Activation of angiotensin II subtype 2 receptor induces catecholamine release in an extracellular Ca(2+)-dependent manner through a decrease of cyclic guanosine 3',5'-monophosphate production in cultured porcine adrenal medullary chromaffin Cells.

Journal: Endocrinology 20010701

Title: Angiotensin II type 2 receptor-mediated duodenal mucosal alkaline secretion in the rat.

Journal: American journal of physiology. Gastrointestinal and liver physiology 20010601

Title: Vascular expression of angiotensin type 2 receptor in the adult rat: influence of angiotensin II infusion.

Journal: Journal of hypertension 20010601

Title: Intracellular Angiotensin II and cell growth of vascular smooth muscle cells.

Journal: British journal of pharmacology 20010401

Title: Angiotensin type 2 receptor is expressed in the adult rat kidney and promotes cellular proliferation and apoptosis.

Journal: Kidney international 20001201

Title: Human angiotensin receptor subtypes.

Journal: Current opinion in nephrology and hypertension 19940101

Title: Radioiodinated CGP 42112A: a novel high affinity and highly selective ligand for the characterization of angiotensin AT2 receptors.

Journal: Biochemical and biophysical research communications 19911231

Title: Preliminary biochemical characterization of two angiotensin II receptor subtypes.

Journal: Biochemical and biophysical research communications 19890830

Title: Takekoshi K, et al. Angiotensin-II subtype 2 receptor agonist (CGP-42112) inhibits catecholamine biosynthesis in cultured porcine adrenal medullary chromaffin cells. Biochem Biophys Res Commun. 2000 Jun 7;272(2):544-50.

Title: Speth RC. 25ICGP 42112 binding reveals differences between rat brain and adrenal AT2 receptor binding sites. Regul Pept. 1993 Mar 19;44(2):189-97.

Title: Naveri L, et al. Angiotensin II AT2 receptor stimulation extends the upper limit of cerebral blood flow autoregulation: agonist effects of CGP 42112 and PD 123319. J Cereb Blood Flow Metab. 1994 Jan;14(1):38-44.

Title: Heemskerk FM, et al. Quantitative autoradiography of angiotensin II AT2 receptors with 25ICGP 42112. Brain Res. 1995 Apr 17;677(1):29-38.

Quotation Request
Company Name:
*
Contact Person:
*
Email:
*
Quantity Required:
*
Country:
Additional Info:
SDS
Related Products of 127060-75-7
Tags:127060-75-7 Molecular Formula|127060-75-7 MDL|127060-75-7 SMILES|127060-75-7 CGP 42112